Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue
Open accessPublished version of a preprint
Abstract
Chronic social isolation is linked to increased mammary tumor growth in rodent models of breast cancer. In the C3(1)/SV40 T-antigen FVB/N (TAg) mouse model of “triple-negative” breast cancer, the heightened stress response elicited by social isolation has been associated with increased expression of metabolic genes in the mammary gland before invasive tumors develop (i.e., during the in situ carcinoma stage). To further understand the mechanisms underlying how accelerated mammary tumor growth is associated with social isolation, we separated the mammary gland adipose tissue from adjacent ductal epithelial cells and analyzed individual cell types for changes in metabolic gene expression. Specifically, increased expression of the key metabolic genes Acaca, Hk2, and Acly was found in the adipocyte, rather than the epithelial fraction. Surprisingly, metabolic gene expression was not significantly increased in visceral adipose depots of socially isolated female mice. As expected, increased metabolic gene expression in the mammary adipocytes of socially isolated mice coincided with increased glucose metabolism, lipid synthesis, and leptin secretion from this adipose depot. Furthermore, application of media that had been cultured with isolated mouse mammary adipose tissue (conditioned media) resulted in increased proliferation of mammary cancer cells relative to group-housed–conditioned media. These results suggest that exposure to a chronic stressor (social isolation) results in specific metabolic reprogramming in mammary gland adipocytes that in turn contributes to increased proliferation of adjacent preinvasive malignant epithelial cells. Metabolites and/or tumor growth-promoting proteins secreted from adipose tissue could identify biomarkers and/or targets for preventive intervention in breast cancer. Cancer Prev Res; 6(7); 634–45. ©2013 AACR.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Socially isolated animals show glucocorticoid-related increases in breast cancer burden, and molecular analyses find glucocorticoid signaling to promote cancer-related processes including mammary adipocyte metabolism, inhibition of tumor suppressor genes such as TP53, and resistance to chemotherapy-mediated programmed cell death.
“For example, socially isolated animals show glucocorticoid-related increases in breast cancer burden [46], [47], and molecular analyses find glucocorticoid signaling to promote several cancer-related processes including mammary adipocyte metabolism [47], [48], inhibition of tumor suppressor genes such as TP53 [49], and resistance to chemotherapy-mediated programmed cell death [50], [51].”
From Human Social Genomics (2014) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland
Subbaramaiah, K., Howe, L. R., Bhardwaj, P., Du, B., Gravaghi, C., Yantiss, R. K., Zhou, X. K., Blaho, V. A., Hla, T., Yang, P., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0381 · Cited by 362 · see citing works
RetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
BERKMAN, L. F., & SYME, S. L. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112674 · Cited by 5,341 · see citing works
Sulforhodamine B colorimetric assay for cytotoxicity screening
Vichai, V., & Kirtikara, K. (2006) · Nature Protocols · doi:10.1038/nprot.2006.179 · Cited by 3,679 · see citing works
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · see citing works
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,062 · see citing works
Assessing Reproductive Status/Stages in Mice
Caligioni, C. S. (2009) · Current Protocols in Neuroscience · doi:10.1002/0471142301.nsa04is48 · Cited by 775 · see citing works
Adipose tissue and adipocytes support tumorigenesis and metastasis
Nieman, K. M., Romero, I. L., Houten, B. V., & Lengyel, E. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.010 · Cited by 748 · see citing works
Otero, M., Lago, R., Gómez, R., Lago, F., Diéguez, C., Gómez-Reino, J. J., & Gualillo, O. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.046540 · Cited by 541 · see citing works
