The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Acute-on-Chronic Liver Failure: Pathophysiological Basis of Therapeutic Options
Abstract
The vast majority of patients that are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute-on-chronic liver failure remains poorly defined. With the emergence of newer liver support strategies, it has become necessary to define this entity, its pathophysiology and the short- and long-term prognosis. This review focusses upon how a precipitant such as an episode of gastrointestinal bleeding or sepsis may start a cascade of events that culminate in end-organ dysfunction and liver failure. We briefly review the pathophysiological basis of the therapeutic modalities that are available. Our current strategy for the management of liver failure involves supportive therapy for the end-organs with the hope that liver function would recover if sufficient time for such a recovery is allowed. Because liver failure, whether of the acute or acute-on-chronic variety, is potentially reversible, the stage is set for the application of newer liver-support strategies to enhance the recovery process.
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Cites
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Cited by
Sarin, S. K., Kedarisetty, C. K., Abbas, Z., Amarapurkar, D., Bihari, C., Chan, A. C. Y., Chawla, Y. K., Dokmeci, A. K., Garg, H., Ghazinyan, H., et al. (2014) · Hepatology International · doi:10.1007/s12072-014-9580-2 · Cited by 1,481
Acute-on-Chronic Liver Failure
Arroyo, V., Moreau, R., & Jalan, R. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1914900 · Cited by 650
Self-citationWu, T., Li, J., Shao, L., Xin, J., Jiang, L., Zhou, Q., Shi, D., Jiang, J., Sun, S., Jin, L., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314641 · Cited by 437
Mookerjee, R. P., Pavesi, M., Thomsen, K. L., Mehta, G., Macnaughtan, J., Bendtsen, F., Coenraad, M., Sperl, J., Gines, P., Moreau, R., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.018 · Cited by 248
Self-citationBeyond scoring: a modern interpretation of disease progression in chronic liver disease
Rosselli, M., MacNaughtan, J., Jalan, R., & Pinzani, M. (2013) · Gut · doi:10.1136/gutjnl-2012-302826 · Cited by 96
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Metadata
- Authors
- Jalan, R., & Williams, R.
- Venue
- Blood Purification
- Publisher
- S. Karger AG
- Published
- 2002
- Volume
- 20
- Issue
- 3
- Pages
- 252-261
- ISSN
- 0253-5068 (ISSN-L)
- 1421-9735
- OpenAlex
- W2088488647
- Cited by
- 286
- References
- 63
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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