The multifaceted functions of neutrophils

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works

Getting to the site of inflammation: the leukocyte adhesion cascade updated

Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works

Novel cell death program leads to neutrophil extracellular traps

Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197 · see citing works

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works

Neutrophils in the activation and regulation of innate and adaptive immunity

Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,045 · see citing works

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005 · see citing works

Extracellular DNA traps promote thrombosis

Fuchs, T. A., Brill, A. G., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,517 · see citing works

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910 · see citing works

Neutrophil Function: From Mechanisms to Disease

Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074942 · Cited by 1,695 · see citing works

Netting neutrophils in autoimmune small-vessel vasculitis

Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W. E., Gross, W. L., Werb, Z., Gröne, H., Brinkmann, V., & Jenne, D. E. (2009) · Nature Medicine · doi:10.1038/nm.1959 · Cited by 1,650 · see citing works

Neutrophils, from marrow to microbes.

Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,550 · see citing works

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

Wang, Y., Li, M., Stadler, S. C., Correll, S., Li, P., Wang, D., Hayama, R., Leonelli, L., Han, H., Grigoryev, S. A., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806072 · Cited by 1,532 · see citing works

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

Hakkim, A., Fürnrohr, B. G., Amann, K., Laube, B., Abed, U. A., Brinkmann, V., i, M. H., Voll, R. E., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909927107 · Cited by 1,473 · see citing works

Immune and Inflammatory Mechanisms of Atherosclerosis

Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,446 · see citing works

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

García-Romo, G. S., Caielli, S., Vega, B., Connolly, J., Allantaz, F., Xu, Z., Punaro, M., Baisch, J. M., Guiducci, C., Coffman, R. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001201 · Cited by 1,387 · see citing works

Cooperation of Toll-like receptor signals in innate immune defence

Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,357 · see citing works

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306 · see citing works

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J. D., Meller, S., Chamilos, G., Sebasigari, R., Riccieri, V., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001180 · Cited by 1,306 · see citing works

Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

Falk, R. J., Terrell, R. S., Charles, L., & Jennette, J. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4115 · Cited by 1,254 · see citing works

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Maßberg, S., Grahl, L., von Bruehl, M., Manukyan, D., Pfeiler, S., Goosmann, C., Brinkmann, V., Lorenz, M., Bidzhekov, K., Khandagale, A. B., et al. (2010) · Nature Medicine · doi:10.1038/nm.2184 · Cited by 1,212 · see citing works

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

Yipp, B. G., Petri, B., Salina, D., Jenne, C. N., Scott, B. N. V., Zbytnuik, L. D., Pittman, K., Asaduzzaman, M., Wu, K., Meijndert, H. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2847 · Cited by 1,169 · see citing works

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

Kaplan, M. J., & Radic, M. Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201719 · Cited by 1,168 · see citing works

Neutrophil granules and secretory vesicles in inflammation

Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162 · see citing works

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

Bouchon, A., Facchetti, F., Weigand, M. A., & Colonna, M. (2001) · Nature · doi:10.1038/35074114 · Cited by 1,092 · see citing works

Intracellular NOD-like Receptors in Host Defense and Disease

Kanneganti, T., Lamkanfi, M., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.002 · Cited by 1,056 · see citing works

Neutrophil extracellular traps: Is immunity the second function of chromatin?

Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021 · see citing works

An integrated model of the recognition of Candida albicans by the innate immune system

Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946 · see citing works

Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

Stark, M. A., Huo, Y., Burcin, T. L., MORRIS, M. A., Olson, T. S., & Ley, K. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.011 · Cited by 945 · see citing works

Toll-like receptors stimulate human neutrophil function

Hayashi, F., Means, T. K., & Luster, A. D. (2003) · Blood · doi:10.1182/blood-2003-04-1078 · Cited by 939 · see citing works

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

Nozawa, H., Chiu, C. W., & Hanahan, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601807103 · Cited by 926 · see citing works

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L. (2010) · Blood · doi:10.1182/blood-2010-01-259028 · Cited by 873 · see citing works

Properties of mouse and human IgG receptors and their contribution to disease models

Bruhns, P. (2012) · Blood · doi:10.1182/blood-2012-01-380121 · Cited by 869 · see citing works

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

Pillay, J., Kamp, V. M., van Hoffen, E., Visser, T., Tak, T., Lammers, J. J., Ulfman, L. H., Leenen, L. P. H., Pickkers, P., & Koenderman, L. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57990 · Cited by 829 · see citing works

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

Remijsen, Q., Berghe, T. V., Wirawan, E., Asselbergh, B., Parthoens, E., De Rycke, R., Noppen, S., Delforge, M., Willems, J., & Vandenabeele, P. (2011) · Cell Research · doi:10.1038/cr.2010.150 · Cited by 818 · see citing works

Tumor entrained neutrophils inhibit seeding in the premetastatic lung

Granot, Z., Henke, E., Comen, E. A., King, T. A., Norton, L., & Benezra, R. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.012 · Cited by 782 · see citing works

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A. L., Kliment, C. R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2084 · Cited by 744 · see citing works

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Puga, I., Cols, M., Barra, C., He, B., Cassis, L., Gentile, M., Comerma, L., Chorny, A., Shan, M., Xu, W., et al. (2011) · Nature Immunology · doi:10.1038/ni.2194 · Cited by 731 · see citing works

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow

Yang, L., Froio, R. M., Sciuto, T. E., Dvořàk, A. M., Alon, R., & Luscinskas, F. W. (2005) · Blood · doi:10.1182/blood-2004-12-4942 · Cited by 720 · see citing works

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

Gregory, A. D., & Houghton, A. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2583 · Cited by 707 · see citing works

Tumor-associated neutrophils: friend or foe?

