Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Open accessAbstract
MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc(+/-)) mice exhibit increased lifespan. They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis, and immunosenescence. They also appear to be more active, with a higher metabolic rate and healthier lipid metabolism. Transcriptomic analysis reveals a gene expression signature enriched for metabolic and immune processes. The ancestral role of MYC as a regulator of ribosome biogenesis is reflected in reduced protein translation, which is inversely correlated with longevity. We also observe changes in nutrient and energy sensing pathways, including reduced serum IGF-1, increased AMPK activity, and decreased AKT, TOR, and S6K activities. In contrast to observations in other longevity models, Myc(+/-) mice do not show improvements in stress management pathways. Our findings indicate that MYC activity has a significant impact on longevity and multiple aspects of mammalian healthspan.
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c-Myc is an oncogene that reduces mouse lifespan.
“Among the Yamanaka factors, c-Myc is an oncogene that reduces mouse lifespan20 and is not required for the initiation of cellular reprogramming21.”
From Reprogramming to recover youthful epigenetic information and restore vision (2020) · cites this paper as [20]
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A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Self-citationDang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works
Self-citationThe transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2× · see citing works
“The PI3K and TOR pathways also contain feedback loops that can be affected by MYC, for example, acute deletion of Myc was found to impair TOR signaling during T cell activation (Wang et al., 2011b).”
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D., Gutiérrez, J., Towery, H., Burks, D., Ren, J.-M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,850 · see citing works
Self-citationmTOR is a key modulator of ageing and age-related disease
Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676 · see citing works
Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J., & Toussaint, O. (2009) · Nature Protocols · doi:10.1038/nprot.2009.191 · Cited by 1,668 · see citing works
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575 · see citing works
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works
The retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477 · see citing works
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445 · see citing works
Self-citationYoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works
Self-citationAnalysis of Microarray Data Using Z Score Transformation
Cheadle, C., Vawter, M. P., Freed, W. J., & Becker, K. G. (2003) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60455-2 · Cited by 1,150 · see citing works
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
Kamentsky, L. D., Jones, T. R., Fraser, A. N., Bray, M., Logan, D. J., Madden, K. L., Ljosa, V., Rueden, C., Eliceiri, K. W., & Carpenter, A. E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr095 · Cited by 1,002 · see citing works
Garlick, P. J., McNurlan, M. A., & Preedy, V. R. (1980) · Biochemical Journal · doi:10.1042/bj1920719 · Cited by 974 · see citing works
Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927 · see citing works
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works
Self-citationc-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Lee, C. D., Raffaghello, L., Brandhorst, S., Safdie, F. M., Bianchi, G., Martín‐Montalvo, A., Pistoia, V., Wei, M., Hwang, S., Merlino, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003293 · Cited by 715 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Self-citationGenetics of Longevity in Model Organisms: Debates and Paradigm Shifts
Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works
Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works
Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
Taguchi, A., Wartschow, L. M., & White, M. F. (2007) · Science · doi:10.1126/science.1142179 · Cited by 523 · see citing works
On the utility of pooling biological samples in microarray experiments.
Kendziorski, C., Irizarry, R., Chen, K.-S., Haag, J., & Gould, M. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0500607102 · Cited by 522 · see citing works
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510 · see citing works
Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
Dai, D., Santana, L. F., Vermulst, M., Tomazela, D. M., Emond, M. J., MacCoss, M. J., Gollahon, K. A., Martin, G. M., Loeb, L. A., Ladiges, W., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.822403 · Cited by 497 · see citing works
Not Just Fat: The Structure and Function of the Lipid DropletPreprint
Fujimoto, T., & Parton, R. G. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004838 · Cited by 485 · see citing works
Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
Akbar, A. N., & Henson, S. M. (2011) · Nature Reviews Immunology · doi:10.1038/nri2959 · Cited by 474 · cited 1× · see citing works
“Immunosenescence results in part from thymic involution as well as replicative senescence of some T cell populations (Akbar and Henson, 2011).”
Leventhal, J. R., Abecassis, M. M., Miller, J., Gallon, L. G., Ravindra, K. V., Tollerud, D. J., King, B. J., Elliott, M. J., Herzig, G. P., Herzig, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003509 · Cited by 462 · see citing works
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 445 · see citing works
Self-citationSalmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works
c-Myc regulates mammalian body size by controlling cell number but not cell size
Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434 · see citing works
AGEMAP: A Gene Expression Database for Aging in Mice
Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030201 · Cited by 431 · see citing works
Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
Garcı́a-Cao, I., Song, M. S., Hobbs, R. M., Laurent, G., Giorgi, C., de Boer, V. C. J., Anastasiou, D., Ito, K., Sasaki, A. T., Rameh, L. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.030 · Cited by 403 · see citing works
Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation
de Alborán, I. M., O’Hagan, R. C., Gärtner, F., Malynn, B. A., Davidson, L., Rickert, R. C., Rajewsky, K., DePinho, R. A., & Alt, F. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00088-7 · Cited by 398 · see citing works
Cho, R. H., Sieburg, H. B., & Muller-Sieburg, C. E. (2008) · Blood · doi:10.1182/blood-2007-11-123547 · Cited by 377 · see citing works
Rapamycin extends murine lifespan but has limited effects on aging
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67674 · Cited by 374 · see citing works
Metformin reduces endogenous reactive oxygen species and associated DNA damage
Algire, C., Moiseeva, O., Deschênes-Simard, X., Amrein, L., Petruccelli, L., Birman, E., Viollet, B., Ferbeyre, G., & Pollak, M. N. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0536 · Cited by 372 · see citing works
Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture.
