Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan.

Reidy-Lagunes, Diane; Pandit-Taskar, Neeta; O'Donoghue, Joseph A.; Krebs, Simone; Staton, Kevin D.; Lyashchenko, Serge K.; Lewis, Jason S.; Raj, Nitya; Gönen, Mithat; Lohrmann, Christian; Bodei, Lisa; Weber, Wolfgang A.

doi:10.1158/1078-0432.ccr-19-1026

Cited by 112Neuroendocrine Tumor Research AdvancesRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and Applications

Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan.

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Reidy-Lagunes, Diane, Pandit-Taskar, Neeta, O'Donoghue, Joseph A., Krebs, Simone, Staton, Kevin D., Lyashchenko, Serge K., Lewis, Jason S., Raj, Nitya +4 more·2019·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-19-1026PMC PMC8382090

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Abstract

Abstract Purpose: Radiolabeled somatostatin receptor 2 (SSTR2) antagonists have shown higher tumor uptake and tumor-to-organ ratios than somatostatin agonists in preclinical models of neuroendocrine tumors (NETs). We performed a phase I study to evaluate the safety and efficacy of SSTR2 antagonist 177Lu-satoreotide tetraxetan. Patients and Methods: Twenty patients with advanced SSTR2-positive NETs were treated with 177Lu-satoreotide tetraxetan. Patients first underwent a dosimetry study with 177Lu-satoreotide tetraxetan to determine the therapeutic activity that could be safely administered. This activity was split into two equal cycles to be delivered 3 months apart. The maximum activity was 7.4 GBq per cycle. Results: Of 20 patients with NETs (one lung, seven small bowel, nine pancreatic, one gastric, one rectal, one kidney; mean prior treatments: three), six received one cycle of 177Lu- satoreotide tetraxetan and 14 received two cycles. Hematologic toxicity after cycle 1 was mild-moderate and reversed before cycle 2. However, grade 4 hematologic toxicity occurred in four of seven (57%) patients after cycle 2 of 177Lu-satoreotide tetraxetan. The study was suspended, and the protocol modified to limit the cumulative absorbed bone marrow dose to 1 Gy and to reduce prescribed activity for cycle 2 by 50%. The best overall response rate was 45% [5% complete response (1/20), 40% partial response (8/20)]; with 40% stable disease (8/20) and 15% progression of disease (3/20). Median progression-free survival (PFS) was 21.0 months (95% CI, 13.6–NR). Conclusions: In this trial of heavily treated NETs, preliminary data are promising for the use of 177Lu-satoreotide tetraxetan. Additional studies are ongoing to determine optimal therapeutic dose/schedule.

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Grade 4 hematotoxicity was reported in 4 out of 7 patients after two cycles of 177Lu-DOTA-JR11, resulting in the suspension of this therapy protocol.
“Unfortunately, grade 4 hematotoxicity was reported in 4 out of 7 patients after two cycles of 177Lu-DOTA-JR11, resulting in the suspension of this therapy protocol (138).”
From Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists (2022) · cites this paper as [138]

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Rinke, A., Müller, H., Schade‐Brittinger, C., Klose, K., Barth, P. J., Wied, M., Mayer, C., Aminossadati, B., Pape, U., Bläker, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.8510 · Cited by 2,507 · see citing works
Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors
Caplin, M. E., Pavel, M. E., Ćwikła, J. B., Phan, A. T., Raderer, M., Sedláčková, E., Cadiot, G., Wolin, E. M., Capdevila, J., Wall, L. R., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1316158 · Cited by 1,937 · see citing works
Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients
Krenning, E. P., Kwekkeboom, D. J., Bakker, W. H., Breeman, W. A. P., Kooij, P. P. M., Oei, H. Y., van Hagen, M., Postema, P. T., de Jong, M., Reubi, J. C., et al. (1993) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00181765 · Cited by 1,560 · see citing works
Treatment With the Radiolabeled Somatostatin Analog [ 177 Lu-DOTA 0 ,Tyr 3 ]Octreotate: Toxicity, Efficacy, and Survival
Kwekkeboom, D. J., de Herder, W. W., Kam, B. L. R., van Eijck, C. H. J., van Essen, M., Kooij, P. P. M., Feelders, R. A., van Aken, M. O., & Krenning, E. P. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.2553 · Cited by 1,454 · see citing works
OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine.