Fridlender, Z. G., & Albelda, S. Μ. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs123 · Cited by 699 · see citing works

Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis

Drechsler, M., Megens, R. T. A., van Zandvoort, M., Weber, C., & Soehnlein, O. (2010) · Circulation · doi:10.1161/circulationaha.110.961714 · Cited by 698 · see citing works

A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease

Sandborn, W. J., Feagan, B. G., Hanauer, S. B., Lochs, H. H., Löfberg, R., Modigliani, R., Present, D. H., Rutgeerts, P. J., Schölmerich, J., Stange, E. F., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.31072 · Cited by 687 · see citing works

Phagosome maturation: aging gracefully

Vieira, O. V., Botelho, R. J., & Grinstein, S. (2002) · Biochemical Journal · doi:10.1042/bj20020691 · Cited by 675 · see citing works

Mechanical modes of ‘amoeboid’ cell migration

Lämmermann, T., & Sixt, M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.003 · Cited by 669 · see citing works

The chemotactic receptor for human C5a anaphylatoxin

Gerard, N. P., & Gerard, C. J. (1991) · Nature · doi:10.1038/349614a0 · Cited by 662 · see citing works

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

Carman, C. V., & Springer, T. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404129 · Cited by 658 · see citing works

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works

NETs: a new strategy for using old weapons

Papayannopoulos, V., & Zychlinsky, A. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.011 · Cited by 634 · cited 1× · see citing works

Tumor associated macrophages and neutrophils in cancer

Galdiero, M. R., Bonavita, E., Barajon, I., Garlanda, C., Mantovani, A., & Jaillon, S. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.06.003 · Cited by 597 · see citing works

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

Barreiro, O., Yáñez‐Mó, M., Serrador, J. M., Montoya, M. C., Vicente‐Manzanares, M., Tejedor, R., Furthmayr, H., & Sánchez‐Madrid, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112126 · Cited by 594 · see citing works

An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps

Beiter, K., Wartha, F., Albiger, B., Normark, S. J., Zychlinsky, A., & Henriques‐Normark, B. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.056 · Cited by 588 · see citing works

Neutrophils cascading their way to inflammation

Sadik, C. D., Kim, N. D., & Luster, A. D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.008 · Cited by 577 · see citing works

Neutrophil kinetics in man.

Dancey, J. T., Deubelbeiss, K. A., Harker, L. A., & Finch, C. A. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108517 · Cited by 573 · see citing works

Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

King, K. Y., & Goodell, M. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri3062 · Cited by 565 · see citing works

Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis‐mediated cell death

Gupta, A. K., Joshi, M. B., Philippova, M., Erné, P., Hasler, P., Hahn, S., & Resink, T. J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.006 · Cited by 538 · see citing works

The Ins and Outs of Leukocyte Integrin Signaling

Abram, C. L., & Lowell, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132554 · Cited by 535 · see citing works

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

Leffler, J., Martin, M., Gullstrand, B., Tydén, H., Lood, C., Truedsson, L., Bengtsson, A. A., & Blom, A. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102404 · Cited by 519 · see citing works

Inflammation: Basic Principles and Clinical Correlates

Ehrlich, G. E. (1993) · JAMA · doi:10.1001/jama.1993.03500240106040 · Cited by 511 · see citing works

Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα

Zhang, P., Iwasaki-Arai, J., Iwasaki, H., Fenyus, M. L., Dayaram, T., Owens, B. M., Shigematsu, H., Levantini, E., Huettner, C. S., Lekstrom-Himes, J. A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.006 · Cited by 506 · see citing works

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S. H., Marino, M., Fang, F. C., Dinauer, M. C., & Nathan, C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80004-7 · Cited by 504 · see citing works

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

Klein, C., Grudzien, M., Appaswamy, G., Germeshausen, M., Sandrock, I., Schäffer, A. A., Rathinam, C., Boztuǧ, K., Schwinzer, B., Rezaei, N., et al. (2006) · Nature Genetics · doi:10.1038/ng1940 · Cited by 501 · see citing works

Multiple Roles for Neutrophils in Atherosclerosis

Soehnlein, O. (2012) · Circulation Research · doi:10.1161/circresaha.111.257535 · Cited by 498 · see citing works

Transcellular Diapedesis Is Initiated by Invasive Podosomes

Carman, C. V., Sage, P. T., Sciuto, T. E., de la Fuente, M. Á., Geha, R. S., Ochs, H. D., Dvorak, H. F., Dvořàk, A. M., & Springer, T. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.015 · Cited by 497 · see citing works

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

Collins, R. G., Velji, R., Guevara, J., Hicks, J. M., Chan, L., & Beaudet, A. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.189 · Cited by 493 · see citing works

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

Ambruso, D. R., Knall, C., Abell, A. N., Panepinto, J. A., Kurkchubasche, A. G., Thurman, G. W., Gonzalez-Aller, C., Hiester, A. A., deBoer, M., Harbeck, R. J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080074897 · Cited by 480 · see citing works

