The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure
Abstract
A large proportion of cancer-related deaths are caused by thrombosis and general organ failure. One example is acute renal failure, a major cause of morbidity and mortality in cancer patients. Surprisingly, however, little is known about the situation in organs that are not targets for metastasis or affected by the primary tumor. Recently, neutrophil extracellular traps (NET) were implicated in tumor-induced effects on distant organs unaffected by the actual tumor cells. Formation of NETs (NETosis) was identified a decade ago as a mechanism by which the innate immune system protects us from infections, especially in situations with sepsis. NETs are formed when neutrophils externalize their nuclear DNA together with antimicrobial granule proteins and form a web-like structure that can trap and kill microbes. It is now becoming increasingly clear that NETs also form under noninfectious inflammatory conditions like cancer, thrombosis, autoimmunity, and diabetes and significantly contribute to disease development. The existence of NET-dissolving drugs like heparin and DNase I, already in clinical use, and recent development of specific inhibitors of protein-arginine deiminase 4 (PAD4), an enzyme required for NET formation, should enable clinical targeting of NETosis. Preventing NETosis in cancer could provide a strategy to counteract tumor-induced thrombosis and organ failure as well as to suppress metastasis. Cancer Res; 76(15); 4311–5. ©2016 AACR.
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NETs contribute to etiology of some human pathologies including diabetes and cancer.
“NETs reportedly contribute to the etiology of some human pathologies, including diabetes and cancer [729–731].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [729]
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Metadata
- Authors
- Cedervall, J., Zhang, Y., & Olsson, A.-K.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Olsson, Anna-Karin
- Venue
- Cancer Research
- Published
- 2016-07-31
- Volume
- 76
- Issue
- 15
- Pages
- 4311-4315
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2472958851
- Cited by
- 146
- References
- 35
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 15 · 2023: 12 · 2022: 23 · 2021: 19 · 2020: 22 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophil extracellular traps, NETosis, metastasis, organ failure, acute kidney injury, PAD4 inhibitors, DNase I, heparin, neutrophils, cancer-associated thrombosis
- MeSH terms
- Humans, Multiple Organ Failure, Neoplasm Metastasis, Neoplasms, Risk Factors, Extracellular Traps
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