Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785

The human microbiome: at the interface of health and disease

Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449

The gut microbiota, bacterial metabolites and colorectal cancer

Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718

Esophageal Cancer

Enzinger, P. C., & Mayer, R. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035010 · Cited by 2,613

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)

McShane, L. M., Altman, D. G., Sauerbrei, W., Taube, S. E., Gion, M., & Clark, G. M. (2005) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dji237 · Cited by 2,162

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

Lee, M. (2021) · Cancer Communications · doi:10.1002/cac2.12200 · Cited by 50

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48

Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms

Mukherjee, S., Chopra, A., Karmakar, S., & Bhat, G. S. (2024) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2024.2339260 · Cited by 54

Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review

Reitano, E., de’Angelis, N., Gavriilidis, P., Gaiani, F., Memeo, R., Inchingolo, R., Bianchi, G., de’Angelis, G. L., & Carra, M. C. (2021) · Microorganisms · doi:10.3390/microorganisms9122585 · Cited by 48

Microbiota in cancer: current understandings and future perspectives

Yao, Y., Zhu, Y., Chen, K., Chen, J., Li, Y., Li, D., & Wei, P. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02335-3 · Cited by 56

Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer

Liu, Y., Baba, Y., Ishimoto, T., Iwatsuki, M., Hiyoshi, Y., Miyamoto, Y., Yoshida, N., Wu, R., & Baba, H. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1512-9 · Cited by 47

Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

Wheatley, R. C., Kilgour, E., Jacobs, T., Lamarca, Á., Hubner, R. A., Valle, J. W., & McNamara, M. G. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01583-8 · Cited by 46

Fusobacterium in the microbiome: from health to disease across the oral–gut axis and beyond

Li, Z., Liu, J., Li, J., Zhou, Z., Huang, X., Gopinath, D., Luo, P., Wang, Q., & Shan, D. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00838-z · Cited by 47

Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck

Hsueh, C., Lau, H., Huang, Q., Gong, H., Sun, J., Cao, P., Hu, C., Zhang, M., Tao, L., & Zhou, L. F. (2022) · Cancer · doi:10.1002/cncr.34338 · Cited by 45

The role of the microbiome in drug resistance in gastrointestinal cancers

Garajová, I., Balsano, R., Wang, H., Leonardi, F., Giovannetti, E., Deng, D., & Peters, G. J. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2021.1844007 · Cited by 46

Human microbiomes in cancer development and therapy

Xia, C., Su, J., Liu, C., Mai, Z., Yin, S., Yang, C., & Fu, L. (2023) · MedComm · doi:10.1002/mco2.221 · Cited by 44

Expanding the genetic toolkit helps dissect a global stress response in the early-branching species Fusobacterium nucleatum

Ponath, F., Zhu, Y., Cosi, V., & Vogel, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201460119 · Cited by 37

Fusobacterium nucleatum subsp. nucleatum RadD binds Siglec-7 and inhibits NK cell-mediated cancer cell killing

Galaski, J., Rishiq, A., Liu, M., Bsoul, R., Bergson, A., Lux, R., Bachrach, G., & Mandelboim, O. (2024) · iScience · doi:10.1016/j.isci.2024.110157 · Cited by 42

Barrett’s esophagus: novel strategies for screening and surveillance

Sanghi, V., & Thota, P. N. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319837851 · Cited by 41

Understanding the cross-talk between human microbiota and gastrointestinal cancer for developing potential diagnostic and prognostic biomarkers

Kashyap, S., Pal, S., Chandan, G., Saini, V., Chakrabarti, S., Saini, N. K., Mittal, A., Thakur, V. K., Saini, A. K., & Saini, R. V. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.04.020 · Cited by 39

Bacterial Extracellular Vesicles in Gastrointestinal Tract Cancer: An Unexplored Territory

Amatya, S. B., Salmi, S., Kainulainen, V., Karihtala, P., & Reunanen, J. (2021) · Cancers · doi:10.3390/cancers13215450 · Cited by 43

Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum

Despins, C. A., Brown, S. D., Robinson, A. V., Mungall, A. J. J., Allen‐Vercoe, E., & Holt, R. A. (2021) · mBio · doi:10.1128/mbio.02062-21 · Cited by 40

