The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
New Horizons for Precision Medicine in Biliary Tract Cancers
Open accessAbstract
Biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, are poor-prognosis and low-incidence cancers, although the incidence of intrahepatic cholangiocarcinoma is rising. A minority of patients present with resectable disease but relapse rates are high; benefit from adjuvant capecitabine chemotherapy has been demonstrated. Cisplatin/gemcitabine combination chemotherapy has emerged as the reference first-line treatment regimen; there is no standard second-line therapy. Selected patients may be suitable for liver-directed therapy (e.g., radioembolization or external beam radiation), pending confirmation of benefit in randomized studies. Initial trials targeting the epithelial growth factor receptor and angiogenesis pathways have failed to deliver new treatments. Emerging data from next-generation sequencing analyses have identified actionable mutations (e.g., FGFR fusion rearrangements and IDH1 and IDH2 mutations), with several targeted drugs entering clinical development with encouraging results. The role of systemic therapies, including targeted therapies and immunotherapy for BTC, is rapidly evolving and is the subject of this review. Significance: The authors address genetic drivers and molecular biology from a translational perspective, in an intent to offer a clear view of the recent past, present, and future of BTC. The review describes a state-of-the-art update of the current status and future directions of research and therapy in advanced BTC. Cancer Discov; 7(9); 943–62. ©2017 AACR.
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Cites
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BackgroundVemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations
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BackgroundFrequent mutation of histone-modifying genes in non-Hodgkin lymphoma
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Cited by
Piha‐Paul, S. A., Oh, D., Ueno, M., Malka, D., Chung, H. C., Nagrial, A., Kelley, R. K., Ros, W., Italiano, A., Nakagawa, K., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33013 · Cited by 486
Systemic therapies for intrahepatic cholangiocarcinoma
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Self-citationAssociation Between Aspirin Use and Biliary Tract Cancer Survival
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Metadata
- Authors
- Valle, J. W., Lamarca, A., Goyal, L., Barriuso, J., & Zhu, A. X.
- Venue
- Cancer Discovery
- Published
- 2017-08-31
- Volume
- 7
- Issue
- 9
- Pages
- 943-962
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2745824859
- Cited by
- 626
- References
- 12
- FWCI
- 41.94
- Type
- journal article
- Language
- en
- Open access
- green
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