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Cited by 164Neuroendocrine Tumor Research AdvancesPancreatic and Hepatic Oncology ResearchPancreatic function and diabetes

Met Proto-Oncogene and Insulin-Like Growth Factor Binding Protein 3 Overexpression Correlates with Metastatic Ability in Well-Differentiated Pancreatic Endocrine Neoplasms

Hansel, Donna E., Rahman, Ayman, House, Michael, Ashfaq, Raheela, Berg, Karin, Yeo, Charles J., Maitra, Anirban·2004·Clinical Cancer Research
DOI 10.1158/1078-0432.ccr-04-0285
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Abstract

Pancreatic endocrine neoplasms are neoplastic proliferations of islet cells or islet cell precursors and are capable of secreting a variety of synthetic products, including insulin, glucagon, gastrin, and vasoactive intestinal peptide. The biological behavior of pancreatic endocrine neoplasms is often unpredictable, and there are few reliable histopathologic criteria reliably correlating with metastatic ability. We have used the Affymetrix U133 GeneChip set (HG_U133 A and B; Affymetrix; Santa Clara, CA) representing approximately 33,000 characterized transcripts to examine global gene expression profiles from well-differentiated nonmetastatic (n=5) and metastatic (n=7) pancreatic endocrine neoplasms to determine molecular markers that predict disease progression. Microarray hybridization data were normalized using the GeneLogic GeneExpress Software System to identify differentially up- and down-regulated genes in metastatic versus nonmetastatic pancreatic endocrine neoplasms. Using a 3-fold change in gene expression as a threshold, we have identified 65 overexpressed and 57 underexpressed genes in metastatic pancreatic endocrine neoplasms as compared with nonmetastatic pancreatic endocrine neoplasms. Several classes of genes, including growth factors and growth factor-related molecules (IGFBP1, IGFBP3, and MET), developmental factors (TBX3 and MEIS2), cytoskeletal factors (beta 1 tubulin and ACTN2), cholesterol homeostasis mediators (LRP5, SLC27A2, and RXRG), intracellular si…

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Metadata

Authors
Hansel, D. E., Rahman, A., House, M., Ashfaq, R., Berg, K., Yeo, C. J., & Maitra, A.
Affiliations
  • Johns Hopkins University (US)
  • The University of Texas Southwestern Medical Center (US)
ORCID
Venue
Clinical Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2004-09-15
Volume
10
Issue
18
Pages
6152-6158
ISSN
  • 1078-0432 (ISSN-L)
  • 1557-3265
DOI
10.1158/1078-0432.ccr-04-0285
OpenAlex
W2143387575
Cited by
164
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 11 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 11
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
pancreatic neuroendocrine tumors, metastasis, MET oncogene, insulin-like growth factor binding protein-3, IGFBP-3, gene expression profiling, differentially expressed genes, metastatic markers, tumor progression, TBX3, MEIS2, LRP5, MGMT, Chk1, ACTN2, cholesterol homeostasis, DNA repair genes, methyltransferase, intracellular signaling
MeSH terms
Proto-Oncogene Mas, Aged, Cell Differentiation, DNA, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Metastasis, Pancreatic Neoplasms, RNA, Up-Regulation, Gene Expression Regulation, Neoplastic, Neuroendocrine Tumors, Insulin-Like Growth Factor Binding Protein 3, Proto-Oncogene Proteins c-met

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