Stabin, M. G., Sparks, R. B., & Crowe, E. A. (2005) · PubMed · Cited by 1,340 · see citing works
Treatment of the Malignant Carcinoid Syndrome
Kvols, L. K., Moertel, C. G., O’Connell, M. J., Schutt, A. J., Rubin, J., & Hahn, R. G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198609113151102 · Cited by 858 · see citing works
Response, Survival, and Long-Term Toxicity After Therapy With the Radiolabeled Somatostatin Analogue [ 90 Y-DOTA]-TOC in Metastasized Neuroendocrine Cancers
Imhof, A., Brunner, P., Marincek, N., Briel, M., Schindler, C., Rasch, H. F., Mäcke, H. R., Rochlitz, C. F., Müller‐Brand, J., & Walter, M. A. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.7873 · Cited by 638 · see citing works
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Ginj, M., Zhang, H., Waser, B., Cescato, R., Wild, D., Wang, X., Érchegyi, J., Rivier, J., Mäcke, H. R., & Reubi, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607761103 · Cited by 514 · see citing works
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Bodei, L., Kidd, M., Paganelli, G., Grana, C. M., Drozdov, I., Cremonesi, M., Lepensky, C., Kwekkeboom, D. J., Baum, R. P., Krenning, E. P., et al. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2893-5 · Cited by 465 · see citing works
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Sadowski, S. M., Neychev, V. K., Millo, C., Shih, J. H., Nilubol, N., Herscovitch, P., Pacák, K., Marx, S. J., & Kebebew, E. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.64.0987 · Cited by 356 · see citing works
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Sandström, M., Garske‐Román, U., Granberg, D. O., Johansson, S., Widström, C., Eriksson, B. K., Sundin, A., Lundqvist, H., & Lubberink, M. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.107524 · Cited by 287 · see citing works
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Wild, D., Fani, M., Fischer, R., Pozzo, L. D., Kaul, F., Krebs, S. S., Fischer, R., Rivier, J., Reubi, J. C., Maëcke, H. R., et al. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.138834 · Cited by 267 · see citing works
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Forrer, F., Krenning, E. P., Kooij, P. P. M., Bernard, B. F., Konijnenberg, M., Bakker, W. H., Teunissen, J. J. M., de Jong, M., van Lom, K., de Herder, W. W., et al. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1072-6 · Cited by 202 · see citing works
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Wild, D., Fani, M., Béhé, M. P., Brink, I., Rivier, J., Reubi, J. C., Maëcke, H. R., & Weber, W. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.088922 · Cited by 183 · see citing works
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Bergsma, H., Konijnenberg, M., van der Zwan, W. A., Kam, B. L. R., Teunissen, J. J. M., Kooij, P. P. M., Mauff, K. A. L., Krenning, E. P., & Kwekkeboom, D. J. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3382-9 · Cited by 180 · see citing works
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Bergsma, H., Konijnenberg, M., Kam, B. L. R., Teunissen, J. J. M., Kooij, P. P. M., de Herder, W. W., Franssen, G. J. H., van Eijck, C. H. J., Krenning, E. P., & Kwekkeboom, D. J. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3193-4 · Cited by 177 · see citing works
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Afan, A. M., Broome, C. S., Nicholls, S., Whetton, A. D., & Miyan, J. A. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.2733092.x · Cited by 102 · see citing works
Effectiveness and side-effects of peptide receptor radionuclide therapy for neuroendocrine neoplasms in Germany: A multi-institutional registry study with prospective follow-up
