Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

R: A Language and Environment for Statistical Computing

R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882

Mutations in the p53 gene occur in diverse human tumour types

Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism

Zhang, M., Qiu, Q., Li, Z., Sachdeva, M., Min, H. D., Cardona, D. M., DeLaney, T. F., Han, T. X., Ma, Y., Luo, L., et al. (2015) · Radiation Research · doi:10.1667/rr14016.1 · Cited by 48

Targeting KRAS in Pancreatic Ductal Adenocarcinoma: The Long Road to Cure

de Jesus, V. H. F., Mathias-Machado, M. C., de Farias, J. P. F., Aruquipa, M. P. S., Jacome, A. A. D. A., & Peixoto, R. D. (2023) · Cancers · doi:10.3390/cancers15205015 · Cited by 51

Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer

Koustas, E., Sarantis, P., Theoharis, S., Saetta, A. A., Chatziandreou, I., Kyriakopoulou, G., Giannopoulou, I., Michelli, M., Schizas, D., Papavassiliou, A. G., et al. (2019) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000592 · Cited by 44

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

Cotzomi-Ortega, I., Aguilar‐Alonso, P., Reyes‐Leyva, J., & Maycotte, P. (2018) · Mediators of Inflammation · doi:10.1155/2018/4231591 · Cited by 47

The pleiotropic functions of autophagy in metastasis

Marsh, T., Tolani, B., & Debnath, J. (2021) · Journal of Cell Science · doi:10.1242/jcs.247056 · Cited by 49

Molecular Mechanism of Autophagy and Its Regulation by Cannabinoids in Cancer

Lee, X. C., Werner, E., & Falasca, M. (2021) · Cancers · doi:10.3390/cancers13061211 · Cited by 48

Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies

Rozengurt, E., & Eibl, G. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02499-y · Cited by 49

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

Wang, Z., Du, T., Dong, X., LI, Z., Wu, G., & Zhang, R. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3468 · Cited by 46

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

He, S., Li, Q., Jiang, X., Lü, X., Feng, F., Qu, W., Chen, Y., & Sun, H. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01019 · Cited by 45

An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

Scharenberg, S. G., Dong, W., Ghoochani, A., Nyame, K., Levin‐Konigsberg, R., Krishnan, A. R., Rawat, E. S., Spees, K. K., Bassik, M. C., & Abu-Remaileh, M. (2023) · Science Advances · doi:10.1126/sciadv.adf8966 · Cited by 43

Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m 6 A/ATG5 axis

Wang, C., Meng, Y., Zhao, J., Ma, J., Zhao, Y., Gao, R., Liu, W., & Zhou, X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82081 · Cited by 43

Matrine suppresses KRAS ‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism

Cho, Y.-R., Lee, J. H., Kim, J. H., Lee, S., Yoo, S., Jung, M., Kim, S. J., Yoo, H. J., Pack, C.-G., Rho, J. K., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12324 · Cited by 42

The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside

Görgülü, K., Diakopoulos, K. N., Kaya-Aksoy, E., Ciecielski, K. J., Ai, J., Lesina, M., & Algül, H. (2020) · Cells · doi:10.3390/cells9041063 · Cited by 43

Discovery of Autophagy Inhibitors with Antiproliferative Activity in Lung and Pancreatic Cancer Cells

Nordstrøm, L. U., Sironi, J., Aranda, E., Maisonet, J., Perez-Soler, R., Wu, P., & Schwartz, E. L. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500348p · Cited by 43

A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy

Bian, Y., Zeng, H., Tao, H., Huang, L., Du, Z., Wang, J., & Ding, K. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.054 · Cited by 42

Green nanoparticles as multifunctional nanomedicines: Insights into anti-inflammatory effects, growth signaling and apoptosis mechanism in cancer

Naseer, F., Ahmed, M., Majid, A., Kamal, W., & Phull, A. R. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.014 · Cited by 42

The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes KrasG12D-mediated pancreatic cancer initiation

Loncle, C., Molejon, M. I., Lac, S., Tellechea, J. I., Lomberk, G. A., Gramática, L., Zapico, M. F., Dusetti, N., Urrutia, R. A., & Iovanna, J. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.202 · Cited by 41

MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma

New, M. I., Acker, T. V., Sakamaki, J.-I., Jiang, M., Saunders, R. E., Long, J. S., Wang, V. M.-Y., Behrens, A., Cerveira, J., Sudhakar, P., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2553 · Cited by 41

Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma

Liang, C., Qin, Y., Zhang, B., Ji, S., Shi, S., Xu, W., Liu, J., Xiang, J., Liang, D., Hu, Q., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.09.001 · Cited by 39

