The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Localized in vivo 13C-NMR of Glutamate Metabolism in the Human Brain: Initial Results at 4 Tesla
Open accessAbstract
Using optimized administration of 13 C-labeled glucose, the time course of the specific activity of glucose was measured directly by in vivo 13 C-NMR in the human brain at 4 Tesla. Subsequent label incorporation was measured at the C2, C3 and C4 positions of both glutamate and the well-resolved C2, C3 and C4 resonances of glutamine and at the C2 and C3 positions of aspartate. GABA was clearly observed for the first time in vivo, suggesting a substantial GABA turnover in the normal human visual cortex. Likewise, lactate C3 labeled with an estimated active pool size on the order of 0.5 m M. A model of cerebral glutamate metabolism is proposed which predicts that glutamatergic action (‘neurotransmission’), pyruvate carboxylase flux, TCA cycle activity, glucose consumption and exchange across the mitochondrial membrane can be assessed simultaneously in the human brain.
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Cites
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
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Self-citationEnergetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590
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Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR
Shen, J., Petersen, K. F., Behar, K. L., Brown, P., Nixon, T. W., Mason, G. F., Petroff, O. A. C., Shulman, G. I., Shulman, R. G., & Rothman, D. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8235 · Cited by 462
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408
Metadata
- Authors
- Gruetter, R., Seaquist, E. R., Kim, S., & Ugurbil, K.
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 1998
- Volume
- 20
- Issue
- 4-5
- Pages
- 380-388
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W2121587775
- Cited by
- 194
- References
- 1
- FWCI
- 17.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gruetter, R., Seaquist, E. R., Kim, S., & Ugurbil, K. (1998). Localized in vivo 13C-NMR of Glutamate Metabolism in the Human Brain: Initial Results at 4 Tesla. Developmental Neuroscience. https://doi.org/10.1159/000017334
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