Angiogenesis in endometriosis
Abstract
We evaluated angiogenesis in eutopic endometrium and ectopic endometrium from patients with endometriosis. Microvessels were identified by immunohistochemistry using anti-von-Willebrand factor antibody and vascular parameters were measured using a computerized image analysis system. No relationship was observed between vascular density and type of endometriotic lesion. Heterogeneity in vascular density was observed in different lesions within the same patient. Between red and black peritoneal lesions a significant difference was observed in the frequency distribution of luminal diameter. In black lesions the variability of luminal diameter was decreased and most microvessels were less than 20 mm in diameter. We suggest that the frequency distribution of microvessel luminal diameter of red and black peritoneal lesions may be different and should be important when studying the regulation of angiogenesis in endometriotic implants.
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Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.
“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [77]
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- Authors
- Matsuzaki, S., Canis, M., Darcha, C., Dechelotte, P., Pouly, J. L., & Bruhat, M. A.
- Affiliations
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Venue
- Gynecologic and Obstetric Investigation
- Publisher
- S. Karger AG
- Published
- 1998
- Volume
- 46
- Issue
- 2
- Pages
- 111-115
- ISSN
- 0378-7346 (ISSN-L)
- 1423-002X
- OpenAlex
- W1999876247
- Cited by
- 43
- References
- 24
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecologic and Obstetric Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endometriosis, angiogenesis, microvessel density, eutopic endometrium, ectopic endometrium, von Willebrand factor, vascular heterogeneity
- MeSH terms
- Adult, Endometriosis, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Middle Aged, Neovascularization, Pathologic
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