Autophagy and cancer – insights from mouse models

Mainz, L., & Rosenfeldt, M. T. (2017) · FEBS Journal · doi:10.1111/febs.14274 · Cited by 39

The biological role of metabolic reprogramming in pancreatic cancer

Suzuki, T., Otsuka, M., Seimiya, T., Iwata, T., Kishikawa, T., & Koike, K. (2020) · MedComm · doi:10.1002/mco2.37 · Cited by 38

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Newman, A. C., Kemp, A. J., Drabsch, Y., Behrends, C., & Wilkinson, S. (2017) · Nature Communications · doi:10.1038/s41467-017-00859-z · Cited by 38

In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors

Wood, S. D., Grant, W. M., Adrados, I., Choi, J. Y., Alburger, J. M., Duckett, D. R., & Roush, W. R. (2017) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.7b00344 · Cited by 38

Exploiting Nanomaterial‐Mediated Autophagy for Cancer Therapy

Wei, W., Rosenkrans, Z. T., Luo, Q., Lan, X., & Cai, W. (2018) · Small Methods · doi:10.1002/smtd.201800365 · Cited by 41

Monitoring autophagy in cancer: From bench to bedside

Long, M., & McWilliams, T. G. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.016 · Cited by 30

Autophagy Roles in Genome Maintenance

Ambrosio, S., & Majello, B. (2020) · Cancers · doi:10.3390/cancers12071793 · Cited by 38

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target

Gillson, J., El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., Pavlakis, N., Samra, J. S., Mittal, A., & Sahni, S. (2022) · Cancers · doi:10.3390/cancers14143528 · Cited by 38

Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

Han, X., Zhu, Y., Ke, J., Zhai, Y., Huang, M., Zhang, X., He, H., Zhang, X., Zhao, X., Guo, K., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02092-2 · Cited by 40

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

Yang, C., Zhang, J., Peng, Y., Zhu, Y., Yin, L., Wei, J., Gao, W., Jiang, K., & Miao, Y. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1308-3 · Cited by 38

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma

Schofield, H. K., Zeller, J., Espinoza, C. E., Halbrook, C. J., Vecchio, A. D., Magnuson, B., Fabo, T., Daylan, A. E. C., Kovalenko, I., Lee, H., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97422 · Cited by 38

The Interplay of HIV and Autophagy in Early Infection

Cabrera-Rodríguez, R., Pérez-Yanes, S., Estévez‐Herrera, J., Márquez-Arce, D., Cabrera, C., Espert, L., Blanco, J., & Valenzuela-Fernández, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.661446 · Cited by 37

Autophagy Contributes to Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Tumors

Reyes‐Castellanos, G., Hadi, N. A., & Carrier, A. (2022) · Cells · doi:10.3390/cells11030426 · Cited by 41

Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells

Carvajal, L., Gutiérrez, J., Morselli, E., & Leiva, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.637594 · Cited by 39

The role of autophagy in pancreatic cancer progression

Wang, Y., Qin, C., Yang, G., Zhao, B., & Wang, W. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188592 · Cited by 35

The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance

Ye, W., Fan, C., Fu, K., Wang, X., Lin, J., Nian, S., Liu, C., & Zhou, W. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114846 · Cited by 37

When S -Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases

Montagna, C., Cirotti, C., Rizza, S., & Filomeni, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7872 · Cited by 35

The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy

Mahgoub, E., Taneera, J., Sulaiman, N. D., & Saber-Ayad, M. M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.959348 · Cited by 33

Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics

Jee, S.-C., & Cheong, H. (2023) · Cancers · doi:10.3390/cancers15041112 · Cited by 34

The Role of Autophagy in Pancreatic Cancer—Recent Advances

New, M. I., & Tooze, S. A. (2019) · Biology · doi:10.3390/biology9010007 · Cited by 34

Autophagy Inhibition in BRAF-Driven Cancers

Foth, M., & McMahon, M. (2021) · Cancers · doi:10.3390/cancers13143498 · Cited by 33

Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress

Kong, J., Whelan, K. A., Laczko, D. I., Dang, B., Monroig, A. C., Soroush, A., Falcone, J., Amaravadi, R. K., Rustgi, A. K., Ginsberg, G. G., et al. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22406 · Cited by 33

Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors

Komarla, A., Dufresne, S., & Towers, C. G. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad001 · Cited by 35

The dual role of autophagy in cancer stem cells: implications for tumor progression and therapy resistance

