Cited by 488Autophagy in Disease and TherapyPancreatic and Hepatic Oncology ResearchCalcium signaling and nucleotide metabolism

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

Open access

Yang, Annan, Rajeshkumar, N.V., Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M., Chu, Gerald C., Von Hoff, Daniel D., Maitra, Anirban, Kimmelman, Alec C.·2014·Cancer Discovery

DOI 10.1158/2159-8290.cd-14-0362PMC PMC4125497

Published version of a preprint

Open this paper in CoChat — free account

Abstract

Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously shown that these tumors have elevated autophagy and that inhibition of autophagy leads to decreased tumor growth. Using an autochthonous model of pancreatic cancer driven by oncogenic Kras and the stochastic LOH of Trp53, we demonstrate that although genetic ablation of autophagy in the pancreas leads to increased tumor initiation, these premalignant lesions are impaired in their ability to progress to invasive cancer, leading to prolonged survival. In addition, mouse pancreatic cancer cell lines with differing p53 status are all sensitive to pharmacologic and genetic inhibition of autophagy. Finally, a mouse preclinical trial using cohorts of genetically characterized patient-derived xenografts treated with hydroxychloroquine showed responses across the collection of tumors. Together, our data support the critical role of autophagy in pancreatic cancer and show that inhibition of autophagy may have clinical utility in the treatment of these cancers, independent of p53 status. Significance: Recently, a mouse model with embryonic homozygous Trp53 deletion showed paradoxical effects of autophagy inhibition. We used a mouse model with Trp53 LOH (similar to human tumors), tumor cell lines, and patient-derived xenografts to show that p53 status does not affect response to autophagy inhibition. These findings have important implications on ongoing clinical trials. Cancer Discov; 4(8); 905–13. ©2014 AACR. See related commentary by Amaravadi and Debnath, p. 873 This article is highlighted in the In This Issue feature, p. 855

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1158/2159-8290.cd-14-0362

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citation
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Mutations in the p53 gene occur in diverse human tumour types
Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hosteller, R., Cleary, K. R., Signer, S. H., Davidson, N. E., Baylin, S., Devilee, P., et al. (1989) · Nature · doi:10.1038/342705a0 · Cited by 2,730
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citation
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116

