The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Adaptive Immune Resistance: How Cancer Protects from Immune Attack
Open accessAbstract
Adaptive immune resistance is a process in which the cancer changes its phenotype in response to a cytotoxic or proinflammatory immune response, thereby evading it. This adaptive process is triggered by the specific recognition of cancer cells by T cells, which leads to the production of immune-activating cytokines. Cancers then hijack mechanisms developed to limit inflammatory and immune responses and protect themselves from the T-cell attack. Inhibiting adaptive immune resistance is the mechanistic basis of responses to PD-1 or PD-L1–blocking antibodies, and may be of relevance for the development of other cancer immunotherapy strategies. Significance: Several new immunotherapy strategies to treat cancer are based on inhibiting processes through which cancer adapts and evades from an immune response. Recognizing the specific adaptive resistance mechanisms in each case is likely to allow the personalized development of immunotherapies tailored to block how a particular cancer protects itself from the immune system. Cancer Discov; 5(9); 915–9. ©2015 AACR.
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Self-citationPembrolizumab versus Ipilimumab in Advanced Melanoma
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Self-citationNivolumab in Previously Untreated Melanoma without BRAF Mutation
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Cancer immunotherapy using checkpoint blockade
Ribas, A., & Wolchok, J. D. (2018) · Science · doi:10.1126/science.aar4060 · Cited by 6,791
Self-citationPrimary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
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Self-citationTGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
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Self-citationMutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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Metadata
- Authors
- Ribas, A.
- Venue
- Cancer Discovery
- Published
- 2015-09-01
- Volume
- 5
- Issue
- 9
- Pages
- 915-919
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2164001237
- Cited by
- 613
- References
- 13
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- green
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