TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited

Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · see citing works

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint

Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413 · see citing works

Models, mechanisms and clinical evidence for cancer dormancy

Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,673 · see citing works

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,600 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

Aslakson, C. J., & Miller, F. R. (1992) · PubMed · Cited by 1,234 · see citing works

Systemic Spread Is an Early Step in Breast Cancer

Hüsemann, Y., Geigl, J. B., Schubert, F., Musiani, P., Meyer, M., Burghart, E., Forni, G., Eils, R., Fehm, T. N., Riethmüller, G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.003 · Cited by 1,175 · see citing works

The perivascular niche regulates breast tumour dormancy

Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148 · see citing works

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

Padua, D. M., Zhang, X. H.-F., Wang, Q., Nadal, C., Gerald, W. L., Gomis, R. R., & Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.01.046 · Cited by 947 · see citing works

Betaglycan presents ligand to the TGFβ signaling receptor

López‐Casillas, F., Wrana, J. L., & Massagué, J. (1993) · Cell · doi:10.1016/0092-8674(93)90368-z · Cited by 892 · see citing works

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

Cheifetz, S., Weatherbee, J. A., Tsang, M., Anderson, J. K., Mole, J. E., Lucas, R., & Massagué, J. (1987) · Cell · doi:10.1016/0092-8674(87)90192-9 · Cited by 701 · see citing works

Antibodies to plasminogen activator inhibit human tumor metastasis

Ossowski, L., & Reich, E. (1983) · Cell · doi:10.1016/0092-8674(83)90093-4 · Cited by 634 · see citing works

Chromatin-modifying enzymes as modulators of reprogramming

Önder, T. T., Kara, N., Cherry, A. B. C., Sinha, A. U., Zhu, N., Bernt, K. M., Cahan, P., Mancarci, B. O., Unternaehrer, J., Gupta, P. B., et al. (2012) · Nature · doi:10.1038/nature10953 · Cited by 627 · see citing works

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Sorrentino, A., Thakur, N., Grimsby, S., Marcusson, A., von Bülow, V., Schuster, N., Zhang, S., Heldin, C., & Landström, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1780 · Cited by 553 · see citing works

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

Kim, J., Yu, W., Kovalski, K., & Ossowski, L. (1998) · Cell · doi:10.1016/s0092-8674(00)81478-6 · Cited by 468 · see citing works

ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)

Aguirre‐Ghiso, J. A., Estrada, Y. D., Liu, D., & Ossowski, L. (2004) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2003.12.012 · Cited by 465 · see citing works

Urokinase Receptor and Fibronectin Regulate the ERKMAPK to p38MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo

Aguirre‐Ghiso, J. A., Liu, D., Mignatti, A., Kovalski, K., & Ossowski, L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.4.863 · Cited by 447 · see citing works

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Gao, H., Chakraborty, G., Lee-Lim, A. P., Mo, Q., Decker, M., Vonica, A., Shen, R., Brogi, E., Brivanlou, A. H., & Giancotti, F. G. (2012) · Cell · doi:10.1016/j.cell.2012.06.035 · Cited by 430 · see citing works

Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone

Kobayashi, A., Okuda, H., Xing, F., Pandey, P. R., Watabe, M., Hirota, S., Pai, S. K., Liu, W., Fukuda, K., Chambers, C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110840 · Cited by 428 · see citing works

Incidence and Sites of Distant Metastases from Head and Neck Cancer

Ferlito, A., Shaha, A. R., Silver, C. E., Rinaldo, A., & Mondin, V. (2001) · ORL · doi:10.1159/000055740 · Cited by 386 · see citing works

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

Brown, C. B., Boyer, A. S., Runyan, R. B., & Barnett, J. V. (1999) · Science · doi:10.1126/science.283.5410.2080 · Cited by 383 · see citing works

ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK).