Show all 33 references

Sorted by citations

Items 101–200 of 488

Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression
Blessing, A. M., Rajapakshe, K., Bollu, L. R., Shi, Y., White, M. A., Pham, A. H., Lin, C., Jonsson, P., Cortés, C. J., Cheung, E. C. W., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1268300 · Cited by 120
The unfolded protein response as a target for anticancer therapeutics
Wang, M., Law, M. E., Castellano, R. K., & Law, B. K. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.05.003 · Cited by 121
Molecular Pathways: Autophagy in Cancer—A Matter of Timing and Context
Cicchini, M., Karantza, V., & Xia, B. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2438 · Cited by 118
Amino acid management in cancer
Tsun, Z.-Y., & Possemato, R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.002 · Cited by 120
Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Qiang, L., Sample, A., Shea, C. R., Soltani, K., Macleod, K. F., & He, Y. (2017) · Autophagy · doi:10.1080/15548627.2017.1380757 · Cited by 111
A perspective on the role of autophagy in cancer
Ariosa, A., Lahiri, V., Lei, Y., Yang, Y., Yin, Z., Zhang, Z., & Klionsky, D. J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166262 · Cited by 115
Autophagy promotes mammalian survival by suppressing oxidative stress and p53
Yang, Y., Karsli-Uzunbas, G., Poillet-Perez, L., Sawant, A., Hu, Z. S., Zhao, Y., Moore, D., Hu, W., & White, E. (2020) · Genes & Development · doi:10.1101/gad.335570.119 · Cited by 100
Systematic Review of Patient-Derived Xenograft Models for Preclinical Studies of Anti-Cancer Drugs in Solid Tumors
Koga, Y., & Ochiai, A. (2019) · Cells · doi:10.3390/cells8050418 · Cited by 111
State of the art and future directions of pancreatic ductal adenocarcinoma therapy
Neuzillet, C., Tijeras‐Raballand, A., Bourget, P., Cros, J. F., Couvelard, A., Sauvanet, A., Vullierme, M., Tournigand, C., & Hammel, P. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.08.006 · Cited by 114
Autophagy and Its Effects: Making Sense of Double-Edged Swords
Thorburn, A. M. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001967 · Cited by 102
Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review
Ruze, R., Song, J., Yin, X., Chen, Y., Xu, R., Wang, C., & Zhao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01376-w · Cited by 111
A Phase III Open-Label Trial to Evaluate Efficacy and Safety of CPI-613 Plus Modified FOLFIRINOX (MFFX) versus FOLFIRINOX (FFX) in Patients with Metastatic Adenocarcinoma of the Pancreas
Philip, P. A., Buyse, M. E., Alistar, A. T., Lima, C. M. S. R., Luther, S., Pardee, T. S., & Cutsem, E. V. (2019) · Future Oncology · doi:10.2217/fon-2019-0209 · Cited by 101
Till Death Do Us Part: The Marriage of Autophagy and Apoptosis
Cooper, K. F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4701275 · Cited by 104
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer
Zhou, C., Liang, Y., Zhou, L., Yan, Y., Liu, N., Zhang, R., Huang, Y., Wang, M., Tang, Y., Ali, D. W., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1826689 · Cited by 97
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
Towers, C. G., Fitzwalter, B. E., Regan, D. P., Goodspeed, A. E., Morgan, M. J., Liu, C., Gustafson, D. L., & Thorburn, A. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.07.010 · Cited by 97
RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer
Kang, R., Hou, W., Zhang, Q., Chen, R., Lee, Y. J., Bartlett, D. L., Lotze, M. T., Tang, D., & Zeh, H. J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.445 · Cited by 93
Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and Neurodegenerative Disorders
Butera, G., Mullappilly, N., Masetto, F., Palmieri, M., Scupoli, M. T., Pacchiana, R., & Donadelli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092062 · Cited by 93
Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers
Aguirre, A. J., & Hahn, W. C. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031518 · Cited by 90
Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
Rajeshkumar, N. V., Yabuuchi, S., Pai, S. G., Oliveira, E. D., Kamphorst, J. J., Rabinowitz, J. D., Tejero, H., Al‐Shahrour, F., Hidalgo, M. M., Maitra, A., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1115 · Cited by 89
Self-citation
The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment
Aquila, S., Santoro, M., Caputo, A., Panno, M. L., Pezzi, V., & Amicis, F. D. (2020) · Cells · doi:10.3390/cells9071725 · Cited by 90
Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation
Yang, S., Imamura, Y., Jenkins, R. W., Cañadas, I., Kitajima, S., Aref, A. R., Brannon, A., Oki, E., Castoreno, A. B., Zhu, Z., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0235 · Cited by 92
Self-citation
You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia
Sehgal, A. R., Koenig, H., Johnson, D. E., Tang, D., Amaravadi, R. K., Boyiadzis, M. M., & Lotze, M. T. (2014) · Leukemia · doi:10.1038/leu.2014.349 · Cited by 89
Inflammation as a driver and vulnerability of KRAS mediated oncogenesis
Kitajima, S., Thummalapalli, R., & Barbie, D. A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.009 · Cited by 83
Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity
Janji, B., Berchem, G., & Chouaı̈b, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00887 · Cited by 86
Autophagy at the intersection of aging, senescence, and cancer
