Cited by 488Autophagy in Disease and TherapyPancreatic and Hepatic Oncology ResearchCalcium signaling and nucleotide metabolism

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

Open access

Yang, Annan, Rajeshkumar, N.V., Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M., Chu, Gerald C., Von Hoff, Daniel D., Maitra, Anirban, Kimmelman, Alec C.·2014·Cancer Discovery

DOI 10.1158/2159-8290.cd-14-0362PMC PMC4125497

Published version of a preprint

Open this paper in CoChat — free account

Abstract

Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously shown that these tumors have elevated autophagy and that inhibition of autophagy leads to decreased tumor growth. Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and the stochastic LOH of Trp53, we demonstrate that although genetic ablation of autophagy in the pancreas leads to increased tumor initiation, these premalignant lesions are impaired in their ability to progress to invasive cancer, leading to prolonged survival. In addition, mouse pancreatic cancer cell lines with differing p53 status are all sensitive to pharmacologic and genetic inhibition of autophagy. Finally, a mouse preclinical trial using cohorts of genetically characterized patient-derived xenografts treated with hydroxychloroquine showed responses across the collection of tumors. Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibition of autophagy may have clinical utility in the treatment of these cancers, independent of p53 status. Significance: Recently, a mouse model with embryonic homozygous Trp53 deletion showed paradoxical effects of autophagy inhibition. We used a mouse model with Trp53 LOH (similar to human tumors), tumor cell lines, and patient-derived xenografts to show that p53 status does not affect response to autophagy inhibition. These findings have important implications on ongoing clinical trials. Cancer Discov; 4(8); 905–13. ©2014 AACR. See related commentary by Amaravadi and Debnath, p. 873 This article is highlighted in the In This Issue feature, p. 855

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/2159-8290.cd-14-0362

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citation
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Mutations in the p53 gene occur in diverse human tumour types
Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citation
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 401–488 of 488