Aguirre‐Ghiso, J. A., Estrada, Y. D., Liu, D., & Ossowski, L. (2003) · PubMed · Cited by 350 · see citing works

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms

Cheifetz, S., Hernandez, H., Laiho, M., ten Dijke, P., Iwata, K. K., & Massagué, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30535-5 · Cited by 348 · see citing works

Functional Coupling of p38-Induced Up-regulation of BiP and Activation of RNA-Dependent Protein Kinase–Like Endoplasmic Reticulum Kinase to Drug Resistance of Dormant Carcinoma Cells

Ranganathan, A. C., Zhang, L., Adam, A. P., & Aguirre‐Ghiso, J. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3092 · Cited by 331 · see citing works

TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

Yamazaki, S., Iwama, A., Takayanagi, S., Eto, K., Ema, H., & Nakauchi, H. (2008) · Blood · doi:10.1182/blood-2008-04-146480 · Cited by 327 · see citing works

The “seed and soil” hypothesis revisited

Fidler, I. J., & Poste, G. H. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70201-8 · Cited by 319 · see citing works

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

Shiozawa, Y., Pedersen, E. A., Patel, L. R., Ziegler, A. M., Havens, A. M., Jung, Y., Wang, J., Zalucha, S., Loberg, R. D., Pienta, K. J., et al. (2010) · Neoplasia · doi:10.1593/neo.91384 · Cited by 317 · see citing works

Review: Biological relevance of disseminated tumor cells in cancer patients

Riethdorf, S., Wikman, H., & Pantel, K. (2008) · International Journal of Cancer · doi:10.1002/ijc.23825 · Cited by 310 · see citing works

The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151

Zijlstra, A., Lewis, J. D., Degryse, B., Stuhlmann, H., & Quigley, J. P. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.031 · Cited by 250 · see citing works

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

Montagner, M., Enzo, E., Forcato, M., Zanconato, F., Parenti, A. R., Rampazzo, E., Basso, G., Leo, G., Rosato, A., Bicciato, S., et al. (2012) · Nature · doi:10.1038/nature11207 · Cited by 247 · see citing works

The type III TGF-β receptor suppresses breast cancer progression

Dong, M., How, T., Kirkbride, K. C., Gordon, K. J., Lee, J. D., Hempel, N., Kelly, P., Moeller, B. J., Marks, J. R., & Blobe, G. C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29293 · Cited by 246 · see citing works

Transplantable human neoplasms maintained in cortisone-treated laboratory animals: H.S. No. 1; H.Ep. No. 1; H.Ep. No. 2; H.Ep. No. 3; and H.Emb.Rh. No. 1.

Toolan, H. W. (1954) · PubMed · Cited by 231 · see citing works

Dormancy Signatures and Metastasis in Estrogen Receptor Positive and Negative Breast Cancer

Kim, R. S., Avivar‐Valderas, A., Estrada, Y. D., Bragado, P., Sosa, M. S., Aguirre‐Ghiso, J. A., & Segall, J. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035569 · Cited by 212 · see citing works

A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction.

Zijlstra, A., Mellor, R. L., Panzarella, G., Aimes, R. T., Hooper, J. D., Marchenko, N. D., & Quigley, J. P. (2002) · PubMed · Cited by 207 · see citing works

Framework models of tumor dormancy from patient-derived observations

Klein, C. A. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.011 · Cited by 207 · see citing works

The Type III Transforming Growth Factor-β Receptor as a Novel Tumor Suppressor Gene in Prostate Cancer

Turley, R. S., Finger, E. C., Hempel, N., How, T., Fields, T. A., & Blobe, G. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3117 · Cited by 181 · see citing works

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

Ossowski, L. (1988) · Cell · doi:10.1016/s0092-8674(88)80025-4 · Cited by 181 · see citing works

Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth

Aguirre‐Ghiso, J. A., Ossowski, L., & Rosenbaum, S. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0113 · Cited by 173 · see citing works

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

Adam, A. P., George, A. D., Schewe, D. M., Bragado, P., Iglesias, B. V., Ranganathan, A. C., Kourtidis, A., Conklin, D. S., & Aguirre‐Ghiso, J. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3820 · Cited by 168 · see citing works

Experimental model for quantitative study of metastasis.

