Vasopressin receptors in the mouse (Mus musculus) brain: sex-related expression in the medial preoptic area and hypothalamus
Abstract
We have investigated the distribution of vasopressin binding sites in the brain of male and female adult mice using a radio-iodinated ligand and film autoradiography. Vasopressin receptors were uncovered in various regions of the brain including the basal nucleus of Meynert, the substantia innominata, the hypothalamic paraventricular nucleus, the substantia nigra pars compacta and the hypoglossal nucleus. A sex-related difference in the expression of vasopressin receptors was seen in the medial preoptic area/anterior hypothalamus corresponding to the rat sexually dimorphic nucleus in the rat and in the hypothalamic mammillary nuclei. In both structures the autoradiographic labeling is more intense in females than in males. These observations confirm that vasopressin binding sites are present in the hypothalamic preoptic area of most species examined so far and that sex-related expression of neuropeptide receptors could trigger sex-related behavioral differences.
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Female C57B6 mice had higher V1aR binding in the MPOA and mammillary nuclei compared to males.
“female C57B6 mice (n=5) had higher V1aR binding in the MPOA and mammillary nuclei compared to males (n=5”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Dubois Dauphin et al., 1996
For these species, studies only analyzed a few brain regions or had few subjects per sex, which might explain the limited brain regions in which sex differences in V1aR binding were found.
“For these species, studies only analyzed a few brain regions or had only a few subjects per sex, which might explain the limited brain regions in which sex differences in V1aR binding were found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Dubois Dauphin et al., 1996
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“Using the 125I linear V1aR antagonist, it was found that female C57B6 mice (n=5) had higher V1aR binding in the MPOA and mammillary nuclei compared to males (n=5; Dubois Dauphin et al., 1996).”
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- Authors
- Dubois-Dauphin, M., Barberis, C., & de Bilbao, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 743
- Issue
- 1-2
- Pages
- 32-39
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1981490198
- Cited by
- 57
- References
- 54
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vasopressin receptor, sex differences, medial preoptic area, anterior hypothalamus, sexually dimorphic nucleus, mouse brain
- MeSH terms
- Animals, Female, Hypothalamus, Limbic System, Male, Olfactory Bulb, Preoptic Area, Radioligand Assay, Sex Characteristics, Species Specificity, Thalamic Nuclei, Receptors, Vasopressin, Mice, Rats
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