High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

Cancer statistics, 2009

Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630

Cancer chemoprevention with dietary phytochemicals

Surh, Y.-J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1189 · Cited by 2,955

Two pathogenetic types of endometrial carcinoma

Bokhman, J. V. (1983) · Gynecologic Oncology · doi:10.1016/0090-8258(83)90111-7 · Cited by 2,508

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224

Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Zhang, D. D., Lo, S., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,284

Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,105

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060

miR-144 reverses chemoresistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway.

Zhou, S., Ye, W., Zhang, Y., Yu, D., Shao, Q., Liang, J., & Zhang, M. (2016) · Europe PMC (PubMed Central) · Cited by 60

NRF2 in human neoplasm: Cancer biology and potential therapeutic target

Liu, Y., Lang, F., & Yang, C. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107664 · Cited by 61

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Tian, Y., Wu, K., Liu, Q., Han, N., Zhang, L., Chu, Q., & Chen, Y. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0311-0 · Cited by 59

p38MAPK and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y

Filomeni, G., Piccirillo, S., Rotilio, G., & Ciriolo, M. R. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.003 · Cited by 58

MiR-218 inhibits HMGB1-mediated autophagy in endometrial carcinoma cells during chemotherapy.

Ran, X., Yang, J., Liu, C., Zhou, P., Xiao, L., & Zhang, K. (2015) · Europe PMC (PubMed Central) · Cited by 55

Nrf2, the master redox switch: The Achilles' heel of ovarian cancer?

van der Wijst, M. G. P., Brown, R. E., & Rots, M. G. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.09.004 · Cited by 54

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway

Wang, Y., Wang, Y., Zhang, Z., Park, J. Y., Guo, D., Liao, H., Yi, X., Zheng, Y., Zhang, D., Chambers, S. K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7004 · Cited by 53

HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Furfaro, A. L., Piras, S., Passalacqua, M., Domenicotti, C., Parodi, A., Fenoglio, D., Pronzato, M. A., Marinari, U. M., Moretta, L., Traverso, N., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.008 · Cited by 53

Role of Nrf2 and mitochondria in cancer stem cells; in carcinogenesis, tumor progression, and chemoresistance

Payandeh, Z., Tazehkand, A. P., Barati, G., Pouremamali, F., Kahroba, H., Baradaran, B., & Samadi, N. (2020) · Biochimie · doi:10.1016/j.biochi.2020.09.014 · Cited by 54

Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells

Lee, Y.-J., Lee, D. M., & Lee, S.-H. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2268 · Cited by 51

Prognostic and predictive values of Nrf2, Keap1, p16 and E-cadherin expression in ovarian epithelial carcinoma.

Liew, P., Hsu, C.-S., Liu, W.-M., Lee, Y., Lee, Y.-C., & Chen, C. (2015) · PubMed Central · Cited by 48

RKIP-Mediated Chemo-Immunosensitization of Resistant Cancer Cells via Disruption of the NF-κB/Snail/YY1/RKIP Resistance-Driver Loop

Bonavida, B. (2014) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2014011929 · Cited by 48

An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers

Dama, E., Melocchi, V., Dezi, F., Pirroni, S., Carletti, R. M., Brambilla, D., Bertalot, G., Casiraghi, M., Maisonneuve, P., Barberis, M. C. P., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3005 · Cited by 48

The Cystine/Cysteine Cycle and GSH Are Independent and Crucial Antioxidant Systems in Malignant Melanoma Cells and Represent Druggable Targets

Venè, R., Castellani, P., Delfino, L., Lucibello, M., Ciriolo, M. R., & Rubartelli, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3830 · Cited by 47

Frequent alteration of the protein synthesis of enzymes for glucose metabolism in hepatocellular carcinomas

Shimizu, T., Inoue, K.-I., Hachiya, H., Shibuya, N., Shimoda, M., & Kubota, K. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0895-x · Cited by 47

Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression

Liu, D., Zhang, Y., Wei, Y., Liu, G., Liu, Y., Gao, Q., Zou, L., Zeng, W., & Zhang, N. (2016) · Oncotarget · doi:10.18632/oncotarget.11700 · Cited by 47

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway

Liao, H., Zhu, D., Bai, M., Chen, H., Yan, S., Yu, J. Q., Zhu, H., Zheng, W., & Fan, G. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01470-x · Cited by 47

Applications of the Keap1–Nrf2 system for gene and cell therapy

Kanninen, K. M., Pomeshchik, Y., Leinonen, H. M., Malm, T., Koıstınaho, J., & Levonen, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.037 · Cited by 47

Inflammatory Macrophages Induce Nrf2 Transcription Factor-dependent Proteasome Activity in Colonic NCM460 Cells and Thereby Confer Anti-apoptotic Protection

Sebens, S., Bauer, I., Geismann, C., Grage‐Griebenow, E., Ehlers, S., Kruse, M., Arlt, A., & Schäfer, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274902 · Cited by 46

Human-Derived Model Systems in Gynecological Cancer Research

Lõhmussaar, K., Boretto, M., & Clevers, H. C. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.07.007 · Cited by 47

NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity

Manandhar, S., Choi, B.-H., Jung, K.-A., Ryoo, I.-G., Song, M., Kang, S. J., Choi, H.-G., Kim, J.-A., Park, P.-H., & Kwak, M.-K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.031 · Cited by 45

Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu

Renu, K., & Gopalakrishnan, A. V. (2019) · Reproductive Biology · doi:10.1016/j.repbio.2019.02.004 · Cited by 45

Combination of siRNA-directed gene silencing with epigallocatechin-3-gallate (EGCG) reverses drug resistance in human breast cancer cells

Esmaeili, M. A. (2015) · Journal of Chemical Biology · doi:10.1007/s12154-015-0144-2 · Cited by 44

A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

Al‐Mulla, F., Bitar, M. S., Feng, J., Park, S., & Yeung, K. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029532 · Cited by 44

Loss of ARID1A expression leads to sensitivity to ROS-inducing agent elesclomol in gynecologic cancer cells

Kwan, S.-Y., Cheng, X., Tsang, Y. T. M., Choi, J.-S., Kwan, S., Izaguirre, D. I., Kwan, H. S., Gershenson, D. M., & Wong, K. (2016) · Oncotarget · doi:10.18632/oncotarget.10921 · Cited by 43

The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer

Arlt, A., Schäfer, H., & Kalthoff, H. (2012) · Oncogenesis · doi:10.1038/oncsis.2012.35 · Cited by 44

High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer

Oshi, M., Angarita, F. A., Tokumaru, Y., Yan, L., Matsuyama, R., Endo, I., & Takabe, K. (2020) · Cancers · doi:10.3390/cancers12123856 · Cited by 43

Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies

Gao, X., Wang, B., Huang, Y., Wu, M., Li, Y., Li, Y., Zhu, X., & Wu, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713327 · Cited by 44

Deregulation of UCA1 expression may be involved in the development of chemoresistance to cisplatin in the treatment of non‐small‐cell lung cancer via regulating the signaling pathway of microRNA‐495/NRF2

Li, C., Fan, K., Qu, Y., Zhai, W., Huang, A., Sun, X., & Xing, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29266 · Cited by 46

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Furfaro, A. L., Macay, J. R. Z., Marengo, B., Nitti, M., Parodi, A., Fenoglio, D., Marinari, U. M., Pronzato, M. A., Domenicotti, C., & Traverso, N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.007 · Cited by 42

Suppression of NRF2–ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells

Peng, H., Wang, H., Xue, P., Hou, Y., Dong, J., Zhou, T., Qu, W., Peng, S., Li, J., Carmichael, P. L., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.12.008 · Cited by 43

Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms With Endometrioid Endometrial Adenocarcinoma Survival

Wong, T. F., Yoshinaga, K., Monma, Y., Ito, K., Niikura, H., Nagase, S., Yamamoto, M. P., & Yaegashi, N. (2011) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31822d0eb2 · Cited by 42

Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress–induced apoptosis

Méndez-García, L., Castillo, M. M., Villegas‐Sepúlveda, N., Orozco, L., & Córdova, E. J. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119845035 · Cited by 42

Progestin Resistance and Corresponding Management of Abnormal Endometrial Hyperplasia and Endometrial Carcinoma

Lv, M., Chen, P., Bai, M., Huang, Y., Li, L., Feng, Y., Liao, H., Zheng, W., Chen, X., & Zhang, Z. (2022) · Cancers · doi:10.3390/cancers14246210 · Cited by 45

Interaction Energetics and Druggability of the Protein–Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

Zhong, M., Lynch, A. J., Muellers, S. N., Jehle, S., Luo, L., Hall, D. R., Iwase, R., Carolan, J. P., Egbert, M. E., Wakefield, A., et al. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00943 · Cited by 40

Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line

Perna, A., Luca, A. D., Adelfi, L., Pasquale, T., Varriale, B., & Esposito, T. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2125-9 · Cited by 39

Shadows of NRF2 in cancer: Resistance to chemotherapy

Choi, B.-H., & Kwak, M. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.08.003 · Cited by 39

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

Ning, S., Sekar, T. V., Scicinski, J. J., Oronsky, B. T., Peehl, D. M., Knox, S. J., & Paulmurugan, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4249 · Cited by 37

Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents

Samatiwat, P., Prawan, A., Senggunprai, L., Kukongviriyapan, U., & Kukongviriyapan, V. (2016) · Tumor Biology · doi:10.1007/s13277-016-5015-0 · Cited by 37

Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

Li, W., Bai, H., Liu, S., Cao, D., Wu, H., Shen, K., Tai, Y., & Yang, J. (2018) · Oncotarget · doi:10.18632/oncotarget.24304 · Cited by 37

Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha

Wu, J., Wang, H., & Tang, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.111 · Cited by 36

Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells

Roy, R. V., Pratheeshkumar, P., Son, Y.-O., Wang, L., Hitron, J. A., Divya, S. P., Zhang, Z., & Shi, X. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.07.016 · Cited by 35

Recurrent Human Papillomavirus–Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation

Vyas, A., Harbison, R. A., Faden, D. L., Kubik, M., Palmer, D., Zhang, Q., Osmanbeyoglu, H. U., Kiselyov, K. I., Méndez, E., & Duvvuri, U. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4789 · Cited by 37

Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1

Biswas, M., Kwong, E. K., Park, E., Nagra, P., & Chan, J. Y. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.04.013 · Cited by 34

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons

Nakayama, Y., & Inoue, T. (2016) · Molecules · doi:10.3390/molecules21050663 · Cited by 36

Prevention of tumor growth by needle-free jet injection of anti-C7orf24 siRNA

Hama, S., Arata, M., Nakamura, I., Kasetani, T., Itakura, S., Tsuchiya, H., Yoshiki, T., & Kogure, K. (2012) · Cancer Gene Therapy · doi:10.1038/cgt.2012.31 · Cited by 33

The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario

Mukherjee, A. G., & Gopalakrishnan, A. V. (2023) · Medical Oncology · doi:10.1007/s12032-023-02124-4 · Cited by 33

NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones

Feng, Y. (2012) · Oncology Reports · doi:10.3892/or.2012.1700 · Cited by 32

Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling

Jawa, Y., Yadav, P., Gupta, S., Mathan, S. V., Pandey, J., Saxena, A. K., Kateriya, S., Tiku, A. B., Mondal, N., Bhattacharya, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.676948 · Cited by 36

Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma

Shimizu, T., Inoue, K.-I., Hachiya, H., Shibuya, N., Aoki, T., & Kubota, K. (2016) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.364 · Cited by 30

Cancer chemoprevention via activation of proteostatic modules

Sklirou, A. D., Papanagnou, E., Fokialakis, N., & Trougakos, I. P. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.034 · Cited by 32

Nrf2 expression in endometrial serous carcinomas and its precancers.