Ossowski, L., & Reich, E. (1980) · PubMed · Cited by 156 · see citing works

The role of tumor microenvironment in prostate cancer bone metastasis

Morrissey, C. M., & Vessella, R. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21214 · Cited by 107 · see citing works

Metastasis Awakening: Targeting dormant cancer

Aguirre‐Ghiso, J. A., Bragado, P., & Sosa, M. S. (2013) · Nature Medicine · doi:10.1038/nm.3120 · Cited by 97 · see citing works

Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2

Sun, C. K.-W., Chua, M., He, J., & Samuel, K. S. (2011) · Neoplasia · doi:10.1593/neo.11664 · Cited by 92 · see citing works

Unexpected Effect of Matrix Metalloproteinase Down-Regulation on Vascular Intravasation and Metastasis of Human Fibrosarcoma Cells Selected In vivo for High Rates of Dissemination

Deryugina, E. I., Zijlstra, A., Partridge, J. J., Kupriyanova, T. A., Madsen, M. A., Papagiannakopoulos, T. Y., & Quigley, J. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2228 · Cited by 91 · see citing works

Mechanisms of breast cancer bone metastasis

Zhang, Y., Ma, B., & Fan, Q. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.11.003 · Cited by 91 · see citing works

TGFBR3 loss and consequences in prostate cancer

Sharifi, N., Hurt, E. M., Kawasaki, B. T., & Farrar, W. L. (2006) · The Prostate · doi:10.1002/pros.20526 · Cited by 62 · see citing works

Minimal Residual Disease in Head and Neck Cancer

Gath, H. J., & Brakenhoff, R. H. (1999) · Cancer and Metastasis Reviews · doi:10.1023/a:1006268621730 · Cited by 62 · see citing works

Characterization of F3II, a sarcomatoid mammary carcinoma cell line originated from a clonal subpopulation of a mouse adenocarcinoma

Alonso, D. F., Farias, E., Urtreger, A. J., Ladeda, V., Vidal, M., & Joffé, E. B. D. K. (1996) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(199608)62:4 · Cited by 58 · see citing works

The type III TGF- receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation

You, H. J., Bruinsma, M. W., How, T., Ostrander, J. H., & Blobe, G. C. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm195 · Cited by 57 · see citing works

Knockdown of the Transforming Growth Factor-β Type III Receptor Impairs Motility and Invasion of Metastatic Cancer Cells

Criswell, T. L., Dumont, N., Barnett, J. V., & Arteaga, C. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6777 · Cited by 47 · see citing works

The Positive Regulatory Effect of TGF-β2 on Primitive Murine Hemopoietic Stem and Progenitor Cells Is Dependent on Age, Genetic Background, and Serum Factors

Henckaerts, E., Langer, J., Orenstein, J., & Snoeck, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2486 · Cited by 28 · see citing works

Growth of a human carcinoma (HEp3) in nude mice: Rapid and efficient metastasis

Ossowski, L., Russo, H., Gartner, M., & Wilson, E. L. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041330212 · Cited by 26 · see citing works

The analysis of metastasis in transgenic mouse models

Hüsemann, Y., & Klein, C. A. (2008) · Transgenic Research · doi:10.1007/s11248-008-9225-0 · Cited by 23 · see citing works

More than an accessory: implications of type III transforming growth factor‐β receptor loss in prostate cancer

Ajiboye, S., Sissung, T. M., Sharifi, N., & Figg, W. D. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2009.08999.x · Cited by 15 · see citing works

Emerging Biological Principles of Metastasis

Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.037 · Cited by 3,075 · see citing works

Cancer stem cells revisited

Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769 · see citing works

Molecular principles of metastasis: a hallmark of cancer revisited

Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A., & Fares, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0134-x · Cited by 2,423 · see citing works

Metastatic colonization by circulating tumour cells

Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062 · see citing works

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works

Mechanisms of disseminated cancer cell dormancy: an awakening field

Sosa, M. S., Bragado, P., & Aguirre‐Ghiso, J. A. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3793 · Cited by 1,125 · see citing works

Targeting the tumour stroma to improve cancer therapy

Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084 · see citing works

Targeting metastatic cancer

Ganesh, K., & Massagué, J. (2021) · Nature Medicine · doi:10.1038/s41591-020-01195-4 · Cited by 1,070 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Lawson, D. A., Bhakta, N. R., Kessenbrock, K., Prummel, K. D., Yu, Y., Takai, K., Zhou, A. Y., Eyob, H., Balakrishnan, S., Wang, C., et al. (2015) · Nature · doi:10.1038/nature15260 · Cited by 894 · see citing works

