The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women
Abstract
Circadian disruption has been indicated as a risk factor for breast cancer in recent epidemiologic studies. A novel finding in circadian biology is that genes responsible for circadian rhythm also regulate many other biological pathways, including cell proliferation, cell cycle regulation, and apoptosis. Therefore, mutations in circadian genes could conceivably result in deregulation of these processes and contribute to tumor development, and be markers for susceptibility to human cancer. In this study, we investigated the association between an exonic length variation in a circadian gene, Period3 (Per3), and breast cancer risk using blood samples collected from a recently completed breast cancer case-control study in Connecticut. There were 389 Caucasian cases and 432 Caucasian controls included in our analysis. We found that the variant Per3 genotype (heterozygous + homozygous 5-repeat alleles) was associated with an increased risk of breast cancer among premenopausal women (odds ratio, 1.7; 95% confidence interval, 1.0-3.0). Our finding suggests that the circadian genes might be a novel panel of potential biomarkers for breast cancer and worth further investigation.
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Cites
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930
Self-citationThe circadian clock: pacemaker and tumour suppressor
Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678
Increased breast cancer risk among women who work predominantly at night
Hansen, J. (2001) · Epidemiology · doi:10.1097/00001648-200101000-00013 · Cited by 503
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341
Cited by
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 489
Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 432
Stevens, R. G., Hansen, J., Costa, G., Haus, E., Kauppinen, T., Aronson, K. J., Castaño-Vinyals, G., Davis, S., Frings-Dresen, M. H. W., Fritschi, L., et al. (2011) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.053512 · Cited by 421
Self-citationStevens, R. G., Blask, D. E., Brainard, G. C., Hansen, J., Lockley, S. W., Provencio, I., Rea, M. S., & Reinlib, L. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10200 · Cited by 358
Self-citationLight-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345
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Metadata
- Authors
- Zhu, Y., Brown, H. N., Zhang, Y., Stevens, R. G., & Zheng, T.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2005-01-01
- Volume
- 14
- Issue
- 1
- Pages
- 268-270
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2181752043
- Cited by
- 176
- References
- 5
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, Y., Brown, H. N., Zhang, Y., Stevens, R. G., & Zheng, T. (2005). Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.268.14.1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