Cassidy, L. D., & Narita, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13269 · Cited by 93
Autophagy in cancer
Zhi, X., & Zhong, Q. (2015) · F1000Prime Reports · doi:10.12703/p7-18 · Cited by 83
Autophagy modulation: a prudent approach in cancer treatment?
Bishop, E., & Bradshaw, T. D. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3669-6 · Cited by 87
Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice
Görgülü, K., Diakopoulos, K. N., Ai, J., Schoeps, B., Kabacaoğlu, D., Karpathaki, A., Ciecielski, K. J., Kaya-Aksoy, E., Ruess, D. A., Berninger, A., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.09.053 · Cited by 81
Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11
Mukhopadhyay, S., Biancur, D. E., Parker, S. J., Yamamoto, K., Banh, R. S., Paulo, J. A., Mancias, J. D., & Kimmelman, A. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021475118 · Cited by 83
Self-citation
Autophagy is a major metabolic regulator involved in cancer therapy resistance
Poillet-Perez, L., Sarry, J., & Joffre, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109528 · Cited by 85
The Evolving, Multifaceted Roles of Autophagy in Cancer
Liu, J., & Debnath, J. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.01.005 · Cited by 82
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Gupta, S., Yano, J., Mercier, V., Htwe, H. H., Shin, H. R., Rademaker, G., Cakir, Z., Ituarte, T., Wen, K. W., Kim, G., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00644-7 · Cited by 79
Autophagy in the cancer-immunity dialogue
Yamazaki, T., Pedro, J. M. B., Galluzzi, L., Kroemer, G., & Pietrocola, F. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.003 · Cited by 80
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy
Gubbiotti, M. A., Neill, T., Frey, H., Schaefer, L., & Iozzo, R. V. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.09.001 · Cited by 81
Mutations of p53 associated with pancreatic cancer and therapeutic implications
Voutsadakis, I. A. (2021) · Annals of Hepato-Biliary-Pancreatic Surgery · doi:10.14701/ahbps.2021.25.3.315 · Cited by 75
The post‐translational regulation of transcription factor EB (TFEB) in health and disease
Takla, M., Keshri, S., & Rubinsztein, D. C. (2023) · EMBO Reports · doi:10.15252/embr.202357574 · Cited by 77
The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism
Lee, S. B., Sellers, B. N., & DeNicola, G. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7356 · Cited by 78
Autophagy-related microRNAs: Possible regulatory roles and therapeutic potential in and gastrointestinal cancers
Pourhanifeh, M. H., Vosough, M., Mahjoubin‐Tehran, M., Hashemipour, M., Nejati, M., Abbasi‐Kolli, M., Sahebkar, A., & Mirzaei, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105133 · Cited by 76
Autophagy in cancer cell remodeling and quality control
Hernandez, G. A., & Perera, R. M. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.03.023 · Cited by 73
Impact of context-dependent autophagy states on tumor progression
Assi, M., & Kimmelman, A. C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00546-7 · Cited by 80
Self-citation
Autophagy in cancer: Recent advances and future directions
Ishaq, M., Ojha, R., Sharma, A. J., & Singh, S. K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.010 · Cited by 75
Autophagy in natural and therapy-driven anticancer immunosurveillance
Pietrocola, F., Pedro, J. M. B., Galluzzi, L., & Kroemer, G. (2017) · Autophagy · doi:10.1080/15548627.2017.1310356 · Cited by 75
In vivo photoprotective effects of cosmetic formulations containing UV filters, vitamins, Ginkgo biloba and red algae extracts
Mercúrio, D. G., Wagemaker, T. A. L., Alves, V. M., Benevenuto, C. G., Gaspar, L. R., & Campos, P. M. B. G. M. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.09.016 · Cited by 76
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential
Kwon, J. J., Willy, J. A., Quirin, K. A., Wek, R. C., Korc, M., Yin, X., & Kota, J. (2016) · Oncotarget · doi:10.18632/oncotarget.11928 · Cited by 75
The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting
Jonckheere, N., Vasseur, R., & SEUNINGEN, I. V. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.01.002 · Cited by 73
Colorectal cancer cells respond differentially to autophagy inhibition in vivo
Lauzier, A., Normandeau-Guimond, J., Vaillancourt‐Lavigueur, V., Boivin, V., Charbonneau, M., Rivard, N., Scott, M. S., Dubois, C. M., & Jean, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-47659-7 · Cited by 75
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy
Deng, W., Shang, H., Tong, Y., Liu, X., Huang, Q., He, Y. T., Wu, J., Ba, X., Chen, Z., Chen, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02297-8 · Cited by 80
Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic
Fokas, E., O’Neill, E., Gordon-Weeks, A. N., Mukherjee, S., McKenna, W. G., & Muschel, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.12.001 · Cited by 75
Targeting KRAS: The Elephant in the Room of Epithelial Cancers
Merz, V., Gaule, M., Zecchetto, C., Cavaliere, A., Casalino, S., Pesoni, C., Contarelli, S., Sabbadini, F., Bertolini, M., Mangiameli, D., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638360 · Cited by 74
Autophagy and tumorigenesis
Rangel, M., Kong, J., Bhatt, V. D., Khayati, K., & Guo, J. Y. (2021) · FEBS Journal · doi:10.1111/febs.16125 · Cited by 76
Identification of breast cancer cell subtypes sensitive to ATG4B inhibition
