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Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells

Don‐Doncow, N., Escobar, Z., Johansson, M., Kjellström, S., Garcia, V., Muñóz, E., Sterner, O., Bjartell, A. S., & Hellsten, R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.564252 · Cited by 94 · see citing works

Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

Schulenburg, A., Blatt, K., Cerny‐Reiterer, S., Sadovnik, I., Herrmann, H., Marian, B., Grunt, T. W., Zielinski, C. C., & Valent, P. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0113-9 · Cited by 94 · see citing works

Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Qureshi-Baig, K., Ullmann, P., Haan, S., & Letellier, E. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0602-2 · Cited by 99 · see citing works

Cancer-associated fibroblasts promote endometrial cancer growth via activation of interleukin-6/STAT-3/c-Myc pathway.

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MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression

Dallavalle, C., Albino, D., Civenni, G., Merulla, J., Ostano, P., Grand, M. M., Rossi, S., Losa, M., D’Ambrosio, G., Sessa, F., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86505 · Cited by 88 · see citing works

Biological effects of interleukin-6: Clinical applications in autoimmune diseases and cancers

Ho, L., Luo, S., & Lai, J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.009 · Cited by 87 · see citing works

New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation

Aghajani, M., Mansoori, B., Mohammadi, A., Asadzadeh, Z., & Baradaran, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28824 · Cited by 83 · see citing works

A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer

Arumuggam, N., Bhowmick, N. A., & Rupasinghe, H. P. V. (2015) · Phytotherapy Research · doi:10.1002/ptr.5327 · Cited by 79 · see citing works

Silibinin is a direct inhibitor of STAT3

Verdura, S., Cuyàs, E., Llorach-Parés, L., Pérez-Sánchez, A., Micol, V., Nonell‐Canals, A., Joven, J., Valiente, M., Sánchez-Martínez, M., Bosch‐Barrera, J., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.04.028 · Cited by 78 · see citing works

Proinflammatory cytokine interleukin-6 in prostate carcinogenesis.

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Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling

Wu, X., Tang, W., Marquez, R. T., Li, K., Highfill, C., He, F., Lian, J., Lin, J., Fuchs, J. R., Ji, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7336 · Cited by 70 · see citing works

Therapy escape mechanisms in the malignant prostate

Santer, F. R., Erb, H. H. H., & McNeill, R. V. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.08.005 · Cited by 64 · see citing works

Inflammation, Microbiota, and Prostate Cancer

Puhr, M., Marzo, A. M. D., Isaacs, W. B., Lucia, M. S., Sfanos, K. S., Yegnasubramanian, S., & Čulig, Z. (2016) · European Urology Focus · doi:10.1016/j.euf.2016.08.010 · Cited by 66 · see citing works

Role of STAT3 pathway in genitourinary tumors

Santoni, M., Conti, A., Piva, F., Massari, F., Ciccarese, C., Burattini, L., Liang Cheng, C., Antonio Lopez-beltran, B., Scarpelli, M., Santini, D., et al. (2015) · Future Science OA · doi:10.4155/fso.15.13 · Cited by 65 · see citing works

Cancer stem cell in prostate cancer progression, metastasis and therapy resistance

Verma, P., Shukla, N., Kumari, S., Ansari, M. S., Gautam, N. K., & Patel, G. K. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188887 · Cited by 65 · see citing works

Siltuximab (CNTO 328): a promising option for human malignancies

Chen, B.-A., & Chen, R. (2015) · Drug Design, Development and Therapy · doi:10.2147/dddt.s86438 · Cited by 65 · see citing works

Targeting Neuroendocrine Prostate Cancer: Molecular and Clinical Perspectives

Vlachostergios, P. J., & Papandreou, C. N. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00006 · Cited by 63 · see citing works

Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics

Bighetti‐Trevisan, R. L., Sousa, L. O., CASTILHO, R. M., & Almeida, L. O. (2019) · Stem Cells International · doi:10.1155/2019/9618065 · Cited by 62 · see citing works

Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer

Ojo, D., Lin, X., Wong, N., Gu, Y. J., & Tang, D. (2015) · Cancers · doi:10.3390/cancers7040890 · Cited by 62 · see citing works

Androgen receptor and prostate cancer stem cells: biological mechanisms and clinical implications

Deng, Q., & Tang, D. G. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0217 · Cited by 61 · see citing works

Inhibition of STAT3 with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity

Odate, S., Veschi, V., Yan, S., Lam, N., Woessner, R. D., & Thiele, C. J. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1317 · Cited by 61 · see citing works

SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells

Yu, H., Liu, Y., McFarland, B. C., Deshane, J. S., Hurst, D. R., Ponnazhagan, S., Benveniste, E. N., & Qin, H. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0004 · Cited by 60 · see citing works

Chronic inflammatory mediators enhance prostate cancer development and progression

Thapa, D., & Ghosh, R. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.023 · Cited by 59 · see citing works

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

Wu, J., Keng, V. W., Patmore, D. M., Kendall, J. J., Patel, A. V., Jousma, E., Jessen, W. J., Choi, K., Tschida, B. R., Silverstein, K. A. T., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.074 · Cited by 58 · see citing works

KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1

Ma, J., Bai, J., Zhang, H., Jia, J., Shi, Q., Yang, C., Wang, X., He, D., & Guo, P. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2671-1 · Cited by 59 · see citing works

Regulation of tumor cell plasticity by the androgen receptor in prostate cancer

Bishop, J. L., Davies, A., Ketola, K., & Zoubeidi, A. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0137 · Cited by 54 · see citing works

Interleukin-30/IL27p28 Shapes Prostate Cancer Stem-like Cell Behavior and Is Critical for Tumor Onset and Metastasization

Sorrentino, C., Ciummo, S. L., Cipollone, G., Caputo, S., Bellone, M., & Carlo, E. D. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3117 · Cited by 54 · see citing works

Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth In Vivo

Kroon, J., Buijs, J. T., van der Horst, G., Cheung, H., van der Mark, M. H., van Bloois, L., Rizzo, L. Y., Lammers, T., Pelger, R. C. M., Storm, G., et al. (2015) · The Prostate · doi:10.1002/pros.22963 · Cited by 52 · see citing works

Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance

Hashimoto, S., Hashimoto, A., Muromoto, R., Kitai, Y., Oritani, K., & Matsuda, T. (2022) · Cells · doi:10.3390/cells11162618 · Cited by 50 · see citing works

4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Chang, T., Yeh, C., Bamodu, O. A., Lin, Y., Deng, L., Rao, Y. K., Huang, C.-C., Lee, W., Wu, A. T. H., Hsiao, M., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.025 · Cited by 51 · see citing works

Effects on prostate cancer cells of targeting RNA polymerase III

Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay‐Odelot, H., Teichmann, M., Maitland, N. J., & White, R. J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz128 · Cited by 48 · see citing works

STAT3 and STAT5A are potential therapeutic targets in castration-resistant prostate cancer

Mohanty, S. K., Yagiz, K., Pradhan, D., Luthringer, D., Amin, M. B., Alkan, S., & Cinar, B. (2017) · Oncotarget · doi:10.18632/oncotarget.20844 · Cited by 47 · see citing works

Immunotargeting of Cancer Stem Cells

Köseer, A. S., Gaetano, S. D., Arndt, C., Bachmann, M. P., & Dubrovska, A. (2023) · Cancers · doi:10.3390/cancers15051608 · Cited by 46 · see citing works

Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma

Mochizuki, D., Adams, A., Warner, K. A., Zhang, Z., Pearson, A. T., Misawa, K., McLean, S. A., Wolf, G. T., & Nor, J. E. (2015) · Oncotarget · doi:10.18632/oncotarget.4477 · Cited by 45 · see citing works

Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties

Liu, Y., Wang, S., Xu, Q., Yuan, H., Guo, Y., Wang, Q., Kong, F., Lin, Z., Sun, D., Wang, R., et al. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0157-9 · Cited by 45 · see citing works