Jia, H., Wei, J., Zheng, W., & Li, Z. Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06595-z · Cited by 33

Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive

Rojas-Sánchez, G., Cotzomi-Ortega, I., Pazos-Salazar, N. G., Reyes‐Leyva, J., & Maycotte, P. (2019) · Biology · doi:10.3390/biology8040071 · Cited by 32

Beclin 1 Promotes Endosome Recruitment of Hepatocyte Growth Factor Tyrosine Kinase Substrate to Suppress Tumor Proliferation

Matthew-Onabanjo, A. N., Janusis, J., Mercado-Matos, J., Carlisle, A. E., Kim, D., Levine, F. A., Cruz‐Gordillo, P., Richards, R., Lee, M. J., & Shaw, L. M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1555 · Cited by 34

Unraveling the Intricacies of Autophagy and Mitophagy: Implications in Cancer Biology

Lee, S., Son, J.-Y., Lee, J., & Cheong, H. (2023) · Cells · doi:10.3390/cells12232742 · Cited by 31

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Bettoun, A., Joffre, C., Zago, G., Surdez, D., Vallerand, D., Gündoğdu, R., Sharif, A. A. D., Gómez-Ferrer, M., Cascone, I., Meunier, B., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9875 · Cited by 31

Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression

Tsang, Y. H., Wang, Y., Kong, K., Grzeskowiak, C. L., Zagorodna, O., Dogruluk, T., Lu, H., Villafañe, N., Bhavana, V. H., Moreno, D., et al. (2020) · eLife · doi:10.7554/elife.48963 · Cited by 31

Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!

Letai, A. G. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1204 · Cited by 31

Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms

Marchand, B., Poulin, M.-A., Lawson, C., Tai, L., Jean, S., & Boucher, M. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01342-z · Cited by 32

Emerging Trends in Gastrointestinal Cancer Targeted Therapies: Harnessing Tumor Microenvironment, Immune Factors, and Metabolomics Insights

Rauth, S., Malafa, M. P., Ponnusamy, M. P., & Batra, S. K. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.005 · Cited by 29

miR-30a-5p suppresses lung squamous cell carcinoma via ATG5 - mediated autophagy

Yang, J., Rao, S., Cao, R., Xiao, S., Cui, X., & Ye, L. (2021) · Aging · doi:10.18632/aging.203235 · Cited by 29

Targeting autophagy as a therapeutic strategy against pancreatic cancer

Yamamoto, K., Iwadate, D., Kato, H., Nakai, Y., Tateishi, K., & Fujishiro, M. (2022) · Journal of Gastroenterology · doi:10.1007/s00535-022-01889-1 · Cited by 29

Blocking autophagy to starve pancreatic cancer

Bryant, K. L., & Der, C. J. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0120-8 · Cited by 32

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

Zhang, X., Kumstel, S., Jiang, K., Meng, S., Gong, P., Vollmar, B., & Zechner, D. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.04.006 · Cited by 29

The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer

Curcio, C., Brugiapaglia, S., Bulfamante, S., Follia, L., Cappello, P., & Novelli, F. (2021) · Molecules · doi:10.3390/molecules26061642 · Cited by 28

The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy

Lei, Y., Chen, L., Liu, J., Zhong, Y., & Deng, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841625 · Cited by 28

ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis

Long, J. S., Kania, E., McEwan, D. G., Barthet, V. J. A., Brucoli, M., Ladds, M. J. G. W., Nössing, C., & Ryan, K. M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113465119 · Cited by 28

Investigating the role of transcription factors of pancreas development in pancreatic cancer

Naqvi, A. A. T., Hasan, G. M., & Hassan, M. I. (2017) · Pancreatology · doi:10.1016/j.pan.2017.12.013 · Cited by 28

Anti-tumor immunity influences cancer cell reliance upon ATG7

Arensman, M. D., Yang, X. S., Zhong, W., Bisulco, S., Upeslacis, E., Rosfjord, E. C., Deng, S., Abraham, R. T., & Eng, C. H. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1800162 · Cited by 27

Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma

Rebelo, R., Polónia, B. R. G., Santos, L. L., Vasconcelos, M. H., & Xavier, C. P. R. (2021) · Pharmaceuticals · doi:10.3390/ph14030280 · Cited by 30

Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells

Suzuki, T., Kishikawa, T., Sato, T., Takeda, N., Sugiura, Y., Seimiya, T., Sekiba, K., Ohno, M., Iwata, T., Ishibashi, R., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00326-4 · Cited by 28

Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer

Du, Y.-X., Mamun, A. A., Lü, A., & Zhang, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087310 · Cited by 25

