Cited by 84Nanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsNanoplatforms for cancer theranostics

Targeted Cancer Therapy with a 2-Deoxyglucose-Based Adriamycin Complex

Cao, Jie, Cui, Sisi, Li, Siwen, Du, Changli, Tian, Junmei, Wan, Shunan, Qian, Zhiyu, Gu, Yueqing +2 more·2013·Cancer Research

Published version of a preprint

Abstract

Adriamycin (ADM) has been effective against many types of solid tumors in clinical applications. However, its use is limited because of systemic toxicities, primarily cardiotoxicity, and multidrug resistance. In this study, a new active receptor-mediated complex, ADM conjugated with 2-amino-2-deoxy-d-glucose and succinic acid (2DG-SUC-ADM), was designed to target tumor cells through glucose transporter 1 (GLUT1). MTT assay and confocal images showed that the complex had better inhibition rate to tumor cells and low toxicity to normal cells. Most importantly, the complex displayed a potential to reverse overcome multidrug resistance in cancer cells, with more complex transported into the nucleus of tumor cells. Our in vivo experiments also showed that this new complex could significantly decrease organ toxicity and enhance the antitumor efficacy compared with free ADM, indicating a promising drug of 2DG-SUC-ADM for targeted cancer therapy.

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-12-2072

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin, experienced a higher therapeutic efficacy in vivo.

    “Glucose conjugates of several cancer chemotherapeutics, including paclitaxel and doxorubicin [159,160,161], experienced a higher therapeutic efficacy in vivo.”

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Authors
Cao, J., Cui, S., Li, S., Du, C., Tian, J., Wan, S., Qian, Z., Gu, Y., Chen, W. R., & Wang, G.
Affiliations
University of Central Oklahoma (US)
Corresponding author
Gu, Yueqing
Venue
Cancer Research
Published
2013-02-14
Volume
73
Issue
4
Pages
1362-1373
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W2121167229
Cited by
84
References
39
Citations by year
2026: 1 · 2025: 4 · 2024: 11 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 6 · 2016: 11 · 2015: 3 · 2014: 2 · 2013: 4
FWCI
2.54
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
doxorubicin, 2-deoxyglucose, 2-amino-2-deoxy-D-glucose, glucose transporter 1, multidrug resistance reversal, cardiotoxicity, antitumor efficacy, targeted cancer therapy, tumor cell uptake
MeSH terms
Animals, Antibiotics, Antineoplastic, Cell Survival, Chemistry, Pharmaceutical, Deoxyglucose, Doxorubicin, Humans, Mice, Nude, Models, Chemical, Neoplasms, Quercetin, Molecular Structure, Microscopy, Confocal, Succinic Acid, Xenograft Model Antitumor Assays, Cell Line, Tumor, Tumor Burden, Glucose Transporter Type 1, Mice, Hep G2 Cells, MCF-7 Cells

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