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Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis
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Abstract
Purpose: Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits the oral cavity. It causes periodontal disease and has also been implicated in the development of human cancers. Although there are several reports of the relationship between F. nucleatum and the clinical outcome in human cancers, its prognostic significance in esophageal cancer remains unclear. Experimental Design: We quantified F. nucleatum DNA in 325 resected esophageal cancer specimens by qPCR. Significant pathways in F. nucleatum–positive esophageal cancer tissues were identified by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis using microarray data. Results: Esophageal cancer tissues contained significantly more F. nucleatum DNA than matched normal esophageal mucosa (P = 0.021; n = 60). F. nucleatum DNA was detected in 74 of 325 cases (23%). F. nucleatum DNA positivity was significantly associated with tumor stage, but not with sex, age, performance status, tobacco use, alcohol use, histology, tumor location, or preoperative treatment. F. nucleatum DNA positivity was also significantly associated with cancer-specific survival [log-rank P = 0.0039; univariate HR = 2.01; 95% confidence interval (CI), 1.22–3.23; P = 0.0068; multivariate HR = 1.78; 95% CI, 1.06–2.94; P = 0.031]. The top-ranked KEGG pathway in F. nucleatum–positive tissues was “cytokine–cytokine receptor interaction.” A significant relationship between F. nucleatum and the chemokine CCL20 was validated by IHC. Conclusions: F. nucleatum in esophageal cancer tissues was associated with shorter survival, suggesting a potential role as a prognostic biomarker. F. nucleatum might also contribute to aggressive tumor behavior through activation of chemokines, such as CCL20. Clin Cancer Res; 22(22); 5574–81. ©2016 AACR.
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“Fusobacterium spp. is important in the development and progression of gastrointestinal tumors1,19,34,35”
From RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach (2020) · cites this paper as [34]
Citations
Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Enzinger, P. C., & Mayer, R. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035010 · Cited by 2,613
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)
McShane, L. M., Altman, D. G., Sauerbrei, W., Taube, S. E., Gion, M., & Clark, G. M. (2005) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dji237 · Cited by 2,162
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Schmidt, M., HACKETT, R. J., Baker, A., McDonald, S. A. C., Quante, M., & Graham, T. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00531-4 · Cited by 17
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Song, X., Greiner-Tollersrud, O. K., & Zhou, H. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07245-2 · Cited by 19
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Asawa, S., Nüesch, M., Gvozdenovic, A., & Aceto, N. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02228-8 · Cited by 17
Immuno-oncology-microbiome axis of gastrointestinal malignancy
Lin, Q., Guan, S.-W., & Yu, H. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i5.757 · Cited by 20
Kovaleva, O. V., Алексеевна, П. П., Rashidova, M. A., Samoilova, D. V., Petrenko, A., Mochalnikova, V. V., Kataev, V., Khlopko, Y. A., Plotnikov, A. O., & Gratchev, A. N. (2021) · Biomedicines · doi:10.3390/biomedicines9070743 · Cited by 18
Nutrition and Cancer Risk from the Viewpoint of the Intestinal Microbiome
Tanaka, Y., Shimizu, S., Shirotani, M., Yorozu, K., Kitamura, K., Oehorumu, M., Kawai, Y., & Fukuzawa, Y. (2021) · Nutrients · doi:10.3390/nu13103326 · Cited by 20