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

Malladi, S., Macalinao, D. G., Jin, X., He, L., Basnet, H., Zou, Y., de Stanchina, E., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.02.025 · Cited by 791 · see citing works

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

Zhang, Y., Alexander, P. B., & Wang, X.-F. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022145 · Cited by 626 · see citing works

The dormant cancer cell life cycle

Phan, T. G., & Croucher, P. I. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0263-0 · Cited by 581 · see citing works

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Harper, K. L., Sosa, M. S., Entenberg, D. R., Hosseini, H., Cheung, J. F., Nobre, A. R., Avivar‐Valderas, A., Nagi, C., Girnius, N., Davis, R. J., et al. (2016) · Nature · doi:10.1038/nature20609 · Cited by 569 · see citing works

Biology, detection, and clinical implications of circulating tumor cells

Joosse, S. A., Gorges, T. M., & Pantel, K. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201303698 · Cited by 531 · see citing works

TGF-β receptors: In and beyond TGF-β signaling

Ark, A. V., Cao, J., & Li, X. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.09.002 · Cited by 471 · see citing works

EMT, CTCs and CSCs in tumor relapse and drug-resistance

Mitra, A., Mishra, L., & Li, S. (2015) · Oncotarget · doi:10.18632/oncotarget.4037 · Cited by 467 · see citing works

T cell‐targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

Schmid, D., Park, C. G., Hartl, C. A., Subedi, N., Cartwright, A. N., Puerto, R. B., Zheng, Y., Maiarana, J., Freeman, G. J., Wucherpfennig, K. W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01830-8 · Cited by 449 · see citing works

Bone metastasis: mechanisms, therapies, and biomarkers

Clézardin, P., Coleman, R., Puppo, M., Ottewell, P. D., Bonnelye, E., Paycha, F., Confavreux, C. B., & Holen, I. (2020) · Physiological Reviews · doi:10.1152/physrev.00012.2019 · Cited by 427 · see citing works

Macrophages orchestrate breast cancer early dissemination and metastasis

Linde, N., Casanova-Acebes, M., Sosa, M. S., Mortha, A., Rahman, A. H., Farias, E., Harper, K. L., Tardio, E., Reyes-Torres, I., Jones, J. G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02481-5 · Cited by 416 · see citing works

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Chen, W., Dong, J., Haiech, J., Kilhoffer, M., & Zeniou, M. (2016) · Stem Cells International · doi:10.1155/2016/1740936 · Cited by 408 · see citing works

Cancer progression and the invisible phase of metastatic colonization

Klein, C. A. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00300-6 · Cited by 379 · see citing works

Overcoming TGFβ-mediated immune evasion in cancer

Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377 · see citing works

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

Sosa, M. S., Parikh, F., Gaspar‐Maia, A., Estrada, Y. D., Bosch, A., Bragado, P., Ekpin, E., George, A. D., Zheng, Y., Lam, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms7170 · Cited by 357 · see citing works

Targeting Cancer Cell Dormancy

Recasens, A., & Munoz, L. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.004 · Cited by 356 · see citing works

A framework for the development of effective anti-metastatic agents

Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., EVANS, J., Hall, J. A., Kinrade, S. A., Jones, D., Jones, P. S., Jones, R. J., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0134-8 · Cited by 341 · see citing works

Cancer cell plasticity during tumor progression, metastasis and response to therapy

Pérez-González, A., Bévant, K., & Blanpain, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00595-y · Cited by 353 · see citing works

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Fluegen, G., Avivar‐Valderas, A., Wang, Y., Padgen, M. R., Williams, J. K., Nobre, A. R., Calvo, V., Cheung, J. F., Bravo‐Cordero, J. J., Entenberg, D. R., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3465 · Cited by 331 · see citing works

Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis

Liu, Q., Zhang, H., Jiang, X., Qian, C., Liu, Z., & Luo, D. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0742-4 · Cited by 328 · see citing works

A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy

Martino, J. S. D., Nobre, A. R., Mondal, C., Taha, I. N., Farias, E., Fertig, E. J., Naba, A., Aguirre‐Ghiso, J. A., & Bravo‐Cordero, J. J. (2021) · Nature Cancer · doi:10.1038/s43018-021-00291-9 · Cited by 330 · see citing works

