Cited by 496Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsCancer, Lipids, and Metabolism

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

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Vona-Davis, Linda, Rose, David P·2007·Endocrine-Related Cancer

Abstract

Adipokines (leptin, adiponectin, and hepatocyte growth factor (HGF)) secreted from adipose tissue have come to be recognized for their contribution to the mechanisms by which obesity and related metabolic disorders influence breast cancer risk. In this review, we discuss the direct and indirect effects of these protein factors on the biological and clinical aspects of breast cancer biology, and emphasize their distinctive modes of action through endocrine-, paracrine-, and autocrine-mediated pathways. The stimulatory effects of leptin on breast cancer growth were considered to occur primarily via activation of the estrogen receptor; however, new evidence suggests that leptin may be acting on downstream cell signaling pathways in both estrogen-dependent and -independent cell types. Another secretory adipokine, HGF, may act largely not only to promote tumor cell invasion, but also to enhance tumor growth indirectly by stimulating angiogenesis. In contrast, adiponectin, an endogenous insulin sensitizer, exerts a direct growth-inhibitory effect on tumor cells by downregulating cell proliferation and upregulating apoptosis, and also inhibits tumor-related angiogenesis.

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Crossref · 10.1677/erc-06-0068

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  • Some studies have suggested anti-angiogenic properties for adiponectin, but these studies rely on recombinant preparations of the protein, and the quality of these preparations varies widely.

    “Some studies have suggested anti-angiogenic properties for adiponectin (72), but these studies rely on recombinant preparations of the protein, and the quality of these preparations varies widely.”

    From Adipose tissue remodeling and obesity (2011) · cites this paper as [72]

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Research works printed but not linked: 3

  1. Blundell JE, Goodson S & Halford JC 2001 Regulation of appetite: role of leptin in signaling systems for drive and satiety. International Journal of Obesity and Related Metabolic Disorders 25 S29-S34.
  2. Hausman GJ & Richardson RL 2004 Adipose tissue angiogenesis. Journal of Animal Science 82 925-934.
  3. Purohit A, Singh A, Ghilchik MW, Serlupi-Crescenzi O & Reed MJ 2003 Inhibition of IL-6CIL-6 soluble receptor- stimulated aromatase activity by the IL-6 antagonist, Sant 7, in breast tissue-derived fibroblasts. British Journal of Cancer 88 630-635.

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Authors
Vona-Davis, L., & Rose, D. P.
Affiliations
West Virginia University (US)
Venue
Endocrine-Related Cancer
Published
2007-06-01
Volume
14
Issue
2
Pages
189-206
ISSN
  • 1351-0088 (ISSN-L)
  • 1479-6821
OpenAlex
W2129731670
Cited by
496
References
145
Citations by year
2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 14 · 2020: 22 · 2019: 22 · 2018: 27 · 2017: 54 · 2016: 29 · 2015: 42 · 2014: 28 · 2013: 53 · 2012: 36
FWCI
3.76
Type
journal article
Language
en
Open access
Locations
  • Endocrine Related Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
adipokines, breast cancer, leptin, adiponectin, hepatocyte growth factor, obesity, hormone signaling, paracrine signaling, autocrine signaling, estrogen receptor, tumor angiogenesis, tumor invasion, apoptosis, cell proliferation, insulin sensitivity
MeSH terms
Breast Neoplasms, Female, Humans, Risk, Hepatocyte Growth Factor, Disease Progression, Autocrine Communication, Paracrine Communication, Leptin, Adiponectin

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