Brunner, E. J., Hemingway, H., Walker, B. R., Page, M., Clarke, P., Juneja, M., Shipley, M. J., Kumari, M., Andrew, R., Seckl, J. R., et al. (2002) · Circulation · doi:10.1161/01.cir.0000038364.26310.bd · Cited by 539 · see citing works
Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
Vona-Davis, L., & Rose, D. P. (2007) · Endocrine-Related Cancer · doi:10.1677/erc-06-0068 · Cited by 496 · see citing works
Backé, E.-M., Seidler, A., Latza, U., Rossnagel, K., & Schumann, B. (2011) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-011-0643-6 · Cited by 483 · see citing works
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
Faggioni, R., Feingold, K. R., & Grünfeld, C. (2001) · The FASEB Journal · doi:10.1096/fj.01-0431rev · Cited by 471 · see citing works
Hu, X. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.22.1704 · Cited by 451 · see citing works
Molecular links between obesity and breast cancer
Lorincz, A., & Sukumar, S. V. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.00729 · Cited by 440 · see citing works
Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes
Mueller, W. M., Gregoire, F. M., Stanhope, K. L., Mobbs, C. V., Mizuno, T. M., Warden, C. H., Stern, J. S., & Havel, P. J. (1998) · Endocrinology · doi:10.1210/endo.139.2.5716 · Cited by 427 · see citing works
Macfarlane, D. P., Forbes, S., & Walker, B. R. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0054 · Cited by 385 · see citing works
Structural and biochemical characteristics of various white adipose tissue depots
Wrońska, A., & Kmieć, Z. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02409.x · Cited by 370 · see citing works
Iyengar, P., Combs, T. P., Shah, S. J., Gouon–Evans, V., Pollard, J. W., Albanese, C., Flanagan, L., Tenniswood, M., Guha, C., Lisanti, M. P., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206737 · Cited by 364 · see citing works
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
Park, J., Euhus, D., & Scherer, P. E. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0030 · Cited by 349 · see citing works
Wu, W., Chaudhuri, S., Brickley, D. R., Pang, D., Karrison, T., & Conzen, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2546 · Cited by 316 · see citing works
Self-citationGreen, J. E., Shibata, M., Yoshidome, K., Liu, M., Jorcyk, C. L., Anver, M. R., Wigginton, J. M., Wiltrout, R. H., Shibata, E., Kaczmarczyk, S. J., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203280 · Cited by 261 · see citing works
Leptin signaling in breast cancer: An overview
Cirillo, D., Rachiglio, A. M., Montagna, R. L., Giordano, A., & Normanno, N. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21911 · Cited by 236 · see citing works
Hermes, G. L., Delgado, B., Tretiakova, M., Cavigelli, S. A., Krausz, T., Conzen, S. D., & McClintock, M. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910753106 · Cited by 207 · see citing works
Self-citationThe association between stressful life events and breast cancer risk: A meta‐analysis
Duijts, S. F. A., Zeegers, M. P., & van den Borne, B. H. P. (2003) · International Journal of Cancer · doi:10.1002/ijc.11504 · Cited by 194 · see citing works
Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
Hovey, R. C., & Aimo, L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9187-8 · Cited by 188 · see citing works
Górska, E., Popko, K., Stelmaszczyk‐Emmel, A., Ciepiela, O., Kucharská, A., & Wasik, M. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-50 · Cited by 185 · see citing works
Gonzalez-Perez, R. R., Xu, Y., Guo, S., Watters, A. L., Zhou, W., & Leibovich, S. J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.05.003 · Cited by 169 · see citing works
Bartolomucci, A., Cabassi, A., Govoni, P., Ceresini, G., Cero, C., Berra, D., Dadomo, H., Franceschini, P., Dell’Omo, G., Parmigiani, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004331 · Cited by 165 · see citing works
González, R. R., Watters, A. L., Xu, Y., Singh, U. P., Mann, D. R., Rueda, B. R., & Penichet, M. L. (2009) · Breast Cancer Research · doi:10.1186/bcr2321 · Cited by 159 · see citing works
Williams, J. B., Pang, D., Delgado, B., Kocherginsky, M., Tretiakova, M., Krausz, T., Pan, D., He, J., McClintock, M. K., & Conzen, S. D. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0238 · Cited by 137 · see citing works
