FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

Deshmane, S. L., Kremlev, S., Amini, S., & Sawaya, B. E. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0027 · Cited by 3,889

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544

Monocyte recruitment during infection and inflammation

Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085

Non-invasive profiling of the tumour microenvironment with spatial ecotypes

Zhang, W., Brown, E. L., Usmani, A., Earland, N. J., Kang, M., Olelewe, C., Viswanathan, A., Chauhan, P. S., Steen, C. B., Jeon, H. S., et al. (2026) · Nature · doi:10.1038/s41586-026-10452-4 · Cited by 35

Evaluation of the circulating level of fibroblast activation protein α for diagnosis of esophageal squamous cell carcinoma

Liao, Y., Xing, S., Xu, B., Liu, W., & Zhang, G. (2017) · Oncotarget · doi:10.18632/oncotarget.16274 · Cited by 31

Immune contexture of cholangiocarcinoma

Paillet, J., Kroemer, G., & Pol, J. G. (2019) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000613 · Cited by 31

Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives

Han, X., Zhang, W.-H., Wang, W., Yu, X., & Liu, L. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188444 · Cited by 31

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

Filipescu, D., Carcamo, S., Agarwal, A., Tung, N., Humblin, É., Goldberg, M. S., Vyas, N. S., Beaumont, K. G., Demircioğlu, D., Sridhar, S., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01208-7 · Cited by 32

Immunosuppressive Microenvironment Revealed by Immune Cell Landscape in Pre-metastatic Liver of Colorectal Cancer

Zeng, D., Wang, M., Wu, J., Lin, S., Ye, Z., Zhou, R., Wang, G., Wu, J., Sun, H., Bin, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.620688 · Cited by 30

IDH Inhibitors and Immunotherapy for Biliary Tract Cancer: A Marriage of Convenience?

Brandi, G., & Rizzo, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810869 · Cited by 30

Myofibroblast depletion reduces kidney cyst growth and fibrosis in autosomal dominant polycystic kidney disease

Dwivedi, N., Jamadar, A., Mathew, S., Fields, T. A., & Rao, R. (2022) · Kidney International · doi:10.1016/j.kint.2022.08.036 · Cited by 30

Secretory leukocyte protease inhibitor (SLPI) in cancer pathophysiology: Mechanisms of action and clinical implications

Zhang, X., Liu, S. S., Ma, J., & Qu, W. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154633 · Cited by 32

Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression

Wenta, T., Nastały, P., Lipińska, B., & Manninen, A. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.10.007 · Cited by 33

Immunobiology of cancer-associated fibroblasts in the context of radiotherapy

Hellevik, T., Berzaghi, R., Lode, K., Islam, A., & Martínez-Zubiaurre, I. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03112-w · Cited by 32

A DNA vaccine expressing an optimized secreted FAPα induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer

Geng, F., Guo, J., Guo, Q., Xie, Y., Dong, L., Zhou, Y., Liu, C., Yu, B., Wu, H., Wu, J., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.06.012 · Cited by 30

Emerging Trends in Gastrointestinal Cancer Targeted Therapies: Harnessing Tumor Microenvironment, Immune Factors, and Metabolomics Insights

Rauth, S., Malafa, M. P., Ponnusamy, M. P., & Batra, S. K. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.005 · Cited by 29

The prognostic significance of fibroblast activation protein-α in human lung adenocarcinoma

Shi, J., Hou, Z., Yan, J., Qiu, W., Liang, L., Meng, M., Li, L., Wang, X., Xie, Y., Jiang, L., et al. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.01.82 · Cited by 29

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment

Muñoz, R., Girotti, A., Hileeto, D., & Arias, F. J. (2021) · Cancers · doi:10.3390/cancers13215414 · Cited by 31

Tumor microenvironment in pancreatic ductal adenocarcinoma: Implications in immunotherapy

Smith, C., Zheng, W., Dong, J., Wang, Y., Lai, J., Liu, X., & Yin, F. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i27.3297 · Cited by 29

Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance

Miari, K. E., & Williams, M. T. S. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16028 · Cited by 29

The Superiority of Fibroblast Activation Protein Inhibitor (FAPI) PET/CT Versus FDG PET/CT in the Diagnosis of Various Malignancies

Dong, Y., Zhou, H., Alhaskawi, A., Wang, Z., Lai, J., Yao, C., Liu, Z., Ezzi, S. H. A., Kota, V. G., Abdulla, M. H. A. H., et al. (2023) · Cancers · doi:10.3390/cancers15041193 · Cited by 29