Autophagy-Driven Cancer Drug Development
Belaïd, A., Roméo, B., Filippakis, H., Meyer, M., Grosjean, I., Yazbeck, N., Domdom, M. A., Crépeaux, G., Gherardi, R. K., Lagadic‐Gossmann, D., et al. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00021-3 · Cited by 4
Autophagic Degradation of Misfolded Nuclear Receptor Co-repressor (NCoR) Is Linked to the Growth of Tumor Cells in HBX Positive Hepatocellular Carcinoma (HCC)
Tan, S. Y., Visvanathan, S., Hassan, R. A., & Khan, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01335 · Cited by 4
Tissue distribution and tumor concentrations of hydroxychloroquine and quinacrine analogs in micePreprint
Solitro, A. R., & MacKeigan, J. P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/496018 · Cited by 4
The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survivalPreprint
Brun, S. N., Sancar, G., Lumibao, J. C., Limpert, A. S., Ren, H., Ianniciello, A., Tiriac, H., Downes, M., Engle, D. D., Evans, R. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.15.444304 · Cited by 5
Mechanisms of drug resistance in nutrient-depleted colorectal cancer cells: insights into lysosomal and mitochondrial drug sequestration
Köse, S. G., & Taşkıran, A. E. G. (2024) · Biology Open · doi:10.1242/bio.060448 · Cited by 3
2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS ‐enhanced PI3K /Akt/ mTOR pathway on autophagy in breast cancer
Chen, L., Chen, M., Xie, Y., Zhang, Y., Mo, S., He, Y., Liang, T., Liao, Y., Huang, R., Huang, G., et al. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13940 · Cited by 3
CDK11 Mediates Autophagy to Promote Breast Cancer Cell Proliferation and Migration by Regulating BCL‐2
Zhou, Y., Zhu, L., Yang, K., Yang, J., Wang, D., Zhang, W., Zhang, J., Zhang, A., & Duan, Z. (2025) · The FASEB Journal · doi:10.1096/fsb2.70997 · Cited by 3
Inflammasomes and autophagy in cancer: unlocking targeted therapies
Gupta, J., Mohammed, M. H., Alghazali, T. A. H., Uthirapathy, S., Roopashree, R., Thakur, V., Kaur, M., Naidu, K. S., Kubaev, A., & AL-Mukhtar, M. M. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04184-x · Cited by 5
Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth
Sinha, S., Panda, A. K., das Neves, R. X., Nwosu, Z. C., Xu, K., van Beek, E., Desai, P. P., Sindiri, S., Chempati, S., Remmert, K., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1055 · Cited by 3
Sustained Partial Response to Inhibition of the Mitogen-Activated Protein Kinase and Autophagy Pathways in Combination With Immune Checkpoint Blockade inKRAS-Mutated Adenocarcinoma of the Small Bowel
Raufi, A. G., Wong, W., Chen, K., Iuga, A. C., Ahmed, F. S., & Manji, G. A. (2020) · JCO Precision Oncology · doi:10.1200/po.20.00134 · Cited by 4
Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53
Mainz, L., Sarhan, M. A. F. E., Roth, S., Sauer, U., Maurus, K., Hartmann, E., Seibert, H.-D., Rosenwald, A., Diefenbacher, M. E., & Rosenfeldt, M. T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.785252 · Cited by 3
The Role of Autophagy in Childhood Central Nervous System Tumors
Wang, Y., Xu, Y., & Zhu, C. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01015-6 · Cited by 3
Increased expression of autophagy‐related gene 5 indicates poor prognosis in patients with hepatocellular carcinoma
Guo, H., Yu, X. N., Zhang, G. C., Yin, J., Dong, L., Liu, T. T., Qian, Z. P., Zhu, J. M., & Shen, X. (2023) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13220 · Cited by 3
Regulation of the DNA Damage Response by Autophagy
Eapen, V. V., Waterman, D. P., Lemos, B. R., & Haber, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805420-8.00010-x · Cited by 3
Metabolism in Pancreatic Cancer
Poursaitidis, I., & Lamb, R. F. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_68 · Cited by 3
A lysosomal lipid transport pathway that enables cell survival under choline limitationPreprint
Scharenberg, S. G., Dong, W., Nyame, K., Levin‐Konigsberg, R., Krishnan, A. R., Rawat, E. S., Spees, K. K., Bassik, M. C., & Abu-Remaileh, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.27.517422 · Cited by 3
Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor ResistancePreprint
Drizyte‐Miller, K., Degan, S. E., Mouery, R. D., Amparo, A. M., Mouery, B. L., Chang, W.-H., Yang, R. Y., Peña, S. R. N., Baldelli, E., Klomp, J. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.01.691471 · Cited by 3
Autophagy Inhibition Reprograms the Tumor Microenvironment of Pancreatic Cancer to Promote Macrophage Phagocytosis of Tumor Cells
Lin, E. Y., Mukhopadhyay, S., Corcoran, D., Assi, M., Encarnación-Rosado, J., Sohn, A. S. W., Biancur, D. E., Yu, P. Y., Deng, J., Chen, T., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-2451 · Cited by 2