Self-citationOelmann, E. M., Haghgu, S., Kulimova, E., Serve, H. L., Schmitmann, C., & Berdel, W. E. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg007 · Cited by 136 · see citing works
Biobehavioral Influences on Cancer Progression
Costanzo, E. S., Sood, A. K., & Lutgendorf, S. K. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.09.001 · Cited by 130 · see citing works
Ray, A., Nkhata, K. J., & Cleary, M. P. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.6.1499 · Cited by 127 · see citing works
Chronic social defeat stress disrupts regulation of lipid synthesis
Chuang, J.-C., Cui, H., Mason, B. L., Mahgoub, M., Bookout, A. L., Yu, H. G., Perello, M., Elmquist, J. K., Repa, J. J., Zigman, J. M., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002196 · Cited by 126 · see citing works
Jardé, T., Caldefie‐Chezet, F., Damez, M., Mishellany, F., Penault-Llorca, F. M., Guillot, J., & Vasson, M. (2008) · Oncology Reports · doi:10.3892/or.19.4.905 · Cited by 117 · see citing works
Social Isolation Affects the Development of Obesity and Type 2 Diabetes in Mice
Nonogaki, K., Nozue, K., & Oka, Y. (2007) · Endocrinology · doi:10.1210/en.2007-0296 · Cited by 115 · see citing works
Tumour-Stromal Interactions in Breast Cancer: The Role of Stroma in Tumourigenesis
Kim, J. B., Stein, R. C., & O'Hare, M. J. (2005) · Tumor Biology · doi:10.1159/000086950 · Cited by 114 · see citing works
Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm
Davis, A. A., & Kaklamani, V. (2011) · International Journal of Breast Cancer · doi:10.1155/2012/809291 · Cited by 95 · see citing works
Adiponectin and adiponectin receptor in relation to colorectal cancer progression
Byeon, J., Jeong, J., Kim, M. J., Lee, S., Nam, W., Myung, S., Kim, J. G., Yang, S., Kim, J., & Suh, D. J. (2010) · International Journal of Cancer · doi:10.1002/ijc.25301 · Cited by 93 · see citing works
Park, J., Kusminski, C. M., Chua, S. C., & Scherer, P. E. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100595 · Cited by 80 · see citing works
Increase of chemotherapy use in older women with breast carcinoma from 1991 to 1996
Du, X. L., & Goodwin, J. S. (2001) · Cancer · doi:10.1002/1097-0142(20010815)92:4 · Cited by 65 · see citing works
Riolfi, M., Ferla, R., Valle, L. D., Piña‐Oviedo, S., Scolaro, L. M., Micciolo, R., Guidi, M., Terrasi, M., Cetto, G. L., & Surmacz, E. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00323.x · Cited by 62 · see citing works
Breast cancer prevention based on gene–environment interaction
Song, M., Lee, K., & Kang, D. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20639 · Cited by 54 · see citing works
Holzer, R. G., MacDougall, C. A., Cortright, G., Atwood, K., Green, J. E., & Jorcyk, C. L. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1021175931177 · Cited by 46 · see citing works
Inhibition of mammary tumorigenesis in the C3(1)/SV40 mouse model by green tea
Leong, H., Mathur, P., & Greene, G. L. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9568-x · Cited by 46 · see citing works
Yuen, V. G., & McNeill, J. H. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(01)00117-4 · Cited by 45 · see citing works
Jurczak, M. J., Danos, A. M., Rehrmann, V. R., Allison, M. B., Greenberg, C. C., & Brady, M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00559.2006 · Cited by 38 · see citing works
Self-citationHasen, N. S., O’Leary, K. A., Auger, A. P., & Schuler, L. A. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0225 · Cited by 28 · see citing works
Merrill, M. A. L., Baston, D. S., Denison, M. S., Birnbaum, L. S., Pomp, D., & Threadgill, D. W. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90368.2008 · Cited by 20 · see citing works
Boyd, A. L., Salleh, A., Humber, B., Yee, J., Tomes, L., & Kerr, L. R. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0111 · Cited by 17 · see citing works
Rodríguez‐Sureda, V., López-Tejero, M. D., Llobera, M., & Peinado‐Onsurbe, J. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.038 · Cited by 11 · see citing works
Leptin secretion is related to glucose-derived lipogenesis in isolated adipocytes