Molecular mechanism of antimicrobial peptides: The origin of cooperativity

Huang, H. W. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.02.001 · Cited by 473 · see citing works

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

Karsten, C. M., Pandey, M. K., Figge, J., Kilchenstein, R., Taylor, P. R., Rosas, M., McDonald, J. U., Orr, S. J., Berger, M., Petzold, D., et al. (2012) · Nature Medicine · doi:10.1038/nm.2862 · Cited by 471 · see citing works

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

Jensen, H. K., Donskov, F. N., Marcussen, N., Nordsmark, M., Lundbeck, F., & von der Maase, H. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.9498 · Cited by 460 · see citing works

TREM and TREM-like receptors in inflammation and disease

Ford, J. W., & McVicar, D. W. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.009 · Cited by 434 · see citing works

Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

Allen, L. H., & Aderem, A. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.627 · Cited by 431 · see citing works

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

Diana, J., Simoni, Y., Furio, L., Beaudoin, L., Agerberth, B., Barrat, F. J., & Lehuen, A. (2012) · Nature Medicine · doi:10.1038/nm.3042 · Cited by 428 · see citing works

C/EBPβ is required for 'emergency' granulopoiesis

Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G. (2006) · Nature Immunology · doi:10.1038/ni1354 · Cited by 425 · see citing works

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

Zernecke, A., Bot, I., Djalali-Talab, Y., Shagdarsuren, E., Bidzhekov, K., Meiler, S. U., Krohn, R. M., Schober, A., Sperandio, M., Soehnlein, O., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.160697 · Cited by 417 · see citing works

Demand-adapted regulation of early hematopoiesis in infection and inflammation

Takizawa, H., Boettcher, S., & Manz, M. G. (2012) · Blood · doi:10.1182/blood-2011-12-380113 · Cited by 404 · see citing works

Getting Leukocytes to the Site of Inflammation

Müller, W. A. (2013) · Veterinary Pathology · doi:10.1177/0300985812469883 · Cited by 401 · see citing works

Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

van Gisbergen, K. P. J. M., Sánchez‐Hernández, M., Geijtenbeek, T. B. H., & van Kooyk, Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041276 · Cited by 401 · see citing works

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency

Pïcard, C., Casanova, J., & Puel, A. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-11 · Cited by 394 · see citing works

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

Kreisel, D., Nava, R. G., Li, W., Zinselmeyer, B. H., Wang, B., Lai, J., Pless, R. B., Gelman, A. E., Krupnick, A. S., & Miller, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008737107 · Cited by 392 · see citing works

A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.

Wong, J., Johnston, B., Lee, S. S., Bullard, D. C., Smith, C. W., Beaudet, A. L., & Kubes, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119468 · Cited by 392 · see citing works

Immunoreceptor tyrosine-based inhibition motifs

Vivier, É., & Daëron, M. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80025-4 · Cited by 388 · see citing works

Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis

Gasser, O., & Schifferli, J. A. (2004) · Blood · doi:10.1182/blood-2004-01-0361 · Cited by 385 · see citing works

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

Sheppard, F. R., Kelher, M. R., Moore, E. E., McLaughlin, N. J. D., Banerjee, A. M., & Silliman, C. C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804442 · Cited by 374 · see citing works

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L., & Lowell, C. A. (2006) · Nature Immunology · doi:10.1038/ni1407 · Cited by 369 · see citing works

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

Piccard, H., Muschel, R. J., & Opdenakker, G. (2011) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2011.06.004 · Cited by 369 · see citing works

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

Gautam, N., Olofsson, A. M., Herwald, H., Iversen, L., Evy Lundgren-akerlund, B., Hedqvist, P., Arfors, K. ‐., Flodgaard, H. J., & Lindbom, L. (2001) · Nature Medicine · doi:10.1038/nm1001-1123 · Cited by 364 · see citing works

Pathogenesis of human systemic lupus erythematosus: recent advances

Crispín, J. C., Liossis, S. C., Kis‐Tóth, K., Lieberman, L. A., Kyttaris, V. C., Juang, Y., & Tsokos, G. C. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.12.005 · Cited by 361 · see citing works

Chediak-Higashi syndrome

Kaplan, J., Domenico, I. D., & Ward, D. M. (2008) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3282f2bcce · Cited by 360 · see citing works

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

Huh, S. J., Liang, S., Sharma, A. K., Dong, C., & Robertson, G. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4442 · Cited by 354 · see citing works

Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation

Chou, J., Mackman, N., Merrill‐Skoloff, G., Pedersen, B., Furie, B. C., & Furie, B. (2004) · Blood · doi:10.1182/blood-2004-03-0935 · Cited by 347 · see citing works

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

McDonald, B., McAvoy, E. F., Lam, F., Gill, V., de la Motte, C., Savani, R., & Kubes, P. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071765 · Cited by 345 · see citing works

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

Chou, R. C., Kim, N. D., Sadik, C. D., Seung, E., Lan, Y., Byrne, M. H., Haribabu, B., Iwakura, Y., & Luster, A. D. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.018 · Cited by 342 · see citing works

Anti-CCP antibodies: the past, the present and the future

VENROOIJ, W. J. V., van Beers, J. J. B. C., & Pruijn, G. J. M. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.76 · Cited by 342 · see citing works

Transepithelial Migration of Neutrophils

Zemans, R. L., Colgan, S. P., & Downey, G. P. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0348tr · Cited by 339 · see citing works

Insect haemocytes: What type of cell is that?

