The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
Open accessAbstract
Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in osteosarcoma. However, no study has shown specific markers to identify osteosarcoma TICs with in vivo tumor formation ability. Additionally, there has been a lack of investigations gauging the contribution of osteosarcoma TICs to metastatic and drug-resistant properties. In this study, we have identified mouse and human osteosarcoma TICs using mesenchymal stem cell markers CD117 and Stro-1. These markers were preferentially expressed in spheres and doxorubicin-resistant cells. Both mouse and human cells expressing these markers were sorted and analyzed for their abilities of tumor formation with as few as 200 cells, self-renewability, multipotency, drug resistance, metastatic potential, and enrichment of a metastasis-associated marker (CXCR4) and a drug resistance marker (ABCG2). CD117+Stro-1+ cells efficiently formed serially transplantable tumors, whereas CD117−Stro-1− cells rarely initiated tumors. On orthotopic injections, CD117+Stro-1+ cell-derived tumors metastasized at a high frequency. Further, CD117+Stro-1+ cells showed high invasive and drug-resistant properties and were efficiently enriched for CXCR4 (20–90%) and ABCG2 (60–90%). These results suggest possible mechanisms for the high metastatic and drug-resistant properties of osteosarcoma TICs. In summary, CD117 and Stro-1 identify osteosarcoma TICs associated with the most lethal characteristics of the disease—metastasis and drug resistance—and these markers offer candidates for TIC-targeted drug delivery aimed at eradicating osteosarcoma. Cancer Res; 70(11); 4602–12. ©2010 AACR.
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Molecular Biology of Osteosarcoma
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Metadata
- Authors
- Adhikari, A. S., Agarwal, N., Wood, B. M., Porretta, C., Ruiz, B., Pochampally, R. R., & Iwakuma, T.
- Venue
- Cancer Research
- Published
- 2010-06-01
- Volume
- 70
- Issue
- 11
- Pages
- 4602-4612
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2018321310
- Cited by
- 261
- References
- 39
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Adhikari, A. S., Agarwal, N., Wood, B. M., Porretta, C., Ruiz, B., Pochampally, R. R., & Iwakuma, T. (2010). CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance. Cancer Research. https://doi.org/10.1158/0008-5472.can-09-3463
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