Walker, C. G., Bryson, J. M., Hancock, D., & Caterson, I. D. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803462 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Guzik, T. J., MOHIDDIN, S. A., Dimarco, A. D., Patel, V., Savvatis, K., Marelli‐Berg, F. M., Madhur, M. S., Tomaszewski, M., Maffia, P., D’Acquisto, F., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa106 · Cited by 1,451 · see citing works
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415 · see citing works
An overview of cancer health disparities: new approaches and insights and why they matter
Minas, T. Z., Bailey‐Whyte, M., Ajao, A., & Ambs, S. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa121 · Cited by 117 · see citing works
Breast cancer and social environment: getting by with a little help from our friends
Hinzey, A. H., Gaudier‐Diaz, M. M., Lustberg, M. B., & DeVries, A. C. (2016) · Breast Cancer Research · doi:10.1186/s13058-016-0700-x · Cited by 102 · see citing works
Szpunar, M. J., Belcher, E. K., Dawes, R. P., & Madden, K. S. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.12.014 · Cited by 92 · see citing works
Stress and coping in women with breast cancer:unravelling the mechanisms to improve resilience
Borgi, M., Collacchi, B., Ortona, E., & Cirulli, F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.011 · Cited by 90 · see citing works
Iyer, H. S., Hart, J. E., James, P., Elliott, E. G., DeVille, N. V., Holmes, M. D., Vivo, I. D., Mucci, L. A., Laden, F., & Rebbeck, T. R. (2022) · Environment International · doi:10.1016/j.envint.2022.107164 · Cited by 81 · see citing works
Spera, G., Fresco, R., Fung, H., Dyck, J. R. B., Pituskin, E., Paterson, D. I., & Mackey, J. R. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx264 · Cited by 75 · see citing works
Wang, J., Shidfar, A., Ivancic, D. Z., Ranjan, M., Liu, L., Choi, M.-R., Parimi, V., Gursel, D. B., Sullivan, M. E., Najor, M. S., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30680 · Cited by 62 · see citing works
Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women
Bower, J. E., Shiao, S. L., Sullivan, P., Lamkin, D. M., Atienza, R., Mercado, F., Arevalo, J. M. G., Asher, A., Ganz, P. A., & Cole, S. W. (2018) · JNCI Cancer Spectrum · doi:10.1093/jncics/pky029 · Cited by 55 · see citing works
Metabolic Effects of Social Isolation in Adult C57BL/6 Mice
Sun, M., Choi, E., Magee, D., Stets, C. W., During, M. J., & Lin, E.-J. D. (2014) · International Scholarly Research Notices · doi:10.1155/2014/690950 · Cited by 52 · see citing works
Long-term impact of social isolation and molecular underpinnings
Arzate-Mejía, R. G., Lottenbach, Z., Schindler, V., Jawaid, A., & Mansuy, I. M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.589621 · Cited by 51 · see citing works
Kalezic, A., Udicki, M., Srdić, B., Aleksic, M., Korać, A., Janković, A., & Korać, B. (2021) · Cancers · doi:10.3390/cancers13112731 · Cited by 43 · see citing works
Volden, P. A., Skor, M. N., Johnson, M. B., Singh, P., Patel, F. N., McClintock, M. K., Brady, M., & Conzen, S. D. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0107 · Cited by 43 · see citing works
Self-citationGilabert‐Juan, J., Bueno-Fernández, C., Castillo-Gómez, E., & Nácher, J. (2016) · Brain and Behavior · doi:10.1002/brb3.534 · Cited by 38 · see citing works
Aktipis, A., Ellis, B. J., Nishimura, K. K., & Hiatt, R. A. (2014) · Evolution Medicine and Public Health · doi:10.1093/emph/eou028 · Cited by 38 · see citing works
Biobehavioral modulation of the exosome transcriptome in ovarian carcinoma
Lutgendorf, S. K., Thaker, P. H., Arevalo, J. M., Goodheart, M. J., Slavich, G. M., Sood, A. K., & Cole, S. W. (2018) · Cancer · doi:10.1002/cncr.31078 · Cited by 34 · see citing works
Analysis of Tumor Biology to Advance Cancer Health Disparity Research
Smith, C. J., Minas, T. Z., & Ambs, S. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.06.019 · Cited by 34 · see citing works
King, K. E., Kane, J. B., Scarbrough, P. M., Hoyo, C., & Murphy, S. K. (2016) · Biodemography and Social Biology · doi:10.1080/19485565.2015.1126501 · Cited by 29 · see citing works