Ribeiro, C., & Brehélin, M. (2006) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2006.01.005 · Cited by 332 · see citing works

Capsule and d-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps

Wartha, F., Beiter, K., Albiger, B., Fernebro, J., Zychlinsky, A., Normark, S. J., & Henriques‐Normark, B. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00857.x · Cited by 329 · see citing works

Phagosome dynamics during phagocytosis by neutrophils

Nordenfelt, P., & Tapper, H. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810457 · Cited by 325 · see citing works

The role of microparticles in the pathogenesis of rheumatic diseases

Beyer, C., & Pisetsky, D. S. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.229 · Cited by 324 · see citing works

Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation

Basu, S., HODGSON, G. S., Katz, M., & Dunn, A. R. (2002) · Blood · doi:10.1182/blood.v100.3.854 · Cited by 316 · see citing works

Neutrophils efficiently cross-prime naive T cells in vivo

Beauvillain, C., Delneste, Y., Scotet, M., Peres, A., Gascan, H., Guermonprez, P., Barnaba, V., & Jeannin, P. (2007) · Blood · doi:10.1182/blood-2006-12-063826 · Cited by 316 · see citing works

An Extracellular Matrix–Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans

Byrd, A. S., O’Brien, X. M., Johnson, C. M., Lavigne, L. M., & Reichner, J. S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202671 · Cited by 311 · see citing works

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

Fridlender, Z. G., Sun, J., Mishalian, I., Singhal, S. K., Cheng, G., Kapoor, V., Horng, W.-H., Fridlender, G., Bayuh, R., Worthen, G. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031524 · Cited by 311 · see citing works

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

Evans, T. J., Buttery, L. D. K., Carpenter, A., Springall, D. R., Polak, J. M., & Cohen, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9553 · Cited by 311 · see citing works

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

Guo, Y., Audry, M., Ciancanelli, M. J., Alsina, L., Azevedo, J., Casadio, M., Anguiano, E., Sancho‐Shimizu, V., Lorenzo, L., Pauwels, E., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101568 · Cited by 310 · see citing works

The Role of Neutrophils in the Induction of Glomerulonephritis by Anti-Myeloperoxidase Antibodies

Xiao, H., Heeringa, P., Liu, Z., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62951-3 · Cited by 307 · see citing works

Mouse and human neutrophils induce anaphylaxis

Jönsson, F., Mancardi, D. A., Kita, Y., Karasuyama, H., Iannascoli, B., van Rooijen, N., Shimizu, T., Daëron, M., & Bruhns, P. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45232 · Cited by 306 · see citing works

High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions

Ionita, M. G., van den Borne, P., Catanzariti, L. M., Moll, F. L., de Vries, J. P. P. M., Pasterkamp, G., Vink, A., & de Kleijn, D. P. V. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.209296 · Cited by 304 · see citing works

Bacterial infection induces nitric oxide synthase in human neutrophils.

Wheeler, M. A., Smith, S. D., García‐Cardeña, G., Nathan, C., Weiss, R. M., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119121 · Cited by 296 · see citing works

The interferon signature in autoimmune diseases

Rönnblom, L., & Eloranta, M. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32835c7e32 · Cited by 294 · see citing works

Biochemistry and Physiology of the Neutrophil

Edwards, S. W. (1994) · Cambridge University Press eBooks · doi:10.1017/cbo9780511608421 · Cited by 286 · see citing works

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

Dalli, J., Norling, L. V., Renshaw, D. W., Cooper, D., Leung, K., & Perretti, M. (2008) · Blood · doi:10.1182/blood-2008-02-140533 · Cited by 277 · see citing works

Mechanisms of Leukocyte Sequestration in Inflamed Lungs

Doerschuk, C. M. (2001) · Microcirculation · doi:10.1111/j.1549-8719.2001.tb00159.x · Cited by 277 · see citing works

Hepatic platelet and leukocyte adherence during endotoxemia

Croner, R. S., Hoerer, E., Kulu, Y., Hackert, T., Gebhard, M. M., Herfarth, C., & Klar, E. (2006) · Critical Care · doi:10.1186/cc3968 · Cited by 275 · see citing works

K-ras activation generates an inflammatory response in lung tumors

Ji, H., Houghton, A. M., Mariani, T. J., Perera, S. A., Kim, C. B. Y., Padera, R. F., Tonon, G., McNamara, K. L., Marconcini, L. A. L., Hezel, A. F., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209237 · Cited by 271 · see citing works

Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

Nathan, C. F. (1989) · Blood · doi:10.1182/blood.v73.1.301.bloodjournal731301 · Cited by 266 · see citing works

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

Abdallah, D. S. A., Egan, C. E., Butcher, B. A., & Denkers, E. (2011) · International Immunology · doi:10.1093/intimm/dxr007 · Cited by 265 · see citing works

Regulation of Neutrophil Function by Adenosine

Barletta, K. E., Ley, K. F., & Mehrad, B. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226845 · Cited by 260 · see citing works

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

Bianchi, M., Niemiec, M. J., Siler, U., Urban, C. F., & Reichenbach, J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.021 · Cited by 251 · see citing works

Neutrophil β2 integrins: moderators of life or death decisions

Mayadas, T. N., & Culleré, X. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.05.002 · Cited by 247 · see citing works

