Angiogenic activity of peritoneal fluid from women with endometriosis
Open accessAbstract
Objective To investigate the presence of angiogenic factors in peritoneal fluid (PF) and follicular fluid (FF).Design The PF samples of 48 women with (n = 24) or without (n = 24) endometriosis were investigated. Angiogenesis was assayed using the chorioallantoic membrane of 11-day-old fertilized chicken embryos. Glass fiber prefilters impregnated with the fluids were placed on the chorioallantoic membrane.Main outcome measure The vascular reaction was analyzed by an independent observer after 72 hours.Results There was a positive reaction in 58.3% of the PF from women with endometriosis and in 12.5% of the women without endometriosis. No correlation was found between the angiogenic response and the severity of endometriosis. The reaction remained after charcoal treatment of the PF. Positive reaction was found in three of six FF samples.Conclusion The PF of women with endometriosis contain more angiogenic factors than PF from women without endometriosis. This angiogenic activity could be important for the further outgrowth and progression of the lesions.
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Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.
“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [73]
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Peritoneal Growth Factors and Endometriosis
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Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis
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The Impact of Endometriosis on Fertility
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Endometrial Perivascular Progenitor Cells and Uterus Regeneration
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Peritoneal endometriotic lesions differentially express a haptoglobin-like gene*
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Self-citation
- Authors
- Oosterlynck, D. J., Meuleman, C., Sobis, H., Vandeputte, M., & Koninckx, P. R.
- Affiliations
- Rega Institute for Medical Research (BE)
- ORCID
- Meuleman, Christel
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1993-04
- Volume
- 59
- Issue
- 4
- Pages
- 778-782
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2404389558
- Cited by
- 182
- References
- 21
- Citations by year
- 2025: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, angiogenic factors, peritoneal fluid, follicular fluid, angiogenesis, chorioallantoic membrane assay, endometriosis progression
- MeSH terms
- Animals, Ascitic Fluid, Biological Assay, Chick Embryo, Endometriosis, Female, Humans, Killer Cells, Natural, Angiogenesis Inducing Agents
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