The oral microbiome and oral and upper gastrointestinal diseases

Liu, S., Wang, S., Zhang, N., & Li, P. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2355823 · Cited by 41

Helicobacter pylori: Perturbation and restoration of gut microbiome

Saxena, A., Mukhopadhyay, A. K., & Nandi, S. P. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00078-7 · Cited by 40

Microbiota and cancer: current understanding and mechanistic implications

Khan, A. A., Sirsat, A., Singh, H., & Cash, P. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02690-x · Cited by 40

Fusobacterium nucleatum promotes the early occurrence of esophageal cancer through upregulation of IL ‐32/ PRTN3 expression

Lei, J., Xu, F., Deng, C., Nie, X., Zhong, L., Wu, Z., Li, J., Wu, X., He, S., & Chen, Y. (2023) · Cancer Science · doi:10.1111/cas.15787 · Cited by 38

Intratumoral microbiome impacts immune infiltrates in tumor microenvironment and predicts prognosis in esophageal squamous cell carcinoma patients

Zhang, S., Zhang, S., Ma, X., Zhan, J., Pan, C., Zhang, H., Xie, X., Wen, J., & Xie, X. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1165790 · Cited by 41

Oral microbiota and gastrointestinal cancer

Zhang, Y., Niu, Q., Fan, W., Huang, F. P., & He, H. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194153 · Cited by 39

Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Zhang, X., Zhang, Y., Gui, X., Zhang, Z., Zhang, Z., Zhang, X., chen, W., Zhang, X., Wang, Y., Shang, Z., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104203 · Cited by 41

Increased Variance in Oral and Gastric Microbiome Correlates With Esophagectomy Anastomotic Leak

Reddy, R. M., Weir, W. B., Barnett, S. L., Heiden, B. T., Orringer, M. B., Lin, J., Chang, A. C., Carrott, P. W., Lynch, W. R., Beer, D. G., et al. (2018) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2017.08.061 · Cited by 38

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

Mima, K., Hamada, T., Inamura, K., Baba, H., Ugai, T., & Ogino, S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2269623 · Cited by 39

Barrett’s esophagus and esophageal cancer: Links to microbes and the microbiome

Ajayi, T. A., Cantrell, S. E., Spann, A., & Garman, K. S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007384 · Cited by 37

The Bacterial Microbiota of Gastrointestinal Cancers: Role in Cancer Pathogenesis and Therapeutic Perspectives

Elsalem, L., Jum’ah, A. A., Alfaqih, M. A., & Aloudat, O. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s243337 · Cited by 38

Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view

Muszyński, D., Kudra, A., Sobocki, B. K., Folwarski, M., Vitale, E., Filetti, V., Dudzic, W., Kaźmierczak-Siedlecka, K., & Połom, K. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1057668 · Cited by 36

Conceptual Perspectives: Bacterial Antimicrobial Peptide Induction as a Novel Strategy for Symbiosis with the Human Host

Ghosh, S. K., Feng, Z., Fujioka, H., Lux, R., McCormick, T. S., & Weinberg, A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00302 · Cited by 36

The role of the symbiotic microecosystem in cancer: gut microbiota, metabolome, and host immunome

Xue, X., Li, R., Chen, Z., Li, G., Liu, B., Guo, S., Yue, Q., Yang, S., Xie, L., Zhang, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1235827 · Cited by 37

Impact of the Gastrointestinal Microbiome in Health and Disease: Co-evolution with the Host Immune System

Hold, G. L., & Hansen, R. (2019) · Current topics in microbiology and immunology · doi:10.1007/978-3-030-15138-6_12 · Cited by 35

High TLR4 expression predicts a poor prognosis after esophagectomy for advanced thoracic esophageal squamous cell carcinoma

Sato, Y., Motoyama, S., Wakita, A., Kawakita, Y., Liu, J., Nagaki, Y., Nanjo, H., Ito, S., Terata, K., Imai, K., et al. (2020) · Esophagus · doi:10.1007/s10388-020-00732-x · Cited by 34

Intratumoral levels and prognostic significance of Fusobacterium nucleatum in cervical carcinoma

