Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy

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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

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B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

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Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity

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Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies

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Stress and cancer: mechanisms, significance and future directions

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β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

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The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion

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Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

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Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

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Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

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Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies

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Perioperative COX-2 and β-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial

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Tumor Neurobiology and the War of Nerves in Cancer

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Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2

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Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

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Surgery and stress promote cancer metastasis: New outlooks on perioperative mediating mechanisms and immune involvement

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Neurotransmitters: emerging targets in cancer

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Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial

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Molecular Mechanisms Underlying β-Adrenergic Receptor-Mediated Cross-Talk between Sympathetic Neurons and Immune Cells

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Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

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Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial

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β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

Qiao, G., Bucsek, M. J., Winder, N. M., Chen, M., Giridharan, T., Olejniczak, S. H., Hylander, B. L., & Repasky, E. A. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2243-8 · Cited by 209 · see citing works

Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications

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Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

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The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

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Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

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Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment

Qiao, G., Chen, M., Mohammadpour, H., MacDonald, C. R., Bucsek, M. J., Hylander, B. L., Barbi, J. J., & Repasky, E. A. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0445 · Cited by 179 · see citing works

Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo

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Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options

Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 164 · see citing works

Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

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Utilizing chemokines in cancer immunotherapy

Märkl, F., Huynh, D., Endres, S., & Kobold, S. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.04.001 · Cited by 157 · see citing works

Cancer and stress: NextGen strategies

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Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Liu, D., Li, L., Fan, Y., Poteete, A., Lim, S.-O., Howells, K., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aao4307 · Cited by 146 · see citing works

Chronic psychological stress promotes lung metastatic colonization of circulating breast cancer cells by decorating a pre‐metastatic niche through activating β‐adrenergic signaling

Chen, H., Liu, D., Guo, L., Cheng, X., Guo, N., & Shi, M. (2017) · The Journal of Pathology · doi:10.1002/path.4988 · Cited by 143 · see citing works

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

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Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis

Kruk, J., Aboul-Enein, B. H., Bernstein, J., & Gronostaj, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1270397 · Cited by 140 · see citing works

Chronic stress increases experimental pancreatic cancer growth, reduces survival and can be antagonised by beta-adrenergic receptor blockade

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The neural addiction of cancer

Magnon, C., & Hondermarck, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00556-8 · Cited by 126 · see citing works

β-Adrenergic Signaling Impairs Antitumor CD8+ T-cell Responses to B-cell Lymphoma Immunotherapy

Nissen, M. D., Sloan, E. K., & Mattarollo, S. R. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0401 · Cited by 125 · see citing works

Perioperative COX2 and β‐adrenergic blockade improves biomarkers of tumor metastasis, immunity, and inflammation in colorectal cancer: A randomized controlled trial

Haldar, R., Ricon‐Becker, I., Radin, A., Gutman, M., Cole, S. W., Zmora, O., & Ben‐Eliyahu, S. (2020) · Cancer · doi:10.1002/cncr.32950 · Cited by 122 · see citing works

Functional neuronal circuits promote disease progression in cancer

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Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells

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Sensory Neurotransmitter Calcitonin Gene‐Related Peptide Modulates Tumor Growth and Lymphocyte Infiltration in Oral Squamous Cell Carcinoma

McIlvried, L. A., Atherton, M. A., Horan, N. L., Goch, T. N., & Scheff, N. N. (2022) · Advanced Biology · doi:10.1002/adbi.202200019 · Cited by 116 · see citing works

Neurobiology of Cancer: The Role of β-Adrenergic Receptor Signaling in Various Tumor Environments

Mravec, B., Horváthová, Ľ., & Hunáková, Ľ. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217958 · Cited by 114 · see citing works

Sympathetic and parasympathetic innervation in cancer: therapeutic implications

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Blockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy

Daher, C., Vimeux, L., Stoeva, R., Peranzoni, E., Bismuth, G., Wieduwild, É., Lucas, B., Donnadieu, E., Bercovici, N., Trautmann, A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0833 · Cited by 108 · see citing works

Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression

Radford‐Smith, D. E., & Anthony, D. C. (2023) · Nutrients · doi:10.3390/nu15081880 · Cited by 108 · see citing works

Depression-Induced Neuropeptide Y Secretion Promotes Prostate Cancer Growth by Recruiting Myeloid Cells

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Harnessing cancer immunotherapy during the unexploited immediate perioperative period

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Tumour innervation and neurosignalling in prostate cancer

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Novel strategies for cancer immunotherapy: counter-immunoediting therapy

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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer

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Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1

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Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation

Chen, M., Qiao, G., Hylander, B. L., Mohammadpour, H., Wang, X., Subjeck, J. R., Singh, A. K., & Repasky, E. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15676-0 · Cited by 95 · see citing works

Interplay between stress and cancer—A focus on inflammation

Vignjević, S., Milošević, M. S., Marković, D. C., & Momčilović, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1119095 · Cited by 95 · see citing works

Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment.

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Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments

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Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages

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Perioperative inhibition of β-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome

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