Does microbiome shift play a role in carcinogenesis? A systematic review
Mallika, L., Augustine, D., Rao, R. S., Patil, S., Alamir, A. H., Awan, K. H., Sowmya, S., Haragannavar, V. C., & Prasad, K. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.02.11 · Cited by 17
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D’Antonio, D. L., Zenoniani, A., Umme, S., Piattelli, A., & Curia, M. C. (2024) · Pathogens · doi:10.3390/pathogens14010002 · Cited by 21
Liao, X., Si, H., Lai, Y., Zhang, X., Feng, Y., Zhou, T., Feng, Y., & Yu, L. (2025) · Journal of Oral Microbiology · doi:10.1080/20002297.2025.2482924 · Cited by 18
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Surlari, Z., Virvescu, D. I., Baciu, E.-R., Vasluianu, R.-I., & Budală, D. G. (2021) · Applied Sciences · doi:10.3390/app112412100 · Cited by 17
Pan, F., Xu, X., Zhang, L.-L., Luo, H., Chen, Y., Long, L., Wang, X., Zhuang, P.-T., Li, E., & Xu, L. (2020) · Food & Function · doi:10.1039/d0fo01944e · Cited by 17
The rise and evolving role of Fusobacterium nucleatum subspecies
Wolf, M., Steinberg, T., Scholz, K. J., Kruse, A., Rezasoltani, S., Conrads, G., Al‐Ahmad, A., & Cieplik, F. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100414 · Cited by 15
Fusobacteria: physiology, form, and function
Robinson, A. V., Wilde, J., & Allen‐Vercoe, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819672-4.00006-4 · Cited by 17
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Dan, W., Peng, L., Yan, B., Li, Z., & Pan, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.791274 · Cited by 16
Diwan, P., Nirwan, M., Bahuguna, M., Kumari, S. P., Wahlang, J., & Gupta, R. K. (2023) · Pathogens · doi:10.3390/pathogens12080996 · Cited by 20
Yamamoto, Y., Kamiya, T., Yano, M., Huyen, V. T., Oishi, M., Nishio, M., Suzuki, A., Sunami, K., & Ohtani, N. (2023) · Microorganisms · doi:10.3390/microorganisms11122957 · Cited by 19
Wang, K., Wang, J., Chen, Y., Long, H., Pan, W., Liu, Y., Xu, M., & Guo, Q. (2024) · Aging · doi:10.18632/aging.205547 · Cited by 16
Mechanistic Insights on Microbiota-Mediated Development and Progression of Esophageal Cancer
Moe, K. T., & Tan, K. S. W. (2024) · Cancers · doi:10.3390/cancers16193305 · Cited by 16
Gyawali, C. P., Sonu, I. S., Becker, L. S., & Sarosiek, J. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14521 · Cited by 16
Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer
Udayasuryan, B., Nguyen, T. T. D., Slade, D. J., & Verbridge, S. S. (2020) · iScience · doi:10.1016/j.isci.2020.101878 · Cited by 15
Advancements in understanding tumor‑resident bacteria and their application in cancer therapy
Luo, Y., Huang, X., Wang, R., Lin, Y., Sun, J., Li, K., Wang, D. Y., Yan, Y., & Qiao, Y. (2025) · Military Medical Research · doi:10.1186/s40779-025-00623-1 · Cited by 16
Intratumoral microbiota remodeling of the tumor microenvironment impact solid tumor immunotherapy
Jia, J., Gao, W., Wang, C., Liu, L., Li, Y., Sun, Z., Yang, C., Chen, Y., Yu, H., & Cheng, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08211-w · Cited by 18
Standardized studies of the oral microbiome: From technology‐driven to hypothesis‐driven
Gao, C., Li, X., Zhao, X., Yang, P., Wang, X., Chen, X., Chen, N., & Chen, F. (2022) · iMeta · doi:10.1002/imt2.19 · Cited by 15
Comprehensive analysis of microbiota signature across 32 cancer types
Yang, X., An, H., He, Y., Fu, G., & Jiang, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1127225 · Cited by 15
McGregor, A. K., Chan, A., Schroeder, M. D., Do, L. T. M., Saini, G., Murphy, M. E. P., & Wolthers, K. R. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104902 · Cited by 13
Grover, K., Gregory, S., Gibbs, J. F., & Emenaker, N. J. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-2019-gi-07 · Cited by 16