Ecarot, B., Glorieux, F. H., REST, M. V. D., & Pereira, G. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.3.639 · Cited by 359 · see citing works
Pten positively regulates brown adipose function, energy expenditure, and longevity
Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.001 · Cited by 356 · see citing works
Life Extension in the Dwarf Mouse
Bartke, A., & Brown‐Borg, H. M. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63006-7 · Cited by 354 · see citing works
Wu, J., Liu, J., Chen, E. B., Wang, J., Cao, L., Narayan, N., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.030 · Cited by 328 · see citing works
Of mice and men: the benefits of caloric restriction, exercise, and mimetics
Mercken, E. M., Carboneau, B. A., Krzysik-Walker, S. M., & de Cabo, R. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.005 · Cited by 318 · see citing works
Lee, C., & Longo, V. D. (2011) · Oncogene · doi:10.1038/onc.2011.91 · Cited by 305 · see citing works
Conover, C. A., Bale, L. K., Overgaard, M. T., Johnstone, E. W., Laursen, U. H., Füchtbauer, E., Oxvig, C., & van Deursen, J. (2004) · Development · doi:10.1242/dev.00997 · Cited by 304 · see citing works
Ikeno, Y., Bronson, R. T., Hubbard, G. B., Lee, S., & Bartke, A. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.4.b291 · Cited by 298 · see citing works
Self-citationSomatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity
Bartke, A., Sun, L. Y., & Longo, V. D. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2012 · Cited by 286 · see citing works
T cell development and receptor diversity during aging
Goronzy, J. J., & Weyand, C. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.020 · Cited by 278 · see citing works
Automated home-cage behavioural phenotyping of mice
Jhuang, H., Garrote, E., Yu, X., Khilnani, V., Poggio, T., Steele, A. D., & Serre, T. (2010) · Nature Communications · doi:10.1038/ncomms1064 · Cited by 274 · see citing works
Self-citationNutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila
Teleman, A. A., Hietakangas, V., Sayadian, A.-C., & Cohen, S. M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.010 · Cited by 253 · see citing works
Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway
Xiao, H., Ma, X., Feng, W., Fu, Y., Lü, Z., Xu, M., Shen, Q., Zhu, Y., & Zhang, Y. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq066 · Cited by 231 · see citing works
Self-citationLanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.003 · Cited by 227 · see citing works
An aging Interventions Testing Program: study design and interim report
Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00311.x · Cited by 217 · see citing works
Self-citationNagy, A., Moens, C. B., Iványi, E., Pawling, J., Gertsenstein, M., Hadjantonakis, A., Pirity, M. K., & Rossant, J. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70254-4 · Cited by 198 · see citing works
Yang, H., Youm, Y.-H., & Dixit, V. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900562 · Cited by 196 · see citing works
Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 169 · see citing works
Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation
Vezeridis, P. S., Semeins, C. M., Chen, Q., & Klein‐Nulend, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.146 · Cited by 159 · see citing works
Deficits in Female Reproductive Function in GH-R-KO Mice; Role of IGF-I
Danilovich, N., Wernsing, D. R., Coschigano, K. T., Kopchick, J. J., & Bartke, A. (1999) · Endocrinology · doi:10.1210/endo.140.6.6992 · Cited by 156 · see citing works
Harper, J. M., Salmon, A. B., Leiser, S. F., Gałecki, A. T., & Miller, R. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00255.x · Cited by 156 · see citing works
Self-citationLoss of pregnancy‐associated plasma protein A extends lifespan in mice
Conover, C. A., & Bale, L. K. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00328.x · Cited by 154 · see citing works
Age‐associated increase in heterochromatic marks in murine and primate tissues
Kreiling, J. A., Tamamori‐Adachi, M., Sexton, A. N., Jeyapalan, J. C., Munoz‐Najar, U., Peterson, A. L., Manivannan, J., Rogers, E. S., Pchelintsev, N. A., Adams, P. D., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00666.x · Cited by 152 · see citing works
Self-citationDoes Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?
