Cited by 100Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Implantation versus infiltration: the Sampson versus the endometriotic disease theory

Koninckx, P.R., Barlow, D., Kennedy, S.·1999·Gynecologic and Obstetric Investigation

Abstract

It has been assumed that endometriosis is a progressive disease, with growth and development of lesions being inevitable once the disease has started. The implantation and the metaplasia theories describe the mechanism of initiation of endometriotic lesions, but do not explain the different clinical manifestations of endometriosis. To explain the variable expression, growth and development of lesions into severe disease, a new endometriotic disease theory is proposed. This theory suggests that progression of endometriosis to endometriotic disease is considered similar to the onset and progression of a benign tumour. In this theory, the most important factor in the development of endometriotic disease is not the initial implantation/metaplasia, but cellular changes such as mutations. According to this theory, endometriotic disease develops from endometriotic cells that have 'escaped' the influence of protective and regulatory factors in the peritoneal fluid.

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Crossref · 10.1159/000052853

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81 of 81 references verified0 citation errors · 0 not checkable

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  • The endometriotic disease theory postulated that genetic incidents are required for the development of typical, cystic, or deep endometriosis.

    “The endometriotic disease theory (EDT) postulated (246) that genetic incidents are required for the development of typical, cystic, or deep endometriosis.”

    From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [246]

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Authors
Koninckx, P. R., Barlow, D., & Kennedy, S.
Affiliations
John Radcliffe Hospital (GB)
Venue
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Published
1999
Volume
47
Issue
Suppl. 1
Pages
3-10
ISSN
  • 0378-7346 (ISSN-L)
  • 1423-002X
OpenAlex
W2017568708
Cited by
100
References
81
Citations by year
2026: 4 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 6
FWCI
3.42
Type
journal article
Language
en
Open access
closed
Locations
  • Gynecologic and Obstetric Investigation (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ipsen
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, disease progression, peritoneal fluid
MeSH terms
Animals, Endometriosis, Extracellular Space, Female, Humans, Menstruation Disturbances, Metaplasia, Peritoneum

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