Zanetta, P., Squarzanti, D. F., Sorrentino, R., Rolla, R., Valletti, P. A., Garzaro, M., Dell’Era, V., Amoruso, A., & Azzimonti, B. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1872487 · Cited by 15
Zakrzewski, M., Gannon, O. M., Panizza, B. J., Saunders, N. A., & Antonsson, A. (2021) · Head & Neck · doi:10.1002/hed.26821 · Cited by 14
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Jiang, Z., Li, L., Chen, J., Wei, G., Ji, Y., Chen, X., Liu, J., & Huo, J.-G. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104946 · Cited by 14
Du, Y., Feng, R., Chang, E. T., Debelius, J. W., Yin, L., Xu, M., Huang, T., Zhou, X., Xiao, X., Li, Y., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.831409 · Cited by 15
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Ghosh, S. K., Man, Y., Fraiwan, A., Waters, C., McKenzie, C., Lu, C. Y., Pfau, D., Kawsar, H. I., Bhaskaran, N., Pandiyan, P., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101447 · Cited by 13
Dysbiosis linking periodontal disease and oral squamous cell carcinoma-A brief narrative review
Acharya, S., Hegde, U., Acharya, A. B., & Nitin, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32259 · Cited by 8
Shaikh, F. Y., Lee, S., White, J. R., Zhao, Y., Ferri, J. T., Pereira, G., Landon, B. V., Ke, S., Hu, C., Feliciano, J. L., et al. (2024) · Cancers · doi:10.3390/cancers16213644 · Cited by 15
Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy
Miura, S., Nakamura, T., Hasegawa, T., Miura, Y., Takiguchi, G., Urakawa, N., Hasegawa, H., Yamamoto, M., Kanaji, S., Matsuda, Y., et al. (2019) · Annals of Surgical Oncology · doi:10.1245/s10434-019-07903-w · Cited by 13
Fusobacterium nucleatum in Health and Disease
Yang, X., Zhang, S., Ning, T., & Wu, J. (2025) · MedComm · doi:10.1002/mco2.70465 · Cited by 15
Bacteria and macrophages in the tumor microenvironment
Xu, S. S., Xiong, Y., Fu, B., Guo, D. L., Sha, Z., Lin, X., & Wu, H. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1115556 · Cited by 13
Zhuang, X., Li, B., Liu, X., Fan, T., Lan, X., Wang, X., & Yu, M. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.141982 · Cited by 12
Okawa, Y., Sasagawa, S., Kato, H., Johnson, T. A., Nagaoka, K., Kobayashi, Y., Hayashi, A., Shibayama, T., Maejima, K., Tanaka, H., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216499 · Cited by 12
Gao, S., Zhang, Z., Sun, K., Li, M.-X., & Qi, Y. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2295401 · Cited by 12
Cern, A., Skoczen, S. L., Snapp, K. S., Hod, A., Zilbersheid, D., Bavli, Y., Alon‐Maimon, T., Bachrach, G., Wei, X., Berman, B., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.045 · Cited by 13
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Liu, X., Li, B., Liang, L., Han, J., Mai, S., & Liu, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1450927 · Cited by 12
Nicolae, F. M., Didilescu, A. C., Șurlin, P., Ungureanu, B. S., Şurlin, V., Pătrașcu, Ș., Râmboiu, S., Jelihovschi, I., Iancu, L. S., Ghiluşi, M. C., et al. (2022) · Pathogens · doi:10.3390/pathogens11030360 · Cited by 12
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Mascaretti, F., Haider, S., Amoroso, C., Caprioli, F., Ramai, D., & Ghidini, M. (2024) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-024-01021-x · Cited by 12
Profir, M., Roşu, O., Creţoiu, S. M., & Gașpar, B. S. (2024) · Microorganisms · doi:10.3390/microorganisms12050955 · Cited by 12
Matsumura, Y., Hinode, D., Fukui, M., Yoshioka, M., Asakuma, H., & Takii, H. (2019) · Clinical and Experimental Dental Research · doi:10.1002/cre2.262 · Cited by 12
Harnessing intratumoral microbiota: new horizons in immune microenvironment and immunotherapy
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Yan, D., Yu, Y., Liang, C., Cui, Z., Shi, L., Li, G., & Ren, C. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02566-6 · Cited by 11