Chen, N., Yi, X., Abushahin, N., Pang, S., Zhang, D., Kong, B., & Zheng, W. (2010) · PubMed Central · Cited by 31

Targeting Metabolic–Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy

Wang, Y., He, J., Lian, S., Zeng, Y., He, S., Xu, J., Luo, L., Yang, W., & Jiang, J. (2024) · Antioxidants · doi:10.3390/antiox13070828 · Cited by 32

Significance of Polymorphisms and Expression of Enzyme-Encoding Genes Related to Glutathione in Hematopoietic Cancers and Solid Tumors

Zmorzyński, S., Świderska-Kołacz, G., Koczkodaj, D., & Filip, A. A. (2015) · BioMed Research International · doi:10.1155/2015/853573 · Cited by 31

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

Barbagallo, I. A., Giallongo, C., Volti, G. L., Distefano, A., Camiolo, G., Raffaele, M., Salerno, L., Pittalà, V., Sorrenti, V., Avola, R., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1133-6 · Cited by 30

Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs

Pal, D., Rai, A., Checker, R., Patwardhan, R. S., Singh, B., Sharma, D., & Sandur, S. K. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108890 · Cited by 29

PA‐MSHA inhibits the growth of doxorubicin‐resistant MCF‐7/ADR human breast cancer cells by downregulating Nrf2/p62

Wei, Y., Liu, D., Jin, X., Gao, P., Wang, Q., Zhang, J., & Zhang, N. (2016) · Cancer Medicine · doi:10.1002/cam4.938 · Cited by 30

Expression Patterns of Nrf2 and Keap1 in Ovarian Cancer Cells and their Prognostic Role in Disease Recurrence and Patient Survival

Cho, H. Y., Kim, K., Kim, Y.-B., Kim, H., & No, J. H. (2017) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000908 · Cited by 30

Overexpression of NRF 2 is correlated with prognoses of patients with malignancies: A meta‐analysis

Guo, Y., & Shen, L. (2017) · Thoracic Cancer · doi:10.1111/1759-7714.12462 · Cited by 29

Cancer Stem Cell Properties as Factors Predictive of Chemoresistance in Neoadjuvantly-treated Patients with Ovarian Cancer.

Pylväs-Eerola, M., Liakka, A., Puistola, U., Koivunen, J. P., & Karihtala, P. (2016) · PubMed · Cited by 29

Interaction of ERα and NRF2 Impacts Survival in Ovarian Cancer Patients

Czogalla, B., Kahaly, M., Mayr, D. C., Schmoeckel, E., Niesler, B., Kolben, T., Burges, A., Mahner, S., Jeschke, U., & Trillsch, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010112 · Cited by 29

γ-tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2

Takano, H., Momota, Y., Kani, K., Aota, K., Yamamura, Y., Yamanoi, T., & AZUMA, M. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2849 · Cited by 27

Nrf2 expression is associated with poor outcome in osteosarcoma

Park, J. Y., Kim, Y. W., & Park, Y.-K. (2012) · Pathology · doi:10.1097/pat.0b013e328359d54b · Cited by 27

Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats

Sharmila, R., Sindhu, G., & Arockianathan, P. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0085 · Cited by 29

The role of interleukin-6 in gynaecological malignancies

Coward, J. I. G., & Kulbe, H. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.08.005 · Cited by 26

In vitro exosomal transfer of Nrf2 led to the oxaliplatin resistance in human colorectal cancer LS174T cells

Mostafazadeh, M., Kahroba, H., Haiaty, S., Tazehkand, A. P., Samadi, N., Rahbarghazi‬, R., & Nouri, M. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3703 · Cited by 26

Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation

Lee, Y.-J., Im, J.-H., Lee, D. M., Park, J.-S., Won, S. Y., Cho, M. K., Nam, H.-S., Lee, Y.-J., & Lee, S. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.11.111 · Cited by 26

Nrf2 Expressions Correlate with WHO Grades in Gliomas and Meningiomas

Tsai, W., Hueng, D., Lin, C.-R., Yang, T. C. ‐., & Gao, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050722 · Cited by 26

Reduced mRNA expression levels of NFE2L2 are associated with poor outcome in breast cancer patients

Wolf, B., Goebel, G., Hackl, H., & Fiegl, H. (2016) · BMC Cancer · doi:10.1186/s12885-016-2840-x · Cited by 26

Targeting the NF-E2-related factor 2 pathway: A novel strategy for glioblastoma (Review)

Zhu, J., Wang, H., Fan, Y., Lin, Y., Zhang, L., Ji, X., & Zhou, M. (2014) · Oncology Reports · doi:10.3892/or.2014.3259 · Cited by 27

Prognostic value of a novel glycolysis-related gene expression signature for gastrointestinal cancer in the Asian population

Xia, R. M., Tang, H., Shen, J., Xu, S., Liang, Y., Zhang, Y., Gong, X., Min, Y., Zhang, D., Tao, C., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01857-4 · Cited by 25

Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells

Mikac, S., Rychłowski, M., Dziadosz, A., Szabelska‐Beręsewicz, A., Fåhræus, R., Hupp, T. R., & Sznarkowska, A. (2021) · Antioxidants · doi:10.3390/antiox10050786 · Cited by 26

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling

Liu, P., Dodson, M. B., Fang, D., Chapman, E., & Zhang, D. D. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000620 · Cited by 25

Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion

van der Wijst, M. G. P., Huisman, C., Mposhi, A., Roelfes, G., & Rots, M. G. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.03.003 · Cited by 25

Exploring the effects of isothiocyanates on chemotherapeutic drugs

Minarini, A., Milelli, A., Fimognari, C., Simoni, E., Turrini, E., & Tumiatti, V. (2013) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2013.843668 · Cited by 24

Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma.

Wu, Y.-J. J., Neuwelt, A. J., Muldoon, L. L., & Neuwelt, E. A. (2013) · PubMed · Cited by 24

Tetrachlorobenzoquinone Activates Nrf2 Signaling by Keap1 Cross-Linking and Ubiquitin Translocation but Not Keap1-Cullin3 Complex Dissociation

Su, C., Zhang, P., Song, X., Shi, Q., Fu, J., Xia, X., Bai, H., Hu, L., Xu, D., Song, E., et al. (2015) · Chemical Research in Toxicology · doi:10.1021/tx500513v · Cited by 24

Chemopreventive effects of atractylenolide II on mammary tumorigenesis via activating Nrf2-ARE pathway

Wang, T., Long, F., Zhang, X., Yang, Y., Jiang, X., & Wang, L. (2017) · Oncotarget · doi:10.18632/oncotarget.20546 · Cited by 24

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies

Poornima, P., Kankia, I. H., Langdon, S. P., & Deeni, Y. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.57 · Cited by 24

Molecular Mechanisms of Nickel-Induced Carcinogenesis

Son, Y. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666191125112728 · Cited by 25

Identification and Validation of an m7G-Related lncRNAs Signature for Prognostic Prediction and Immune Function Analysis in Endometrial Cancer

Sun, J., Li, L., Chen, H., Gan, L., Guo, X., & Sun, J. (2022) · Genes · doi:10.3390/genes13081301 · Cited by 24

Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide

Dunlap, T. L., Piyankarage, S. C., Wijewickrama, G. T., Abdul‐Hay, S. O., Vanni, M., Litosh, V. A., Luo, J., & Thatcher, G. R. J. (2012) · Chemical Research in Toxicology · doi:10.1021/tx3003609 · Cited by 23

KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma

Saglam, O., Tang, Z., Tang, G., Medeiros, L. J., & Törüner, G. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238477 · Cited by 24

Repression of Nrf2 enhances antitumor effect of 5-fluorouracil and gemcitabine on cholangiocarcinoma cells

Samatiwat, P., Prawan, A., Senggunprai, L., & Kukongviriyapan, V. (2015) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1101-x · Cited by 22

Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

Linke, F., Johnson, J. E. C., Kern, S., Bennett, C., Lourdusamy, A., Lea, D., Clifford, S. C., Merry, C. L. R., Stolnik, S., Alexander, M. R., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01496-4 · Cited by 25

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway.

Fan, R., Wang, Y., Wang, Y., Li, W., & Zheng, W. (2017) · PubMed Central · Cited by 22

Mechanisms used by cancer cells to tolerate drug-induced replication stress

Segeren, H. A., & Westendorp, B. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215804 · Cited by 23

A549 cell proliferation inhibited by RNAi mediated silencing of the Nrf2 gene

Zhang, B., Xie, C., Zhong, J., Chen, H., Zhang, H., & Wang, X. (2014) · Bio-Medical Materials and Engineering · doi:10.3233/bme-141222 · Cited by 21

Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology

Czogalla, B., Kahaly, M., Mayr, D. C., Schmoeckel, E., Niesler, B., Hester, A., Zeder-Göß, C., Kolben, T., Burges, A., Mahner, S., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s210004 · Cited by 21

Heteroleptic Gold(I)-bisNHC complex with excellent activity in vitro, ex vivo and in vivo against endometrial cancer

Xiao, Q., Liu, Y., Jiang, G., Liu, Y., Huang, Y., Liu, W., & Zhang, Z. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114302 · Cited by 20

Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells

Chen, H.-H., Chang, H.-H., Chang, J., Tang, Y.-C., Cheng, Y.-C., Lin, L.-M., Cheng, S.-Y., Huang, C.-H., Sun, M.-W., Chen, C.-T., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.375 · Cited by 20

The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions

Wang, J., Jin, Y., Cao, M., Zhao, Z., Cao, B., & Yu, S. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100028 · Cited by 20

Endometrial Intraepithelial Neoplasia

Abushahin, N., Pang, S., Li, J., Fadare, O., & Zheng, W. (2012) · InTech eBooks · doi:10.5772/30988 · Cited by 20

PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway

Huang, B., Xiong, X., Zhang, L., Liu, X., Wang, Y., Gong, X., Sang, Q., Lu, Y., Qu, H., Zheng, H., et al. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab033 · Cited by 19

VPA and MEL induce apoptosis by inhibiting the Nrf2-ARE signaling pathway in TMZ-resistant U251 cells

Pan, H., Wang, H., Jia, Y., Wang, Q., Li, L., Wu, Q., & Chen, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6621 · Cited by 19

Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis

Chen, N., Du, B., Zhou, H., Shen, F., Li, J., & Xie, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182773 · Cited by 19

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway

Liao, H., Zhu, D., Bai, M., Chen, H., Yan, S., Yu, J. Q., Zhu, H., Zheng, W., & Fan, G. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01470-x · Cited by 47

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839

Nrf2 knockdown by shRNA inhibits tumor growth and increases efficacy of chemotherapy in cervical cancer

Ma, X., Zhang, J., Liu, S., Huang, Y., Chen, B., & Wang, D. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1722-9 · Cited by 88

Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers

Tossetta, G., & Marzioni, D. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175503 · Cited by 81

T-Box Transcription Factor 2 Enhances Chemoresistance of Endometrial Cancer by Mediating NRF2 Expression

Zhuang, S., Ding, N., Zhang, T., & Yu, X. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220823152239 · Cited by 7