The airway epithelium: more than just a structural barrier

Tam, A., Wadsworth, S. J., Dorscheid, D. R., Man, S. F. P., & Sin, D. D. (2011) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810396539 · Cited by 245 · see citing works

Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration

Shaw, S. K., Ma, S., Kim, M. B., Rao, R. M., Hartman, C. U., Froio, R. M., Yang, L., Jones, T., Liu, Y., Nusrat, A., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040965 · Cited by 240 · see citing works

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

Jaeger, B. N., Donadieu, J., Cognet, C., Bernat, C., Ordoñez‐Rueda, D., Barlogis, V., Mahlaoui, N., Fenis, A., Narni-Mancinelli, É., Beaupain, B., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111908 · Cited by 239 · see citing works

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

Filardy, A. A., Pires, D. R., Nunes, M. P., Takiya, C. M., Freire-de-Lima, C. G., Ribeiro-Gomes, F. L., & DosReis, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000017 · Cited by 237 · see citing works

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability

Distasi, M. R., & Ley, K. F. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.012 · Cited by 237 · see citing works

Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation

Choi, K.-Y. G., Chow, L. N. Y., & Mookherjee, N. (2012) · Journal of Innate Immunity · doi:10.1159/000336630 · Cited by 237 · see citing works

Biosynthesis, processing, and sorting of human myeloperoxidase

Hansson, M., Olsson, I., & Nauseef, W. M. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.08.009 · Cited by 236 · see citing works

Alarmins link neutrophils and dendritic cells

Yang, D., de la Rosa, G., Tewary, P., & Oppenheim, J. J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.004 · Cited by 234 · see citing works

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

Döring, Y., Drechsler, M. D., Wantha, S., Kemmerich, K., Lievens, D., Vijayan, S., Gallo, R. L., Weber, C., & Soehnlein, O. (2012) · Circulation Research · doi:10.1161/circresaha.112.265868 · Cited by 230 · see citing works

Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: results of a long-term survey

Germeshausen, M., Ballmaier, M., & Welte, K. (2006) · Blood · doi:10.1182/blood-2006-02-004275 · Cited by 229 · see citing works

CCR7 is involved in the migration of neutrophils to lymph nodes

Beauvillain, C., Cunin, P., Doni, A., Scotet, M., Jaillon, S., Loiry, M.-L., Magistrelli, G., Masternak, K., Chevailler, A., Delneste, Y., et al. (2010) · Blood · doi:10.1182/blood-2009-11-254490 · Cited by 227 · see citing works

Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: Cell fate is regulated at the level of gene expression

Kobayashi, S. D., Voyich, J. M., Buhl, C. L., Stahl, R. M., & DeLeo, F. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092148299 · Cited by 225 · see citing works

Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo

Chen, K., Nishi, H., Travers, R. J., Tsuboi, N., Martinod, K., Wagner, D. D., Stan, R. V., Croce, K., & Mayadas, T. N. (2012) · Blood · doi:10.1182/blood-2011-12-401133 · Cited by 218 · see citing works

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

Sun, S., Sursal, T., Adibnia, Y., Zhao, C., Zheng, Y. Z., Li, H., Otterbein, L. E., Hauser, C. J., & Itagaki, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059989 · Cited by 216 · see citing works

The molecular basis of leukocyte recruitment and its deficiencies

Schmidt, S., Moser, M., & Sperandio, M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.11.006 · Cited by 215 · see citing works

A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

Tang, T., Rosenkranz, A. R., Assmann, K. J. M., Goodman, M. J., Gutierrez-Ramos, J.-C., Carroll, M. C., Cotran, R. S., & Mayadas, T. N. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.11.1853 · Cited by 214 · see citing works

Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides

Kallenberg, C. G. M., Heeringa, P., & Stegeman, C. A. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0355 · Cited by 208 · see citing works

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis

Grenda, D. S., Murakami, M. A., Ghatak, J., Xia, J., Boxer, L. A., Dale, D. C., Dinauer, M. C., & Link, D. C. (2007) · Blood · doi:10.1182/blood-2006-11-057299 · Cited by 202 · see citing works

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

Furze, R. C., & Rankin, S. M. (2008) · The FASEB Journal · doi:10.1096/fj.08-109876 · Cited by 202 · see citing works

IL‐8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer

Rotondo, R., Barisione, G., Mastracci, L., Grossi, F., Orengo, A. M., Costa, R., Truini, M., Fabbi, M., Ferrini, S., & Barbieri, O. (2009) · International Journal of Cancer · doi:10.1002/ijc.24448 · Cited by 198 · see citing works

Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties

Dalli, J., Montero‐Melendez, T., Norling, L. V., Yin, X., Hinds, C., Haskard, D. O., Mayr, M., & Perretti, M. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.028589 · Cited by 197 · see citing works

Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR −/− Mice

van Leeuwen, M., Gijbels, M. J., Duijvestijn, A. M., Smook, M., Mj, V. D. G., Heeringa, P., de Winther, M. P. J., & Tervaert, J. W. C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.154807 · Cited by 195 · see citing works

IL ‐23: One cytokine in control of autoimmunity

Croxford, A. L., Mair, F., & Becher, B. (2012) · European Journal of Immunology · doi:10.1002/eji.201242598 · Cited by 194 · see citing works

Up-Regulated Expression of the CXCR2 Ligand KC/GRO-α in Atherosclerotic Lesions Plays a Central Role in Macrophage Accumulation and Lesion Progression

