Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation
Open accessAbstract
Multiplexed imaging of 8 molecular targets with SERS nanoprobes in mice reveals spatially heterogeneous tumor responses to immunotherapy. Multichannel image segmentation enables classification of the tumor regions into responders and naïve.
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Self-citation
- Authors
- Andreou, C., Plakas, K., Berisha, N., Gigoux, M., Rosch, L. E., Mirsafavi, R., Oseledchyk, A., Pal, S., Zamarin, D., Merghoub, T., Detty, M. R., & Kircher, M. F.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- University at Buffalo, State University of New York (US)
- The Graduate Center, CUNY (US)
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Nanoscale Horizons
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 7
- Issue
- 12
- Pages
- 1540-1552
- ISSN
- 2055-6756 (ISSN-L)
- 2055-6764
- PMC
- PMC10360075
- OpenAlex
- W4307336208
- Semantic Scholar
- 4adf2286be2b9357de9ea7f2c22fbba35ac2776f
- Cited by
- 28
- References
- 50
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-06-29)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nanoscale Horizons (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pershing Square Sohn Cancer Research Alliance (Pershing Square Sohn Prize)
- Memorial Sloan-Kettering Cancer Center (Center for Molecular Imaging & Nanotechnology (CMI, Technology Development Grants, P30-CA008748)
- Damon Runyon Cancer Research Foundation (Rachleff Innovation Award DRR-29-14)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- surface-enhanced Raman scattering, SERS nanoprobes, Raman imaging, immune checkpoint blockade, immunotherapy response, tumor microenvironment, superpixel segmentation, machine learning classification, treatment response prediction, treatment resistance, tumor heterogeneity
- MeSH terms
- Animals, Antibodies, Immunologic Factors, Immunotherapy, Neoplasms, Spectrum Analysis, Raman, Mice, Molecular Imaging, Tumor Microenvironment
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