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Cited by 707

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

Gregory, Alyssa D., McGarry Houghton, A.·2011·Cancer Research

Abstract

Studies have begun to emerge showing critical roles for neutrophils in tumorigenesis. Neutrophils can have a significant impact on the tumor microenvironment via their production of cytokines and chemokines, which influence inflammatory cell recruitment and activation. Additionally, products secreted from neutrophils, such as reactive oxygen species and proteinases, have defined and specific roles in regulating tumor cell proliferation, angiogenesis, and metastasis. Although evidence suggests that neutrophils act in a decidedly protumor capacity in vivo, recent studies indicate that neutrophils may be manipulated to exhibit cytotoxicity against tumors. Herein, we explore the idea of targeting tumor-associated neutrophils as a means of antitumor therapy and the important ramifications such manipulation could pose to host tissues. Cancer Res; 71(7); 2411–6. ©2011 AACR.

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Crossref · 10.1158/0008-5472.can-10-2583

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Metadata

Authors
Gregory, A. D., & McGarry Houghton, A.
Venue
Cancer Research
Published
2011-03-31
Volume
71
Issue
7
Pages
2411-2416
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2167363836
Cited by
707
References
4
FWCI
16.69
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tumor-Associated Neutrophils: New Targets for Cancer Therapy. https://app.cochat.ai/papers/10.1158/0008-5472.can-10-2583
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Gregory, A. D., & McGarry Houghton, A. (2011). Tumor-Associated Neutrophils: New Targets for Cancer Therapy. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-2583

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.