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Biodistribution and radiation dose estimates for 68Ga-DOTA-JR11 in patients with metastatic neuroendocrine tumors
Krebs, S. S., Pandit-Taskar, N. D., Reidy‐Lagunes, D. L., Beattie, B. J., Lyashchenko, S. K., Lewis, J. S., Bodei, L., Weber, W., & O’Donoghue, J. A. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4193-y · Cited by 61 · see citing works
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Oomen, S. P. M. A., van Hennik, P. B., Antonissen, C., Lichtenauer-Kaligis, E. G. R., Hofland, L. J., Lamberts, S. W. J., Löwenberg, B., & Touw, I. P. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00772-x · Cited by 54 · see citing works
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Broomé, Whetton, A. D., & Miyan, J. A. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01808.x · Cited by 51 · see citing works
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Self-citation
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Krebs, S. S., O’Donoghue, J. A., Biegel, E., Beattie, B. J., Reidy‐Lagunes, D. L., Lyashchenko, S. K., Lewis, J. S., Bodei, L., Weber, W., & Pandit-Taskar, N. D. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04832-9 · Cited by 35 · see citing works
Self-citation
Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in 177Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment
Jiménez‐Franco, L. D., Glatting, G., Prasad, V., Weber, W., Beer, A. J., & Kletting, P. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.245068 · Cited by 34 · see citing works
Self-citation
Pretherapeutic Comparative Dosimetry of177Lu-rhPSMA-7.3 and177Lu-PSMA I&T in Patients with Metastatic Castration-Resistant Prostate Cancer
Feuerecker, B., Chantadisai, M., Allmann, A., Tauber, R., Allmann, J., Steinhelfer, L., Rauscher, I., Wurzer, A. J., Wester, H., Weber, W., et al. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262671 · Cited by 34 · see citing works
Self-citation
Targeted Cancer Therapy: What’s New in the Field of Neuroendocrine Neoplasms?
Salvia, A. L., Espinosa-Olarte, P., Martínez, M. C. R., Antón-Pascual, B., & García‐Carbonero, R. (2021) · Cancers · doi:10.3390/cancers13071701 · Cited by 33 · see citing works
Radiolabeled Nanocarriers as Theranostics—Advancement from Peptides to Nanocarriers
Desai, P. B., Rimal, R., Sahnoun, S. E. M., Mottaghy, F. M., Möller, M., Morgenroth, A., & Singh, S. (2022) · Small · doi:10.1002/smll.202200673 · Cited by 33 · see citing works
Novel therapeutics for patients with well-differentiated gastroenteropancreatic neuroendocrine tumors
Das, S., & Dasari, A. N. (2021) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359211018047 · Cited by 30 · see citing works
Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [177Lu]Lu-OPS201 Compared to the Agonist [177Lu]Lu-DOTA-TATE
Mansi, R., Plas, P., Vauquelin, G., & Fani, M. (2021) · Pharmaceuticals · doi:10.3390/ph14121265 · Cited by 30 · see citing works
Multimodal Imaging of 2-Cycle PRRT with 177Lu-DOTA-JR11 and 177Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model
Albrecht, J., Exner, S., Grötzinger, C., Prasad, S., Konietschke, F., Beindorff, N., Kühl, A. A., Prasad, V., Brenner, W., & Koziolek, E. J. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.250274 · Cited by 28 · see citing works
Comparison of the tolerability of 161Tb- and 177Lu-labeled somatostatin analogues in the preclinical setting
Busslinger, S. D., Mapanao, A. K., Kegler, K., Bernhardt, P., Flühmann, F., Fricke, J., Zeevaart, J. R., Köster, U., van der Meulen, N. P., Schibli, R., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06827-2 · Cited by 25 · see citing works
177Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
