Up-regulation of vasopressin and angiotensin II receptors in the thalamus and brainstem of inbred polydipsic mice
Abstract
Vasopressin (AVP), angiotensin II (Ang II) and oxytocin (OT) receptors were mapped in the brain of inbred polydipsic mice of the STR/N strain by quantitative in vitro autoradiography and receptor binding levels, compared with those found in control non-polydipsic mice of the ICR strain. A remarkable difference was evidenced in the thalamic paraventricular nucleus where AVP receptor binding was 7- to 10-fold higher in polydipsic mice than in control mice. Another disparity was observed in the hypothalamic paraventricular nucleus, which contained AVP binding sites in the control mice, but was unlabelled in the polydipsic animals. Ang II receptor binding was reduced in the hypothalamic paraventricular nucleus of the polydipsic mice, whereas it was abundant in the brainstem region, encompassing area postrema and the nucleus of the solitary tract. The distribution and amount of OT receptor binding were similar in the polydipsic and control mice. Strain-related differences of AVP and Ang II receptor binding were observed both in male and female animals. A sex-related difference was seen only for OT receptor binding in the hypothalamic ventromedial nucleus, where labelling was less intense in males than in females of both strains. Altogether, our results support the view that central AVP and Ang II systems are involved in the mechanisms responsible for polydipsia in STR/N mice.
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ICR mice showed no sex differences in V1aR binding in all regions analyzed.
“In ICR mice, using the 125I linear V1aR antagonist, males (n=6) and females (n=6) showed a lack of sex differences in all regions analyzed”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Tribollet et al., 2002
Other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions.
“other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Tribollet et al., 2002
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- Authors
- Tribollet, E., Ueta, Y., Heitz, F., Marguerat, A., Koizumi, K., & Yamashita, H.
- Affiliations
- University of Geneva (CH)
- University of Occupational and Environmental Health Japan (JP)
- State University of New York (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2002
- Volume
- 75
- Issue
- 2
- Pages
- 113-123
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2047204382
- Cited by
- 20
- References
- 30
- Citations by year
- 2026: 2 · 2024: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- vasopressin receptor, angiotensin II receptor, oxytocin receptor, polydipsia, hypothalamic paraventricular nucleus, area postrema, nucleus tractus solitarius, brainstem, sex differences, receptor binding, strain differences
- MeSH terms
- Angiotensin II, Animals, Drinking, Female, Iodine Radioisotopes, Male, Mice, Inbred ICR, Mice, Mutant Strains, Oxytocin, Paraventricular Hypothalamic Nucleus, Polyuria, Radioligand Assay, Receptors, Angiotensin, Sex Characteristics, Ventromedial Hypothalamic Nucleus, Up-Regulation, Receptors, Vasopressin, Solitary Nucleus, Receptors, Oxytocin, Midline Thalamic Nuclei, Mice
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