Targeted Cancer Therapy with a 2-Deoxyglucose-Based Adriamycin Complex
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Abstract
Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy-d-glucose and succinic acid (2DG-SUC-ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG-SUC-ADM for targeted cancer therapy.
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Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin, experienced a higher therapeutic efficacy in vivo.
“Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin [159,160,161], experienced a higher therapeutic efficacy in vivo.”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [161]
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- Authors
- Cao, J., Cui, S., Li, S., Du, C., Tian, J., Wan, S., Qian, Z., Gu, Y., Chen, W. R., & Wang, G.
- Affiliations
- University of Central Oklahoma (US)
- Corresponding author
- Gu, Yueqing
- Venue
- Cancer Research
- Published
- 2013-02-14
- Volume
- 73
- Issue
- 4
- Pages
- 1362-1373
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2121167229
- Cited by
- 84
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 11 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 6 · 2016: 11 · 2015: 3 · 2014: 2 · 2013: 4
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- doxorubicin, 2-deoxyglucose, 2-amino-2-deoxy-D-glucose, glucose transporter 1, multidrug resistance reversal, cardiotoxicity, antitumor efficacy, targeted cancer therapy, tumor cell uptake
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Cell Survival, Chemistry, Pharmaceutical, Deoxyglucose, Doxorubicin, Humans, Mice, Nude, Models, Chemical, Neoplasms, Quercetin, Molecular Structure, Microscopy, Confocal, Succinic Acid, Xenograft Model Antitumor Assays, Cell Line, Tumor, Tumor Burden, Glucose Transporter Type 1, Mice, Hep G2 Cells, MCF-7 Cells
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