Hallqvist, A., Brynjarsdóttir, E., Krantz, T., Sjögren, M., Svensson, J., & Bernhardt, P. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.124.268902 · Cited by 25 · see citing works
Molecular imaging Theranostics of Neuroendocrine Tumors
Fortunati, E., Bonazzi, N., Zanoni, L., Fanti, S., & Ambrosini, V. (2023) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2022.12.007 · Cited by 25 · see citing works
Digestive Well-Differentiated Grade 3 Neuroendocrine Tumors: Current Management and Future Directions
Pellat, A., Cottereau, A., Palmieri, L., Soyer, P. A., Marchèse, U., Brézault, C., & Coriat, R. (2021) · Cancers · doi:10.3390/cancers13102448 · Cited by 23 · see citing works
68Ga-SSO-120 PET for Initial Staging of Small Cell Lung Cancer Patients: A Single-Center Retrospective Study
Kersting, D., Sandach, P., Sraieb, M., Wiesweg, M., Metzenmacher, M., Darwiche, K., Oezkan, F., Bölükbas, S., Stuschke, M., Umutlu, L., et al. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.123.265664 · Cited by 17 · see citing works
Nuclear Medicine and Radiological Imaging of Pancreatic Neuroendocrine Neoplasms: A Multidisciplinary Update
Prosperi, D., Silveri, G. G., Panzuto, F., Faggiano, A., Russo, V., Caruso, D., Polici, M., Lauri, C., Filice, A., Laghi, A., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226836 · Cited by 22 · see citing works
Radiolabeled Somatostatin Receptor Antagonist Versus Agonist for Peptide Receptor Radionuclide Therapy in Patients with Therapy-Resistant Meningioma: PROMENADE Phase 0 Study
Eigler, C., McDougall, L., Bauman, A., Bernhardt, P., Hentschel, M., Blackham, K. A., Nicolas, G., Fani, M., Wild, D., & Cordier, D. (2024) · Journal of Nuclear Medicine · doi:10.2967/jnumed.123.266817 · Cited by 22 · see citing works
First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
Handula, M., Beekman, S., Konijnenberg, M., Stuurman, D. C., de Ridder, C., Bruchertseifer, F., Morgenstern, A., Denkova, A. G., de Blois, E., & Seimbille, Y. (2023) · EJNMMI Radiopharmacy and Chemistry · doi:10.1186/s41181-023-00197-0 · Cited by 21 · see citing works
Radionuclide Theranostics in Neuroendocrine Neoplasms: An Update
Franco, M. D., Zanoni, L., Fortunati, E., Fanti, S., & Ambrosini, V. (2024) · Current Oncology Reports · doi:10.1007/s11912-024-01526-5 · Cited by 21 · see citing works
The Emergence of Somatostatin Antagonist–Based Theranostics: Paving the Road Toward Another Success?
Impériale, A., Jha, A., Meuter, L., Nicolas, G. P., Taïeb, D., & Pacák, K. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.123.265406 · Cited by 19 · see citing works
Current status of peptide receptor radionuclide therapy in grade 1 and 2 gastroenteropancreatic neuroendocrine tumours
Kuiper, J., Zoetelief, E., Brabander, T., de Herder, W. W., & Hofland, J. (2024) · Journal of Neuroendocrinology · doi:10.1111/jne.13469 · Cited by 18 · see citing works
Therapy Resistant Gastroenteropancreatic Neuroendocrine Tumors
McClellan, K. V., Chen, E. Y.-S., Kardosh, A., Lopez, C. D., Rivero, J. D., Mallak, N., Rocha, F. G., Koethe, Y., Pommier, R. F., Mittra, E., et al. (2022) · Cancers · doi:10.3390/cancers14194769 · Cited by 20 · see citing works
Dosimetry and pharmacokinetics of [177Lu]Lu-satoreotide tetraxetan in patients with progressive neuroendocrine tumours
Beykan, S., Eberlein, U., Ansquer, C., Beauregard, J., Durand‐Gasselin, L., Grønbæk, H., Haug, A. R., Hicks, R. J., Lenzo, N. P., Navalkissoor, S., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06682-1 · Cited by 18 · see citing works
Diagnostic Value of Radiolabelled Somatostatin Analogues for Neuroendocrine Tumour Diagnosis: The Benefits and Drawbacks of [64Cu]Cu-DOTA-TOC