Treatment with FAP-targeted zinc ferrite nanoparticles for rheumatoid arthritis by inducing endoplasmic reticulum stress and mitochondrial damage

Qi, W., Jin, L., Wu, C., Liao, H., Zhang, M., Zhu, Z., Han, W., Chen, Q., & Ding, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100702 · Cited by 28

The Emerging Role of Immunotherapy in Intrahepatic Cholangiocarcinoma

Fiste, O., Ntanasis‐Stathopoulos, I., Gavriatopoulou, M., Liontos, M., Koutsoukos, K., Dimopoulos, M. A., & Zagouri, F. (2021) · Vaccines · doi:10.3390/vaccines9050422 · Cited by 27

Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors

Shi, Y., Kong, Z., Liu, P., Hou, G., Wu, J., Ma, W., Cheng, X., & Wang, Y. (2021) · Cells · doi:10.3390/cells10051142 · Cited by 31

Bête Noire of Chemotherapy and Targeted Therapy: CAF-Mediated Resistance

De, P. K., Aske, J. C., Sulaiman, R. A., & Dey, N. (2022) · Cancers · doi:10.3390/cancers14061519 · Cited by 29

Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions

Thiery, J. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00103 · Cited by 29

Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Timperi, E., & Romano, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194642 · Cited by 29

An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments

Xue, X., Wang, X., Pang, M., Yu, L., Qian, J., Li, X., Tian, M., Lu, C. Y., Xiao, C., & Liu, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02452-1 · Cited by 29

Collagen remodeling-mediated signaling pathways and their impact on tumor therapy

Yuan, Z., Lin, B., Wang, C., Yan, Z., Yang, F., & Su, H. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108330 · Cited by 26

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

Li, Y., Liu, Q., Jing, X., Wang, Y., Jia, X., Yang, X., & Chen, K. (2025) · MedComm · doi:10.1002/mco2.70292 · Cited by 32

Targeting FAPα-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis

Li, X., Chen, M., Lu, W., Tang, J., Deng, L., Wen, Q., Huang, M., Deng, R., Ye, G., Ye, W., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.01.013 · Cited by 29

Tumor Microenvironment in Hepatocellular Carcinoma: Key Players for Immunotherapy

Feng, H., Zhuo, Y., Zhang, X., Li, Y., Li, Y., Duan, X., Shi, J., Xu, C., Gao, Y., & Yu, Z. (2022) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s381764 · Cited by 29

CCL3 secreted by hepatocytes promotes the metastasis of intrahepatic cholangiocarcinoma by VIRMA-mediated N6-methyladenosine (m6A) modification

Zhou, S., Yang, K., Chen, S., Lian, G., Huang, Y., Yao, H., Zhao, Y., Huang, K., Yin, D., Lin, H., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03897-y · Cited by 27

Cold atmospheric plasma: Novel opportunities for tumor microenvironment targeting

Dai, X., & Zhu, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5491 · Cited by 28

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1129831 · Cited by 27

Cancer-associated mesenchymal stem/stromal cells: role in progression and potential targets for therapeutic approaches

Hazrati, A., Malekpour, K., Mirsanei, Z., Khosrojerdi, A., Rahmani-Kukia, N., Heidari, N., Abbasi, A., & Soudi, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1280601 · Cited by 27

Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice

Taddio, M. F., Doshi, S., Masri, M., Jeanjean, P., Hikmat, F., Gerlach, A., Nyiranshuti, L., Rosser, E. W., Schaue, D., Besserer‐Offroy, É., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06809-4 · Cited by 30

Regulation of Fibroblast Activation Protein-α Expression: Focus on Intracellular Protein Interactions

Juillerat‐Jeanneret, L., Tafelmeyer, P., & Golshayan, D. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01010 · Cited by 27

An osteoimmunomodulatory Ca2+/Zn2+-doped scaffold promotes M2 macrophage polarization via the src-mediated chemoking signaling pathway to enhance osteoinduction

Wang, K., Jiang, K., Luo, C., You, X., Shen, H., Wu, D., Huang, F.-W., Li, L., Huang, S., Xu, J., et al. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111653 · Cited by 26

Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein

Dvořáková, P., Bušek, P., Knedlík, T., Schimer, J., Etrych, T., Kostka, L., Šromová, L., Šubr, V., Šácha, P., Šedo, A., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00767 · Cited by 26

Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner

Monslow, J., Todd, L., Chojnowski, J. E., Govindaraju, P. K., Assoian, R. K., & Puré, E. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.01.004 · Cited by 25

VDAC1 Silencing in Cancer Cells Leads to Metabolic Reprogramming That Modulates Tumor Microenvironment

Zerbib, E., Arif, T., Shteinfer‐Kuzmine, A., Caspi, V. C., & Shoshan‐Barmatz, V. (2021) · Cancers · doi:10.3390/cancers13112850 · Cited by 27

Natural Compounds Targeting Cancer-Associated Fibroblasts against Digestive System Tumor Progression: Therapeutic Insights

Chiu, K.-J., Chiou, H.-Y. C., Huang, C.-H., Lu, P.-C., Kuo, H.-R., Wang, J., & Lin, M. (2022) · Biomedicines · doi:10.3390/biomedicines10030713 · Cited by 25

The role of immunosuppressive myofibroblasts in the aging process and age-related diseases

Salminen, A. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02360-1 · Cited by 26

Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production

Shahpar, M. G., Pakravan, K., Razmara, E., Amooie, F., Mahmoudian, M., Heshmati, M., & Babashah, S. (2024) · BMC Cancer · doi:10.1186/s12885-024-12190-0 · Cited by 27

Fibroblast activation proteins-α suppress tumor immunity by regulating T cells and tumor-associated macrophages

Hou, C. M., Qu, X. M., Zhang, J., Ding, T., Han, W., Ji, G. C., Zhong, Z. H., Chen, H., & Zhang, F. (2017) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2017.12.003 · Cited by 24

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

Rymenant, Y. V., Tanç, M., Elzen, R. V., Bracke, A., Wever, O. D., Augustyns, K., Lambeir, A., Kockx, M. M., Meester, I. D., & der Veken, P. V. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.640566 · Cited by 24

Biodegradable Polymeric Nanoparticles Containing an Immune Checkpoint Inhibitor (aPDL1) to Locally Induce Immune Responses in the Central Nervous System

Zhang, M., Jiang, X., Zhang, Q., Zheng, T., Mohammadniaei, M., Wang, W., Shen, J., & Sun, Y. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102274 · Cited by 24

Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal Cancer

Miyashita, N., & Saito, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010973 · Cited by 27

Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting

Cerella, C., Dicato, M. A., & Diederich, M. F. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106914 · Cited by 24

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges

Jiang, Z., Zheng, X., Li, M., & Liu, M. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1050-6 · Cited by 24

Crosstalk between heterogeneous cancer-associated fibroblast subpopulations and the immune system in breast cancer: key players and promising therapeutic targets

Liu, L., Wan, W., Chang, Y., Ao, L., Xu, Y., & Xu, X. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03527-z · Cited by 27

STAT3 axis in cancer and cancer stem cells: From oncogenesis to targeted therapies

Godugu, D., Chilamakuri, R., & Agarwal, S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189461 · Cited by 26

The Urokinase-Type Plasminogen Activator Receptor (uPAR) as a Mediator of Physiological and Pathological Processes: Potential Therapeutic Strategies

Iftikhar, A., Mahmood, N., & Rabbani, S. A. (2025) · Cancers · doi:10.3390/cancers17203309 · Cited by 23

Role of Chemokines in the Biology of Cholangiocarcinoma

Caligiuri, A., Pastore, M., Lori, G., Raggi, C., Maira, G. D., Marra, F., & Gentilini, A. (2020) · Cancers · doi:10.3390/cancers12082215 · Cited by 23

Chemokine signaling in cancer-stroma communications

Singh, A. J., & Gray, J. W. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00621-7 · Cited by 23

Cancer-associated fibroblasts: Versatile mediators in remodeling the tumor microenvironment

Zhang, Q., Wang, Y., & Liu, F. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110567 · Cited by 23

Lactate induced mesenchymal stem cells activation promotes gastric cancer cells migration and proliferation

Tao, Z., Huang, C., Wang, D., Wang, Q., Gao, Q., Zhang, H., Zhao, Y., Wang, M., Xu, J., Shen, B., et al. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113492 · Cited by 23

Clinical prospective study of Gallium 68 (68Ga)–labeled fibroblast-activation protein inhibitor PET/CT in the diagnosis of biliary tract carcinoma