Bortnik, S. B., Choutka, C., Horlings, H. M., Leung, S. C. Y., Baker, J. H. E., Lebovitz, C. B., Dragowska, W. H., Go, N. E., Bally, M. B., Minchinton, A. I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11408 · Cited by 70
Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches
Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Koltai, T., Alfarouk, K. O., Reshkin, S. J., & Cardone, R. A. (2021) · Cancers · doi:10.3390/cancers13236135 · Cited by 76
Autophagy and Cancer Dormancy
Akkoç, Y., Peker, N., Akçay, A., & Gözüaçık, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.627023 · Cited by 71
Genetics and Biology of Pancreatic Ductal Adenocarcinoma
Dunne, R. F., & Hezel, A. F. (2015) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.04.003 · Cited by 68
Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy
Yu, Z., Yu, Z., Chen, Z., Yang, L., Ma, M., Lu, S., Wang, C., Teng, C., & Nie, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28670 · Cited by 64
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Cheng, C., Hu, J., Mannan, R., He, T., Bhattacharyya, R., Magnuson, B., Wisniewski, J. P., Peters, S., Karim, S. A., MacLean, D., et al. (2025) · Nature · doi:10.1038/s41586-025-08917-z · Cited by 79
The Emerging Roles of Autophagy in Human Diseases
Lei, Y., & Klionsky, D. J. (2021) · Biomedicines · doi:10.3390/biomedicines9111651 · Cited by 68
mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
Lampada, A., O’Prey, J., Szabadkai, G., Ryan, K. M., Hochhauser, D., & Salomoni, P. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.41 · Cited by 66
Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer
Mukhopadhyay, S., Encarnación-Rosado, J., Lin, E. Y., Sohn, A. S. W., Zhang, H., Mancias, J. D., & Kimmelman, A. C. (2023) · Science Advances · doi:10.1126/sciadv.adf9284 · Cited by 67
Self-citation
The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities
Kung, H., Zheng, K., Zimmerman, J. W., & Zheng, L. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01077-z · Cited by 86
Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer
Das, C. K., Banerjee, I., & Mandal, M. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.020 · Cited by 70
Autophagy-related MicroRNAs in chronic lung diseases and lung cancer
Rezaei, S., Mahjoubin‐Tehran, M., Aghaee‐Bakhtiari, S. H., Jalili, A., Movahedpour, A., Khan, H. Z., Moghoofei, M., Shojaei, Z., Hamblin, M. R., & Mirzaei, H. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103063 · Cited by 63
Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
Zhou, S.-F., Wang, F., Wang, Q., Zhou, Z.-W., Song, N., Pan, S., He, Z., Zhang, X., Wang, D., Yang, Y., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s73689 · Cited by 63
Retracted
Neoplasms of the Exocrine Pancreas
Wolff, R. A., Crane, C. H., Li, D., Evans, D. B., Maitra, A., & Tsai, S. (2017) · Wiley eBooks · doi:10.1002/9781119000822.hfcm094 · Cited by 64
Self-citation
Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance
Xu, J., Patel, N. H., & Gewirtz, D. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238991 · Cited by 66
Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy
Zada, S., Hwang, J. S., Ahmed, M., Lai, T. H., Pham, T. M., Elashkar, O., & Kim, D. R. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188565 · Cited by 65
Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Stalnecker, C. A., Grover, K. R., Edwards, A. C., Coleman, M. F., Yang, R., DeLiberty, J. M., Papke, B., Goodwin, C. M., Pierobon, M., Petricoin, E. F., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1443 · Cited by 64
Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
Zhou, S.-F., Wang, F., Li, H., Yan, X.-G., Zhou, Z.-W., Yi, Z., He, Z., Pan, S.-T., Yang, Y.-X., Wang, Z.-Z., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s75221 · Cited by 62
Retracted
Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
Rademaker, G., Hennequière, V., Brohée, L., Nokin, M., Lovinfosse, P., Durieux, F., Gofflot, S., Bellier, J., Costanza, B., Herfs, M. F., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0287-z · Cited by 65
Autophagy in cancer: a complex relationship
Wilde, L. R., Tanson, K., Curry, J., & Martinez‐Outschoorn, U. (2018) · Biochemical Journal · doi:10.1042/bcj20170847 · Cited by 62
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Santana-Codina, N., Gableske, S., del Rey, M. Q., Małachowska, B., Jedrychowski, M. P., Biancur, D. E., Schmidt, P. J., Fleming, M. D., Fendler, W. M., Harper, J. W., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.204123 · Cited by 61
Self-citation
MIR506induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway
Sun, L., Hu, L., Cogdell, D. E., Lü, L., Gao, C., Tian, W., Zhang, Z., Kang, Y., Fleming, J. B., & Zhang, W. (2017) · Autophagy · doi:10.1080/15548627.2017.1280217 · Cited by 58
Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy.
Tompkins, K. D., & Thorburn, A. M. (2019) · Europe PMC (PubMed Central) · Cited by 59
Targeting Autophagy to Treat Cancer: Challenges and Opportunities
Lim, J., & Murthy, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.590344 · Cited by 61
An iridium (III) complex as potent anticancer agent induces apoptosis and autophagy in B16 cells through inhibition of the AKT/mTOR pathway
Tang, B., Wan, D., Wang, Y.-J., Yi, Q.-Y., Guo, B., & Liu, Y. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.087 · Cited by 58
Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy
Zhang, J. C., Wang, G., Zhou, Y., Chen, Y., Ouyang, L., & Liu, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2759-2 · Cited by 59
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer
Ferretti, G. D. S., Quaas, C. E., Bertolini, I., Zuccotti, A., Saatci, Ö., Kashatus, J. A., Sharmin, S., Lu, D. Y., Poli, A. N. R., Quesnelle, A. F., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01310-9 · Cited by 60
Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics
Ajoolabady, A., Aghanejad, A., Bi, Y., Zhang, Y., Aslkhodapasandhukmabad, H., Abhari, A., & Ren, J. T. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188366 · Cited by 57
Sorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha, P., Chioureas, D., Baltatzis, G., Fonseca, P., Rodriguez, P. Q., Gogvadze, V. G., Lennartsson, L., Björklund, A.-C., Zhivotovsky, B., Grandér, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5797 · Cited by 56
The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion
Yang, J. Z., Liu, Y., & Liu, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06032-3 · Cited by 61
XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation
Lin, F., Ghislat, G., Luo, S., Renna, M., Siddiqi, F. H., & Rubinsztein, D. C. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv052 · Cited by 57
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer
Cozzo, A. J., Coleman, M. F., Pearce, J. B., Pfeil, A. J., Etigunta, S. K., & Hursting, S. D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590192 · Cited by 55
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
Khezri, R., Holland, P., Schoborg, T. A., Abramovich, I., Takáts, S., Dillard, C., Jain, A., O’Farrell, F., Schultz, S. W., Hagopian, W. M., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020107336 · Cited by 54
RETRACTED ARTICLE: Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy
Tan, Q., Joshua, A. M., Saggar, J. K., Yu, M., Wang, M., Kanga, N. D., Zhang, J. Y., Chen, X., Wouters, B. G., & Tannock, I. F. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.17 · Cited by 54
Retracted
Synergy of Tumor Microenvironment Remodeling and Autophagy Inhibition to Sensitize Radiation for Bladder Cancer Treatment
Lin, T., Zhang, Q., Yuan, A., Wang, B., Zhang, F., Ding, Y., Cao, W., Chen, W., & Guo, H. (2020) · Theranostics · doi:10.7150/thno.45358 · Cited by 56
Nutrient Sensing in Cancer
Torrence, M. E., & Manning, B. D. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050329 · Cited by 55
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening
Strohecker, A. M., Joshi, S., Possemato, R., Abraham, R. T., Sabatini, D. M., & White, E. (2015) · Oncogene · doi:10.1038/onc.2015.23 · Cited by 55
Molecular Pathways Controlling Autophagy in Pancreatic Cancer
New, M. I., Acker, T. V., Long, J. S., Sakamaki, J.-I., Ryan, K. M., & Tooze, S. A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00028 · Cited by 56
The interplay between autophagy and cGAS-STING signaling and its implications for cancer
Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61
Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions
Kim, S. E., Park, H.-J., Jeong, H. K., Kim, M.-J., Kim, M., Bae, O., & Baek, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.022 · Cited by 60
Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis
He, S., Zhou, Q., Luo, B., Chen, B., Li, L., & Yan, F. (2019) · Inflammation · doi:10.1007/s10753-019-01111-0 · Cited by 52
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
Lin, H., Chung, Y., Cheng, C.-T., Ouyang, C., Fu, Y., Kuo, C., Chi, K. K., Sadeghi, M., Chu, P. G., Kung, H.-J., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1450708 · Cited by 53
Chimeric peptide supramolecular nanoparticles for plectin-1 targeted miRNA-9 delivery in pancreatic cancer
Wu, Y., Tang, Y., Xie, S., Zheng, X., Zhang, S., Mao, J., Wang, B., Hou, Y., Hu, L., Chai, K., et al. (2019) · Theranostics · doi:10.7150/thno.38327 · Cited by 52
The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy
Lorente, J., Velandia, C., Leal, J. A., Garcia‐Mayea, Y., Lyakhovich, A., Kondoh, H., & LLeonart, M. E. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12337 · Cited by 51
Plant Polyphenols for Aging Health: Implication from Their Autophagy Modulating Properties in Age-Associated Diseases
Brimson, J. M., Prasanth, M. I., Malar, D. S., Thitilertdecha, P., Kabra, A., Tencomnao, T., & Prasansuklab, A. (2021) · Pharmaceuticals · doi:10.3390/ph14100982 · Cited by 53
Tumor-intrinsic determinants of immunogenic cell death modalities
Workenhe, S. T., Pol, J. G., & Kroemer, G. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1893466 · Cited by 52
Autophagy and cancer therapy
Pimentel, J. M., Zhou, J. Y., & Wu, G. S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217285 · Cited by 55
Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis
Liu, W., Wang, X., Sun, J., Yang, Y., Li, W., & Song, J. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s117250 · Cited by 49
Self-citation
Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs
Wei, D., Jiang, M., Lin, P., Yang, H., Dang, Y., Qiao, Y., Liao, D., Luo, D., & Chen, G. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4660 · Cited by 47
Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment
Yamamoto, K., Iwadate, D., Kato, H., Nakai, Y., Tateishi, K., & Fujishiro, M. (2022) · Cancers · doi:10.3390/cancers14184351 · Cited by 52