Vahidfar, N., Farzanehfar, S., Abbasi, M., Mirzaei, S., Delpassand, E. S., Abbaspour, F., Salehi, Y., Biersack, H. J., & Ahmadzadehfar, H. (2022) · Cancers · doi:10.3390/cancers14081914 · Cited by 17 · see citing works
Rethinking Dosimetry: The Perils of Extrapolated External-Beam Radiotherapy Constraints to Radionuclide Therapy
Strosberg, J., Hofman, M. S., Al‐Toubah, T., & Hope, T. A. (2024) · Journal of Nuclear Medicine · doi:10.2967/jnumed.123.267167 · Cited by 16 · see citing works
Somatostatin receptor radionuclide therapy in neuroendocrine tumors
Haider, M., Das, S., Al‐Toubah, T., Pellè, E., El-Haddad, G. E., & Strosberg, J. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0360 · Cited by 16 · see citing works
Clinical Pharmacology of Radiotheranostics in Oncology
Beek, E. T. T., Burggraaf, J., Teunissen, J. J. M., & Vriens, D. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2598 · Cited by 15 · see citing works
Strategies Towards Improving Clinical Outcomes of Peptide Receptor Radionuclide Therapy
Minczeles, N. S., Hofland, J., de Herder, W. W., & Brabander, T. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01037-7 · Cited by 15 · see citing works
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study
Guo, W., Wen, X., Chen, Y., Zhao, T., Liu, J., Tao, Y., Fu, H., Wang, H., Xu, W., Pang, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.022 · Cited by 14 · see citing works
Head-to-Head Comparison of SSTR Antagonist [68Ga]Ga-DATA5m-LM4 with SSTR Agonist [68Ga]Ga-DOTANOC PET/CT in Patients with Well Differentiated Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Imaging Study
Viswanathan, R., Ballal, S., Yadav, M. P., Roesch, F., Sheokand, P., Satapathy, S., Tripathi, M., Agarwal, S., Moon, E. S., & Bal, C. (2024) · Pharmaceuticals · doi:10.3390/ph17030275 · Cited by 13 · see citing works
Treatment of Neuroendocrine Neoplasms with Radiolabeled Peptides—Where Are We Now
Naik, M., AL-NAHHAS, A. M., & Khan, S. R. (2022) · Cancers · doi:10.3390/cancers14030761 · Cited by 13 · see citing works
Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist
Ahenkorah, S., Cawthorne, C., Murce, E., Deroose, C. M., Cardinaels, T., Seimbille, Y., Bormans, G. M., Ooms, M., & Cleeren, F. (2023) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2023.108338 · Cited by 13 · see citing works
Limitations of the radiotheranostic concept in neuroendocrine tumors due to lineage-dependent somatostatin receptor expression on hematopoietic stem and progenitor cells
Nguyen, N. T., Min, Y., Rivière, J., van der Garde, M., Ghosh, S. C., Bartos, L. M., Brendel, M., Bassermann, F. C., Azhdarinia, A., Weber, W., et al. (2025) · Theranostics · doi:10.7150/thno.113354 · Cited by 11 · see citing works
Self-citation
Comparison of the Anti-Tumour Activity of the Somatostatin Receptor (SST) Antagonist [177Lu]Lu-Satoreotide Tetraxetan and the Agonist [177Lu]Lu-DOTA-TATE in Mice Bearing AR42J SST2-Positive Tumours
Plas, P., Limana, L., Carré, D., Thiongane, A., Raguin, O., Mansi, R., Meyer-Losic, F., & Lezmi, S. (2022) · Pharmaceuticals · doi:10.3390/ph15091085 · Cited by 10 · see citing works
Drug Development in Neuroendocrine Tumors: What Is on the Horizon?
García‐Álvarez, A., Cubero, J. H., & Capdevila, J. (2021) · Current Treatment Options in Oncology · doi:10.1007/s11864-021-00834-3 · Cited by 10 · see citing works
Diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms by nuclear medicine: Update and future perspective
Ma, X., Ding, Y., Li, W., Li, Q., & Yang, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1061065 · Cited by 10 · see citing works
A clinical score for neuroendocrine tumor patients under consideration for Lu-177-DOTATATE therapy