Li, J., Xu, K., Deliang, G., Liao, B., Zhu, Q., Haitao, W., Jiang, Y., Dong-de, W., Xia, X., Jiang, P., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06137-z · Cited by 23

FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review

Öztürk, A. A., & Flamen, P. (2023) · Cancer Imaging · doi:10.1186/s40644-023-00598-z · Cited by 23

The CCL2-CCR2 Axis in Lymph Node Metastasis From Oral Squamous Cell Carcinoma: An Immunohistochemical Study

Fujita, S., & Ikeda, T. (2016) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2016.09.052 · Cited by 23

Development of a Cross-Reactive Monoclonal Antibody for Detecting the Tumor Stroma

Hintz, H. M., Cowan, A. E., Shapovalova, M., & LeBeau, A. M. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00206 · Cited by 22

Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer

Li, Y., Wei, Y., Tang, W., Luo, J., Wang, M., Lin, H., Guo, H., Ma, Y., Zhang, J., & Li, Q. (2019) · PeerJ · doi:10.7717/peerj.8067 · Cited by 23

Prognostic Interactions between FAP+ Fibroblasts and CD8a+ T Cells in Colon Cancer

Herrera, M., Mezheyeuski, A., Villabona, L. E. E., Corvigno, S., Strell, C., Klein, C., Hölzlwimmer, G., Glimelius, B. L. G., Masucci, G. V., Sjöblom, T., et al. (2020) · Cancers · doi:10.3390/cancers12113238 · Cited by 23

Mechanoimmunology in the solid tumor microenvironment

Golo, M., Newman, P. L. H., Kempe, D., & Biro, M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231427 · Cited by 23

SpottedPy quantifies relationships between spatial transcriptomic hotspots and uncovers environmental cues of epithelial-mesenchymal plasticity in breast cancer

Withnell, E., & Secrier, M. (2024) · Genome biology · doi:10.1186/s13059-024-03428-y · Cited by 24

Neuronal CCL2 responds to hyperglycaemia and contributes to anxiety disorders in the context of diabetes

Pan, K., Gao, Y.-N., Zong, H., Zhang, Y.-M., Qi, Y., Wang, H., Chen, W., Zhou, T. J., Zhao, J., Yin, T., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01281-2 · Cited by 27

Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance

Ravichandra, A., Bhattacharjee, S., & Affò, S. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2022.01.009 · Cited by 23

Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

He, Z., Xin, Z., Yang, Q., Wang, C., Li, M., Rao, W., Du, Z., Bai, J. Q. A., Guo, Z., Ruan, X., et al. (2022) · eLife · doi:10.7554/elife.78616 · Cited by 24

Three categories of similarities between the placenta and cancer that can aid cancer treatment: Cells, the microenvironment, and metabolites

Pang, H., Lei, D., Guo, Y., Yu, Y., Liu, T., Liu, Y., Chen, T., & Fan, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.977618 · Cited by 23

Fibroblast activation protein-based theranostics in pancreatic cancer

Cheng, C., Yang, P., Sun, Y., Song, S., & Chen, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.969731 · Cited by 23

Reprogramming of cancer-associated fibroblasts combined with immune checkpoint inhibitors: A potential therapeutic strategy for cancers

Li, M., Wu, B., Li, L., Lv, C., & Tian, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188945 · Cited by 23

The Impact of Cancer-Associated Fibroblasts on Drug Resistance, Stemness, and Epithelial-Mesenchymal Transition in Bladder Cancer: A Comparison between Recurrent and Non-Recurrent Patient-Derived CAFs

Rastegar‐Pouyani, N., Montazeri, V., Marandi, N., Aliebrahimi, S., Andalib, M., Jafarzadeh, E., Montazeri, H., & Ostad, S. N. (2023) · Cancer Investigation · doi:10.1080/07357907.2023.2237576 · Cited by 22

FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway

Jiang, K., Xu, L., Ning, J., & Fan, C. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03073-8 · Cited by 22

The Role of Chemokines in Orchestrating the Immune Response to Pancreatic Ductal Adenocarcinoma

Lekan, A. A., & Weiner, L. M. (2024) · Cancers · doi:10.3390/cancers16030559 · Cited by 24

The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells

Zhang, X., Zhang, M., Sun, H., Wang, X., Wang, X., Sheng, W., & Xu, M. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.01.033 · Cited by 22

