Cancer stem cells in osteosarcoma
Open accessAbstract
Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.
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The seed and soil phenomenon in osteosarcoma is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration and drug resistance, and contributes to intrinsic heterogeneity.
“This seed and soil phenomenon is driven by a microenvironment that modulates osteosarcoma cell behaviour and facilitates proliferation, quiescence, invasion, migration, and drug resistance 15,51,52,53 and contributes to their intrinsic heterogeneity 54,55 .”
From Osteosarcoma (2022) · cites this paper as [52]
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- Authors
- Brown, H. K., Tellez-Gabriel, M., & Heymann, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Brown, Hannah K.
- Heymann, Dominique
- ORCID
- Heymann, Dominique
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 386
- Pages
- 189-195
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2551783204
- Cited by
- 303
- References
- 47
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 43 · 2023: 33 · 2022: 41 · 2021: 49 · 2020: 50 · 2019: 34 · 2018: 10 · 2017: 8
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Bone Cancer Research Trust (144681)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- osteosarcoma, cancer stem cells, drug resistance, carcinogenesis, metastasis, cancer stem cell isolation, molecular markers, therapeutic target, pediatric bone tumors
- MeSH terms
- Animals, Antineoplastic Agents, Bone Neoplasms, Cell Separation, Humans, Phenotype, Osteosarcoma, Biomarkers, Tumor, Neoplastic Stem Cells, Drug Resistance, Neoplasm
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