Dietary advanced glycation end products and their relevance for human health
Open accessAbstract
Due to their bioactivity and harmful potential, advanced glycation end products (AGEs) are discussed to affect human health. AGEs are compounds formed endogenously in the human body andexogenously, especially, in foods while thermal processing. In contrast to endogenous AGEs, dietary AGEs are formed in much higher extent. However, their risk potential is also depending on absorption, distribution, metabolism and elimination. For over 10 years an intense debate on the risk of dietary AGEs on human health is going on. On the one hand, studies provided evidence that dietary AGEs contribute to clinical outcomes. On the other hand, human studies failed to observe any association. Because it was not possible to draw a final conclusion, the call for new interdisciplinary approaches arose. In this review, we will give an overview on the current state of scientific knowledge in this field. In particular, we focus on (I) the occurrence of AGEs in foods and the daily uptake of AGEs, (II) contribution to endogenous levels and (III) the effect on health-/disease-related biomarkers in humans.
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Foods with high pH values (up to 10) have elevated AGEs due to free amino groups under alkaline conditions.
“Foods with high pH values (up to 10) have elevated AGEs due to free amino groups under alkaline conditions21.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [21]
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Self-citation
- Authors
- Nowotny, K., Schröter, D., Schreiner, M., & Grune, T.
- Affiliations
- German Institute of Human Nutrition (DE)
- Universität Hamburg (DE)
- Leibniz Institute of Vegetable and Ornamental Crops (DE)
- University of Potsdam (DE)
- Corresponding author
- Grune, Tilman
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 47
- Pages
- 55-66
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2811317264
- Cited by
- 255
- References
- 121
- Citations by year
- 2026: 25 · 2025: 26 · 2024: 34 · 2023: 44 · 2022: 41 · 2021: 40 · 2020: 23 · 2019: 21
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Ageing Research Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Leibniz Research Alliance "Sustainable Food Production and Healthy Nutrition"
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- advanced glycation end products, dietary AGEs, thermal food processing, disease risk
- MeSH terms
- Aging, Diet, Health Status, Humans, Glycation End Products, Advanced
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