Roubertoux, P. L., Baril, N., Cau, P., Scajola, C., Ghata, A. S., Bartoli, C., Bourgeois, P., di Christofaro, J., Tordjman, S., & Carlier, M. (2017) · Behavior Genetics · doi:10.1007/s10519-017-9835-5 · Cited by 26 · see citing works
Oiwa, Y., Oka, K., Yasui, H., Higashikawa, K., Bono, H. U., Kawamura, Y., Miyawaki, S., Watarai, A., Kikusui, T., Shimizu, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74929-6 · Cited by 23 · see citing works
Berry, A., Collacchi, B., Capoccia, S., D’Urso, M. T., Cecchetti, S., Raggi, C., Sestili, P., Aricò, E., Pontecorvi, G., Puglisi, R., et al. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.660738 · Cited by 23 · see citing works
Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk
Sumis, A. M., Cook, K. L., Andrade, F. D. O., Hu, R., Kidney, E., Zhang, X., Kim, D., Carney, E., Nguyen, N., Yu, W., et al. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0359 · Cited by 23 · see citing works
Social Isolation and Breast Cancer
Hilakivi-Clarke, L. A., & Andrade, F. D. O. (2023) · Endocrinology · doi:10.1210/endocr/bqad126 · Cited by 18 · see citing works
Implication of Spiritual Network Support System in Epigenomic Modulation and Health Trajectory
Holmes, L., Chinaka, C., Elmi, H., Deepika, K., Pelaez, L., Enwere, M., Akinola, O., & DABNEY, K. W. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16214123 · Cited by 18 · see citing works
Mustafi, D., Fernandez, S., Markiewicz, E. J., Fan, X., Zamora, M. A., Mueller, J. S., Brady, M., Conzen, S. D., & Karczmar, G. S. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3758 · Cited by 14 · see citing works
Self-citationPsychosocial stressors and breast cancer gene expression in the Black Women’s Health Study
Barnard, M. E., Wang, X., Petrick, J. L., Zirpoli, G., Jones, D., Johnson, W. E., & Palmer, J. R. (2023) · Breast Cancer Research and Treatment · doi:10.1007/s10549-023-07182-w · Cited by 13 · see citing works
Association of Social Isolation and Plasma Metabolites With the Risk of Venous Thromboembolism
Xiang, H., Gan, X., Zhang, Y., Zhang, Y., Ye, Z., Yang, S., Huang, Y., Wu, Y., Zhang, Y., & Qin, X. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322112 · Cited by 12 · see citing works
Kerkvliet, C. J. P., Truong, T. H., Ostrander, J. H., & Lange, C. A. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200165 · Cited by 13 · see citing works
Mitra, S., Kumar, G. S. S., Lakshmi, B. J., Thakur, S. S., & Kumar, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00133 · Cited by 10 · see citing works
Psychosocial Stress Exposure Disrupts Mammary Gland Development
Johnson, M. B., Hoffmann, J. N., You, H. M., Lastra, R. R., Fernandez, S., Strober, J. W., Allaw, A. B., Brady, M., Conzen, S. D., & McClintock, M. K. (2018) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-018-9392-4 · Cited by 5 · see citing works
Self-citationDifferences in Breast Cancers Among American Indian/Alaska Native and non-Hispanic Whites in the USA
Gaba, A. G., Cao, L., Renfrew, R. J., Witte, D., Wernisch, J. M., Sahmoun, A. E., Goel, S., Egland, K. A., & Crosby, R. D. (2023) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-023-01704-4 · Cited by 5 · see citing works
Mustafi, D., Leinroth, A., Fan, X., Markiewicz, E. J., Zamora, M. A., Mueller, J. S., Conzen, S. D., & Karczmar, G. S. (2019) · International Journal of Biomedical Imaging · doi:10.1155/2019/5987425 · Cited by 5 · see citing works
Self-citationSocial Determinants of Health and the Environmental Exposures: A Promising Partnership
Fordyce, L., Berrigan, D. A., & Srinivasan, S. (2017) · John Wiley & Sons, Inc. eBooks · doi:10.1002/9781119023647.ch11 · Cited by 3 · see citing works
Strober, J. W., Fernandez, S., Ye, H., & Brady, M. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2021 · Cited by 2 · see citing works
Self-citationMaintaining Mice for Neurobehavioral Examination
Roubertoux, P. L. (2014) · Neuromethods · doi:10.1007/978-1-4939-2250-5_13 · Cited by 2 · see citing works
Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk
Sumis, A. M., Cook, K. L., Andrade, F. O., Hu, R., Kidney, E., Zhan, X., Kim, D., Carney, E., Nguyen, N., Yu, W., et al. (2017) · Endocrine Abstracts · doi:10.1530/endoabs.50.ja3 · Cited by 2 · see citing works
Chronic psychosocial stress: a role in breast cancer etiology?
