Cited by 104Spectroscopy Techniques in Biomedical and Chemical ResearchGold and Silver Nanoparticles Synthesis and ApplicationsOptical Imaging and Spectroscopy Techniques

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Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy

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Wang, Yu “Winston”, Reder, Nicholas P., Kang, Soyoung, Glaser, Adam K., Yang, Qian, Wall, Matthew A., Javid, Sara H., Dintzis, Suzanne M., Liu, Jonathan T.C.·2017·Cancer Research

DOI 10.1158/0008-5472.can-17-0709PMC PMC5559330

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Abstract

Intraoperative identification of carcinoma at lumpectomy margins would enable reduced re-excision rates, which are currently as high as 20% to 50%. Although imaging of disease-associated biomarkers can identify malignancies with high specificity, multiplexed imaging of such biomarkers is necessary to detect molecularly heterogeneous carcinomas with high sensitivity. We have developed a Raman-encoded molecular imaging (REMI) technique in which targeted nanoparticles are topically applied on excised tissues to enable rapid visualization of a multiplexed panel of cell surface biomarkers at surgical margin surfaces. A first-ever clinical study was performed in which 57 fresh specimens were imaged with REMI to simultaneously quantify the expression of four biomarkers HER2, ER, EGFR, and CD44. Combined detection of these biomarkers enabled REMI to achieve 89.3% sensitivity and 92.1% specificity for the detection of breast carcinoma. These results highlight the sensitivity and specificity of REMI to detect biomarkers in freshly resected tissue, which has the potential to reduce the rate of re-excision procedures in cancer patients. Cancer Res; 77(16); 4506–16. ©2017 AACR.

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Authors: Wang, Y. “., Reder, N. P., Kang, S., Glaser, A. K., Yang, Q., Wall, M. A., Javid, S. H., Dintzis, S. M., & Liu, J. T. C.
Affiliations: University of Washington (US)
ORCID: Wang, Yu “Winston”
Reder, Nicholas P.
Kang, Soyoung
Glaser, Adam K.
Yang, Qian
Wall, Matthew A.
Javid, Sara H.
Dintzis, Suzanne M.
Liu, Jonathan T.C.
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2017-08-14
Volume: 77
Issue: 16
Pages: 4506-4516
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-17-0709
PMC: PMC5559330
OpenAlex: W2626913208
Semantic Scholar: c4100819a6ead48fd46116a0bd8d31c5f1470873
Cited by: 104
References: 57
Citations by year: 2026: 4 · 2025: 8 · 2024: 12 · 2023: 13 · 2022: 7 · 2021: 13 · 2020: 14 · 2019: 12 · 2018: 17 · 2017: 4
FWCI: 7.54
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Washington
National Cancer Institute (R21CA215561, P30CA015704)
National Institute of Biomedical Imaging and Bioengineering (R21EB015016)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords: breast cancer, breast-conserving surgery, surgical margin assessment, HER2, estrogen receptor, EGFR, CD44, cell surface markers, multiplexed biomarker detection, intraoperative guidance
MeSH terms: Breast Neoplasms, Female, Humans, Mastectomy, Segmental, Nanoparticles, Molecular Imaging

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Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy

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