Das, S., Du, L., Schad, A., Jain, S., Jessop, A., Shah, C., Eisner, D., Cardin, D. B., Ciombor, K. K., Goff, L. W., et al. (2021) · Endocrine Related Cancer · doi:10.1530/erc-20-0482 · Cited by 9 · see citing works
Theranostics with somatostatin receptor antagonists in SCLC: Correlation of 68 Ga-SSO120 PET with immunohistochemistry and survival
Mavroeidi, I. A., Romanowicz, A., Haake, T., Wienker, J., Metzenmacher, M., Darwiche, K., Öezkan, F., Bölükbas, S., Stuschke, M., Umutlu, L., et al. (2024) · Theranostics · doi:10.7150/thno.98819 · Cited by 8 · see citing works
Optimisation of radioligand therapy in neuroendocrine tumours: Current and evolving evidence
Navalkissoor, S., Gnanasegaran, G., & Grossman, A. B. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13208 · Cited by 7 · see citing works
Theranostic Radiopharmaceuticals of Somatostatin Receptors for Patients with Neuroendocrine Tumors: Agonists Versus Antagonists—A Systematic Review and Meta-Analysis
Wang, Q., Librizzi, D., Bagheri, S., Ebrahimifard, A., Shamami, A. H., Rinke, A., Eilsberger, F., Luster, M., & Yousefi, B. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178539 · Cited by 5 · see citing works
Targeted β − -Particle Plus Conversion and Auger-Electron Therapy with 161 Tb-Labeled Somatostatin Receptor Antagonist DOTA-LM3: A Phase 0 Study
Fricke, J. G., Westerbergh, F., McDougall, L., Favaretto, C., Christ, E., Nicolas, G. P., Geistlich, S., Schmid, D. E., Borgna, F., Fani, M., et al. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.125.270654 · Cited by 5 · see citing works
The Latest Advances in Peptide Receptor Radionuclide Therapy for Gastroenteropancreatic Neuroendocrine Tumors
Hindié, E., Baudin, É., Hicks, R. J., & Taïeb, D. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264422 · Cited by 5 · see citing works
New approaches in nuclear medicine theranostics
Enke, J. S., Fenzl, L., Lapa, C., & Viering, O. (2025) · British Journal of Radiology · doi:10.1093/bjr/tqaf143 · Cited by 4 · see citing works
The Role of [177Lu] Lu-Satoreotide Tetraxetan in Somatostatin Receptor-Positive Neuroendocrine Tumors
Shekhda, K. M., & Navalkissoor, S. (2025) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2025.07.002 · Cited by 4 · see citing works
Molecular Imaging in neuroendocrine neoplasias
Christ, E., Wild, D., & Refardt, J. C. (2022) · La Presse Médicale · doi:10.1016/j.lpm.2022.104115 · Cited by 4 · see citing works
Radiolabeled somatostatin analogs for cancer treatment. Review
Тищенко, В. К., Петриев, В. М., Крылов, В. В., Власова, О. П., Шегай, П. В., Иванов, С. А., & Каприн, А. Д. (2022) · Radiation and Risk Bulletin of the National Radiation and Epidemiological Registry · doi:10.21870/0131-3878-2022-31-2-76-96 · Cited by 4 · see citing works
Racial, ethnic, sex, and age representation in clinical trials of radiopharmaceutical tumor therapy: a systematic review and meta-analysis
Zhao, M., Jiang, Y., Shao, T., & Tang, W. (2025) · BMC Cancer · doi:10.1186/s12885-025-14527-9 · Cited by 3 · see citing works
Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68–labeled somatostatin receptor antagonists
Xing, H., Zhu, W., Cheng, Y., Yang, Q., Jia, R., Zhao, H., Bai, C., Huo, L., & Wu, W. (2022) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000101 · Cited by 3 · see citing works
Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms
Jiao, F., Cui, J., Fu, D., Li, Q., Wu, Z., Teng, Z., Zhang, H., Zhou, J., Zhang, Z., Chen, X., et al. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002848 · Cited by 3 · see citing works
Perspective of molecular imaging and peptide receptor radionuclide therapy in pancreatic neuroendocrine tumors: where do we stand?