Boisvert, W. A., Rose, D. M., Johnson, K. A., Fuentes, M. E., Lira, S. A., Curtiss, L. K., & Terkeltaub, R. A. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.040748 · Cited by 189 · see citing works

Trans-cellular migration: cell–cell contacts get intimate

Carman, C. V., & Springer, T. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.05.007 · Cited by 189 · see citing works

Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

Nathan, C. F. (1989) · Blood · doi:10.1182/blood.v73.1.301.301 · Cited by 189 · see citing works

Innate and adaptive immunity in atherosclerosis

Packard, R. R. S., Lichtman, A. H., & Libby, P. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0153-8 · Cited by 188 · see citing works

Lupus neutrophils

Knight, J. S., & Kaplan, M. J. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283546703 · Cited by 185 · see citing works

Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment

Mamdouh, Z., Mikhailov, A. V., & Müller, W. A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082745 · Cited by 185 · see citing works

Expression, activation, and function of integrin αMβ2 (Mac-1) on neutrophil-derived microparticles

Pluskota, E., Woody, N. M., Szpak, D., Ballantyne, C. M., Soloviev, D. A., Simon, D. I., & Plow, E. F. (2008) · Blood · doi:10.1182/blood-2007-12-127183 · Cited by 184 · see citing works

Kinetics of fusion of the cytoplasmic granules with phagocytic vacuoles in human polymorphonuclear leukocytes. Biochemical and morphological studies.

Segal, A. W., Dorling, J., & Coade, S. B. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.1.42 · Cited by 183 · see citing works

‘Slings’ enable neutrophil rolling at high shear

Sundd, P., Gutierrez, E., Koltsova, E. K., Kuwano, Y., Fukuda, S., Pospieszalska, M. K., Groisman, A., & Ley, K. F. (2012) · Nature · doi:10.1038/nature11248 · Cited by 181 · see citing works

Neutrophil Priming in Host Defense: Role of Oxidants as Priming Agents

Swain, S. D., Rohn, T. T., & Quinn, M. T. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753625870 · Cited by 181 · see citing works

Determinants of the Phagosomal pH in Neutrophils

Jankowski, A. W., Scott, C. C., & Grinstein, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110059200 · Cited by 181 · see citing works

Human Neutrophil Fcγ Receptors Initiate and Play Specialized Nonredundant Roles in Antibody-Mediated Inflammatory Diseases

Tsuboi, N., Asano, K., Lauterbach, M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.013 · Cited by 180 · see citing works

Expression Profile of FcγRIIb on Leukocytes and Its Dysregulation in Systemic Lupus Erythematosus

Su, K., Yang, H., Li, X., Li, X., Gibson, A., Cafardi, J. M., Zhou, T., Edberg, J. C., & Kimberly, R. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3272 · Cited by 179 · see citing works

The expression and roles of Toll-like receptors in the biology of the human neutrophil

Parker, L. C., Whyte, M. K. B., Dower, S., & Sabroe, I. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104636 · Cited by 175 · see citing works

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

Devi, S., Li, A., Westhorpe, C. L. V., Lo, C. Y.-W., Abeynaike, L., Snelgrove, S. L., Hall, P., Ooi, J. D., Sobey, C. G., Kitching, A. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.3024 · Cited by 174 · see citing works

Neutrophil granule proteins tune monocytic cell function

Soehnlein, O., Weber, C., & Lindbom, L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.06.006 · Cited by 174 · see citing works

Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease

Koelink, P. J., Overbeek, S. A., Braber, S., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303252 · Cited by 169 · see citing works

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

Scapini, P., Bazzoni, F., & Cassatella, M. A. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.11.009 · Cited by 168 · see citing works

The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

Rabiet, M., HUET, E., & Boulay, F. (2007) · Biochimie · doi:10.1016/j.biochi.2007.02.015 · Cited by 166 · see citing works

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

Duffy, D., Perrin, H., Abadie, V., Benhabilès, N., Boissonnas, A., Liard, C., Descours, B., Reboulleau, D., Bonduelle, O., Verrier, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.015 · Cited by 166 · see citing works

Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania major Inoculation in Resistant Mice

Charmoy, M., Brunner-Agten, S., Aebischer, D., Auderset, F., Launois, P., Milon, G., Proudfoot, A. E. I., & Tacchini‐Cottier, F. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000755 · Cited by 162 · see citing works

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

Rotzius, P., Thams, S., Soehnlein, O., Kenne, E., Tseng, C.-N., Björkström, N., Malmberg, K., Lindbom, L., & Eriksson, E. (2010) · American Journal of Pathology · doi:10.2353/ajpath.2010.090480 · Cited by 162 · see citing works

Regulation of endothelial barrier function by reactive oxygen and nitrogen species

Boueiz, A. R., & Hassoun, P. M. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.10.005 · Cited by 161 · see citing works

The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases

Karsten, C. M., & Köhl, J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.015 · Cited by 159 · see citing works

GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors

Gijsbers, K., Gouwy, M., Struyf, S., Wuyts, A., Proost, P., Opdenakker, G., PENNINCKX, F. M., Ectors, N., Geboes, K. J., & Damme, J. V. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.027 · Cited by 158 · see citing works

Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis

Daniel, L., Fakhouri, F., Joly, D., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5000306 · Cited by 156 · see citing works