Metastasis prevention by targeting the dormant niche

Ghajar, C. M. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3910 · Cited by 317 · see citing works

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview

Kim, D., Xing, T., Yang, Z., Dudek, R. W., Lu, Q., & Chen, Y. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm7010001 · Cited by 308 · see citing works

Mouse models of metastasis: progress and prospects

Gómez-Cuadrado, L., Tracey, N., Ma, R., Qian, B., & Brunton, V. G. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030403 · Cited by 298 · see citing works

Therapy resistance mediated by cancer stem cells

Steinbichler, T. B., Dudás, J., Skvortsov, S., Ganswindt, U., Riechelmann, H., & Skvortsova, I. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.11.006 · Cited by 289 · see citing works

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

Johnson, R. W., Finger, E. C., Olcina, M. M., Vilalta, M., Aguilera, T. A., Miao, Y. R., Merkel, A. R., Johnson, J., Sterling, J. A. R., Wu, J. Y., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3408 · Cited by 261 · see citing works

Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness

Lee, K., Kuo, Y., Ho, Y., & Huang, Y. (2019) · Cancers · doi:10.3390/cancers11091334 · Cited by 263 · see citing works

Liquid–liquid phase separation in tumor biology

Tong, X., Tang, R., Xu, J., Wang, W., Zhao, Y., Yu, X., & Shi, S. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01076-x · Cited by 256 · see citing works

STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma

Hu, J. Y., Rivera, F. J. S., Wang, Z., Johnson, G. N., Ho, Y.-J., Ganesh, K., Umeda, S., Gan, S., Mujal, A. M., Delconte, R. B., et al. (2023) · Nature · doi:10.1038/s41586-023-05880-5 · Cited by 252 · see citing works

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

Gao, H., Chakraborty, G., Zhang, Z., Akalay, I., Gadiya, M. M., Gao, Y., Sinha, S., Hu, J. M., Jiang, C., Akram, M. M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.009 · Cited by 247 · see citing works

Targeting TGF-β Signaling for Therapeutic GainPreprint

Akhurst, R. J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022301 · Cited by 243 · see citing works

The current paradigm and challenges ahead for the dormancy of disseminated tumor cells

Risson, E., Nobre, A. R., Maguer‐Satta, V., & Aguirre‐Ghiso, J. A. (2020) · Nature Cancer · doi:10.1038/s43018-020-0088-5 · Cited by 235 · see citing works

Circulating and disseminated tumor cells: harbingers or initiators of metastasis?

Dasgupta, A., Lim, A. R., & Ghajar, C. M. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12022 · Cited by 224 · see citing works

Update on Epithelial-Mesenchymal Plasticity in Cancer Progression

Fontana, R., Mestre‐Farrera, A., & Yang, J. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-122423 · Cited by 230 · see citing works

Cancer stem cells: A brief review of the current status

Kuşoğlu, A., & Avcı, Ç. B. (2018) · Gene · doi:10.1016/j.gene.2018.09.052 · Cited by 220 · see citing works

The force awakens: metastatic dormant cancer cells

Park, S., & Nam, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0423-z · Cited by 209 · see citing works

Novel approaches to target the microenvironment of bone metastasis

Hofbauer, L. C., Bözec, A., Rauner, M., Jakob, F. J., Perner, S., & Pantel, K. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00499-9 · Cited by 213 · see citing works

Role of TGFβ in regulation of the tumor microenvironment and drug delivery (Review)

Papageorgis, P., & Stylianopoulos, T. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2816 · Cited by 205 · see citing works

The Stress Kinase p38α as a Target for Cancer Therapy

Igea, A., & Nebreda, Á. R. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0173 · Cited by 190 · see citing works

Tumor cell dormancy

Gomis, R. R., & Gawrzak, S. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.09.009 · Cited by 190 · see citing works

Dormant tumour cells, their niches and the influence of immunity

Goddard, E. T., Božić, I., Riddell, S. R., & Ghajar, C. M. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0214-0 · Cited by 176 · see citing works

Breast Cancer Stem Cells as Drivers of Tumor Chemoresistance, Dormancy and Relapse: New Challenges and Therapeutic Opportunities