Zhu, W., Liu, M., & Huo, L. (2023) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000122 · Cited by 2 · see citing works
Theranostic Imaging and Radiopharmaceutical Therapy
Duan, H., & Iagaru, A. H. (2023) · Springer eBooks · doi:10.1007/978-3-031-39005-0_22 · Cited by 2 · see citing works
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors
Guo, Z., Han, X., Chen, J., Zhang, L., Sun, J., Li, Q., Du, X., Dong, F., & Xiu, P. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10303-0 · Cited by 2 · see citing works
Evolving Therapeutic Strategies in Neuroendocrine Neoplasms: A New Era of Personalized Therapies
Grewal, U. S., Shaheen, S., Zhen, D. B., Mittra, E., Halfdanarson, T. R., Singh, S., & Chan, J. A. (2026) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk-26-518934 · Cited by 2 · see citing works
Theranostics with Somatostatin Receptor Antagonists
Wild, D. (2024) · Springer eBooks · doi:10.1007/978-3-031-33533-4_35 · Cited by 2 · see citing works
State-of-the-Art Hybrid Imaging of Neuroendocrine Neoplasms
Ambrosini, V., Fortunati, E., Fanti, S., Ursprung, S., Asmundo, L., O’Shea, A., Kako, B., Lee, S. I., Furtado, F., Blake, M. A., et al. (2024) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0000000000001594 · Cited by 2 · see citing works
Systemic Therapy for Pancreatic Neuroendocrine Tumors
Wheless, M. C., & Das, S. (2022) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2022.08.003 · Cited by 2 · see citing works
Case Study #6: [177Lu]Lu-DOTA-JR11: A Somatostatin Receptor Subtype 2 Antagonist for Radiopharmaceutical Therapy
Wild, D., & Fani, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-39005-0_16 · Cited by 1 · see citing works
Neuroendocrine Tumors
Bodei, L., Jayaprakasam, V. S., Wong, B. Z. Y., & Aparici, C. M. (2024) · PET Clinics · doi:10.1016/j.cpet.2024.06.003 · Cited by 1 · see citing works
Self-citation
Radionuclides for imaging and therapy in oncology
Velikyan, I. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22253-5.00026-1 · Cited by 1 · see citing works
177Lu-labelled peptide receptor radionuclide therapy in patients with neuroendocrine tumors: a systematic review and meta-analysis
Wang, J., Pang, X., Lian, J., & Lu, H. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1758639 · Cited by 1 · see citing works
Clinical Applications of Theranostics
Kuten, J., Bodei, L., & Lewis, J. S. (2026) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-032-21415-7_17 · Cited by 1 · see citing works
Self-citation
Radionuclide‑drug conjugates in lung cancer: advances in precision therapy and clinical translation
Liu, J., Zuo, X., Yang, X., Wang, X., Gan, L., & Xue, J. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02695-6 · Cited by 1 · see citing works
Theranostics and Molecular-targeted Endo-radiotherapy: The Current Landscape and Future Directions
Nazar, A. K., & Basu, S. K. (2025) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000006120 · Cited by 1 · see citing works
Small Intestinal, Colorectal, and Appendicular Neuroendocrine Tumors
Anthony, L. B., Gupta, G., & Chauhan, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-56968-5_20 · Cited by 1 · see citing works
Systemic Therapy Improvements Will Render Locoregional Treatments Obsolete for Patients with Cancer with Liver Metastases
Das, S., & Berlin, J. D. (2020) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2020.08.008
Emerging Systemic Therapies for Neuroendocrine Tumors
Gupta, M., Prinzing, G., & Iyer, R. V. (2021) · Springer eBooks · doi:10.1007/978-3-030-62241-1_20
Peptide radio receptor therapy: The huff and puff strategy of neuroendocrine disease management
Bodei, L., Kidd, M. S., & Modlin, I. M. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.06.002
Self-citation
RECENT DEVELOPMENT OF RADIONUCLIDE-BASED IMAGING IN DIAGNOSIS AND THERAPY OF LUNG CANCER: A REVIEW
Holik, H. A., & Aristawidya, L. (2022) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2022.v14s4.pp05
Receptor-Specific Radionuclide Therapy
Lepareur, N., & Bourgeois, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_303-1
Theranostics in Neuroendocrine Tumors
Vallabhajosula, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-23205-3_21
Systemic Therapy Improvements Will Render Locoregional Treatments Obsolete for Patients with Cancer with Liver Metastases
Das, S., & Berlin, J. D. (2024) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2024.08.008