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

Hong, C., Kidani, Y., A-González, N., Phung, T., Ito, A., Rong, X., Ericson, K. R., Mikkola, H. K. A., Beaven, S. W., Miller, L. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58393 · Cited by 152 · see citing works

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

Bäck, M., Dahlén, S., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T., & Rovati, G. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004184 · Cited by 151 · see citing works

Transepithelial migration of neutrophils into the lung requires TREM-1

Klesney‐Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64181 · Cited by 149 · see citing works

Clinical implications of ELA2‐, HAX1‐, and G‐CSF‐receptor (CSF3R) mutations in severe congenital neutropenia

Zeidler, C., Germeshausen, M., Klein, C., & Welte, K. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07425.x · Cited by 148 · see citing works

Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles

Hong, Y., Eleftheriou, D., Hussain, A., et al. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011030298 · Cited by 148 · see citing works

The β-Glucan Receptor Dectin-1 Activates the Integrin Mac-1 in Neutrophils via Vav Protein Signaling to Promote Candida albicans Clearance

Li, X., Utomo, A. R. H., Culleré, X., Choi, M., Milner, D. A., Venkatesh, D., Yun, S. H., & Mayadas, T. N. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.009 · Cited by 147 · see citing works

“Emergency” granulopoiesis in G-CSF–deficient mice in response to Candida albicans infection

Basu, S., HODGSON, G. S., Zhang, H., Katz, M., Quilici, C., & Dunn, A. R. (2000) · Blood · doi:10.1182/blood.v95.12.3725 · Cited by 144 · see citing works

Microparticles and acute lung injury

McVey, M. J., Tabuchi, A., & Kuebler, W. M. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00354.2011 · Cited by 143 · see citing works

Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis

Edfeldt, K., Agerberth, B., Rottenberg, M. E., Gudmundsson, G. H., Wang, X.-B., Mandal, K., Xu, Q., & Yan, Z. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000223901.08459.57 · Cited by 142 · see citing works

A Novel Role for Neutrophils As Critical Activators of NK Cells

Spörri, R., Joller, N., Hilbi, H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7121 · Cited by 142 · see citing works

Leukocyte–epithelial interactions

Zen, K., & Parkos, C. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00103-0 · Cited by 135 · see citing works

Dectin‐1 promotes fungicidal activity of human neutrophils

Kennedy, A. D., Willment, J. A., Dorward, D. W., Williams, D. L., Brown, G. D., & DeLeo, F. R. (2007) · European Journal of Immunology · doi:10.1002/eji.200636653 · Cited by 134 · see citing works

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels

Hyun, Y., Sumagin, R., Sarangi, P. P., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111426 · Cited by 132 · see citing works

Impaired Integrin-Dependent Function in Wiskott-Aldrich Syndrome Protein-Deficient Murine and Human Neutrophils

Zhang, H., Schaff, U. Y., Green, C. E., Chen, H., Sarantos, M. R., Hu, Y., Wara, D. W., Simon, S. I., & Lowell, C. A. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.014 · Cited by 131 · see citing works

Revisiting Crohn's disease as a primary immunodeficiency of macrophages

Casanova, J., & Abel, L. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091683 · Cited by 128 · see citing works

Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity

Oikonomou, K., Kapsoritakis, A. N., Theodoridou, C. T., Karangelis, D., Germenis, A. E., Stefanidis, I., & Potamianos, S. P. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0516-5 · Cited by 128 · see citing works

Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells

Iking‐Konert, C., Ostendorf, B., Sander, O., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.034132 · Cited by 125 · see citing works

Mac-1 Signaling via Src-Family and Syk Kinases Results in Elastase-Dependent Thrombohemorrhagic Vasculopathy

Hirahashi, J., Mekala, D. J., Ziffle, J. V., Xiao, L., Saffaripour, S., Wagner, D. D., Shapiro, S. D., Lowell, C. A., & Mayadas, T. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.014 · Cited by 123 · see citing works

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

Dwivedi, N., Upadhyay, J., Neeli, I., Khan, S. N., Pattanaik, D., Myers, L. K., Kirou, K. A., Hellmich, B., Knuckley, B., Thompson, P. R., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33432 · Cited by 123 · see citing works

ANCA Disease

Falk, R. J., & Jennette, J. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009121238 · Cited by 120 · see citing works

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

Phillipson, M., Kaur, J., Colarusso, P., Ballantyne, C. M., & Kubes, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001649 · Cited by 119 · see citing works

Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4.

Doerfler, M. E., Danner, R. L., Shelhamer, J. H., et al. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113983 · Cited by 118 · see citing works

Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFNγ: role of CD18, ICAM-1, and ICAM-3

Costantini, C., Calzetti, F., Perbellini, O., Micheletti, A., Scarponi, C., Lonardi, S., Pelletier, M., Schäkel, K., Pizzolo, G., Facchetti, F., et al. (2010) · Blood · doi:10.1182/blood-2010-06-287243 · Cited by 118 · see citing works

Phagosome-lysosome fusion is a calcium-independent event in macrophages.

