Cited by 43Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementAngiogenesis and VEGF in Cancer

Angiogenesis in endometriosis

Matsuzaki, S., Canis, M., Darcha, C., Dechelotte, P., Pouly, J.L., Bruhat, M.A.·1998·Gynecologic and Obstetric Investigation

Abstract

We evaluated angiogenesis in eutopic endometrium and ectopic endometrium from patients with endometriosis. Microvessels were identified by immunohistochemistry using anti-von-Willebrand factor antibody and vascular parameters were measured using a computerized image analysis system. No relationship was observed between vascular density and type of endometriotic lesion. Heterogeneity in vascular density was observed in different lesions within the same patient. Between red and black peritoneal lesions a significant difference was observed in the frequency distribution of luminal diameter. In black lesions the variability of luminal diameter was decreased and most microvessels were less than 20 mm in diameter. We suggest that the frequency distribution of microvessel luminal diameter of red and black peritoneal lesions may be different and should be important when studying the regulation of angiogenesis in endometriotic implants.

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Crossref · 10.1159/000010013

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  • Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.

    “Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [77]

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Authors
Matsuzaki, S., Canis, M., Darcha, C., Dechelotte, P., Pouly, J. L., & Bruhat, M. A.
Affiliations
Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Venue
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Published
1998
Volume
46
Issue
2
Pages
111-115
ISSN
  • 0378-7346 (ISSN-L)
  • 1423-002X
OpenAlex
W1999876247
Cited by
43
References
24
Citations by year
2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 4
FWCI
5.42
Type
journal article
Language
en
Open access
closed
Locations
  • Gynecologic and Obstetric Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
endometriosis, angiogenesis, microvessel density, eutopic endometrium, ectopic endometrium, von Willebrand factor, vascular heterogeneity
MeSH terms
Adult, Endometriosis, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Middle Aged, Neovascularization, Pathologic

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