Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Open accessPublished version of a preprint
Abstract
Fusobacterium species are part of the gut microbiome in humans. Recent studies have identified overrepresentation of Fusobacterium in colorectal cancer tissues, but it is not yet clear whether this is pathogenic or simply an epiphenomenon. In this study, we evaluated the relationship between Fusobacterium status and molecular features in colorectal cancers through quantitative real-time PCR in 149 colorectal cancer tissues, 89 adjacent normal appearing mucosae and 72 colonic mucosae from cancer-free individuals. Results were correlated with CpG island methylator phenotype (CIMP) status, microsatellite instability (MSI), and mutations in BRAF, KRAS, TP53, CHD7, and CHD8. Whole-exome capture sequencing data were also available in 11 cases. Fusobacterium was detectable in 111 of 149 (74%) colorectal cancer tissues and heavily enriched in 9% (14/149) of the cases. As expected, Fusobacterium was also detected in normal appearing mucosae from both cancer and cancer-free individuals, but the amount of bacteria was much lower compared with colorectal cancer tissues (a mean of 250-fold lower for Pan-fusobacterium). We found the Fusobacterium-high colorectal cancer group (FB-high) to be associated with CIMP positivity (P = 0.001), TP53 wild-type (P = 0.015), hMLH1 methylation positivity (P = 0.0028), MSI (P = 0.018), and CHD7/8 mutation positivity (P = 0.002). Among the 11 cases where whole-exome sequencing data were available, two that were FB-high cases also had the highest number of somatic mutations (a mean of 736 per case in FB-high vs. 225 per case in all others). Taken together, our findings show that Fusobacterium enrichment is associated with specific molecular subsets of colorectal cancers, offering support for a pathogenic role in colorectal cancer for this gut microbiome component.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Numerous studies of multiple cohorts worldwide have found similar associations between Fusobacterium nucleatum and colorectal cancer.
“Numerous studies, of multiple cohorts, of patients with CRC worldwide have found similar associations.23–27”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma
Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., Knowles, D. M., & Moore, P. S. (1994) · Science · doi:10.1126/science.7997879 · Cited by 5,608 · see citing works
Human papillomavirus and cervical cancer
SCHIFFMAN, M. H., Castle, P. E., Jerónimo, J., Rodríguez, A. C., & Wacholder, S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61416-0 · Cited by 3,046 · see citing works
Ribic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022289 · Cited by 2,160 · see citing works
<i>Fusobacterium nucleatum</i> infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · see citing works
Genomic analysis identifies association of <i>Fusobacterium</i> with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · see citing works
Systematic Review of Microsatellite Instability and Colorectal Cancer Prognosis
Popat, S., Hubner, R. A., & Houlston, R. S. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.086 · Cited by 1,830 · see citing works
Genetic prognostic and predictive markers in colorectal cancer
Walther, A., Johnstone, E. C., Swanton, C., Midgley, R. S., Tomlinson, I. P. M., & Kerr, R. S. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2645 · Cited by 700 · see citing works
Accelerated age-related CpG island methylation in ulcerative colitis.
Issa, J. J., Ahuja, N., Toyota, M., Bronner, M. P., & Brentnall, T. A. (2001) · PubMed · Cited by 627 · see citing works
Self-citationStrauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 574 · see citing works
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
Shen, L., Toyota, M., Kondo, Y., Lin, E. H., Zhang, L., Guo, Y., Hernandez, N., Chen, X., Ahmed, S., Konishi, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704652104 · Cited by 556 · see citing works
Self-citationThe genetics of hereditary colon cancerPreprint
Rustgi, A. K. (2007) · Genes & Development · doi:10.1101/gad.1593107 · Cited by 528 · see citing works
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
Toyota, M., Ohe-Toyota, M., Ahuja, N., & Issa, J. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.710 · Cited by 471 · see citing works
Self-citationAcute appendicitis is characterised by local invasion with Fusobacterium nucleatum / necrophorum
Swidsinski, A. V., Dörffel, Y., Loening-Baucke, V. A., Theissig, F., Rueckert, J.-C., Ismail, M., Rau, W. A., Gaschler, D., Weizenegger, M., Kühn, S., et al. (2009) · Gut · doi:10.1136/gut.2009.191320 · Cited by 441 · see citing works
Han, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3140-3146.2000 · Cited by 435 · see citing works
Krisanaprakornkit, S., Kimball, J. R., Weinberg, A., Darveau, R. P., Bainbridge, B. W., & Dale, B. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2907-2915.2000 · Cited by 419 · see citing works
Ogino, S., Nosho, K., Irahara, N., Meyerhardt, J. A., Baba, Y., Shima, K., Glickman, J. N., Ferrone, C. R., Mino-Kenudson, M. A., Tanaka, N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1438 · Cited by 418 · see citing works
Fusobacterium nucleatumin Periodontal Health and Disease
Signat, B., Roques, C. G., Poulet, P. P., & Duffaut, D. (2011) · Current Issues in Molecular Biology · doi:10.21775/cimb.013.025 · Cited by 332 · see citing works
Neut, C., Bulois, P., Desreumaux, P., Membré, J., Lederman, E., Gambiez, L. P., Cortot, A., Quandalle, P. A., Kruiningen, H. J. V., & Colombel, J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05613.x · Cited by 274 · see citing works
Jover, R., Nguyen, T., Pérez–Carbonell, L., Zapater, P., Payá, A., Alenda, C., Rojas, E., Cubiella, J., Balaguer, F., Morillas, J. D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.12.035 · Cited by 205 · see citing works
Ohkusa, T., Sato, N., Ogihara, T., Morita, K., Ogawa, M., & Okayasu, I. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02834.x · Cited by 198 · see citing works
Kimura, T., Yamamoto, E., Yamano, H., Suzuki, H., Kamimae, S., Nojima, M., Sawada, T., Ashida, M., Yoshikawa, K., Takagi, R., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.457 · Cited by 197 · see citing works
Self-citationPeriodontal pathogens: A quantitative comparison of anaerobic culture and real-time PCR
Boutaga, K., Winkelhoff, A. J. V., Vandenbroucke‐Grauls, C. M. J. E., & Savelkoul, P. H. M. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2005.03.011 · Cited by 169 · see citing works
Kusano, M., Toyota, M., Suzuki, H., Akino, K., Aoki, F., Fujita, M., Hosokawa, M., Shinomura, Y., Imai, K., & Tokino, T. (2006) · Cancer · doi:10.1002/cncr.21789 · Cited by 167 · see citing works
Self-citationWilson, G. M., Flibotte, S., Chopra, V. S., Melnyk, B. L., Honer, W. G., & Holt, R. A. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi489 · Cited by 167 · see citing works
Epstein–Barr virus and gastric carcinoma: virus–host interactions leading to carcinoma
Fukayama, M., Hino, R., & Uozaki, H. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00888.x · Cited by 161 · see citing works
DNA methylation predicts recurrence from resected stage III proximal colon cancer
Ahn, J. B., Chung, W., Maeda, O., Shin, S. J., Kim, H. S., Chung, H. C., Kim, N. K., & Issa, J. J. (2010) · Cancer · doi:10.1002/cncr.25737 · Cited by 153 · see citing works
Self-citationFusobacterium nucleatum Increases Collagenase 3 Production and Migration of Epithelial Cells
Uitto, V., Baillie, D., Wu, Q., Gendron, R., Grenier, D., Putnins, E. E., Kanervo, A., & Firth, J. D. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.1171-1179.2005 · Cited by 122 · see citing works
Suzuki, H., Igarashi, S., Nojima, M., Maruyama, R., Yamamoto, E., Kai, M., Akashi, H., Watanabe, Y., Yamamoto, H., Sasaki, Y., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp179 · Cited by 104 · see citing works
Self-citationOgino, S., Odze, R. D., Kawasaki, T., et al. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000213266.84725.d0 · Cited by 103 · see citing works
Tahara, T., Yamamoto, E., Madireddi, P., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelı́nek, J., Yamano, H.-O., Sugai, T., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.060 · Cited by 91 · see citing works
Self-citationRare CpG Island Methylator Phenotype in Ulcerative Colitis–Associated Neoplasias
Konishi, K., Shen, L., Wang, S., Meltzer, S. J., Harpaz, N., & Issa, J. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.035 · Cited by 91 · see citing works
Self-citationMoore, R. A., Warren, R. M., Freeman, J., Gustavsen, J., Chénard, C., Friedman, J. M., Suttle, C. A., Zhao, Y., & Holt, R. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019838 · Cited by 60 · see citing works
TLR2 sensing of F. nucleatum and S. sanguinis distinctly triggered gingival innate response
Peyret-Lacombe, A., Brunel, G., Watts, M., Charvéron, M., & Duplan, H. (2009) · Cytokine · doi:10.1016/j.cyto.2009.01.006 · Cited by 47 · see citing works
DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis
Konishi, K., Watanabe, Y., Shen, L., Guo, Y., Castoro, R. J., Kondo, K., Chung, W., Ahmed, S., Jelı́nek, J., Boumber, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027889 · Cited by 41 · see citing works
Self-citationBachrach, G., Ianculovici, C., Naor, R., & Weiss, E. I. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.05.055 · Cited by 39 · see citing works
An, B., Kondo, Y., Okamoto, Y., Shinjo, K., Kanemitsu, Y., Komori, K., Hirai, T., Sawaki, A., Tajika, M., Nakamura, T., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25225 · Cited by 37 · see citing works
Self-citationA rare presentation of ventriculitis and brain abscess caused by Fusobacterium nucleatum
Kai, A. C., Cooke, F. J., Antoun, N. M., et al. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47710-0 · Cited by 34 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer
Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works
Yachida, S., Mizutani, S., Shiroma, H., Shiba, S., Nakajima, T., Sakamoto, T., Watanabe, H., Masuda, K., Nishimoto, Y., Kubo, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0458-7 · Cited by 1,429 · see citing works
Potential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375 · see citing works
Fusobacterium nucleatum — symbiont, opportunist and oncobacterium
Brennan, C. A., & Garrett, W. S. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0129-6 · Cited by 1,205 · see citing works
Diet, microorganisms and their metabolites, and colon cancer
O'Keefe, S. J. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.165 · Cited by 1,100 · see citing works
<i>Fusobacterium nucleatum</i> in colorectal carcinoma tissue and patient prognosis
Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310101 · Cited by 1,080 · see citing works
Abed, J., Emgård, J. E. M., Zamir, G., Faroja, M., Almogy, G., Grenov, A., Sol, A., Naor, R., Pikarsky, E., Atlan, K. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.006 · Cited by 888 · see citing works
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752 · see citing works
Gut mucosal microbiome across stages of colorectal carcinogenesis
Nakatsu, G., Li, X., Zhou, H., Sheng, J., Wong, S. H., Wu, W. K. K., Ng, S. C., Tsoi, H., Dong, Y., Zhang, N., et al. (2015) · Nature Communications · doi:10.1038/ncomms9727 · Cited by 701 · see citing works
The oral microbiota in colorectal cancer is distinctive and predictive
Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O‘Riordain, M., Shanahan, F., & O‘Toole, P. W. (2018) · Gut · doi:10.1136/gutjnl-2017-314814 · Cited by 646 · see citing works
<i>Fusobacterium nucleatum</i> and T Cells in Colorectal Carcinoma
Mima, K., Sukawa, Y., Nishihara, R., Qian, Z. R., Yamauchi, M., Inamura, K., Kim, S. A., Masuda, A., Nowak, J. A., Nosho, K., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.1377 · Cited by 669 · see citing works
Microbiota disbiosis is associated with colorectal cancer
Gao, Z., Guo, B., Gao, R., Zhu, Q., & Qin, H. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00020 · Cited by 537 · see citing works
Interaction between the microbiome and TP53 in human lung cancer
Greathouse, K. L., White, J. R., Vargas, A. J., Bliskovsky, V. V., Beck, J. A., von Muhlinen, N., Polley, E. C., Bowman, E. D., Khan, M. A., Robles, A. I., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1501-6 · Cited by 446 · see citing works
The role of gut microbiota in cancer treatment: friend or foe?
Cheng, W. Y., Wu, C.-Y., & Yu, J. (2020) · Gut · doi:10.1136/gutjnl-2020-321153 · Cited by 384 · see citing works
Environmental Factors, Gut Microbiota, and Colorectal Cancer Prevention
Song, M., & Chan, A. T. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.012 · Cited by 355 · see citing works
Xiao, Y., & Freeman, G. J. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1397 · Cited by 368 · see citing works
The Oral Microbiome and Cancer
Irfan, M., Delgado, R. Z. R., & Frias-Lopez, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.591088 · Cited by 341 · see citing works
Nosho, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.557 · Cited by 344 · see citing works
Mehta, R. S., Nishihara, R., Cao, Y., Song, M., Mima, K., Qian, Z. R., Nowak, J. A., Kosumi, K., Hamada, T., Masugi, Y., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.6374 · Cited by 325 · see citing works
Ito, M., Kanno, S., Nosho, K., Sukawa, Y., Mitsuhashi, K., Kurihara, H., Igarashi, H., Takahashi, T., Tachibana, M., Takahashi, H., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29488 · Cited by 288 · see citing works
Self-citationFusobacterium nucleatum in colorectal carcinoma tissue according to tumor location
Mima, K., Cao, Y., Chan, A. T., Qian, Z. R., Nowak, J. A., Masugi, Y., Shi, Y., Song, M., da Silva, A., Gu, M., et al. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.53 · Cited by 284 · see citing works
<i>Fusobacterium nucleatum</i>and colorectal cancer: A review
Shang, F.-M., & Liu, H.-L. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i3.71 · Cited by 258 · see citing works
Viljoen, K. S., Dakshinamurthy, A., Goldberg, P., & Blackburn, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119462 · Cited by 256 · see citing works
Gut microbiota, inflammation and colorectal cancer
Sun, J., & Kato, I. (2016) · Genes & Diseases · doi:10.1016/j.gendis.2016.03.004 · Cited by 257 · see citing works
“These observations were further confirmed by quantitative (q) PCR and in situ hybridization in tumor tissue.(16,86,89) Using qPCR, McCoy et al studied F counts in normal rectal mucosa of the cases with or without colorectal adenoma, revealing a 3 fold increase in risk of adenoma among subjects with highest tertile of…”
MethodGut microbiota and colorectal cancer
Gao, R., Gao, Z., Huang, L., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2881-8 · Cited by 205 · see citing works
Yu, J., Chen, Y., Fu, X., Zhou, X., Peng, Y., Shi, L., Chen, T., & Wu, Y. (2016) · International Journal of Cancer · doi:10.1002/ijc.30168 · Cited by 176 · see citing works
Association of <i>Fusobacterium nucleatum</i> infection with colorectal cancer in Chinese patients
Li, Y.-Y., Ge, Q.-X., Cao, J., Zhou, Y.-J., Du, Y.-L., Shen, B., Wan, Y.-J. Y., & Nie, Y.-Q. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3227 · Cited by 175 · see citing works
Drago, L. (2019) · Microorganisms · doi:10.3390/microorganisms7030066 · Cited by 171 · see citing works
Periodontal disease, tooth loss and colorectal cancer risk: results from the Nurses’ Health Study
Momen-Heravi, F., Babic, A., Tworoger, S. S., Zhang, L., Wu, K., Smith-Warner, S. A., Ogino, S., Chan, A. T., Meyerhardt, J., Giovannucci, E., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30486 · Cited by 137 · see citing works
Kamarajan, P., Ateia, I., Shin, J. M., Fenno, J. C., Le, C., Zhan, L., Chang, A., Darveau, R., & Kapila, Y. L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008881 · Cited by 134 · see citing works
Borelli, B., Antoniotti, C., Carullo, M., Germani, M. M., Conca, V., & Masi, G. (2022) · Cancers · doi:10.3390/cancers14204974 · Cited by 62 · see citing works
Borozan, I., Zaidi, S. H., Harrison, T. A., Phipps, A. I., Zheng, J., Lee, S., Trinh, Q. M., Steinfelder, R. S., Adams, J., Banbury, B. L., et al. (2022) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-21-0463 · Cited by 57 · see citing works
Hu, J.-M., Shen, C.-J., Chou, Y.-C., Hung, C.-F., Tian, Y.-F., You, S.-L., Chen, C.-Y., Hsu, C.-H., Hsiao, C.-W., Lin, C.-Y., et al. (2018) · International Journal of Colorectal Disease · doi:10.1007/s00384-018-2965-2 · Cited by 39 · see citing works
Greathouse, K. L., White, J. R., Padgett, R. N., Perrotta, B. G., Jenkins, G. D., Chia, N., & Chen, J. (2019) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2018-000247 · Cited by 35 · see citing works
Chang, S.-C., Lin, P.-C., Lin, J.-K., Lin, C.-H., Yang, S.-H., Liang, W.-Y., Chen, W.-S., & Jiang, J.-K. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4899-z · Cited by 31 · see citing works
Jamal, R., Messaoudene, M., de Figuieredo, M., & Routy, B. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101754 · Cited by 31 · see citing works
- Authors
- Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., Shureiqi, I., Toyota, M., Kondo, Y., Estécio, M. R. H., & Issa, J.-P. J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Authors' Affiliations: 1Fels Institute for Cancer Research & Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania; 2Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake; First Departments of 3Internal Medicine and 4Molecular Biology, Sapporo Medical University, Sapporo; 5Department of Gastroenterology, Akita Red Cross Hospital, Akita; 6Department of Pathology, Iwate Medical University, Morioka; 7Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan; 8Division of OVP, Department of Clinical Cancer Prevention, Cancer Prevention and Population Sciences; 9Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston; and 10Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas
- Corresponding author
- Tahara, Tomomitsu
- ORCID
- Venue
- Cancer Research
- Published
- 2014-03-01
- Volume
- 74
- Issue
- 5
- Pages
- 1311-1318
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4396185
- OpenAlex
- W1971000774
- Cited by
- 465
- References
- 37
- Citations by year
- 2026: 24 · 2025: 35 · 2024: 44 · 2023: 38 · 2022: 41 · 2021: 47 · 2020: 50 · 2019: 47 · 2018: 49 · 2017: 27 · 2016: 34 · 2015: 23 · 2014: 6
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (25290048, 23501261)
- National Cancer Institute (CA158112, R01CA158112, R01CA098006, CA098006, P30CA016672)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Fusobacterium, colorectal cancer, gut microbiota, CpG island methylator phenotype, microsatellite instability, TP53 mutation, CHD7 mutations, BRAF mutation, KRAS mutation, somatic mutations, colonic mucosa
- MeSH terms
- Aged, DNA Helicases, DNA-Binding Proteins, Female, Fusobacterium, Fusobacterium Infections, Humans, Male, Middle Aged, Mucous Membrane, Mutation, Transcription Factors, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, ras Proteins, CpG Islands, DNA Methylation, Proto-Oncogene Proteins B-raf, Microsatellite Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