Huang, S., Chen, J., Lian, L.-Y., Cai, H., Zeng, H.-S., Zheng, M., & Liu, M. (2020) · Aging · doi:10.18632/aging.104188 · Cited by 35

Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance

Mai, Z., Fu, L., Su, J., To, K. K. W., Yang, C., & Xia, C. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02202-9 · Cited by 35

Preliminary insights into the impact of primary radiochemotherapy on the salivary microbiome in head and neck squamous cell carcinoma

Kumpitsch, C., Moissl‐Eichinger, C., Pock, J., Thurnher, D., & Wolf, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-73515-0 · Cited by 33

Clinical Significance of Fusobacterium nucleatum Infection and Regulatory T Cell Enrichment in Esophageal Squamous Cell Carcinoma

Zhang, N., Liu, Y., Yang, H., Liang, M., Wang, X., Wang, M., Kong, J., Yuan, X., & Zhou, F. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.1609846 · Cited by 32

Fusobacterium nucleatum : a novel immune modulator in breast cancer?

Little, A., Tangney, M., Tunney, M. M., & Buckley, N. E. (2023) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2023.9 · Cited by 33

Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes

Robinson, W., Stone, J. K., Schischlik, F., Gasmi, B., Kelly, M. C., Seibert, C., Dadkhah, K., Gertz, E. M., Lee, J. S., Zhu, K., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7402 · Cited by 37

Lytic Bacteriophage EFA1 Modulates HCT116 Colon Cancer Cell Growth and Upregulates ROS Production in an Enterococcus faecalis Co-culture System

Kabwe, M., Meehan-Andrews, T., Ku, H., Petrovski, S., Batinovic, S., Chan, H. T., & Tucci, J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.650849 · Cited by 32

Microbiome and Cancers of the Esophagus: A Review

Yano, Y., Etemadi, A., & Abnet, C. C. (2021) · Microorganisms · doi:10.3390/microorganisms9081764 · Cited by 33

Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects

Kashiwagi, S., Naito, Y., Inoüe, R., Takagi, T., Nakano, T., Inada, Y., Fukui, A., Katada, K., Mizushima, K., Kamada, K., et al. (2019) · Digestion · doi:10.1159/000496102 · Cited by 31

Mucosal cancer-associated microbes and anastomotic leakage after resection of colorectal carcinoma

Mima, K., Sakamoto, Y., Kosumi, K., Ogata, Y., Miyake, K., Hiyoshi, Y., Ishimoto, T., Iwatsuki, M., Baba, Y., Iwagami, S., et al. (2019) · Surgical Oncology · doi:10.1016/j.suronc.2019.11.005 · Cited by 33

Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

Zhou, J., Sun, S., Luan, S., Xiao, X., Yang, Y., Mao, C., Chen, L., Zeng, X., Zhang, Y., & Yuan, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.717242 · Cited by 35

Esophageal microflora in esophageal diseases

Zou, Q., Feng, L., Cai, X., Qian, Y., & Xu, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1145791 · Cited by 31

High toll-like receptor (TLR) 9 expression is associated with better prognosis in surgically treated pancreatic cancer patients

Leppänen, J., Helminen, O., Huhta, H. I., Kauppila, J. H., Isohookana, J., Haapasaari, K., Lehenkari, P. P., Saarnio, J., & Karttunen, T. J. (2017) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-017-2087-1 · Cited by 31

Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer

Belibasakis, G. N., Seneviratne, C. J., Jayasinghe, R. D., Vo, P. T., Bostancı, N., & Choi, Y. (2024) · Periodontology 2000 · doi:10.1111/prd.12558 · Cited by 30

Reexamining the role of Fusobacterium nucleatum subspecies in clinical and experimental studies

Krieger, M., Guo, M., & Merritt, J. L. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2415490 · Cited by 33

Modification of the Gastric Mucosal Microbiota by a Strain-Specific Helicobacter pylori Oncoprotein and Carcinogenic Histologic Phenotype

Noto, J. M., Zackular, J. P., Varga, M. G., Delgado, A., Romero–Gallo, J., Scholz, M. B., Piazuelo, M. B., Skaar, E. P., & Peek, R. M. (2019) · mBio · doi:10.1128/mbio.00955-19 · Cited by 30

Structural changes in the oral microbiome of the adolescent patients with moderate or severe dental fluorosis