Self-citation
Carbon‐ion irradiation together with autophagy inhibition and immune checkpoint inhibitors protect against pancreatic cancer development in mouse model
Sudo, M., Wang, Y., Wang, J., Yasuda, K., Mitani, K., Hayashi, S., Ohmuraya, M., Tsutsui, H., & Fujimoto, J. (2025) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.12148 · Cited by 2
Targeting Metabolic Vulnerabilities in RAS-Mutant Cells
Rao, A. D., & McArthur, G. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803505-4.00011-4 · Cited by 2
Overview of Autophagy
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805420-8.00001-9 · Cited by 3
HMG Box-containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression
Lee, S.-W., Ekstrom, T. J., Manalo, E. C., Ye, S., Berry, M., Grygoryev, D., Szczepaniak, M., Lee, J., Marmolejo, C. A. O., Haverlack, S., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101536 · Cited by 1
Enhancement of 3-MA in Paclitaxel Treatment of MDA-MB-231 Tumor-Bearing Nude Mice and Its Mechanisms
Wang, J., Xiong, Z., Liu, Y., Jamal, M. A., Wang, X., Yang, C. Q., Gu, Z., Chen, X., Xiong, J., Qing, Y., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136191 · Cited by 1
Self-citation
Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities
Ballarò, R., Penna, F., & Beltrà, M. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.08.008 · Cited by 1
Unraveling the interplay of glycolysis, lactylation, and autophagy
Cordani, M., Michetti, F., Strippoli, R., Rumio, C., Velasco, G., & Marcucci, F. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.08.007 · Cited by 1
The role of autophagy in chronic pain
Zhu, F.-Q., Zhang, W., & Guan, B.-Z. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578757 · Cited by 1
Molecular dynamics of autophagy in cancer metabolism
Pandey, R., Kanwar, J. R., Kumar, D., Gupta, V. K., & Kumar, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00005-5 · Cited by 1
Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy
Xing, Z., Jiang, X., Wu, Y., & Yu, Z. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096273730231206054104 · Cited by 1
Isobavachin induces autophagy-mediated cytotoxicity in AML12 cells via AMPK and PI3K/Akt/mTOR pathways
Xia, N., Chen, Q.-H., Meng, Z.-J., Ma, S.-Y., Huang, J.-L., Shen, R., Dong, Y.-T., Du, H.-W., & Zhou, K. (2024) · Toxicology in Vitro · doi:10.1016/j.tiv.2024.105919 · Cited by 1
[The regulatory role of autophagy in tumor process].
Liu, H., & Shao, R. (2016) · PubMed · Cited by 1
A Topical Report on the Design Principles of Metabolism
Halbrook, C. J., Lee, H., Cantley, L. C., & Lyssiotis, C. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-61401-4_2 · Cited by 1
Autophagy and Cancer: Current Biology and Drug Development
Theiss, A. L. (2021) · Physiology in health and disease · doi:10.1007/978-3-030-67951-4_12 · Cited by 1
Autophagy in cancer: friend or foe?
Vega-Rubín-de-Celis, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00009-7 · Cited by 1
Overview of Autophagy
Hayat, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805421-5.00001-x · Cited by 1
Autophagy as a Survival Mechanism for Tumor Cells Exposed to Chemotherapy or Hypoxia, and its Inhibition by Pantoprazole to Improve Outcome of Treatment
Tan, Q. (2015) · TSpace (University of Toronto) · Cited by 1
Dosage of Atg5 Gene Affects Pancreatic Tumorigenesis and Progression
Han, H. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.11.038 · Cited by 1
Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression
Karantanou, C. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.65950 · Cited by 1
Minimized combinatorial CRISPR screens identify genetic interactions in autophagy
Diehl, V. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.67332 · Cited by 1
Inhibition in Cancer Therapy Mouse Models Address Key Concerns Regarding Autophagy
Amaravadi, R. K., & Debnath, J. (2014)
IN THE SPOTLIGHT Targeting Autophagy in BRAF -Mutant Tumors
Thorburn, A. M., & Morgan, M. J. (2015)
Physiological Role of Autophagy and Implications in Disease
Karanasios, E., & Ktistakis, N. T. (2016) · Springer eBooks · doi:10.1007/978-3-319-33145-4_5
Autophagy as a Therapeutic Target in Cancer
Samson, J. M., & Thorburn, A. M. (2016) · Current cancer research · doi:10.1007/978-3-319-42740-9_1
Metabolism in Pancreatic Cancer
Poursaitidis, I., & Lamb, R. F. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_68-1
Role of Autophagy Inhibition in Tumor Proliferative Arrest
Guo, J. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00011-1