Macrophages Orchestrate the Liver Tumor Microenvironment

Quaranta, V., Ballarò, C., & Giannelli, G. (2024) · Cancers · doi:10.3390/cancers16091772 · Cited by 21

Dual targeting chimeric antigen receptor cells enhance antitumour activity by overcoming T cell exhaustion in pancreatic cancer

Ruixin, S., Yifan, L., Yansha, S., Zhou, M., Yiwei, D., Xiao-li, H., Bizhi, S., Hua, J., & Li, Z. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16505 · Cited by 22

Functional heterogeneity of cancer-associated fibroblasts with distinct neoadjuvant immunotherapy plus chemotherapy response in esophageal squamous cell carcinoma

Jiang, J., Xu, C., Han, D., Lu, Y., Yang, F., Wang, J., Yan, X., Mu, X., Zhang, J., Jia, C., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00656-z · Cited by 24

Cancer‑associated fibroblasts: a pivotal regulator of tumor microenvironment in the context of radiotherapy

Zheng, L., Cai, W., Ke, Y., Hu, X., Yang, C., Zhang, R., Wu, H., Liu, D., Yu, H., & Wu, C. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02138-7 · Cited by 23

Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment

Cao, L., Meng, X., Zhang, Z., Liu, Z., & He, Y. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01201-z · Cited by 28

DDR2/STAT3 Positive Feedback Loop Mediates the Immunosuppressive Microenvironment by Upregulating PD-L1 and Recruiting MDSCs in Oxaliplatin-Resistant HCC

Liu, W., Zhang, F., Quan, B., Yao, F., Chen, R., Ren, Z., Dong, L., & Yin, X. H. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101377 · Cited by 20

New targets and new drugs for hepatobiliary cancers

Chan, S. L., Lamarca, Á., Hsu, C., Moreno, V., Chan, L. L., & Keenan, B. P. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.08.018 · Cited by 23

FAP positive cancer‐associated fibroblasts promote tumor progression and radioresistance in esophageal squamous cell carcinoma by transferring exosomal lncRNA AFAP1‐AS1

Zhou, X., Tong, Y., Yu, C., Pu, J., Zhu, W., Zhou, Y. F., Wang, Y., Xiong, Y., & Sun, X. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23782 · Cited by 20

Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma

Eom, J., Park, S. M., Feisst, V., Chen, C. J., Mathy, J. E., McIntosh, J. D., Angel, C. E., Bartlett, A. S., Martin, R., Mathy, J. A., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0796 · Cited by 20

Phenotypic Heterogeneity of Cancer Associated Fibroblasts in Cervical Cancer Progression: FAP as a Central Activation Marker

Bueno-Urquiza, L. J., Godínez-Rubí, M., Villegas‐Pineda, J. C., Vega‐Magaña, N., Jave‐Suárez, L. F., Puebla‐Mora, A. G., Aguirre-Sandoval, G. E., Martínez-Silva, M. G., Ramírez-de-Arellano, A., & Pereira-Suárez, A. L. (2024) · Cells · doi:10.3390/cells13070560 · Cited by 19

Rhein and hesperidin nanoparticles remodel tumor immune microenvironment by reducing CAFs and CCL2 secreted by CAAs for efficient triple-negative breast cancer therapy

Huang, J., Zhang, H., Ma, L., Ma, N., Luo, N., Jin, W., Shi, J., Xu, S., & Xiong, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113001 · Cited by 19

Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Regulatory Mechanisms, Functions, and Therapeutic Implications

Ricci, A. D., Rizzo, A., Schirizzi, A., D’Alessandro, R., Frega, G., Brandi, G., Shahini, E., Cozzolongo, R., Lotesoriere, C., & Giannelli, G. (2024) · Cancers · doi:10.3390/cancers16203542 · Cited by 19

Chemokine ligand 2: beyond chemotaxis—a multifaceted role in tumor progression

Jin, Y., Wang, Y., & Yang, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1685474 · Cited by 23

A Mercaptoacetamide‐Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

Nam, J. H., Cho, H., Kang, H., Lee, J., Jung, M., Chang, Y., Kim, K., & Hoe, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26133 · Cited by 19

Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis

Mousavi, M. J., Farhadi, E., Vodjgani, M., Karami, J., Tahmasebi, M. N., Vaziri, A. S., Asgari, M., Rezaei, N., Mostafaei, S., Jamshidi, A., et al. (2021) · Iranian Journal of Allergy Asthma and Immunology · doi:10.18502/ijaai.v20i3.6335 · Cited by 19