Authors: Yang, A., Rajeshkumar, N. V., Wang, X., Yabuuchi, S., Alexander, B. M., Chu, G. C., Von Hoff, D. D., Maitra, A., & Kimmelman, A. C.
Affiliations: Dana-Farber Cancer Institute (US)
Johns Hopkins University (US)
Brigham and Women's Hospital (US)
4Translational Genomics Research Institute, Phoenix, Arizona; Departments of
The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Kimmelman, Alec C.
ORCID: Yang, Annan
Wang, Xiaoxu
Alexander, Brian M.
Maitra, Anirban
Kimmelman, Alec C.
Venue: Cancer Discovery
Publisher: American Association for Cancer Research (AACR)
Published: 2014-08-01
Volume: 4
Issue: 8
Pages: 905-913
ISSN: 2159-8274 (ISSN-L)
2159-8290
DOI: 10.1158/2159-8290.cd-14-0362
PMC: PMC4125497
OpenAlex: W2148330792
Cited by: 486
References: 33
Citations by year: 2026: 16 · 2025: 32 · 2024: 28 · 2023: 34 · 2022: 47 · 2021: 61 · 2020: 44 · 2019: 43 · 2018: 41 · 2017: 45 · 2016: 37 · 2015: 43 · 2014: 15
FWCI: 35.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cancer Discovery (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P50CA127003, R01CA157490, P30CA016672)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, pancreatic ductal adenocarcinoma, p53 status, autophagy inhibition, hydroxychloroquine, KRAS-driven tumors, premalignant pancreatic lesions, tumor progression, patient-derived xenografts
MeSH terms: Animals, Autophagy, Cell Transformation, Neoplastic, Disease Models, Animal, Humans, Pancreatic Neoplasms, Tumor Suppressor Protein p53, Loss of Heterozygosity, Xenograft Model Antitumor Assays, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks