The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

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Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

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The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

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Thirty years of Oncogene

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Modulating the Tumor Microenvironment to Enhance Immunotherapy Efficacy in Hepatic Metastases from Colorectal Cancer: The Role of TGF-β Inhibition

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Vaincre les résistances aux antagonistes de checkpoint en augmentant l’immunogénicité de la tumeur

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Single cell spatial transcriptomics identifies coordinated cellular programs associated with good prognosis in microsatellite stable colorectal cancerPreprint

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The Outlook for Immune Checkpoint Targeting Strategies in Colorectal Cancer

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Rolle des Pathologen in Hinblick auf therapeutische Entscheidungen beim Magenkarzinom

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Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapies

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Investigating the role of the EHF transcription factor in the regulation of differentiation in colorectal cancer

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Future Therapies in Medical Oncology

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Medical Oncology Management of Hereditary Colorectal Cancer

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Immune Checkpoint Inhibitors Against Colon Cancer

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Therapy Response Imaging in Gastrointestinal Malignancy

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MUC4 mutation correlates with tumor mutation burden and the immune microenvironment in colorectal cancerPreprint

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Regulation of Anti-Tumor Immunity and Immunotherapy Response In Colorectal Cancer

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Integrative Analysis of Multi-Omics Data Identified klrc3 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Lung AdenocarcinomaPreprint

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Regulation of KCNQ1 and CFTR in Colorectal Cancer

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Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single Cell TranscriptomesPreprint

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Novel Epigenetic 12-gene Signature Predictive of Poor Prognosis and MSI-like Phenotype in Human Metastatic Colorectal CarcinomasPreprint

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Effects of Dexamethasone on Trophoblastic, IDO, and Macrophage Cells in Domestic Pregnant Rabbits (Oryctolagus cuniculus)

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“The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers”Preprint

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Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single Cell TranscriptomesPreprint

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3) Immune Checkpoint Inhibitors for Gastrointestinal Tract Cancers

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Chemoattractant receptors BLT1 and CXCR3 regulate anti-tumor immunity by facilitating CD8+ T cell migration to tumors.

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Integrative Analysis of Multi-Omics Data Identified klrc3 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Lung AdenocarcinomaPreprint

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Prognostic implication and immunological value of contactin 1 expression in pan‐cancer

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Anoikis-related signature identifies tumor microenvironment landscape and predicts prognosis in colorectal cancerPreprint

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Implications of Tumor Immune Microenvironment and Molecular Markers for Cancer Immunotherapy

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Bulk and single‐cell spatial transcriptomic analysis reveals cuproptosis‐related molecular subtypes characterized by distinct tumour microenvironment infiltrates in colorectal cancer

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2. Systemic Pharmacotherapy for Gastrointestinal Cancers

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Data from Phase II window study of olaparib alone or with cisplatin or durvalumab in operable Head and Neck Cancer

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Additional file 15 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802314

Additional file 14 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802311

Additional file 13 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802305

Additional file 12 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802302

Additional file 10 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802296

Additional file 11 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802299

Unraveling the Interplay of Autophagy Genes and KLF3/KLF8 in Colorectal Cancer Metastasis: A Bioinformatics and cellular Exploration

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Biological and molecular targets for targeted therapy in colorectal cancer (literature review)

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Immunotherapeutic strategies for the treatment of colorectal cancer

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Therapeutic Advances in Gastrointestinal Cancers: Immuno-oncology and Beyond

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Research Progress of M6A Methylation Modification in Immunotherapy of Colorectal Cancer

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MicroRNAs and target genes as regulators of colon cancer immune signaling

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Additional file 4 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802329

Additional file 8 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802341

Additional file 6 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802335

Additional file 7 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802338

Additional file 5 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802332

Additional file 3 of Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer

Zhou, L., Zhang, Y., Wei, M., Du, K., Lin, J., & Wei, L. (2023) · Figshare · doi:10.6084/m9.figshare.23930242

Additional file 1 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802317

Additional file 2 of Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer

Zhou, L., Zhang, Y., Wei, M., Du, K., Lin, J., & Wei, L. (2023) · Figshare · doi:10.6084/m9.figshare.23930239

Additional file 1 of Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon cancer

Zhou, L., Zhang, Y., Wei, M., Du, K., Lin, J., & Wei, L. (2023) · Figshare · doi:10.6084/m9.figshare.23930236

Additional file 3 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802323

Additional file 2 of Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Luo, W., Xiang, W., Gan, L., Che, J., Li, J., Wang, Y., Han, L., Gu, R., Ye, L., Wang, R., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19802320

Implications of Tumor Immune Microenvironment and Molecular Markers for Cancer Immunotherapy

Soto, L. M. S., & Wang, H. (2025) · Springer eBooks · doi:10.1007/978-3-032-00761-2_115

Discrete Transcriptional States Define Biphasic Immune Response and Dynamic CMS Transitions in Colorectal CancerPreprint

Ishani, K., Wangmo, D., Ali, A. M., Gates, T. J., Yan, Z., Gustafson, A. P., Boytim, E., Storey, K. L., Goffredo, P., Hwang, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703597

Therapeutic challenges and advances in the management of colorectal cancer overcoming resistance mechanisms and exploring future directions

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Classification moléculaire des cancers colorectaux : corrélation anatomo cliniques et implications pronostiques

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Long-term regulation of colorectal cancer cells under mechanical stress

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Revealing the dynamics of follicular T cells and checkpoint engagement in surgically resected colorectal cancer and their relations to clinicopathological aspects

Zahran, A. M., Elsherbiny, N. M., Abdelhakeem, A. G., Rayan, A., Mahran, Z. G., Elsayh, A. K. I., Saad, E., Refaat, A., Torky, R. A., Gamal, D. A., et al. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04468-5

IN THE SPOTLIGHT The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

Xiao, Y., & Freeman, G. J. (2016)

Overview of Microsatellite Instability and Immune Checkpoint Inhibitors in Colorectal Cancer

Kim, D. W., Lee, J.-H., Kim, K., & Imanirad, I. (2018) · Current Colorectal Cancer Reports · doi:10.1007/s11888-018-0413-x

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

Llosa, N. J., Cruise, M., Tam, A., Wicks, E. C., Hechenbleikner, E. M., Taube, J. M., Blosser, R. L., Fan, H., Wang, H., Luber, B. S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0863 · Cited by 1,487

Abstract A141: The vigorous immune microenvironment of microsatellite instable colon cancer isbalanced by multiple counter-inhibitory checkpoints

Llosa, N. J., Housseau, F., Wick, E. C., Hechenbleikner, L., Cruise, M. W., Anders, R. A., Sears, C. L., Pardoll, D. M., Fan, H., Siegel, N. M., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr15-a141

Abstract 451: The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints

Llosa, N. J., Cruise, M. W., Tam, A. J., Wick, E., Hechenbleikner, E. M., Taube, J. M., Blosser, L., Fan, H., Wang, H., Zhang, M., et al. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-451 · Cited by 6