The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies
Open accessAbstract
Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the association between lung cancer risk and intakes of specific carotenoids using the primary data from seven cohort studies in North America and Europe. Carotenoid intakes were estimated from dietary questionnaires administered at baseline in each study. We calculated study-specific multivariate relative risks (RRs) and combined these using a random-effects model. The multivariate models included smoking history and other potential risk factors. During follow-up of up to 7–16 years across studies, 3,155 incident lung cancer cases were diagnosed among 399,765 participants. β-Carotene intake was not associated with lung cancer risk (pooled multivariate RR = 0.98; 95% confidence interval, 0.87–1.11; highest versus lowest quintile). The RRs for α-carotene, lutein/zeaxanthin, and lycopene were also close to unity. β-Cryptoxanthin intake was inversely associated with lung cancer risk (RR = 0.76; 95% confidence interval, 0.67–0.86; highest versus lowest quintile). These results did not change after adjustment for intakes of vitamin C (with or without supplements), folate (with or without supplements), and other carotenoids and multivitamin use. The associations generally were similar among never, past, or current smokers and by histological type. Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in β-cryptoxanthin, such as citrus fruit, may modestly lower the risk.
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The combination of estimates from different experiments
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Self-citationEffects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
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Cited by
Maiani, G., Periago Castón, M. J., Catasta, G., Toti, E., Cambrodón, I. G., Bysted, A., Granado‐Lorencio, F., Olmedilla‐Alonso, B., Knuthsen, P., Valoti, M., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800053 · Cited by 773
Nutrition and cancer: A review of the evidence for an anti-cancer diet
Donaldson, M. S. (2004) · Nutrition Journal · doi:10.1186/1475-2891-3-19 · Cited by 699
Kaulmann, A., & Bohn, T. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.010 · Cited by 664
Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise
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Epidemiology of Lung Cancer: Looking to the Future
Alberg, A. J., Brock, M. V., & Samet, J. M. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.10.462 · Cited by 476
Metadata
- Authors
- Männistö, S., Smith-Warner, S. A., Spiegelman, D., Albanes, D., Anderson, K., van den Brandt, P. A., Cerhan, J. R., Colditz, G., Feskanich, D., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Graham, S., Miller, A. B., Rohan, T. E., Virtamo, J., Willett, W. C., & Hunter, D. J.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2004-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 40-48
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2111392737
- Cited by
- 218
- References
- 10
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Männistö, S., Smith-Warner, S. A., Spiegelman, D., Albanes, D., Anderson, K., van den Brandt, P. A., Cerhan, J. R., Colditz, G., Feskanich, D., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Graham, S., Miller, A. B., Rohan, T. E., Virtamo, J., Willett, W. C., & Hunter, D. J. (2004). Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.epi-038-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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