Wang, Q., Chen, X., Hu, H., Wei, X., Wang, X., Peng, Z., Ma, R., Zhao, Q., Zhao, J., Liu, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82709-z · Cited by 22

Periodontal pathogens and cancer development

Zhou, Y., Meyle, J., & Groeger, S. E. (2024) · Periodontology 2000 · doi:10.1111/prd.12590 · Cited by 29

The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates

Kan, L., Yu, Y., Wang, Y., Shi, L., Fan, T., Chen, H., & Ren, C. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02328-4 · Cited by 32

Effects of Porphyromonas gingivalis and Fusobacterium nucleatum on inflammasomes and their regulators in H400 cells

Aral, K., Milward, M. R., Gupta, D., & Cooper, P. R. (2020) · Molecular Oral Microbiology · doi:10.1111/omi.12302 · Cited by 28

Analysis of 16S rRNA genes reveals reduced Fusobacterial community diversity when translocating from saliva to GI sites

Richardson, M., Ren, J., Rubinstein, M. R., Taylor, J. A., Friedman, R. A., Shen, B., & Han, Y. W. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1814120 · Cited by 28

SalivaryCCL20Level as a Biomarker for Oral Squamous Cell Carcinoma

Ueda, S., Goto, M., Hashimoto, K., Hasegawa, S., Imazawa, M., TAKAHASHI, M., Oh‐iwa, I., Shimozato, K., Nagao, T., & Nomoto, S. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20245 · Cited by 28

Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response

Zhao, T., Wang, X., Fu, L., & Yang, K. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2021.144 · Cited by 30

Comparison of clinicopathological parameters, prognosis, micro-ecological environment and metabolic function of Gastric Cancer with or without Fusobacterium sp. Infection

Nie, S., Wang, A., & Yuan, Y. (2020) · Journal of Cancer · doi:10.7150/jca.50918 · Cited by 28

Fusobacterium nucleatum Infection Induces Malignant Proliferation of Esophageal Squamous Cell Carcinoma Cell by Putrescine Production

Ding, N., Cheng, Y., Liu, H., Wu, Y., Weng, Y., Cui, H., Chen, C., Zhang, W., & Cui, Y. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02759-22 · Cited by 29

Molecular principles of tissue invasion and metastasis

Dhanisha, S. S., & Guruvayoorappan, C. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00348.2022 · Cited by 29

Awareness of intratumoral bacteria and their potential application in cancer treatment

Liang, Y., Li, Q., Liu, Y., Guo, Y., & Li, Q. (2023) · Discover Oncology · doi:10.1007/s12672-023-00670-x · Cited by 31

Intratumoural microbiota: from theory to clinical application

Ji, H., Jiang, Z., Wei, C., Ma, Y., Zhao, J., Wang, F., Zhao, B., Wang, D., & Tang, D. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01134-z · Cited by 29

The Mycobiome: Impact on Health and Disease States

El‐Jurdi, N., & Ghannoum, M. A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0045-2016 · Cited by 27

Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I

Chen, T., Zhao, X., Ren, Y., Wang, Y., Tang, X., Tian, P., Wang, H., & Xin, H. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9481-8 · Cited by 26

The Role of Gut Microbiota in Modulating Tumor Growth and Anticancer Agent Efficacy

Kim, J.-H., & Lee, H. K. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0032 · Cited by 27

Tumor Microbiome in Nasopharyngeal Carcinoma and Its Association With Prognosis

Zhong, G., Wei, W., Liao, W., Wang, R., Peng, Y., Zhou, Y., Huang, X., Xian, S., Peng, S., Zhang, Z., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.859721 · Cited by 26

Involvement of Fusobacterium nucleatum in malignancies except for colorectal cancer: A literature review

He, Z., Tian, W., Wei, Q., & Xu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968649 · Cited by 27

Unveiling the Hidden Links: Periodontal Disease, Fusobacterium Nucleatum, and Cancers

Akbari, E., Epstein, J. B., & Samim, F. (2024) · Current Oncology Reports · doi:10.1007/s11912-024-01591-w · Cited by 30

Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China: A nested case-control study

