Senescence Can Be BETter without the SASP?
Open accessAbstract
Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo. Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.Cancer Discov; 6(6); 576–8. ©2016 AACR. See related article by Tasdemir et al., p. 612.
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BRD4 inactivation via shRNA or BET inhibitors has been shown to repress SASP gene expression in oncogene-induced senescent cells, suggesting the possibility of senescence without the SASP.
“BRD4 inactivation via shRNA or BET inhibitors has been shown to repress SASP gene expression in oncogene-induced senescent cells [29], suggesting the possibility of senescence without the SASP [30].”
From Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues (2026) · cites this paper as [30]
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Cites
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“Tasdemir and colleagues (4) shed light on this matter by establishing a new player underlying the regulation of SASP genes that is responsible for the interplay between senescent cells and tissue microenvironment.”
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- Authors
- Vizioli, M. G., & Adams, P. D.
- Affiliations
- Cancer Research UK Scotland Institute (GB)
- Corresponding author
- Adams, Peter D.
- ORCID
- Adams, Peter D.
- Venue
- Cancer Discovery
- Published
- 2016-06-01
- Volume
- 6
- Issue
- 6
- Pages
- 576-578
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC6489500
- OpenAlex
- W2408863319
- Cited by
- 6
- References
- 10
- Citations by year
- 2026: 2 · 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Institute on Aging (P01 AG031862)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, senescence-associated secretory phenotype, BRD4, chromatin remodeling, epigenetic regulation, age-related diseases, cancer therapy
- MeSH terms
- Chromatin, Humans, Phenotype, Cellular Senescence
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