MDA-9/Syntenin (SDCBP) Is a Critical Regulator of Chemoresistance, Survival and Stemness in Prostate Cancer Stem Cells

Talukdar, S., Das, S. K., Pradhan, A. K., Emdad, L., Windle, J. J., Sarkar, D., & Fisher, P. B. (2019) · Cancers · doi:10.3390/cancers12010053 · Cited by 43 · see citing works

The critical role of STAT3 in biogenesis of tumor-derived exosomes with potency of inducing cancer cachexia in vitro and in vivo

Fan, M., Sun, W., Gu, X., Lu, S., Shen, Q., Liu, X., & Zhang, X. (2022) · Oncogene · doi:10.1038/s41388-021-02151-3 · Cited by 43 · see citing works

Prostate cancer-derived cathelicidin-related antimicrobial peptide facilitates macrophage differentiation and polarization of immature myeloid progenitors to protumorigenic macrophages

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SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells

Handle, F., Erb, H. H. H., Luef, B., Hoefer, J., Dietrich, D., Parson, W., Kristiansen, G., Santer, F. R., & Čulig, Z. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0495 · Cited by 42 · see citing works

PLA Electrospun Scaffolds for Three-Dimensional Triple-Negative Breast Cancer Cell Culture

Polonio‐Alcalá, E., Rabionet, M., Gallardo, X., Angelats, D., Ciurana, J., Ruiz‐Martínez, S., & Puig, T. (2019) · Polymers · doi:10.3390/polym11050916 · Cited by 42 · see citing works

Establishment of primary patient-derived xenografts of palliative TURP specimens to study castrate-resistant prostate cancer

Lawrence, M. G., Pook, D. W., Wang, H., Porter, L. H., Frydenberg, M., Kourambas, J., Appu, S., Poole, C., Beardsley, E. K., Ryan, A., et al. (2015) · The Prostate · doi:10.1002/pros.23039 · Cited by 41 · see citing works

Aging of the progenitor cells that initiate prostate cancer

Freeland, J., Crowell, P. D., Giafaglione, J. M., Boutros, P. C., & Goldstein, A. S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.014 · Cited by 41 · see citing works

Epigenetic Signaling of Cancer Stem Cells During Inflammation

Liu, Z., Ren, Y., Meng, L., Li, L., Beatson, R., Deng, J., Zhang, T., Liu, J., & Han, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.772211 · Cited by 39 · see citing works

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 3: PD-L1, Intracellular Signaling Pathways and Tumor Microenvironment

Palicelli, A., Croci, S., Bisagni, A., Zanetti, E., de Biase, D., Melli, B., Sanguedolce, F., Ragazzi, M., Zanelli, M., Chaux, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212330 · Cited by 40 · see citing works

CGI-99 promotes breast cancer metastasis via autocrine interleukin-6 signaling

Lin, C., Liao, W., Jian, Y., Peng, Y., Zhang, X., Ye, L., Cui, Y.-L., Wang, B., Wu, X., Xiong, Z., et al. (2017) · Oncogene · doi:10.1038/onc.2016.525 · Cited by 39 · see citing works

JAK3 is a potential biomarker and associated with immune infiltration in kidney renal clear cell carcinoma

Liang, F., Liang, H., Li, Z., & Huang, P. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106706 · Cited by 36 · see citing works

Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer

Ebersbach, C., Beier, A.-M. K., Thomas, C., & Erb, H. H. H. (2021) · Cancers · doi:10.3390/cancers13194854 · Cited by 37 · see citing works

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation

Shen, Y., Wang, C.-Y., Chuang, H., Hwang, J. J.-J., Chi, W.-H., Shu, C.-H., Ho, C., Li, W.-Y., & Chen, Y.-J. (2016) · Oncotarget · doi:10.18632/oncotarget.11113 · Cited by 32 · see citing works

A Positive Feedback Loop Between Prolactin and Stat5 Promotes Angiogenesis

Yang, X., & Friedl, A. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-12114-7_12 · Cited by 30 · see citing works

Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth

Zhu, Y., Wan, F., Shen, Y.-J., Wang, H., Zhang, G.-M., & Ye, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3697 · Cited by 30 · see citing works

Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program

Taurozzi, A. J., Beekharry, R., Wantoch, M., Labarthe, M., Walker, H. F., Seed, R., Simms, M. S., Rodrigues, G., Bradford, J. R., van der Horst, G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188228 · Cited by 29 · see citing works

STAT3 Signaling in Cancer

Gkouveris, I., Nikitakis, N. G., & Sauk, J. J. (2015) · Journal of Cancer Therapy · doi:10.4236/jct.2015.68078 · Cited by 27 · see citing works

CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations

Khanna, A., Rane, J. K., Kivinummi, K. K., Urbanucci, A., Helenius, M. A., Tolonen, T. T., Saramäki, O. R., Latonen, L., Manni, V., Pimanda, J. E., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3875 · Cited by 26 · see citing works

STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population

Canesin, G., Maggio, V., Palominos, M., Stiehm, A., Contreras, H. R., Castellón, E. A., Moróte, J., Paciucci, R., Maitland, N. J., Bjartell, A. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70948-5 · Cited by 26 · see citing works

Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling

Gallaher, J. A., Cook, L. M., Gupta, S., Araujo, A., Dhillon, J., Park, J. Y., Scott, J. G., Pow‐Sang, J. M., Basanta, D., & Lynch, C. C. (2014) · Clinical & Experimental Metastasis · doi:10.1007/s10585-014-9674-1 · Cited by 26 · see citing works

PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells

Gerlach, K., Popp, V., Wirtz, S., Al-Saifi, R., Gonzalez Acera, M., Atreya, R., Dregelies, T., Vieth, M., Fichtner-Feigl, S., McKenzie, A. N. J., et al. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjac097 · Cited by 25 · see citing works

Interleukin-6 Function and Targeting in Prostate Cancer

Čulig, Z. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55617-4_1 · Cited by 25 · see citing works

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9

Hu, R., Cao, Y., Wang, Y., Zhao, T., Yang, K., Fan, M., Guan, M., Hou, Y., Ying, J., Ma, X., et al. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01802-z · Cited by 25 · see citing works

Role of BET Inhibitors in Triple Negative Breast Cancers

Khandekar, D., & Tiriveedhi, V. (2020) · Cancers · doi:10.3390/cancers12040784 · Cited by 25 · see citing works

Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer

He, N., Feng, G., Yang, L., Xu, Y., Xie, X., Wang, H., Wang, Y., Ou, L., Pei, X., Liu, N., et al. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0360-x · Cited by 24 · see citing works

Importance of the IL-6/STAT3 signalling pathway in prostate cancer stem cells

Kroon, P. (2012) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1 · see citing works

302 Transcriptional Cooperation Between p53 and Estrogen Receptors in a Breast Cancer Model

Lion, M., Bisio, A., Sanctis, V. D., Ciribilli, Y., Tebaldi, T., Menendez, D., Resnick, M., & Inga, A. (2012) · European Journal of Cancer · doi:10.1016/s0959-8049(12)70996-6

301 Interleukin-6 Expression and JAK-STat Signalling in Prostate Cancer Stem Cells

Kroon, P., Berry, P. A., Bhasin, D., Li, C., Li, P. K., Stower, M. J., Mann, V. M., Simms, M. S., Maitland, N. J., & Collins, A. T. (2012) · European Journal of Cancer · doi:10.1016/s0959-8049(12)70995-4

Abstract SY06-02: Revisiting the STATs of cancer: Emergence of stem-like cancer cells

Jove, R. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-sy06-02

304 Spontaneous Hybrids Between Breast Cancer and Multipotent Stromal Cells Acquire a Mixed Gene Expression Profile While Maintaining the Histopathological Appearance of Breast Carcinoma

Lorico, A., Mercapide, J., & Rappa, G. (2012) · European Journal of Cancer · doi:10.1016/s0959-8049(12)70998-x