Zimmerli, S., Majeed, M., Gustavsson, M., Stendahl, O. I., Sanan, D. A., & Ernst, J. D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.1.49 · Cited by 115 · see citing works

Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment

Mamdouh, Z., Kreitzer, G. E., & Müller, W. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072328 · Cited by 115 · see citing works

Leukocyte trafficking in alveoli and airway passages

Doerschuk, C. M. (2000) · Respiratory Research · doi:10.1186/rr24 · Cited by 113 · see citing works

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334 · see citing works

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839 · see citing works

Neutrophil-derived cytokines: facts beyond expression

Tecchio, C., Micheletti, A., & Cassatella, M. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00508 · Cited by 699 · see citing works

Neutrophil-to-lymphocyte ratio and mortality in the United States general population

Song, M., Graubard, B. I., Rabkin, C. S., & Engels, E. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-79431-7 · Cited by 434 · see citing works

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442 · see citing works

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood · doi:10.1182/blood-2015-09-618538 · Cited by 413 · see citing works

Neutrophils at the crossroads of innate and adaptive immunity

Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372 · see citing works

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases

Yan, Z., Gibson, S. A., Buckley, J. A., Qin, H., & Benveniste, E. N. (2018) · Clinical Immunology · doi:10.1016/j.clim.2016.09.014 · Cited by 318 · see citing works

Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis

Mazza, M. G., Lucchi, S., Tringali, A. G. M., Rossetti, A., Botti, E. R., & Clerici, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.012 · Cited by 326 · see citing works

Neutrophil-lymphocyte ratio, monocyte-lymphocyte ratio and platelet-lymphocyte ratio in non-affective psychosis: A meta-analysis and systematic review

Mazza, M. G., Lucchi, S., Rossetti, A., & Clerici, M. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1583371 · Cited by 191 · see citing works

Microbial lysate upregulates host oxytocin

Varian, B. J., Poutahidis, T., DiBenedictis, B. T., Levkovich, T., Ibrahim, Y., Didyk, E., Shikhman, L., Cheung, H. K., Hardas, A., Ricciardi, C. E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.002 · Cited by 153 · see citing works

Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer

Ben-Batalla, I., Vargas-Delgado, M. E., von Amsberg, G., Janning, M., & Loges, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01184 · Cited by 149 · see citing works

The Role of Reactive Species on Innate Immunity

Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works

Cell death by phagocytosis

Brown, G. C. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-023-00921-6 · Cited by 129 · see citing works

Neutrophil Functions in Periodontal Homeostasis

Cortés-Vieyra, R., Rosales, C., & Uribe-Querol, E. (2016) · Journal of Immunology Research · doi:10.1155/2016/1396106 · Cited by 108 · see citing works

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis

Cheng, Y., Wang, Y., Wang, X., Jiang, Z., Zhu, L., & Fang, S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.893097 · Cited by 110 · see citing works

Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

Morsink, M., Willemen, N., Leijten, J., Bansal, R., & Shin, S. (2020) · Micromachines · doi:10.3390/mi11090849 · Cited by 73 · see citing works

The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence

Haley, K. P., Delgado, A. G., Piazuelo, M. B., Mortensen, B. L., Correa, P., Damo, S. M., Chazin, W. J., Skaar, E. P., & Gaddy, J. A. (2015) · Infection and Immunity · doi:10.1128/iai.00544-15 · Cited by 68 · see citing works

Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease

Ariño, S., Aguilar-Bravo, B., Coll, M., Lee, W.-Y., Peiseler, M., Cantallops-Vilà, P., Sererols-Viñas, L., Martínez-García de la Torre, R. A., Martínez-Sánchez, C., Pedragosa, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.045 · Cited by 59 · see citing works

Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/Lymphocyte Ratios in Mood Disorders

Marazziti, D., Torrigiani, S., Carbone, M. G., Mucci, F., Flamini, W., Ivaldi, T., & Dell'Osso, L. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867328666210922160116 · Cited by 61 · see citing works

Conquering Neutrophils

Döhrmann, S., Cole, J. N., & Nizet, V. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005682 · Cited by 52 · see citing works

Local antifungal immunity in the kidney in disseminated candidiasis

Jawale, C. V., & Biswas, P. S. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.04.005 · Cited by 25 · see citing works

Comparison of NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) as inflammatory markers in 1st episode mania and bipolar mania: A preliminary study

Goyal, M. K., Solanki, R. K., Jain, A., & Yadav, K. S. (2023) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry.indianjpsychiatry_250_22 · Cited by 12 · see citing works

Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis

Kreimeyer, H., Gonzalez, C. G., Fondevila, M. F., Hsu, C. L., Hartmann, P., Zhang, X., Stärkel, P., Bosques-Padilla, F., Verna, E. C., Abraldes, J. G., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-332730 · Cited by 12 · see citing works

A novel rapid Neutrophil Extracellular Trap (NET) release mechanism without neutrophil death

Kubes⁎, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.097

Activated Platelets do Not Enhance Neutrophil Extracellular Trap (NET) Formation

Hummel, S., Hally, K. E., & Larsen, P. (2023) · Heart Lung and Circulation · doi:10.1016/j.hlc.2023.06.563

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation

Arends, E. J., van Dam, L. S., Kraaij, T., et al. (2019) · Journal of Visualized Experiments · doi:10.3791/59150-v · Cited by 4 · see citing works

Generation of a Phagocytosis-Stimulating Factor by Polymorphonuclear Neutrophils during Phagocytosis

Ishibashi, Y., & Yamashita, T. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000232690 · Cited by 12 · see citing works

Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study

Park, J. H., Kim, J. E., Gu, J. Y., et al. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0042-101792 · Cited by 54 · see citing works