Angelis, M. L. D., Francescangeli, F., & Zeuner, A. (2019) · Cancers · doi:10.3390/cancers11101569 · Cited by 176 · see citing works

The Biology of Bone MetastasisPreprint

Esposito, M., Guise, T. A., & Kang, Y. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031252 · Cited by 174 · see citing works

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII–p38MAPK–pS249/T252RB Pathway

Yu‐Lee, L., Yu, G., Lee, Y., Lin, S.-C., Pan, J., Pan, T., Yu, K., Liu, B., Creighton, C. J., Rodriguez‐Canales, J., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1051 · Cited by 173 · see citing works

Metastatic niche functions and therapeutic opportunities

Celià-Terrassa, T., & Kang, Y. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0145-9 · Cited by 172 · see citing works

Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow

Yumoto, K., Eber, M. R., Wang, J., Cackowski, F. C., Decker, A. M., Lee, E., Nobre, A. R., Aguirre-Ghiso, J. A., Jung, Y., & Taichman, R. S. (2016) · Scientific Reports · doi:10.1038/srep36520 · Cited by 170 · see citing works

The Relationship Between Dormant Cancer Cells and Their Microenvironment

Linde, N., Fluegen, G., & Aguirre‐Ghiso, J. A. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.07.002 · Cited by 164 · see citing works

Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting.

Talukdar, S., Bhoopathi, P., Emdad, L., Das, S. K., Sarkar, D., & Fisher, P. (2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2018.12.002 · Cited by 141 · see citing works

Bone metastasis and the metastatic niche

Ren, G., Esposito, M., & Kang, Y. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1329-4 · Cited by 161 · see citing works

Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2

Nobre, A. R., Risson, E., Singh, D. K., Di Martino, J. S., Cheung, J. F., Wang, J., Johnson, J., Russnes, H. G., Bravo-Cordero, J. J., Birbrair, A., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00179-8 · Cited by 159 · see citing works

Tumor cell–organized fibronectin maintenance of a dormant breast cancer population

Barney, L. E., Hall, C. L., Schwartz, A. D., Parks, A. N., Sparages, C., Galarza, S., Platt, M. O., Mercurio, A. M., & Peyton, S. R. (2020) · Science Advances · doi:10.1126/sciadv.aaz4157 · Cited by 159 · see citing works

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

Borriello, L., Coste, A., Traub, B. C., Sharma, V. P., Karagiannis, G. S., Lin, Y., Wang, Y., Ye, X., Duran, C. L., Chen, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28076-3 · Cited by 158 · see citing works

Role of p38 MAP kinase in cancer stem cells and metastasis

Kudaravalli, S., den Hollander, P., & Mani, S. A. (2022) · Oncogene · doi:10.1038/s41388-022-02329-3 · Cited by 151 · see citing works

TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells

Li, W.-Q., Zhang, X., Wang, J., Li, M., Cao, C., Tan, J.-H., Ma, D., & Gao, Q.-L. (2017) · OncoTarget · doi:10.18632/oncotarget.21635 · Cited by 134 · see citing works

When dormancy fuels tumour relapse

Santos-de-Frutos, K., & Djouder, N. (2021) · Communications Biology · doi:10.1038/s42003-021-02257-0 · Cited by 140 · see citing works

TGF-β and mesenchymal stromal cells in regenerative medicine, autoimmunity and cancer

Farias, V., Carrillo-Gálvez, A. B., Martı́n, F., & Anderson, P. O. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.06.002 · Cited by 138 · see citing works

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis

Esposito, M., Cao, F., Cook, K. C., Park, N., Wei, Y., Spadazzi, C., Bracha, D., Gunaratna, R. T., Laevsky, G. S., DeCoste, C. J., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00641-w · Cited by 129 · see citing works

The key roles of cancer stem cell-derived extracellular vesicles

Su, C., Zhang, J., Yarden, Y., & Fu, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00499-2 · Cited by 133 · see citing works

MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Gawrzak, S., Rinaldi, L., Gregorio, S., Arenas, E. J., Salvador, F., Urosevic, J., Figueras-Puig, C., Rojo, F., Barrantes, I. D. B., Cejalvo, J. M., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0021-z · Cited by 131 · see citing works