Bokov, A. F., Garg, N., Ikeno, Y., Thakur, S., Musi, N., DeFronzo, R. A., Zhang, N., Erickson, R. C., Gelfond, J., Hubbard, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026891 · Cited by 150 · see citing works
Self-citationAdditive regulation of hepatic gene expression by dwarfism and caloric restriction
Tsuchiya, T., Dhahbi, J. M., Cui, X., Mote, P. L., Bartke, A., & Spindler, S. R. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2004 · Cited by 148 · see citing works
Hamrick, M. W., Ding, K.-H., Ponnala, S., Ferrari, S. L., & Isales, C. M. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080213 · Cited by 143 · see citing works
Westbrook, R., Bonkowski, M. S., Strader, A. D., & Bartke, A. (2009) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gln075 · Cited by 143 · see citing works
Adult-onset, short-term dietary restriction reduces cell senescence in mice
Wang, C., Maddick, M., Miwa, S., Jurk, D., Czapiewski, R., Saretzki, G., Langie, S. A. S., Godschalk, R. W. L., Cameron, K., & von Zglinicki, T. (2010) · Aging · doi:10.18632/aging.100196 · Cited by 142 · see citing works
Sex- and age-specific differences in core body temperature of C57Bl/6 mice
Sanchez-Alavez, M., Alboni, S., & Conti, B. (2011) · AGE · doi:10.1007/s11357-010-9164-6 · Cited by 140 · see citing works
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal agingPreprint
Matheu, A., Pantoja, C., Efeyan, A., Criado, L. M., Martín‐Caballero, J., Flores, J. M., Klatt, P., & Serrano, M. (2004) · Genes & Development · doi:10.1101/gad.310304 · Cited by 137 · see citing works
Transcriptional Repression: The Dark Side of Myc
Herkert, B., & Eilers, M. (2010) · Genes & Cancer · doi:10.1177/1947601910379012 · Cited by 130 · see citing works
Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative FunctionPreprint
Jang, Y. C., Sinha, M., Cerletti, M., Dall’Osso, C., & Wagers, A. J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010652 · Cited by 127 · see citing works
Ward, W. F., Qi, W., Remmen, H. V., Zackert, W. E., Roberts, L. J., & Richardson, A. G. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.7.847 · Cited by 118 · see citing works
Self-citationMetabolic effects of intra‐abdominal fat in GHRKO mice
Masternak, M. M., Bartke, A., Wang, F., Spong, A., Gesing, A., Fang, Y., Salmon, A. B., Hughes, L. F., Liberati, T. A., Boparai, R. K., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00763.x · Cited by 108 · see citing works
Immunoaging induced by hematopoietic stem cell aging
Wang, J., Geiger, H., & Rudolph, K. L. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.004 · Cited by 107 · cited 2× · see citing works
“The PI3K and TOR pathways also contain feedback loops that can be affected by MYC, for example, acute deletion of Myc was found to impair TOR signaling during T cell activation (Wang et al., 2011b).”
Steinbaugh, M. J., Sun, L. Y., Bartke, A., & Miller, R. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00110.2012 · Cited by 104 · see citing works
Self-citationLifespan extension in genetically modified mice
Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00491.x · Cited by 101 · see citing works
Self-citationAdipocytokines and Lipid Levels in Ames Dwarf and Calorie-Restricted Mice
Wang, Z., Al-Regaiey, K., Masternak, M. M., & Bartke, A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.323 · Cited by 100 · see citing works
Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo
Miyoshi, H., Kato, K., Iwama, H., Maeda, E., Sakamoto, T., Fujita, K., Toyota, Y., Tani, J., Nomura, T., Mimura, S., et al. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2419 · Cited by 96 · see citing works
Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation
Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., & Holzenberger, M. (2013) · Aging Cell · doi:10.1111/acel.12145 · Cited by 93 · see citing works
Response of aged mice to primary virus infections
Murasko, D. M., & Jiang, J. K. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00273.x · Cited by 93 · see citing works
Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation
Dai, Y., Zheng, K., Clark, J., Swerdlow, R. H., Pulst, S. M., Sutton, J. P., Shinobu, L. A., & Simon, D. K. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt450 · Cited by 91 · see citing works
Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis
Ma, Z., Gibson, S. L., Byrne, M. A., Zhang, J., White, M. F., & Shaw, L. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01032-06 · Cited by 89 · see citing works
Metabolic characteristics of long-lived mice
Bartke, A., & Westbrook, R. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00288 · Cited by 88 · see citing works
Antagonism between FOXO and MYC Regulates Cellular Powerhouse
Peck, B., Ferber, E. C., & Schulze, A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00096 · Cited by 86 · see citing works
Tumor microenvironment: becoming sick of Myc
Whitfield, J. R., & Soucek, L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0860-x · Cited by 80 · see citing works
Kristan, D. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00345.x · Cited by 77 · see citing works
Nyegaard, M., Overgaard, M. T., Su, Y., Hamilton, A. E., Kwintkiewicz, J., Hsieh, M., Nayak, N. R., Conti, M., Conover, C. A., & Giudice, L. C. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.109.079517 · Cited by 76 · see citing works
Body Composition of Prolactin-, Growth Hormone-, and Thyrotropin-Deficient Ames Dwarf Mice
Heiman, M. L., Tinsley, F. C., Mattison, J. A., Hauck, S., & Bartke, A. (2003) · Endocrine · doi:10.1385/endo:20:1-2:149 · Cited by 70 · see citing works
Garcia, A. M., Busuttil, R. A., Calder, R. B., Dollé, M. E. T., Diaz, V., McMahan, C. A., Bartke, A., Nelson, J. F., Reddick, R. L., & Vijg, J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.013 · Cited by 70 · see citing works
Evolution of the holozoan ribosome biogenesis regulon
Brown, S. J., Cole, M. D., & Erives, A. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-442 · Cited by 70 · see citing works
Bonkowski, M. S., Pamenter, R. W., Rocha, J. S., Masternak, M. M., Panici, J. A., & Bartke, A. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.562 · Cited by 69 · see citing works
Harvey, A. E., Lashinger, L. M., Otto, G. M., Núñez, N. P., & Hursting, S. D. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21940 · Cited by 63 · see citing works
Cufí, S., Vázquez‐Martín, A., Oliveras‐Ferraros, C., Quirantes‐Piné, R., Segura‐Carretero, A., Micol, V., Joven, J., Bosch‐Barrera, J., Barco, S. D., Martı́n-Castillo, B., et al. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19665 · Cited by 60 · see citing works
PERK-ing up autophagy during MYC-induced tumorigenesis
Dey, S., Tameire, F., & Koumenis, C. (2013) · Autophagy · doi:10.4161/auto.23486 · Cited by 58 · see citing works
Wang, M., & Miller, R. A. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00833.x · Cited by 53 · see citing works
Self-citationExpression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice
Brown-Borg, H. M., Johnson, W. T., & Rakoczy, S. G. (2012) · AGE · doi:10.1007/s11357-011-9212-x · Cited by 52 · see citing works
mTOR Inhibition: From Aging to Autism and Beyond
Kaeberlein, M. R. (2013) · Scientifica · doi:10.1155/2013/849186 · Cited by 51 · see citing works
Kurki, E., Shi, J. P., Martonen, E., Finckenberg, P., & Mervaala, E. M. A. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-64 · Cited by 51 · see citing works
Myc-Dependent Genome Instability and Lifespan in Drosophila
Greer, C., Lee, M., Westerhof, M., Milholland, B., Spokony, R. F., Vijg, J., & Secombe, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074641 · Cited by 49 · see citing works
Spindler, S. R., & Dhahbi, J. M. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093743 · Cited by 49 · see citing works
Calorie restriction can reverse, as well as prevent, aging cardiomyopathy
Yan, L., Gao, S., Ho, D. W. T., Park, M., Ge, H., Wang, C., Tian, Y., Lai, L., Lorenzo, M. S. D., Vatner, D. E., et al. (2013) · AGE · doi:10.1007/s11357-012-9508-5 · Cited by 47 · see citing works
Müller, A., Zang, C., Chumduri, C., Dörken, B., Daniel, P. T., & Scholz, C. W. (2013) · International Journal of Cancer · doi:10.1002/ijc.28206 · Cited by 47 · see citing works
Arum, O., Rasche, Z. A., Rickman, D. J., & Bartke, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072255 · Cited by 38 · see citing works
Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Prevel, N., Allenbach, Y., Klatzmann, D., Salomon, B. L., & Benvéniste, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074450 · Cited by 36 · see citing works
Rodent Models of Aging Bone: An Update
Syed, F. A., & Melim, T. L. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0074-z · Cited by 27 · see citing works
Key Research Opportunities in Immune System Aging
Swain, S. L., & Nikolich‐Žugich, J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln068 · Cited by 26 · see citing works
Hsieh, C.-C., & Papaconstantinou, J. (2009) · Aging · doi:10.18632/aging.100077 · Cited by 24 · see citing works
Li, X., Bartke, A., Berryman, D. E., Funk, K. R., Kopchick, J. J., List, E. O., Sun, L. Y., & Miller, R. A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00304.2013 · Cited by 21 · see citing works
Self-citationBody weight is not always a good predictor of longevity in mice
Anisimov, V. N., Arbeev, K. G., Popovich, I. G., Zabezhinksi, M. A., Rosenfeld, S. V., Piskunova, T. S., Arbeeva, L. S., Semenchenko, A. V., & Yashin, A. I. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.12.007 · Cited by 16 · see citing works
Jeyapalan, J. C., & Sedivy, J. M. (2013) · Aging · doi:10.18632/aging.100536 · Cited by 11 · see citing works
Self-citationZheng, S., Liu, J., Han, Q., Huang, S., Su, W., Fu, J., Jia, X., Du, S., Zhou, Y., Zhang, X., et al. (2013) · Journal of Diabetes · doi:10.1111/1753-0407.12105 · Cited by 9 · see citing works
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Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,375 · see citing works
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Pietrocola, F., Galluzzi, L., Pedro, J. M. B., Madeo, F., & Kroemer, G. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.014 · Cited by 1,349 · see citing works
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,010 · see citing works
Reprogramming to recover youthful epigenetic information and restore vision
Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2975-4 · Cited by 820 · see citing works
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works
The interplay between cell signalling and the mevalonate pathway in cancer
Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works
Loss of epigenetic information as a cause of mammalian aging
Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.027 · Cited by 643 · see citing works
Self-citationThe Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Yu, C., & Xiao, J.-H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635460 · Cited by 537 · see citing works
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.03.003 · Cited by 431 · see citing works
“Even relatively small constitutive changes in MYC expression level (>2-fold relative to normal) have been demonstrated to have biological consequences and influence tumorigenesis (Bazarov et al., 2001; Hofmann et al., 2015; Murphy et al., 2008).”
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
Madden, S. K., de Araujo, A. D., Gerhardt, M., Fairlie, D. P., & Mason, J. M. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01291-6 · Cited by 404 · see citing works
Benayoun, B. A., Pollina, E. A., Singh, P. P., Mahmoudi, S., Harel, I., Casey, K. M., Dulken, B. W., Kundaje, A., & Brunet, A. (2019) · Genome Research · doi:10.1101/gr.240093.118 · Cited by 360 · see citing works
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation
Yang, Q., Du, W. W., Wu, N., Yang, W., Awan, F. M., Fang, L., Ma, J., Li, X., Zeng, Y., Yang, Z., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.86 · Cited by 329 · see citing works
Self-citationThe Genetics of Aging: A Vertebrate Perspective
Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell · doi:10.1016/j.cell.2019.02.038 · Cited by 259 · see citing works
Alternative approaches to target Myc for cancer treatment
Wang, C., Zhang, J., Yin, J., Gan, Y., Xu, S., Gu, Y., & Huang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00500-y · Cited by 243 · see citing works
Sarosiek, K. A., Fraser, C. S., Muthalagu, N., Bhola, P. D., Chang, W., McBrayer, S. K., Cantlon, A., Fisch, S., Golomb‐Mello, G., Ryan, J. A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.011 · Cited by 224 · see citing works
Self-citationImpaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Turi, Z., Lacey, M., Mistrík, M., & Moudrý, P. (2019) · Aging · doi:10.18632/aging.101922 · Cited by 209 · see citing works
Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works
Kulkarni, A. S., Brutsaert, E. F., Anghel, V., Zhang, K., Bloomgarden, N., Pollak, M., Mar, J. C., Hawkins, M., Crandall, J. P., & Barzilai, N. (2018) · Aging Cell · doi:10.1111/acel.12723 · Cited by 183 · see citing works
Characterization of the direct targets of<scp>FOXO</scp>transcription factors throughout evolution
Webb, A. E., Kundaje, A., & Brunet, A. (2016) · Aging Cell · doi:10.1111/acel.12479 · Cited by 182 · see citing works
Nucleolar Function in Lifespan Regulation
Tiku, V., & Antebi, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.007 · Cited by 179 · see citing works
Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis
Sundaram, K., Mu, J., Kumar, A., Behera, J., Lei, C., Sriwastva, M. K., Xu, F., Dryden, G. W., Zhang, L., Chen, S., et al. (2022) · Theranostics · doi:10.7150/thno.65427 · Cited by 180 · see citing works
Identification and Application of Gene Expression Signatures Associated with Lifespan Extension
Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.018 · Cited by 167 · see citing works
Self-citationJoseph, G. A., Wang, S. X., Jacobs, C. E., Zhou, W., Kimble, G. C., Tse, H. W., Eash, J. K., Shavlakadze, T., & Glass, D. J. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00141-19 · Cited by 161 · see citing works
The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
Guerra, B., Recio, C., Aranda-Tavío, H., Guerra-Rodríguez, M., García-Castellano, J. M., & Fernández‐Pérez, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626971 · Cited by 160 · see citing works
Dorronsoro, A., Santiago, F. E., Grassi, D., Zhang, T., Lai, R. C., McGowan, S. J., Angelini, L., Lavasani, M., Corbo, L., Lu, A., et al. (2021) · Aging Cell · doi:10.1111/acel.13337 · Cited by 153 · see citing works
Cellular reprogramming and epigenetic rejuvenation
Simpson, D. J., Olova, N. N., & Chandra, T. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01158-7 · Cited by 123 · see citing works
Zhang, P., Cao, L., Fan, P., Mei, Y., & Wu, M. (2016) · EMBO Reports · doi:10.15252/embr.201642067 · Cited by 125 · see citing works
Social stress shortens lifespan in mice
Razzoli, M., Nyuyki, K. D., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., et al. (2018) · Aging Cell · doi:10.1111/acel.12778 · Cited by 115 · see citing works
Aging is associated with a systemic length-associated transcriptome imbalance
Stoeger, T., Grant, R. A., McQuattie‐Pimentel, A. C., Anekalla, K. R., Liu, S. S., Navarro, H. T., Singer, B. D., Abdala‐Valencia, H., Schwake, M., Tétreault, M., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00317-6 · Cited by 120 · see citing works
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation
Daskalopoulos, E. P., Dufeys, C., Bertrand, L., Beauloye, C., & Horman, S. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.001 · Cited by 119 · see citing works
Single-cell analysis of the aging female mouse hypothalamus
Hajdarovic, K. H., Yu, D., Hassell, L.-A., Evans, S. A., Packer, S., Neretti, N., & Webb, A. E. (2022) · Nature Aging · doi:10.1038/s43587-022-00246-4 · Cited by 113 · see citing works
Self-citationMouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113 · see citing works
The Biology of Aging and Cancer
Zhang, X., Meng, X., Chen, Y., Leng, S. X., & Zhang, H. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000270 · Cited by 105 · see citing works
Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
Chen, P.-M., Wilson, P. C., Shyer, J. A., Veselits, M., Steach, H. R., Cui, C., Moeckel, G. W., Clark, M. R., & Craft, J. E. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay1620 · Cited by 102 · see citing works
MYC function and regulation in physiological perspective
Jha, R., Kouzine, F., & Levens, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268275 · Cited by 106 · see citing works
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal
Jose, L. H. S., Sunshine, M. J., Dillingham, C. H., Chua, B. A., Krutá, M., Hong, Y., Hatters, D. M., & Signer, R. A. J. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.003 · Cited by 102 · see citing works
The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
Mittal, N., Guimaraes, J. C., Gross, T., Schmidt, A., Viña‐Vilaseca, A., Nedialkova, D. D., Aeschimann, F., Leidel, S. A., Spang, A., & Zavolan, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00539-y · Cited by 100 · see citing works
Huang, Z., Whelan, C., Foley, N. M., Jebb, D., Touzalin, F., PETIT, E. J., Puechmaille, S. J., & Teeling, E. C. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0913-3 · Cited by 97 · see citing works
Paola Sebastiani, B., Federico, A. N., Morris, M. K., Gurinovich, A., Tanaka, T., Chandler, K. B., Andersen, S. L., Denis, G. V., Costello, C. E., Ferrucci, L., et al. (2019) · Aging Cell · doi:10.1111/acel.13290 · Cited by 95 · see citing works
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals
Nakamura, S., Karalay, Ö., Jäger, P. S., Horikawa, M., Klein, C., Nakamura, K., Latza, C., Templer, S. E., Dieterich, C., & Antebi, A. (2016) · Nature Communications · doi:10.1038/ncomms10944 · Cited by 90 · see citing works
RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system
Li, D., Meng, L., Xu, T., Su, Y., Liu, X., Zhang, Z., & Wang, X. (2017) · eLife · doi:10.7554/elife.27692 · Cited by 94 · see citing works
Towards a unified mechanistic theory of aging
Barja, G. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.016 · Cited by 88 · see citing works
Hong, H., Wang, Q., Li, J., Liu, H. B., Meng, X., & Zhang, H. (2019) · Journal of Cancer · doi:10.7150/jca.30723 · Cited by 89 · see citing works
Targeting the nucleolus as a therapeutic strategy in human disease
Corman, A., Sirozh, O., Lafarga, V., & Fernández-Capetillo, Ó. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.09.006 · Cited by 86 · see citing works
Zhao, Q., Assimopoulou, A. N., Klauck, S. M., Damianakos, H., Chinou, İ., Kretschmer, N., Rı́os, J.-L., Papageorgiou, V. P., Bauer, R., & Efferth, T. (2015) · Oncotarget · doi:10.18632/oncotarget.5380 · Cited by 85 · see citing works
The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases
Wanqing, S., Wang, Y., Yang, Z., & Quan, N. (2020) · Aging and Disease · doi:10.14336/ad.2019.0320 · Cited by 80 · see citing works
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives
Naeini, S. H., Mavaddatiyan, L., Kalkhoran, Z. R., Taherkhani, S., & Talkhabi, M. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112154 · Cited by 83 · see citing works
The Biology of Aging and Cancer: Frailty, Inflammation, and Immunity
Zhang, X., Meng, X., Chen, Y., Leng, S. X., & Zhang, H. (2017) · The Cancer Journal · doi:10.1097/00130404-201707000-00002 · Cited by 78 · see citing works
The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological Consequences
Willbanks, A. R., Leary, M., Greenshields, M., Tyminski, C., Heerboth, S., LAPINSKA, K., HASKINS, K. M., & Sarkar, S. (2016) · Genetics & Epigenetics · doi:10.4137/geg.s31863 · Cited by 75 · see citing works
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
Huang, F., Huffman, K. E., Wang, Z., Wang, X., Li, K., Cai, F., Yang, C., Cai, L., Shih, T. S., Zacharias, L. G., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci139929 · Cited by 72 · see citing works
The somatotropic axis and longevity in mice
Brown‐Borg, H. M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00262.2015 · Cited by 73 · see citing works
Ge, J., Yu, W., Li, J., Ma, H., Wang, P., Zhou, Y., Wang, Y., Zhang, J., & Shi, G. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01843-8 · Cited by 73 · see citing works
40 YEARS OF IGF1: IGF1 receptor and thyroid-associated ophthalmopathy
Mohyi, M., & Smith, T. J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0276 · Cited by 69 · see citing works
Health benefits of late-onset metformin treatment every other week in mice
Alfaras, I., Mitchell, S. J., Mora, H., Lugo, D. R., Warren, A., Navas-Enamorado, I., Hoffmann, V., Hine, C., Mitchell, J. R., Le Couteur, D. G., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0018-7 · Cited by 68 · see citing works
Zhao, X., Petrashen, A. P., Sanders, J. A., Peterson, A. L., & Sedivy, J. M. (2019) · Aging Cell · doi:10.1111/acel.12947 · Cited by 68 · see citing works
Self-citationAn isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
Shi, D., Han, T., Chu, X., Lu, H., Yang, X. Y., Zi, T., Zhao, Y., Wang, X., Liu, Z., Ruan, J., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.017 · Cited by 68 · see citing works
Ras signaling in aging and metabolic regulation
Slack, C. (2017) · Nutrition and Healthy Aging · doi:10.3233/nha-160021 · Cited by 64 · see citing works
Dominick, G., Bowman, J., Li, X., Miller, R. A., & Garcia, G. G. (2017) · Aging Cell · doi:10.1111/acel.12525 · Cited by 62 · see citing works
Self-citationLong-lived rodents reveal signatures of positive selection in genes associated with lifespan
Sahm, A., Bens, M., Szafranski, K., Holtze, S., Groth, M., Görlach, M., Calkhoven, C. F., Müller, C., Schwab, M. G., Kraus, J. M., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007272 · Cited by 62 · see citing works
Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenariansPreprint
Xiao, F., Chen, X., Yu, Q., Ye, Y., Liu, Y.-W., Yan, D., Yang, L., Chen, G., Lin, R., Yang, L., et al. (2018) · Genome Research · doi:10.1101/gr.220780.117 · Cited by 63 · see citing works
Lynn, M. A., Eden, G. L., Ryan, F. J., Bensalem, J., Wang, X., Blake, S. J., Choo, J. M., Tee, Y. C., Sribnaia, A., James, J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109564 · Cited by 61 · see citing works
The role of the ribosome in the regulation of longevity and lifespan extension
MacInnes, A. W. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1325 · Cited by 61 · see citing works
Tanaka, H., Takebayashi, S., Sakamoto, A., Igata, T., Nakatsu, Y., Saitoh, N., Hino, S., & Nakao, M. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.021 · Cited by 61 · see citing works
Dave, K., Sur, I., Yan, J., Zhang, J., Kaasinen, E., Zhong, F., Blaas, L., Li, X., Kharazi, S., Gustafsson, C., et al. (2017) · eLife · doi:10.7554/elife.23382 · Cited by 60 · see citing works
Self-citationIn vivo Reprogramming of Cancer Metabolism by MYC
Camarda, R., Williams, J. R., & Goga, A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00035 · Cited by 56 · see citing works
Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx249 · Cited by 59 · see citing works
The complex activities of the SET1/MLL complex core subunits in development and disease
Jiang, H. (2020) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2020.194560 · Cited by 58 · see citing works
Wang, H., Lu, J. L., Edmunds, L. R., Kulkarni, S., Dolezal, J. M., Tao, J., Ranganathan, S., Jackson, L. E., Fromherz, M., Beer–Stolz, D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.754218 · Cited by 58 · see citing works
Liu, S., Kim, T.-H., Franklin, D. A., & Zhang, Y. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.086 · Cited by 55 · see citing works
Self-citationSIRT6 Overexpression Improves Various Aspects of Mouse Healthspan
Roichman, A., Kanfi, Y., Glazz, R., Naiman, S., Amit, U., Landa, N., Tinman, S., Stein, I., Pikarsky, E., Leor, J., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw152 · Cited by 55 · see citing works
What have we learned on aging from omics studies?
Cellerino, A., & Ori, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.06.012 · Cited by 56 · see citing works
Bhawe, K. M., & Roy, D. (2018) · Cellular Oncology · doi:10.1007/s13402-018-0395-3 · Cited by 57 · see citing works
Intestinal MYC modulates obesity-related metabolic dysfunction
Luo, Y., Yang, S., Wu, X., Takahashi, S., Sun, L., Cai, J., Krausz, K. W., Guo, X., Dias, H. B., Gavrilova, O., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00421-8 · Cited by 55 · see citing works
Sirt6 regulates lifespan in Drosophila melanogaster
Taylor, J. R., Wood, J. G., Mizerak, E., Hinthorn, S. J., Liu, J., Finn, M., Gordon, S., Zingas, L., Chang, C.-Y., Klein, M. A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111176119 · Cited by 54 · see citing works
Self-citationAntiaging Strategies and Remedies: A Landscape of Research Progress and Promise
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00532 · Cited by 59 · see citing works
Kim, T., Cui, R., Jeon, Y.-J., Fadda, P., Alder, H., & Croce, C. M. (2015) · Oncotarget · doi:10.18632/oncotarget.3909 · Cited by 55 · see citing works
Akagi, K., Wilson, K. A., Katewa, S. D., Ortega, M., Simons, J., Hilsabeck, T. A. U., Kapuria, S., Sharma, A., Jasper, H., & Kapahi, P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007777 · Cited by 55 · see citing works
Increased Arf/p53 activity in stem cells, aging and cancer
Carrasco‐García, E., Moreno, M., Moreno‐Cugnon, L., & Matheu, A. (2017) · Aging Cell · doi:10.1111/acel.12574 · Cited by 51 · see citing works
Genes and Longevity of Lifespan
Bin-Jumah, M. N., Nadeem, M. S., Gilani, S. J., Al-Abbasi, F. A., Ullah, I., Alzarea, S. I., Ghoneim, M. M., Alshehri, S., Ud-Din, A., Murtaza, B. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031499 · Cited by 50 · see citing works
Ganci, F., Pulito, C., Valsoni, S., Sacconi, A., Turco, C., Vahabi, M., Manciocco, V., Mazza, E. M. C., Meens, J., Karamboulas, C., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2485 · Cited by 51 · see citing works
Biological Functions of Plasmalogens
Hossain, M. S., Mawatari, S., & Fujino, T. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-60204-8_13 · Cited by 50 · see citing works
Jones, R. G., Dimet‐Wiley, A., Haghani, A., da Silva, F. M., Brightwell, C. R., Lim, S., Khadgi, S., Wen, Y., Dungan, C. M., Brooke, R. T., et al. (2022) · The Journal of Physiology · doi:10.1113/jp283836 · Cited by 47 · see citing works
Ferrand, M., Kirsh, O., Griveau, A., Vindrieux, D., Martin, N., Defossez, P., & Bernard, D. (2015) · Aging · doi:10.18632/aging.100845 · Cited by 49 · see citing works
Cheng, W., Li, M., Zhang, L., Zhou, C., Yu, S., Peng, X., Zhang, W., & Zhang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.973116 · Cited by 47 · see citing works
Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice
Ozkurede, U., Kala, R., Johnson, C., Shen, Z., Miller, R. A., & Garcia, G. G. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0021 · Cited by 45 · see citing works
Self-citationLoss of Epigenetic Information as a Cause of Mammalian AgingPreprint
Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Blanchette, M., Munding, E. M., Bhakta, M. S., Salfati, E., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3951490 · Cited by 45 · see citing works
Self-citationMYC—an emerging player in mitochondrial diseases
Purhonen, J., Klefström, J. T., & Kallijärvi, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1257651 · Cited by 40 · see citing works
Reprogramming neurons for regeneration: The fountain of youth
Yang, S., Wang, X., Qian, C., & Zhou, F. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102284 · Cited by 39 · see citing works
Fischer, F., Grigolon, G., Benner, C., & Ristow, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00017.2021 · Cited by 41 · see citing works
Marthandan, S., Menzel, U., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., Kaether, C., & Diekmann, S. (2016) · Biological Research · doi:10.1186/s40659-016-0095-2 · Cited by 39 · see citing works
Jung, M., Jin, S., Zhang, X., Xiong, W., Gogoshin, G., Rodin, A. S., & Pfeifer, G. P. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv473 · Cited by 39 · see citing works
Franzin, R., Stasi, A., Ranieri, E., Netti, G. S., Cantaluppi, V., Gesualdo, L., Stallone, G., & Castellano, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.630419 · Cited by 40 · see citing works
Abnormal lipid processing but normal long-term repopulation potential of myc−/− hepatocytes
Edmunds, L. R., Otero, P. A., Sharma, L., D'Souza, S. S., Dolezal, J. M., David, S., Lu, J. L., Lamm, L., Basantani, M. K., Zhang, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8856 · Cited by 39 · see citing works
Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity
Martínez-Corrales, G., Filer, D., Wenz, K. C., Rogan, A., Phillips, G., Li, M., Feseha, Y., Broughton, S. J., & Alic, N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.017 · Cited by 38 · see citing works
Endicott, S. J., Boynton, D. N., Beckmann, L. J., & Miller, R. A. (2020) · Autophagy · doi:10.1080/15548627.2020.1725378 · Cited by 38 · see citing works
Self-citationMYC, Metabolic Synthetic Lethality, and Cancer
Hsieh, A. L., & Dang, C. V. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_4 · Cited by 36 · see citing works
Rosselot, C., Kumar, A., Lakshmipathi, J., Zhang, P., Lu, G., Katz, L. S., Prochownik, E. V., Stewart, A. F., Lambertini, L., Scott, D. K., et al. (2019) · Diabetes · doi:10.2337/db18-1368 · Cited by 36 · see citing works
Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis
Brightwell, C. R., Kulkarni, A. S., Paredes, W. M., Zhang, K., Perkins, J. B., Gatlin, K. J., Custodio, M. J., Farooq, H., Zaidi, B., Pai, R. N., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150112 · Cited by 35 · see citing works
Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2
Li, R., Zhou, H., Jia, C., Jin, P., & Ma, F. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008989 · Cited by 35 · see citing works
Madonna, M. C., Duer, J. E., Lee, J. V., Williams, J. R., Avşaroğlu, B., Zhu, C., Deutsch, R. J., Wang, R., Crouch, B. T., Hirschey, M. D., et al. (2021) · Cancers · doi:10.3390/cancers13010148 · Cited by 35 · see citing works
- Authors
- Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., Li, X., Serre, T., Qi, W., Van Remmen, H., Miller, R. A., Bath, K. G., de Cabo, R., Xu, H., Neretti, N., & Sedivy, J. M.
- Affiliations
- Brown University (US)
- The University of Texas at San Antonio Health Science Center (US)
- National Institute on Aging (US)
- University of Michigan (US)
- Corresponding author
- Sedivy, John M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 3
- Pages
- 477-488
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4624921
- OpenAlex
- W2019755675
- Cited by
- 293
- References
- 118
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 23 · 2023: 35 · 2022: 30 · 2021: 34 · 2020: 38 · 2019: 24 · 2018: 17 · 2017: 24 · 2016: 21 · 2015: 14
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX002595)
- National Institutes of Health (1s10od016366-01, 5p42es013660-14)
- National Institute on Aging (R37AG016694, P01AG031736, F30AG035592, R01AG016694, P30AG024824, U01AG022303)
- National Institute of General Medical Sciences (P30GM103410)
- National Institute of Environmental Health Sciences (P42ES013660),)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- c-Myc, haploinsufficiency, longevity, healthspan, aging, ribosome biogenesis, mRNA translation, insulin-like growth factor I, AMPK, TOR signaling, S6K, immunosenescence, myocardial fibrosis, osteoporosis, lipid metabolism, metabolic rate, energy sensing
- MeSH terms
- Aging, Animals, Female, Longevity, Lymphoma, Male, Mice, Inbred C57BL, Proto-Oncogene Proteins c-myc, Body Size, Mice, Metabolic Networks and Pathways, Mice, 129 Strain, Transcriptome
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