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Increased Breast Cancer Risk among Women Who Work Predominantly at Night
Abstract
Irregular working hours, including working at night, have serious psychological and physiological effects. In a nationwide population-based case-control study, we investigated the breast cancer risk among 30- to 54-year-old Danish women who worked predominantly at night. Individual employment histories were reconstructed back to 1964 for each of 7035 women with breast cancer and their individually matched controls from the records of a nationwide pension scheme with compulsory membership. Odds ratios, including 5 years of induction time and adjusted for socio-economic status, age at the birth of first and last child and number of children, were estimated by conditional logistic regression analysis. The odds ratio for breast cancer among women who worked at night at least half of a year was 1.5 (95% confidence interval, 1.2 to 1.7), and there was a tendency to increasing odds ratio by increasing duration of nighttime employment.
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Night-shift workers have a higher risk of developing cancer and poorer cancer prognosis.
“Epidemiological studies have revealed that individuals who work night-shifts are at higher risk for developing cancer (Hansen, 2001; Kloog et al., 2009; Megdal et al., 2005; Schernhammer et al., 2006; Schernhammer et al., 2001; Viswanathan et al., 2007) or display poorer cancer prognosis (Lis et al., 2003).”
From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Hansen, 2001
Observational studies consistently suggest positive associations of night shift work with cardiovascular disease and cancer risk.
“Observational studies consistently suggest positive associations of night shift work and cardiovascular disease (CVD)2 and cancer risk.3-18”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [3]
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Metadata
- Authors
- Hansen, J.
- Affiliations
- Danish Cancer Society (DK)
- Corresponding author
- Hansen, Johnni
- Venue
- Epidemiology
- Published
- 2001-01
- Volume
- 12
- Issue
- 1
- Pages
- 74-77
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W1973507159
- Cited by
- 503
- References
- 47
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 9 · 2021: 14 · 2020: 23 · 2019: 19 · 2018: 24 · 2017: 24 · 2016: 20 · 2015: 26 · 2014: 22 · 2013: 29 · 2012: 31
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- breast cancer, night work, shift work, irregular working hours, occupational risk factors, women
- MeSH terms
- Adult, Breast Neoplasms, Circadian Rhythm, Denmark, Employment, Female, Humans, Middle Aged, Personnel Staffing and Scheduling, Risk Factors, Work Schedule Tolerance, Odds Ratio, Case-Control Studies
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