Cancer stem cells and their unique role in metastatic spread

Steinbichler, T. B., Savic, D., Dudás, J., Kvitsaridze, I., Skvortsov, S., Riechelmann, H., & Skvortsova, I. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.007 · Cited by 129 · see citing works

The Contribution of the Immune System in Bone Metastasis Pathogenesis

Xiang, L., & Gilkes, D. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040999 · Cited by 117 · see citing works

Cancer Cell Colonisation in the Bone Microenvironment

Kan, C. W. S., Vargas, G., Pape, F. L., & Clézardin, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101674 · Cited by 116 · see citing works

NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients

Borgen, E., Rypdal, M. C., Sosa, M. S., Renolen, A., Schlichting, E., Lønning, P. E., Synnestvedt, M., Aguirre‐Ghiso, J. A., & Naume, B. (2018) · Breast Cancer Research · doi:10.1186/s13058-018-1049-0 · Cited by 115 · see citing works

Adaptive Stress Responses During Tumor Metastasis and Dormancy

Senft, D., & Ronai, Z. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.06.004 · Cited by 111 · see citing works

Cancer metastasis - tricks of the trade

Zeeshan, R., & Mutahir, Z. (2017) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2017.1908 · Cited by 115 · see citing works

The acidic microenvironment as a possible niche of dormant tumor cells

Peppicelli, S., Andreucci, E., Ruzzolini, J., Laurenzana, A., Margheri, F., Fibbi, G., Rosso, M. D., Bianchini, F., & Calorini, L. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2496-y · Cited by 114 · see citing works

Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

Tejero, R., Huang, Y., Katsyv, I., Kluge, M., Lin, J., Tomé-García, J., Daviaud, N., Wang, Y., Zhang, B., Tsankova, N. M., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.064 · Cited by 113 · see citing works

Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways

Chery, L. J., Lam, H., Coleman, I. M., Lakely, B., COLEMAN, R. T., Larson, S. R., Aguirre‐Ghiso, J. A., Xia, J., Gulati, R., Nelson, P. S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2480 · Cited by 113 · see citing works

Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis

Gao, X., Zhang, M., Tang, Y., & Liang, X. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s140854 · Cited by 113 · see citing works

Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

Butturini, E., de Prati, A. C., Boriero, D., & Mariotto, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174305 · Cited by 114 · see citing works

Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer

Jahanban-Esfahlan, R., Seidi, K., Manjili, M. H., Jahanban-Esfahlan, A., Javaheri, T., & Zare, P. (2019) · Cancers · doi:10.3390/cancers11081207 · Cited by 111 · see citing works

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Montagner, M., Bhome, R., Hooper, S., Chakravarty, P., Qin, X., Sufi, J., Bhargava, A., Ratcliffe, C. D. H., Naito, Y., Pocaterra, A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0474-3 · Cited by 107 · see citing works

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

Khalil, B. D., Sánchez, R., Rahman, T., Rodríguez-Tirado, C., Moritsch, S., Martínez, A. R., Miles, B. A., Farias, E., Mezei, M., Nobre, A. R., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210836 · Cited by 111 · see citing works

Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone

Sharma, S., Xing, F., Liu, Y., Wu, K., Said, N. A., Pochampally, R. R., Shiozawa, Y., Lin, H., Balaji, K. C., & Watabe, K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.737379 · Cited by 108 · see citing works

The Different Routes to Metastasis via Hypoxia-Regulated Programs

Nobre, A. R., Entenberg, D. R., Wang, Y., Condeelis, J. S., & Aguirre‐Ghiso, J. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.008 · Cited by 109 · see citing works

Bone Metastasis: Find Your Niche and Fit in

Zhang, W., Bado, I. L., Wang, H., Lo, H.-C., & Zhang, X. H.-F. (2019) · Trends in cancer · doi:10.1016/j.trecan.2018.12.004 · Cited by 107 · see citing works

Targeting dormant tumor cells to prevent cancer recurrence

Damen, M. P. F., van Rheenen, J., & Scheele, C. L. G. J. (2020) · FEBS Journal · doi:10.1111/febs.15626 · Cited by 108 · see citing works