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Xuan, M., Gu, X., Liu, Y., Li, Y., Li, Y., Huang, D., Li, J., & Xue, C. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01425-5 · Cited by 13
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Nakano, S., Kawamoto, Y., Komatsu, Y., Saito, R., Ito, K., Yamamura, T., Harada, K., Yuki, S., Kawakubo, K., Sugiura, R., et al. (2022) · Pancreas · doi:10.1097/mpa.0000000000002028 · Cited by 11
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Xiao, P., Hua, Z., Kang, X., Lu, B., Li, M., Wu, J., Dong, W., Zhang, J., & Cheng, C. (2022) · Journal of Cancer · doi:10.7150/jca.67068 · Cited by 10
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Bhatnagar, K., Jha, K., Dalal, N., Patki, N., Gupta, G., Kumar, A., Kumar, A., & Chaudhary, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1442788 · Cited by 12
Yabukami, S., Murayama, T., Takahashi, S., Ohno, S., Washio, J., & Takahashi, N. (2022) · IEEE Transactions on Magnetics · doi:10.1109/tmag.2022.3161508 · Cited by 10
Hozaka, Y., Oi, H., Satake, S., Uchino, Y., Goto, Y., Idichi, T., Tanoue, K., Yamasaki, Y., Kawasaki, Y., Mataki, Y., et al. (2022) · Surgery · doi:10.1016/j.surg.2022.10.003 · Cited by 10
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Wu, L., Ma, Q., Huang, W., Liu, X., Qiu, L.-H., Lin, P., Long, H., Zhang, L., & Ma, G. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01636-5 · Cited by 10
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Self-citationDeng, J., Huang, Y., Yu, K., Luo, H., Zhou, D., & Li, D. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106784 · Cited by 9
The emerging role of Fusobacteria in carcinogenesis
Gibbs, R. J., Chambers, A., & Hill, D. J. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14353 · Cited by 9
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Tingting, Y., Xiaoling, Z., Zhang, Y., Luo, Y., Luo, Y., Xueqin, S., & Shikai, T. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1609889 · Cited by 9
Kabwe, M., Ayelign, B., Afshar‐Sterle, S., Büchert, M., & Tucci, J. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1721411 · Cited by 10
Mandal, D. P., Mohanty, N., Behera, P. K., Gopinath, D., Panda, S., Kheraif, A. A. A., Divakar, D. D., Anil, S., & Panda, S. (2021) · Life · doi:10.3390/life11111218 · Cited by 9
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Harrandah, A. M. (2023) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000927 · Cited by 9
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Borroni, E. M., Qehajaj, D., Farina, F. M., Yiu, D., Bresalier, R. S., Chiriva‐Internati, M., Mirandola, L., Štifter, S., Laghi, L., & Grizzi, F. (2019) · Current Colorectal Cancer Reports · doi:10.1007/s11888-019-00442-2 · Cited by 9
Tanda, N., Washio, J., Kamei, T., Akazawa, K., Takahashi, N., & Koseki, T. (2019) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.249.75 · Cited by 9
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Li, N., Gao, L., Ge, Y., Zhao, L., Wang, Y., & Bai, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32770 · Cited by 11
Vadhwana, B., Tarazi, M., Boshier, P. R., & Hanna, G. B. (2023) · Cancers · doi:10.3390/cancers15102668 · Cited by 8
Xiong, J., Liu, H., Li, C., Li, Y., & Feng, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-63447-4 · Cited by 10
Wu, H., Liu, Q., Li, J., Leng, X., He, Y., Liu, Y., Zhang, X., Ouyang, Y., Liu, Y., Liang, W., et al. (2024) · Advanced Science · doi:10.1002/advs.202309742 · Cited by 10
Zhou, Q., Zhou, L., Chen, X., Chen, Q., & Hao, L. (2024) · Cancer Reports · doi:10.1002/cnr2.70063 · Cited by 8