Neue Ansätze in der Nuklearmedizinischen Diagnostik und Therapie
Enke, J. S., Fenzl, L., Lapa, C., & Viering, O. (2025) · Angewandte Nuklearmedizin · doi:10.1055/a-2385-3757
Receptor-Specific Radionuclide Therapy
Lepareur, N., & Bourgeois, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-00773-5_303
Additional file 1 of First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
Handula, M., Beekman, S., Konijnenberg, M., Stuurman, D. C., de Ridder, C., Bruchertseifer, F., Morgenstern, A., Denkova, A. G., de Blois, E., & Seimbille, Y. (2023) · Figshare · doi:10.6084/m9.figshare.23612575
Relationship between absorbed dose and SUV derived from SPECT/CT imaging and dose-response in patients with neuroendocrine tumors treated with [¹⁷⁷Lu]Lu-DOTA-TATE
Liu, F., Yang, H., Zhang, J., Li, J., Qiao, Y., Chen, J., & Song, S. (2026) · EJNMMI Research · doi:10.1186/s13550-026-01402-2

A phase I/II study of the safety and efficacy of [177Lu]Lu-satoreotide tetraxetan in advanced somatostatin receptor-positive neuroendocrine tumours
Wild, D., Grønbæk, H., Navalkissoor, S., Haug, A. R., Nicolas, G. P., Pais, B., Ansquer, C., Beauregard, J., McEwan, A. J. B., Laßmann, M., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06383-1 · Cited by 54 · see citing works
1160O An international open-label study on safety and efficacy of 177Lu-satoreotide tetraxetan in somatostatin receptor positive neuroendocrine tumours (NETs): An interim analysis
Nicolas, G. P., Ansquer, C., Lenzo, N. P., Grønbæk, H., Haug, A. R., Navalkissoor, S., Beauregard, J., Germann, N., McEwan, S., Wild, D., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.08.1373 · Cited by 11 · see citing works
Dosimetry and pharmacokinetics of [177Lu]Lu-satoreotide tetraxetan in patients with progressive neuroendocrine tumours
Beykan, S., Eberlein, U., Ansquer, C., Beauregard, J., Durand‐Gasselin, L., Grønbæk, H., Haug, A. R., Hicks, R. J., Lenzo, N. P., Navalkissoor, S., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06682-1 · Cited by 18 · see citing works
Theranostic trial of well differentiated neuroendocrine tumors (NETs) with somatostatin antagonists 68Ga-OPS202 and 177Lu-OPS201.
Reidy‐Lagunes, D. L., Pandit-Taskar, N. D., Krebs, S. S., Donoghue, J. A. O., Raj, N. P., Cruz, E., Pham, H. M., Lashley, A., Bodei, L., & Weber, W. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2017.35.15_suppl.4094 · Cited by 10 · see citing works
Self-citation
Comparison of the Anti-Tumour Activity of the Somatostatin Receptor (SST) Antagonist [177Lu]Lu-Satoreotide Tetraxetan and the Agonist [177Lu]Lu-DOTA-TATE in Mice Bearing AR42J SST2-Positive Tumours
Plas, P., Limana, L., Carré, D., Thiongane, A., Raguin, O., Mansi, R., Meyer-Losic, F., & Lezmi, S. (2022) · Pharmaceuticals · doi:10.3390/ph15091085 · Cited by 10 · see citing works

Authors: Reidy-Lagunes, D., Pandit-Taskar, N., O'Donoghue, J. A., Krebs, S., Staton, K. D., Lyashchenko, S. K., Lewis, J. S., Raj, N., Gönen, M., Lohrmann, C., Bodei, L., & Weber, W. A.
Affiliations: 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center (US)
3Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
ORCID: Pandit-Taskar, Neeta
Krebs, Simone
Lewis, Jason S.
Raj, Nitya
Gönen, Mithat
Bodei, Lisa
Weber, Wolfgang A.
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2019-12-01
Volume: 25
Issue: 23
Pages: 6939-6947
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-19-1026
PMC: PMC8382090
OpenAlex: W2969596297
Cited by: 112
References: 34
Citations by year: 2026: 17 · 2025: 14 · 2024: 15 · 2023: 16 · 2022: 23 · 2021: 14 · 2020: 11 · 2019: 2
FWCI: 9.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: NIH NCI (P30 CA008748, K12 CA184746)
Topics: Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: well-differentiated neuroendocrine tumors, radiolabeled somatostatin analogs, peptide receptor radionuclide therapy, dosimetry, hematologic toxicity, bone marrow dose, progression-free survival, treatment efficacy and safety
MeSH terms: Adult, Aged, Chelating Agents, Female, Follow-Up Studies, Heterocyclic Compounds, 1-Ring, Humans, Lutetium, Male, Middle Aged, Neoplasm Metastasis, Prognosis, Radioisotopes, Octreotide, Receptors, Somatostatin, Neuroendocrine Tumors, Radiopharmaceuticals, Young Adult

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Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan.

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