Humanization of the Bispecific Epidermal Growth Factor Receptor × CD3 Diabody and Its Efficacy as a Potential Clinical Reagent

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Critical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in Cancer

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Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.

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Epidermal growth factor receptor biology (IMC-C225)

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Expression of the Tyrosine Kinase Activity Growth Factor Receptors (EGFR, ERB B2, ERB B3) in Colorectal Adenocarcinomas and Adenomas

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Food groups and risk of oral and pharyngeal cancer

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Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu

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Selection for a periplasmic factor improving phage display and functional periplasmic expression

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Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers

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Highly efficient recovery of functional single-chain Fv fragments from inclusion bodies overexpressed in Escherichia coli by controlled introduction of oxidizing reagent—application to a human single-chain Fv fragment

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Crystal structure of a diabody, a bivalent antibody fragment

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A revival of bispecific antibodies

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Recombinant bispecific antibodies for cancer therapy

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Two amino acid mutations in an anti-human CD3 single chain Fv antibody fragment that affect the yield on bacterial secretion but not the affinity

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Sunlight and carcinogenesis: Expression ofp53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations

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The epidermal growth factor receptor as a target for colorectal cancer therapy

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Bispecific antibody conjugates in therapeutics

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Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody

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A Bispecific Diabody That Mediates Natural Killer Cell Cytotoxicity Against Xenotransplantated Human Hodgkin’s Tumors

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Bispecific and bifunctional single chain recombinant antibodies

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Immunoglobulin VH Gene Expression in Human Aging

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Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression

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Cytolysis of leukemic B-cells by T-cells activated via two bispecific antibodies.

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Humanization of the murine anti-human CD3 monoclonal antibody OKT3

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Induction of Human T Lymphocyte Cytotoxicity and Inhibition of Tumor Growth by Tumor-Specific Diabody-Based Molecules Secreted from Gene-Modified Bystander Cells

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Bispecific antibodies targeting cancer cells

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Effect of Domain Order on the Activity of Bacterially Produced Bispecific Single-chain Fv Antibodies

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Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions

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The humanized anti-HM1.24 antibody effectively kills multiple myeloma cells by human effector cell-mediated cytotoxicity

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A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells

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Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20×anti-CD3 bispecific diabody

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Tumor-directed lymphocyte-activating cytokines: refolding-based preparation of recombinant human interleukin-12 and an antibody variable domain-fused protein by additive-introduced stepwise dialysis

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Construction of a diabody (small recombinant bispecific antibody) using a refolding system

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Therapeutic Monoclonal Antibodies in Oncology

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Therapeutic monoclonal antibodies in oncology

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Humanized Antibodies: Enhancing Therapeutic Utility Through Antibody Engineering

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A mutated superantigen SEA D227A fusion diabody specific to MUC1 and CD3 in targeted cancer immunotherapy for bile duct carcinoma

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Efficient Construction of a Diabody Using a Refolding System: Anti- Carcinoembryonic Antigen Recombinant Antibody Fragment

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Specific and effective targeting cancer immunotherapy with a combination of three bispecific antibodies

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Functional Construction of the Anti--Mucin Core Protein (MUC1) Antibody MUSE11 Variable Regions in a Bacterial Expression System

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Mutated SEA-D227A-conjugated antibodies greatly enhance antitumor activity against MUC1-expressing bile duct carcinoma

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Bispecific antibodies for cancer therapy: The light at the end of the tunnel?

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Expressing and functionally evaluating anticancer bispecific antibody fragments using cyanobacterium Synechocystis sp. PCC6803 for sustainable production

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Optimized Strategies to Hyperexpress Recombinant Protein in Chinese Hamster Ovary Cells.

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Strategies for Efficient Transfection of CHO-Cells with Plasmid DNA

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A method to stably integrate multiple genetic elements into Chinese hamster ovary (CHO) cells

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Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells

Li, Z.-M., Fan, Z., Wang, X.-Y., & Wang, T. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.880155 · Cited by 74 · see citing works

Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells

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