Cited by 182Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Angiogenic activity of peritoneal fluid from women with endometriosis

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Oosterlynck, Didier J., Meuleman, Christel, Sobis, Halina, Vandeputte, Michel, Koninckx, Philippe R.·1993·Fertility and Sterility

Abstract

Objective To investigate the presence of angiogenic factors in peritoneal fluid (PF) and follicular fluid (FF).Design The PF samples of 48 women with (n = 24) or without (n = 24) endometriosis were investigated. Angiogenesis was assayed using the chorioallantoic membrane of 11-day-old fertilized chicken embryos. Glass fiber prefilters impregnated with the fluids were placed on the chorioallantoic membrane.Main outcome measure The vascular reaction was analyzed by an independent observer after 72 hours.Results There was a positive reaction in 58.3% of the PF from women with endometriosis and in 12.5% of the women without endometriosis. No correlation was found between the angiogenic response and the severity of endometriosis. The reaction remained after charcoal treatment of the PF. Positive reaction was found in three of six FF samples.Conclusion The PF of women with endometriosis contain more angiogenic factors than PF from women without endometriosis. This angiogenic activity could be important for the further outgrowth and progression of the lesions.

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Crossref · 10.1016/s0015-0282(16)55859-2

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  • Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.

    “Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”

    From Pathogenesis of deep endometriosis (2017) · cites this paper as [73]

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Authors
Oosterlynck, D. J., Meuleman, C., Sobis, H., Vandeputte, M., & Koninckx, P. R.
Affiliations
Rega Institute for Medical Research (BE)
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1993-04
Volume
59
Issue
4
Pages
778-782
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2404389558
Cited by
182
References
21
Citations by year
2025: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 6
FWCI
6.24
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, angiogenic factors, peritoneal fluid, follicular fluid, angiogenesis, chorioallantoic membrane assay, endometriosis progression
MeSH terms
Animals, Ascitic Fluid, Biological Assay, Chick Embryo, Endometriosis, Female, Humans, Killer Cells, Natural, Angiogenesis Inducing Agents

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