Autophagy in the pancreatic islets after the administration of cladribine in accordance to two different modes of therapy
Jasiński, L., Lis-Sochocka, M., Chylińska‐Wrzos, P., Wawryk‐Gawda, E., & Jodłowska‐Jędrych, B. (2017) · Current Issues in Pharmacy and Medical Sciences · doi:10.1515/cipms-2017-0020
Role of Autophagy in Cancer Cell Metabolism
Pedroza, D. A., Chandel, V., Kumar, D., Doddapattar, P., Biradar, M. S., Lakshmanaswamy, R., Gadad, S. S., & Choudhari, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_6
Urokinase-type plasminogen activator receptor contributes to chemosensitivity and epithelial-to-mesenchymal transition in PDAC
Peng, L. (2020) · doi:10.53846/goediss-8274
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity
Siddiqui, F. A., Vukić, V., Salminen, T. A., & Abankwa, D. (2021) · Biomolecules · doi:10.3390/biom11060836 · Cited by 16
Prognostic value and immunological characteristics of a novel autophagy-related signature in pancreatic cancer
Jiang, P., Bao, T., Zhi, J., & Bu, S. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00189-9
Defining Roles of Metabolic Reprogramming in Pancreatic Tumorigenesis and Tumor Maintenance
Nelson, B. S. (2020) · Deep Blue (University of Michigan)
Prognostic Implications of an Autophagy-related Gene Signature in Pancreatic Ductal Adenocarcinoma
Liu, W.-S., Feng, Y.-X., Li, S.-N., Shao, Y.-J., & Wang, K. (2022) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000890
[Prognosis prediction model for hepatocellular carcinoma based on autophagy related genes].
Huang, W., Han, N., Du, L., Cao, D., & Tang, H. (2022) · PubMed Central · doi:10.7507/1001-5515.202101090
Faculty Opinions recommendation of Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Raghavan, M., & Kaur, A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737795659.793574735
Meta-analysis of gemcitabine plus nab-paclitaxel combined with targeted agents in the treatment of metastatic pancreatic cancer
Li, Z., Ma, Y.-J., Jia, Z.-H., Weng, Y.-Y., Zhang, P., Zhu, S.-J., & Wang, F. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i27.9703
A Time and Place for Inhibiting Autophagy
Gan, B. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-3024
The Role of Autophagy Regulation as a Novel Approach for Cancer Immunotherapy
Moradian, N., & Rezaei, N. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_197-1
Unraveling the Interplay of Autophagy Genes and KLF3/KLF8 in Colorectal Cancer Metastasis: A Bioinformatics and cellular Exploration
Mahgoub, E., Taneera, J., Ahmed, S. B., Hafezi, S., Venkatachalam, T., Hachim, M. Y., Sulaiman, N. D., Hamoudi, R., & Saber-Ayad, M. M. (2024) · F1000Research · doi:10.12688/f1000research.150115.1
Identificación de biomarcadores de resistencia a taxanos en cáncer de cabeza y cuello. Estudio de alternativas terapéuticas
Gestoso-Uzal, N. (2024) · Gredos (University of Salamanca) · doi:10.14201/gredos.159292
Leveraging autophagy and pyrimidine metabolism to target pancreatic cancerPreprint
Dufresne, S., Kuna, R. S., Wong, K., Komarla, A., Parham, L. R., Shen, C., Mondal, P., Estrada-Cardenas, A., Rock, A. E., Encarnación-Rosado, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656904
Autophagy and Mitophagy in Cancer Metabolic Remodeling
Husain, A., Khanam, A., Agarwal, N., Sharma, D., Farhan, M., & Aatif, M. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-3836-0.ch002
The Role of Autophagy Regulation as a Novel Approach for Cancer Immunotherapy
Moradian, N., & Rezaei, N. (2025) · Springer eBooks · doi:10.1007/978-3-032-00767-4_197
Attack cancer: Through autophagic modulations as suppressor or promoter
Gupta, P., Parveen, S., Kumar, S., Ahtsham, A., & Banerjee, M. (2025) · World Journal of Clinical Oncology · doi:10.5306/wjco.v16.i11.112313
Additional file 1 of Six immune-related promising biomarkers may promote hepatocellular carcinoma prognosis: a bioinformatics analysis and experimental validation
Lin, X.-H., Li, D.-P., Liu, Z.-Y., Zhang, S., Tang, W.-Q., Chen, R.-X., 翁书强, Tseng, Y.-J., 薛如意, & Dong, L. (2023) · Figshare · doi:10.6084/m9.figshare.22625648
Additional file 1 of ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Hu, W.-H., Liu, T.-T., Liu, P.-F., Morgan, P. M., Lin, I.-L., Tsai, W.-L., Cheng, Y.-Y., Hsieh, A.-T., Hu, T.-H., & Shu, C.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26581394
Additional file 2 of ATG4B and pS383/392-ATG4B serve as potential biomarkers and therapeutic targets of colorectal cancer
Hu, W.-H., Liu, T.-T., Liu, P.-F., Morgan, P. M., Lin, I.-L., Tsai, W.-L., Cheng, Y.-Y., Hsieh, A.-T., Hu, T.-H., & Shu, C.-W. (2024) · Figshare · doi:10.6084/m9.figshare.26581397
