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Cited by 404Cancer survivorship and careChildhood Cancer Survivors' Quality of LifeCancer-related cognitive impairment studies

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Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

Brown, Justin C., Huedo-Medina, Tania B., Pescatello, Linda S., Pescatello, Shannon M., Ferrer, Rebecca A., Johnson, Blair T.·2011·Cancer Epidemiology, Biomarkers & Prevention
DOI 10.1158/1055-9965.epi-10-0988

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Abstract

Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex Rx), methodologic considerations, and subject characteristics modulate CRF. Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue. Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d+ = 0.31 (95% CI = 0.22–0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (β = 0.60, P = 0.01), a pattern that was stronger in higher quality studies (β = 0.23, P < 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (β = 0.48, P < 0.001) or cancer survivors were older (β = 0.24, P = 0.04). Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory. Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123–33. ©2011 AACR.

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Metadata

Authors
Brown, J. C., Huedo-Medina, T. B., Pescatello, L. S., Pescatello, S. M., Ferrer, R. A., & Johnson, B. T.
Affiliations
National Cancer Institute (US)
ORCID
Venue
Cancer Epidemiology, Biomarkers & Prevention
Publisher
American Association for Cancer Research (AACR)
Published
2011-01-01
Volume
20
Issue
1
Pages
123-133
ISSN
  • 1055-9965 (ISSN-L)
  • 1538-7755
DOI
10.1158/1055-9965.epi-10-0988
OpenAlex
W2117207392
Cited by
404
References
15
Citations by year
2026: 7 · 2025: 8 · 2024: 19 · 2023: 15 · 2022: 32 · 2021: 28 · 2020: 28 · 2019: 23 · 2018: 26 · 2017: 38 · 2016: 38 · 2015: 39 · 2014: 33 · 2013: 19 · 2012: 38
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
cancer-related fatigue, exercise intervention, cancer survivors, resistance training, exercise intensity, non-pharmacological treatment, older adults, individualized exercise prescription
MeSH terms
Adult, Exercise Therapy, Fatigue, Humans, Neoplasms, Exercise, Survival Analysis, Randomized Controlled Trials as Topic, Treatment Outcome, Survivors

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