Autophagy therapeutics: preclinical basis and initial clinical studies

Zhan, L., Li, J., & Wei, B. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3688-3 · Cited by 25

A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS

Ropolo, A., Catrinacio, C., Renna, F. J., Boggio, V., Orquera, T., González, C. D., & Vaccaro, M. I. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00411 · Cited by 26

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

Krueger, J., Santinon, F., Kazanova, A., Issa, M. E., Larrivée, B., Kremer, R. B., Milhalcioiu, C., & Rudd, C. E. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251731 · Cited by 25

Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions

Bandi, D. S. R., Sarvesh, S., Farran, B., Nagaraju, G. P., & El‐Rayes, B. F. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.06.006 · Cited by 26

Using enhanced-mitophagy to measure autophagic flux

Baudot, A. D., Haller, M., Mrschtik, M., Tait, S. W. G., & Ryan, K. M. (2014) · Methods · doi:10.1016/j.ymeth.2014.11.014 · Cited by 24

Mouse Models Address Key Concerns Regarding Autophagy Inhibition in Cancer Therapy

Amaravadi, R. K., & Debnath, J. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0618 · Cited by 25

Inhibiting heat shock protein 90 and the ubiquitin‐proteasome pathway impairs metabolic homeostasis and leads to cell death in human pancreatic cancer cells

Belalcazar, A., Shaib, W. L., Farren, M. R., Zhang, C., Chen, Z., Yang, L. P. H., Lesinski, G. B., El‐Rayes, B. F., & Nagaraju, G. P. (2017) · Cancer · doi:10.1002/cncr.30944 · Cited by 24

Nanomaterial-assisted sensitization of oncotherapy

Wang, Y., Liu, J., Ma, X., & Liang, X. (2018) · Nano Research · doi:10.1007/s12274-017-1961-0 · Cited by 24

Mitochondrial E3 ubiquitin ligase 1 promotes autophagy flux to suppress the development of clear cell renal cell carcinomas

Yuan, Y., Li, X., Xu, Y., Zhao, H., SU, Z., Lai, D., Yang, W., Chen, S., He, Y., Li, X., et al. (2019) · Cancer Science · doi:10.1111/cas.14192 · Cited by 24

Advances in the Genetics and Biology of Pancreatic Cancer

Aguirre, A. J., & Collisson, E. A. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000286 · Cited by 23

microRNA-based autophagy inhibition as targeted therapy in pancreatic cancer

Liang, S., Li, X., Gao, C., & Zhang, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110799 · Cited by 25

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

Tan, X., He, Y., Huang, Y., Zheng, C., Li, J., Liu, Q., He, M., Li, B., & Xu, W. (2021) · MedComm · doi:10.1002/mco2.83 · Cited by 23

Novel Effects of Statins on Cancer via Autophagy

Mengual, D., Medrano, L. E., Villamizar-Villamizar, W., Osorio-Llanes, E., Mendoza‐Torres, E., & Bolívar, S. (2022) · Pharmaceuticals · doi:10.3390/ph15060648 · Cited by 26

Autophagy Induced by CX-4945, a Casein Kinase 2 Inhibitor, Enhances Apoptosis in Pancreatic Cancer Cell Lines

Hwang, D. W., So, K. S., Kim, S. C., Park, K.-M., Lee, Y. J., Kim, S., Choi, C., Rho, J. K., Choi, Y. J., & Lee, J. C. (2017) · Pancreas · doi:10.1097/mpa.0000000000000780 · Cited by 24

Indentification of breast cancer subtypes sensitive to HCQ-induced autophagy inhibition

Wang, P., Du, Y., & Wang, J. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.152609 · Cited by 23

Concurrent Inhibition of the RAS-MAPK Pathway and PIKfyve Is a Therapeutic Strategy for Pancreatic Cancer

DeLiberty, J. M., Roach, M. K., Stalnecker, C. A., Robb, R. N., Schechter, E. G., Pieper, N. L., Taylor, K. E., Pita, L. M., Yang, R. Y., Bang, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-1757 · Cited by 27

Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities

Zhang, J., Jinan, Z., & Chen, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06063-0 · Cited by 24

Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy

Santiago‐O’Farrill, J. M., Kleinerman, E. S., Hollomon, M. G., Livingston, A., Wang, W., Tsai, J.-W., & Gordon, N. B. (2017) · Oncotarget · doi:10.18632/oncotarget.20308 · Cited by 21

Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer

Halbrook, C. J., di Magliano, M. P., & Lyssiotis, C. A. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00416.2017 · Cited by 22

The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress.