Additional file 1 of Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy
Saliakoura, M., Sebastiano, M. R., Nikdima, I., Pozzato, C., & Konstantinidou, G. (2022) · Figshare · doi:10.6084/m9.figshare.18093059
Advancement in preclinical development of cancer treatment agents through modulation of Rac1: From EHop-016 to natural products
Liu, Y., Wong, S.-N., Lü, A., & Ko, J. K.-S. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189522
Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics
Pietrocola, F. (2015) · theses.fr (ABES) · doi:10.70675/42d6808dzc206z4e0fzb806z29f806b2f781 · Cited by 1
Rôle et régulation du VEGF-C dans les cancers du rein à cellules claires
Ndiaye, P. D. (2017) · theses.fr (ABES) · doi:10.70675/fa7c4865z5a22z4ef6z828cz73fb034ba31d
Place des signalisations autophagique et neurotrophiques dans le Gliobastome Multiforme : implications pour les cellules souches cancéreuses
Hombourger, S. (2017) · theses.fr (ABES) · doi:10.70675/7fbf4b4ez9839z41a9z951bz369619c0d184
Rôles de l’autophagie dans l'homéostasie des cellules souches intestinales
Trentesaux, C. (2018) · theses.fr (ABES) · doi:10.70675/6bad110bz19b1z4cd6z81d0z74d0fb1e27f3
Control of antitumor immunity by the SQSTM1 dependent signaling
Yazbeck, N. (2018) · doi:10.70675/3eee578bzb29fz4a95z8a1az99fa6d5edb80
Targeting mitochondrial metabolism in pancreatic cancer
Reyes‐Castellanos, G. (2021) · theses.fr (ABES) · doi:10.70675/461953f3z886ez4342za1e2z84c44a9fcaa6
Contrôle de l'oncogenicité de Kras et isoforme beta de PI3K dans la cancérogenèse du pancréas
Arcucci, S. (2019) · theses.fr (ABES) · doi:10.70675/bd0f6cf8zac49z4e36zbe80z39b5e2b4e43a
A review of autophagy in the pancreas: normal physiology and pathophysiology
Piper, M., & Kinsey, C. G. (2026) · Autophagy Reports · doi:10.1080/27694127.2026.2665907
VCP at the crossroads of UPS and autophagy in cancer
Hitchman, C. J., Phillips, J. I., Park, H.-W., & Lu, H. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102264
ATG7 function promotes pancreatic cancer progression independently of autophagyPreprint
Larat, C., de Lomana, A. L. G., Hjaltalin, V. J., & Ogmundsdottir, M. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.729197
Vertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinomaPreprint
Roach, M. K., Degan, S. E., DeLiberty, J. M., Pita, L. M., Pieper, N. L., 杨闰英, Taylor, K. E., Schechter, E. G., Robb, R. N., Pierobon, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.28.734981
COP9 signalosome 8 mediated autophagy drives proliferation, invasion, and metastasis in pancreatic ductal adenocarcinoma
Guo, X., Cheng, H., Wang, D., Wang, Z., Hu, Q., & Zhang, Y. P. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154197
Autophagy in oral cancer: New pathways-new roles
Huertas‐Lárez, R., Navarro‐Lérida, I., & Ribas, C. (2026) · International review of cytology · doi:10.1016/bs.ircmb.2026.07.001
Harnessing autophagy and its transcriptional regulation in tumorigenesis and neurodegeneration: Potential and existing therapeutic strategies
Suri, P., Daartey, A. B., Khan, D. M. I. O., Rayana, N. P., Chilamakuri, R., Godugu, D., Azad, M. G., Reeb, K. L., & Richardson, D. R. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100158
Comparative protein engineering redirects the specificity of Clostridium botulinum proteases
Garrido, J. E., Salcedo, G. S., Strul, M. W., Ashby, S. N., Pamidi, A. S., Cho, J., Waldvogel, K. G., Wiriadinata, E. L., Nedic, T., Kaewtatip, N., et al. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.08.003
The miR-615-5p/ID1 Axis Regulates Autophagy-Associated Migration in Pancreatic Ductal AdenocarcinomaPreprint
Sarkar, A., Ray, S., Ray, A., & Biswas, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.27.747461
Tumor microenvironment-driven therapeutic resistance in pancreatic ductal adenocarcinoma
Li, H., Cui, J., Yang, X., Li, J.-H., Zhao, Q.-C., Li, C.-J., Fu, Q., Li, J.-Y., Zhou, Y., & Zhu, S.-K. (2026) · Cancer Drug Resistance · doi:10.20517/cdr.2026.102
NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy
Zhang, Y.-X., Liu, S.-T., Li, R., Zhang, M.-Y., Yang, G., Zhu, X.-M., & Qu, Y.-Q. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71420
BindingDB Entry 50006761: Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy.
BindingDB (2021) · UC San Diego · doi:10.7270/q2rr22gw
BindingDB Entry 50018807: The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance.
BindingDB (2024) · UC San Diego · doi:10.7270/q2cf9vc6
BindingDB Entry 50001447: HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors.
BindingDB (2020) · UC San Diego · doi:10.7270/q27s7r9h