Fosse, R., & Behr, C. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1790548 · Cited by 1 · see citing works
Pair bonding and disruption impact lung transcriptome in monogamous Peromyscus californicus
Naderi, A., Liles, K., Burns, T., Chavez, B., Huynh-Dam, K.-T., & Kiaris, H. (2023) · BMC Genomics · doi:10.1186/s12864-023-09873-6 · Cited by 1 · see citing works
How Do the Metabolic Effects of Chronic Stress Influence Breast Cancer Biology
Volden, P. A. (2013)
Self-citationBreitenstein, M. K., Pathak, J., & Simon, G. (2015) · Europe PMC (PubMed Central)
Alschuler, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00131-x · Cited by 2 · see citing works
Lippman, S. M. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0443
Hernandez, A. E., Aizpurua‐Perez, I., Borowsky, P. A., Ream, M. E., Taub, C. J., Kanaya, M. R., Plotke, R. L., Blomberg, B. B., Antoni, M. H., & Goel, N. (2025) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2025.100637
Social isolation stress, obesity, and breast cancer risk in mice
Sumis, A. M. (2014) · DigitalGeorgetown (Georgetown University Library)
Naderi, A., Liles, K., Burns, T., Chavez, B., Huynh-Dam, K.-T., & Kiaris, H. (2024) · Figshare · doi:10.6084/m9.figshare.26656066
Naderi, A., Liles, K., Burns, T., Chavez, B., Huynh-Dam, K.-T., & Kiaris, H. (2024) · Figshare · doi:10.6084/m9.figshare.26656063
Naderi, A., Liles, K., Burns, T., Chavez, B., Huynh-Dam, K.-T., & Kiaris, H. (2024) · Figshare · doi:10.6084/m9.figshare.26656060
Campbell, K., Sanogo, F., Beard, T., Jefferson, M. S., Salhia, B., & Halbert, C. H. (2026) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-026-03057-0
Breitenstein, M. K. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
- Authors
- Volden, P. A., Wonder, E. L., Skor, M. N., Carmean, C. M., Patel, F. N., Ye, H., Kocherginsky, M., McClintock, M. K., Brady, M. J., & Conzen, S. D.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Brady, Matthew J.
- Conzen, Suzanne D.
- ORCID
- Venue
- Cancer Prevention Research
- Published
- 2013-07-01
- Volume
- 6
- Issue
- 7
- Pages
- 634-645
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- PMC
- PMC3881320
- OpenAlex
- W2130036505
- Cited by
- 48
- References
- 56
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Prevention Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Chicago
- National Institutes of Health (5t32dk087703-05)
- Diabetes Research and Training Center
- National Cancer Institute (R01CA148814, P30CA014599)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32-DK-087703, P60DK020595, 1 T32 DK087703)
- National Institute of Environmental Health Sciences (P50ES012382)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- chronic social isolation, mammary adipose tissue, breast cancer, triple-negative breast cancer, metabolic gene expression, adipocytes, stress response, carcinoma in situ, mammary tumor growth, glucose metabolism, lipogenesis, leptin secretion, mammary epithelial cell proliferation, visceral adipose tissue, tumor microenvironment, biomarkers
- MeSH terms
- Adipose Tissue, Animals, Antigens, Polyomavirus Transforming, Caloric Tests, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Female, Food, Glucose, Mammary Neoplasms, Experimental, Mice, Transgenic, RNA, Messenger, Social Isolation, Biomarkers, Apoptosis, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Leptin, Gene Expression Profiling, Cell Proliferation, Lipogenesis, Mice, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
