Osteosarcoma neutrophil extracellular trap network-associated gene recurrence and metastasis model
Open accessAbstract
Osteosarcoma (OS) is the most common malignancy in children and adolescents and has a high probability of recurrence and metastasis. A growing number of studies have shown that neutrophil extracellular traps (NETs) are strongly associated with cancer metastasis, but in osteosarcoma, genes associated with NETs that promote osteosarcoma recurrence and metastasis remain to be explored. We systematically investigated the gene expression patterns of NETs in OS samples from the GEO database. NETs molecular typing was evaluated based on NETs expression profiles, and the association between NETs molecular subtypes and immune microenvironment and metastatic features were explored. Ultimately, we constructed a signature model and column line graph associated with metastasis prediction and screened possible potential drugs for metastatic osteosarcoma. We established two different molecular subtypes of NETs, which showed significant differences in metastatic status, metastasis time, tumor immune microenvironment, and biological effects. We also constructed a NETs-related gene metastasis signature(NRGMS) to assess the expression pattern of NETs in patients to predict metastatic recurrence in osteosarcoma patients. We screened for TOMM40 and FH associated with metastatic recurrence in osteosarcoma patients. Overall, this study constructs a predictive model for osteosarcoma metastasis of NETs-related genes, which is expected to provide new insights into the metastasis of osteosarcoma.
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In osteosarcoma, a signature derived from NETs is associated with tumor recurrence and metastasis, and can predict patient prognosis.
“In osteosarcoma, a signature derived from NETs is associated with tumor recurrence and metastasis, and can predict patient prognosis [41, 42].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [42]
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- Authors
- Tang, H., Xie, J., Du, Y.-X., Tan, Z.-J., & Liang, Z.-T.
- Affiliations
- Central South University (CN)
- Corresponding author
- Liang, Zhuo-Tao
- ORCID
- Venue
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-01-29
- Volume
- 150
- Issue
- 2
- Pages
- 48-48
- ISSN
- 0084-5353 (ISSN-L)
- 1432-1335
- PMC
- PMC10824883
- OpenAlex
- W4391305176
- Cited by
- 14
- References
- 41
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 5
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Cancer Research and Clinical Oncology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Fundamental Research Funds for the Central Universities of Central South University.
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- osteosarcoma, neutrophil extracellular traps, tumor recurrence, metastasis prediction, tumor immune microenvironment, molecular subtypes, TOMM40, familial hypercholesterolemia, drug screening, pediatric bone cancer
- MeSH terms
- Adolescent, Bone Neoplasms, Child, Humans, Osteosarcoma, Databases, Factual, Neoplasms, Second Primary, Tumor Microenvironment, Extracellular Traps
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