Authors: Yang, A., Rajeshkumar, N. V., Wang, X., Yabuuchi, S., Alexander, B. M., Chu, G. C., Von Hoff, D. D., Maitra, A., & Kimmelman, A. C.
Affiliations: Dana-Farber Cancer Institute (US)
Johns Hopkins University (US)
Brigham and Women's Hospital (US)
4Translational Genomics Research Institute, Phoenix, Arizona; Departments of
The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Kimmelman, Alec C.
ORCID: Yang, Annan
Wang, Xiaoxu
Alexander, Brian M.
Maitra, Anirban
Kimmelman, Alec C.
Venue: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Published: 2014-08-01
Volume: 4
Issue: 8
Pages: 905-913
ISSN: 2159-8274 (ISSN-L)
2159-8290
DOI: 10.1158/2159-8290.cd-14-0362
PMC: PMC4125497
OpenAlex: W2148330792
Cited by: 486
References: 33
Citations by year: 2026: 16 · 2025: 32 · 2024: 28 · 2023: 34 · 2022: 47 · 2021: 61 · 2020: 44 · 2019: 43 · 2018: 41 · 2017: 45 · 2016: 37 · 2015: 43 · 2014: 15
FWCI: 35.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Discovery (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P50CA127003, R01CA157490, P30CA016672)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, pancreatic ductal adenocarcinoma, p53 status, autophagy inhibition, hydroxychloroquine, KRAS-driven tumors, premalignant pancreatic lesions, tumor progression, patient-derived xenografts
MeSH terms: Animals, Autophagy, Cell Transformation, Neoplastic, Disease Models, Animal, Humans, Pancreatic Neoplasms, Tumor Suppressor Protein p53, Loss of Heterozygosity, Xenograft Model Antitumor Assays, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks