The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Therapeutic Targeting of the Tumor Microenvironment
Abstract
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of-care therapies. Here, we summarize the current knowledge regarding the most advanced TME-directed therapies, which have either been clinically approved or are currently being evaluated in trials, including immunotherapies, antiangiogenic drugs, and treatments directed against cancer-associated fibroblasts and the extracellular matrix. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field. Significance: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
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Cites
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Cited by
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Self-citationNotch signaling pathway: architecture, disease, and therapeutics
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Lactate and lactylation in cancer
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Metadata
- Authors
- Bejarano, L., Jordāo, M. J. C., & Joyce, J. A.
- Venue
- Cancer Discovery
- Published
- 2021-04-01
- Volume
- 11
- Issue
- 4
- Pages
- 933-959
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W3144992645
- Cited by
- 1,653
- References
- 76
- FWCI
- 84.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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