Tumor-derived extracellular vesicles: The metastatic organotropism drivers

Rezaie, J., Ahmadi, M., Gavgani, R. R., Mojarad, B., Mahbubfam, S., Shaban, S. A., Shadi, K., Berenjabad, N. J., & Etemadi, T. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120216 · Cited by 107 · see citing works

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

Yip, R. K. H., Rimes, J. S., Capaldo, B. D., Vaillant, F., Mouchemore, K. A., Pal, B., Chen, Y., Surgenor, E. E., Murphy, A. J., Anderson, R. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26556-6 · Cited by 105 · see citing works

DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli

Kato, Y., Kawamoto, T., Fujimoto, K., & Noshiro, M. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-405943-6.00010-5 · Cited by 100 · see citing works

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban, J., Fock, V., Aryee, D. N. T., & Kovar, H. (2021) · Cells · doi:10.3390/cells10112944 · Cited by 103 · see citing works

Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities

Hen, O., & Barkan, D. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.002 · Cited by 98 · see citing works

The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance

Dianat‐Moghadam, H., Azizi, M., Eslami‐S, Z., Cortés‐Hernández, L. E., Heidarifard, M., Nouri, M., & Alix‐Panabières, C. (2020) · Cancers · doi:10.3390/cancers12040867 · Cited by 97 · see citing works

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

de Lara, P. T., Castañón, H., Vermeer, M., Núñez, N. G., Siliņa, K., Sobottka, B., Urdinez, J., Cecconi, V., Yagita∥, H., Attar, F. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21045-2 · Cited by 100 · see citing works

Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening

Sistigu, A., Musella, M., Galassi, C., Vitale, I., & Maria, R. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02166 · Cited by 98 · see citing works

Mechanisms of Metastatic Tumor Dormancy and Implications for Cancer Therapy

Neophytou, C. M., Kyriakou, T.-C., & Papageorgis, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246158 · Cited by 96 · see citing works

Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Triana-Martínez, F., Loza, M. I., & Domínguez, E. (2020) · Cells · doi:10.3390/cells9020346 · Cited by 96 · see citing works

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

Liu, Y., Zhang, P., Wu, Q., Fang, H., Wang, Y., Xiao, Y., Cong, M., Wang, T., He, Y., Ma, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25552-0 · Cited by 95 · see citing works

ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung

Nobre, A. R., Dalla, E., Yang, J., Huang, X., Wullkopf, L., Risson, E., Razghandi, P., Anton, M. L., Zheng, W., Seoane, J. A., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00424-8 · Cited by 97 · see citing works

Recent advances in understanding the complexities of metastasis

Chitty, J. L., Filipe, E. C., Lucas, M. C., Herrmann, D., Cox, T. R., & Timpson, P. (2018) · F1000Research · doi:10.12688/f1000research.15064.2 · Cited by 94 · see citing works

Abstract 5234: Microenvironmental signals dictate disseminated tumor cells (DTCs) fate through regulation of TGFβII and p38α

Bragado, P., Estrada, Y. D., Sosa, M. S., Schewe, D. M., Capobianco, C. S., Moore, K. A., Fariña, H. G., & Aguirre‐Ghiso, J. A. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-5234 · Cited by 3 · see citing works

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth

Recalde‐Percaz, L., la Guia-Lopez, I. D., Linzoain-Agos, P., Noguera‐Castells, A., Rodrigo‐Faus, M., Jauregui, P., López‐Plana, A., Fernández‐Nogueira, P., Iniesta‐González, M., Cueto‐Remacha, M., et al. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101220 · Cited by 7 · see citing works

Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumour cells dormancy escape and promotes metastasis outgrowthPreprint

Recalde‐Percaz, L., Jáuregui, P., López‐Plana, A., Fernández‐Nogueira, P., Iniesta‐González, M., Manzano, S., Alonso, R., Noguera‐Castells, A., Moragas, N., Baquero, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1956933/v1

Control of disseminated breast cancer cell dormancy in the bone marrow by TGFβ2 and BMP4 signaling

Risson, E. (2022) · doi:10.70675/3371f566z1bcdz4181z87bfza563bd174f81

The role of the microenvironment-dormant prostate disseminated tumor cells in the bone marrow

Lam, H., Vessella, R. L., & Morrissey, C. M. (2014) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2014.02.002 · Cited by 27 · see citing works