Grierson, P. M., Dodhiawala, P. B., Cheng, Y., Chen, T. H.-P., Khawar, I. A., Wei, Q., Zhang, D., Li, L., Herndon, J. M., Monahan, J. B., et al. (2021) · PubMed · doi:10.1126/scitranslmed.abb5445 · Cited by 18

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., & Sahni, S. (2021) · Cancers · doi:10.3390/cancers13246152 · Cited by 22

Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy

Saliakoura, M., Sebastiano, M. R., Nikdima, I., Pozzato, C., & Konstantinidou, G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02231-y · Cited by 21

GK-1 Induces Oxidative Stress, Mitochondrial Dysfunction, Decreased Membrane Potential, and Impaired Autophagy Flux in a Mouse Model of Breast Cancer

Cruz‐Gregorio, A., Aranda‐Rivera, A. K., Aparicio‐Trejo, O. E., Medina‐Campos, O. N., Sciutto, E., Fragoso, G., & Pedraza‐Chaverrí, J. (2022) · Antioxidants · doi:10.3390/antiox12010056 · Cited by 20

Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines?

Lebovitz, C. B., DeVorkin, L., Bosc, D., Rothe, K., Singh, J., Bally, M. B., Jiang, X., Young, R. N., Lum, J. J., & Gorski, S. M. (2015) · Autophagy · doi:10.1080/15548627.2015.1078962 · Cited by 20

p53 mediates PEDF‑induced autophagy in human umbilical vein endothelial cells through sestrin2 signaling

Chen, T., Li, T., & Wang, J. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10319 · Cited by 20

The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz‐Cuesta, E., Novak, I., Stock, C. M., & Pedersen, S. F. (2020) · Cells · doi:10.3390/cells9020465 · Cited by 20

Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer

Lee, J. J., Jain, V., & Amaravadi, R. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212402 · Cited by 20

Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth

Chen, Y., Zhang, Z., Henson, E. S., Cuddihy, A. R., Haigh, K., Wang, R., Haigh, J. J., & Gibson, S. B. (2021) · Autophagy · doi:10.1080/15548627.2021.1973338 · Cited by 19

Identification and validation of an autophagy-related signature for predicting survival in lower-grade glioma

Feng, S., Liu, H., Dong, X., Du, P., Guo, H., & Pang, Q. (2021) · Bioengineered · doi:10.1080/21655979.2021.1985818 · Cited by 19

CCPG1, an unconventional cargo receptor for ER-phagy, maintains pancreatic acinar cell health

Smith, M. D., & Wilkinson, S. (2018) · Molecular & Cellular Oncology · doi:10.1080/23723556.2018.1441631 · Cited by 18

Autophagy and cancer metabolism—The two‐way interplay

Yan, R.-L., & Chen, R. (2021) · IUBMB Life · doi:10.1002/iub.2569 · Cited by 20

The Intricate Metabolism of Pancreatic Cancers

Camelo, F., & Le, A. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77736-8_5 · Cited by 19

A Risk Signature with Autophagy-Related Long Noncoding RNAs for Predicting the Prognosis of Clear Cell Renal Cell Carcinoma: Based on the TCGA Database and Bioinformatics

Xuan, Y., Chen, W., Liu, K., Gao, Y., Zuo, S., Wang, B., Ma, X., & Zhang, X. (2021) · Disease Markers · doi:10.1155/2021/8849977 · Cited by 18

Autophagy and Cancer Metastasis: A Trojan Horse

Alizadeh, J., Lorzadeh, S., & Ghavami, S. (2021) · Journal of Investigative Medicine · doi:10.1136/jim-2021-002016 · Cited by 18

Fatal toxicity of chloroquine or hydroxychloroquine with metformin in micePreprint

Rajeshkumar, N. V., Yabuuchi, S., Pai, S. G., Maitra, A., Hidalgo, M. M., & Dang, C. V. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.31.018556 · Cited by 18

Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status

Yang, A., & Kimmelman, A. C. (2014) · Autophagy · doi:10.4161/auto.29961 · Cited by 102

A suppression switch

Starobinets, H., & Debnath, J. (2013) · Nature · doi:10.1038/nature12841 · Cited by 8

p53 status determines the role of autophagy in pancreatic tumour development

Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature · doi:10.1038/nature12865 · Cited by 713

The Role of Autophagy in Pancreatic Cancer Is Determined by p53 Status

(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-001

p53 and the role of autophagy in pancreatic cancer development

Rosenfeldt, M. T. (2013) · Enlighten: Theses (The University of Glasgow)