Engineered Bifunctional Proteins for Targeted Cancer Therapy: Prospects and Challenges

Du, Y., & Xu, J. (2021) · Advanced Materials · doi:10.1002/adma.202103114 · Cited by 19

Cancer-associated fibroblasts as accomplices to confer therapeutic resistance in cancer

Wang, W., Cheng, B., & Yu, Q. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.67 · Cited by 18

Primed atypical ductal hyperplasia-associated fibroblasts promote cell growth and polarity changes of transformed epithelium-like breast cancer MCF-7 cells via miR-200b/c-IKKβ signaling

Sun, Y., Yang, D., Xi, L., Chen, Y., Fu, L., Sun, K., Yin, J., Li, X., Liu, S., Qin, Y., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0133-1 · Cited by 19

Development of a Bispecific Antibody-Based Platform for Retargeting of Capsid Modified AAV Vectors

Kuklik, J., Michelfelder, S., Schiele, F., Kreuz, S., Lamla, T., Müller, P., & Park, J. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158355 · Cited by 17

CSF1/CSF1R signaling mediates malignant pleural effusion formation

Kosti, C., Vaitsi, P. C., Pappas, A., Iliopoulou, M. P., Psarra, K., Magkouta, S., & Kalomenidis, I. (2022) · JCI Insight · doi:10.1172/jci.insight.155300 · Cited by 19

CAFs and T cells interplay: The emergence of a new arena in cancer combat

Chen, M., Chen, F., Gao, Z., Li, X., Hu, L., Yang, S., Zhao, S., & Song, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117045 · Cited by 20

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models

Garate-Soraluze, E., Serrano-Mendioroz, I., Fernández, L., de Andrea, C. E., Barrio‐Alonso, C., Herrero, C., Teijeira, Á., Luri‐Rey, C., Claus, C., Tanos, T., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009852 · Cited by 18

Effect of cancer-associated fibroblasts on radiosensitivity of cancer cells

Ji, X., Zhu, X., & Lu, X. (2017) · Future Oncology · doi:10.2217/fon-2017-0054 · Cited by 18

Pan‑cancer analysis reveals the role of long non‑coding RNA LINC01614 as a highly cancer‑dependent oncogene and biomarker

Wang, D., Zhang, H., Fang, X., Cao, D., & Liu, H. (2020) · Oncology Letters · doi:10.3892/ol.2020.11648 · Cited by 18

CYB561D2 up-regulation activates STAT3 to induce immunosuppression and aggression in gliomas

Tao, B., Shi, J., Shuai, S., Zhou, H., Zhang, H., Li, B., Wang, X., Li, G., He, H., & Zhong, J. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02987-z · Cited by 18

Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review)

Yang, R., Song, Y., Shakoor, K., Yi, W., Peng, C., & Liu, S. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12687 · Cited by 18

High expressions of CD10, FAP and GPR77 in CAFs are associated with chemoresistance and worse prognosis in gastric cancer

Tong, Y., Zhao, Z., Zhang, J., Wang, W., & Zhu, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.984817 · Cited by 18

Fibroblastic FAP promotes intrahepatic cholangiocarcinoma growth via MDSCs recruitment

Lin, Y., Li, B., Yang, X., Cai, Q., Liu, W., Tian, M., Luo, H., Yin, W., Song, Y. Y., Shi, Y., et al. (2019) · Neoplasia · doi:10.1016/j.neo.2019.10.005 · Cited by 90

Exploiting the STAT3 Nexus in Cancer-Associated Fibroblasts to Improve Cancer Therapy

Allam, A. H., Yakou, M. H., Pang, L., Ernst, M., & Huynh, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767939 · Cited by 38

STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts

Avalle, L., Raggi, L., Monteleone, E., Savino, A., Viavattene, D., Statello, L., Camperi, A., Stabile, S. A., Salemme, V., Marzo, N. D., et al. (2022) · Oncogene · doi:10.1038/s41388-021-02172-y · Cited by 109

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors

Cremasco, V., Astarita, J. L., Grauel, A. L., Keerthivasan, S., MacIsaac, K. D., Woodruff, M. C., Wu, M. P., Spel, L., Santoro, S. P., Amoozgar, Z., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0098 · Cited by 210

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

Fearon, D. T. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0002 · Cited by 288