Liu, F., Liu, M., Liu, Y., Guo, C., Zhou, Y., Li, F., Xu, R., Liu, Z., Deng, Q., Li, X., et al. (2020) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2020.06.07 · Cited by 25

Immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract

Guo, S., Wang, H., Nian, Z., Wang, Y.-D., Zeng, Q., & Zhang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-11127-x · Cited by 27

Time-Course Transcriptome Analysis of Gingiva-Derived Mesenchymal Stem Cells Reveals That Fusobacterium nucleatum Triggers Oncogene Expression in the Process of Cell Differentiation

Kang, W., Sun, T., Tang, D., Zhou, J., & Feng, Q. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00359 · Cited by 26

Biochemical Mechanisms Associating Alcohol Use Disorders with Cancers

Rodriguez, F. D., & Coveñas, R. (2021) · Cancers · doi:10.3390/cancers13143548 · Cited by 27

Upper Gastrointestinal Cancer and Liver Cirrhosis

Jeng, K., Chang, C., Sheen, I., Jeng, C., & Wang, C.-H. (2022) · Cancers · doi:10.3390/cancers14092269 · Cited by 24

Intratumor microbiota: a novel tumor component

Gong, Y., Huang, X., Wang, M., & Liang, X. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04576-7 · Cited by 26

Salivary microbiota may predict the presence of esophageal squamous cell carcinoma

Wei, J., Li, R., Lu, Y., Meng, F., Xian, B., Lai, X., Lin, X., Deng, Y., Yang, D., Zhang, H., et al. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.02.006 · Cited by 23

Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China

Li, H., Luo, Z., Zhang, H., Huang, N., Dong, L., Luo, C., & Wang, T. (2021) · BioMed Research International · doi:10.1155/2021/2259093 · Cited by 23

Novel epigenetic network biomarkers for early detection of esophageal cancer

Maity, A. K., Stone, T., Ward, V., Webster, A. P., Yang, Z., Hogan, Á., McBain, H., Duku, M., Ho, K. M. A., Wolfson, P., et al. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01243-5 · Cited by 25

Fusobacterium nucleatum promotes proliferation in oesophageal squamous cell carcinoma via AHR / CYP1A1 signalling

Yin, H., Zhang, J., Zhang, H., Li, Q., Qiu, H., Hong, K., Wang, W., Xiao, Y., & Yu, B. (2022) · FEBS Journal · doi:10.1111/febs.16619 · Cited by 27

Fusobacterium nucleatum : Unraveling its potential role in gastric carcinogenesis

Petkevičius, V., Lehr, K., Kupčinskas, J., & Link, A. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i35.3972 · Cited by 22

An international report on bacterial communities in esophageal squamous cell carcinoma

Nomburg, J., Bullman, S., Nasrollahzadeh, D., Collisson, E. A., Abedi‐Ardekani, B., Akoko, L., Atkins, J., Buckle, G. C., Gopal, S., Hu, N., et al. (2022) · International Journal of Cancer · doi:10.1002/ijc.34212 · Cited by 24

Intratumour Fusobacterium nucleatum and immune response to oesophageal cancer

Kosumi, K., Baba, Y., Yamamura, K., Nomoto, D., Okadome, K., Yagi, T., Toihata, T., Kiyozumi, Y., Harada, K., Eto, K., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-022-02112-x · Cited by 21

Changes in the distal esophageal microbiota in Chinese patients with reflux esophagitis

Yu, Y., Gao, F., Chen, X., Zheng, S., & Zhang, J. (2018) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12692 · Cited by 22

Presence of Fusobacterium nucleatum in relation to patient survival and an acidic environment in oesophagogastric junction and gastric cancers

Hara, Y., Baba, Y., Oda, E., Harada, K., Yamashita, K., Toihata, T., Kosumi, K., Iwatsuki, M., Miyamoto, Y., Tsutsuki, H., et al. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02753-0 · Cited by 21

The relationship of the microbiome, associated metabolites and the gut barrier with pancreatic cancer

Daniel, N., Farinella, R., Belluomini, F., Fajkić, A., Rizzato, C., Souček, P., Campa, D., & Hughes, D. J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.002 · Cited by 23

Nucleic acid aptamer controls mycoplasma infection for inhibiting the malignancy of esophageal squamous cell carcinoma

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