Shijimaya, T., Tahara, T., Yamazaki, J., Kobayashi, S., Matsumoto, Y., Nakamura, N., Takahashi, Y., Tomiyama, T., Fukui, T., Shibata, T., et al. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01801-z · Cited by 8
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Tourelle, K. M., Boutin, S., Weigand, M. A., & Schmitt, F. C. F. (2021) · Biomedicines · doi:10.3390/biomedicines9101305 · Cited by 11
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Maruyama, S., Okamura, A., Kanie, Y., Sakamoto, K., Fujiwara, D., Kanamori, J., Imamura, Y., Takeda, K., & Watanabe, M. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12166-z · Cited by 8
Self-citationWatanabe, T., Sohda, M., Kim, M., Saito, H., Ubukata, Y., Nakazawa, N., Kuriyama, K., Hara, K., Sano, A., Sakai, M., et al. (2022) · Esophagus · doi:10.1007/s10388-022-00941-6 · Cited by 9
Ahn, H., Min, K., Lee, E., Kim, H., Kim, S., Kim, Y.-J., Kim, G., Cho, B., Jeong, C., Kim, Y., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10101896 · Cited by 8
Hasuda, H., Ikeda, T., Makizaki, Y., Yokota, H., Tanaka, Y., Ohno, H., Shimokawa, M., Matsuoka, H., Kimura, Y., Oki, E., et al. (2022) · Surgery Today · doi:10.1007/s00595-022-02607-3 · Cited by 8
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Greco, G., Zeppa, S. D., Agostini, D., Attisani, G., Stefanelli, C., Ferrini, F., Sestili, P., & Fimognari, C. (2022) · Cancers · doi:10.3390/cancers15010190 · Cited by 8
Interaction of microbiota, mucosal malignancies, and immunotherapy—Mechanistic insights
Mager, L. F., Krause, T., & McCoy, K. D. (2024) · Mucosal Immunology · doi:10.1016/j.mucimm.2024.03.007 · Cited by 8
Emerging roles of intratumoral microbiota: a key to novel cancer therapies
Fang, P., Yang, H. J., Zhang, H., Shuai, D., Li, M., Chen, L., & Liu, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1506577 · Cited by 7
Ochi, T., Fujiki, R., Fukuyo, M., Rahmutulla, B., Nakagawa, T., Ota, M., Ikeda, J., Matsui, Y., Yoshino, I., Suzuki, H., et al. (2025) · Cancer Science · doi:10.1111/cas.70080 · Cited by 8
Fusobacterium nucleatum promotes metastasis of breast cancer via the miR-21-3p/FOXO3 axis
Huang, Y., Guo, Z., Zeng, Z., Shang, C., Zhang, Y., Ran, Z., Luo, G., Shen, S., Liu, Y., Zhou, P., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1530269 · Cited by 7
Lin, X., Chen, X., Chen, M., Li, Y., Deng, Y., Xian, B., & Li, Z. (2025) · MicrobiologyOpen · doi:10.1002/mbo3.70050 · Cited by 7
D’Angelo, A., Zenoniani, A., Masci, M., Aceto, G. M., Piattelli, A., & Curia, M. C. (2025) · Microorganisms · doi:10.3390/microorganisms13091995 · Cited by 8
Fan, Y., Gu, X., Yang, H., Chen, Y., Fang, C., Deng, H., & Dai, L. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00376-2 · Cited by 8
Metadata
- Authors
- Yamamura, K., Baba, Y., Nakagawa, S., Mima, K., Miyake, K., Nakamura, K., Sawayama, H., Kinoshita, K., Ishimoto, T., Iwatsuki, M., Sakamoto, Y., Yamashita, Y., Yoshida, N., Watanabe, M., & Baba, H.
- Affiliations
- Kumamoto University (JP)
- 1Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
- The Cancer Institute Hospital (JP)
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2016-11-14
- Volume
- 22
- Issue
- 22
- Pages
- 5574-5581
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2537571631
- Cited by
- 457
- References
- 50
- Citations by year
- 2026: 33 · 2025: 68 · 2024: 70 · 2023: 60 · 2022: 51 · 2021: 69 · 2020: 54 · 2019: 24 · 2018: 11 · 2017: 16
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Fusobacterium nucleatum, esophageal cancer, gut microbiota, prognostic factors, cancer-specific survival, tumor stage, CCL20, cytokine-cytokine receptor interaction, chemokines, tumor microenvironment, periodontal disease
- MeSH terms
- Aged, DNA, Bacterial, Esophageal Neoplasms, Female, Humans, Male, Prognosis, Fusobacterium nucleatum, Chemokines, Microbiota
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