Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset
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The aim of this study was to label selectively and to map central vasopressin (AVP) and oxytocin (OT) binding sites in the common marmoset. [(125)I]VPA, a compound selective in rodents and human for the AVP V(1a) receptor, yielded the same labeling pattern as [(3)H]AVP, thus suggesting that most AVP receptors present in the marmoset brain are of the V(1a) subtype. Numerous areas exhibited AVP binding sites, among which the olfactory bulb, the accumbens nucleus, the bed nucleus of the stria terminalis, the hypothalamic suprachiasmatic, arcuate and ventromedial nuclei, the medial amygdaloid nucleus, the nucleus of the solitary tract and the cerebral cortex. Binding sites for [(125)I]OTA, a selective OT receptor antagonist in rat and human, were markedly less abundant than [(125)I]VPA ones, and, to a few exceptions, expressed in different areas. Neither AVP, nor OT binding sites were detected in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei identified by neurophysin immunoreactivity. Marked species-related differences were observed in the distribution of both AVP and OT binding sites. Altogether, our data provide a morphological basis to investigate the function of central AVP and OT in the marmoset.
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The common marmoset has dense oxytocin receptor binding in the nucleus accumbens.
“However, the dense OXTR binding seen in the NAcc of the common marmoset (30) makes marmosets a particularly appropriate choice for exploring the role of OT in social reward, which would complement recent discoveries in mice (25).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [30]
Before the pharmacological limitations were understood, these radioligands were used for receptor autoradiography in the common marmoset, rhesus macaque, and human.
“Nevertheless, before these pharmacological limitations were fully understood, these radioligands (as well as the older tritiated versions of the endogenous neuropeptides themselves) were used for receptor autoradiography in three primate species: in the common marmoset for OXTR and AVPR1a (29,30), in the rhesus macaque for AVPR1a (31), and in human for OXTR and AVPR1a (32,33).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [30]
The highly social and selectively breeding marmoset has dense oxytocin receptor binding in the nucleus accumbens, similar to the prairie vole.
“For example, the highly social and selectively breeding marmoset has dense OXTR in the NAcc (Fig. 3a) similar to that of the prairie vole (30,85).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [30]
Other monogamous species, including common marmosets and the California mouse, also have similarly high levels of V1aR in the ventral forebrain region compared to related non-monogamous species.
“Interestingly, other monogamous species, including common marmosets and the California mouse (Peromyscus californicus) also have similarly high levels of V1aR in this ventral forebrain region compared to related non-monogamous species [17, 22].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [17]
Females in non-monogamous vole species as well as mice display very low or no OTR binding in the NAcc.
“Females in non-monogamous vole species as well as mice, display very low or no OTR binding in the NAcc, while the monogamous common marmoset (Callithrix jacchus) has high densities of OTR in this region much like the prairie vole [17].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [17]
The monogamous common marmoset has high densities of OTR in the NAcc much like the prairie vole.
“Females in non-monogamous vole species as well as mice, display very low or no OTR binding in the NAcc, while the monogamous common marmoset (Callithrix jacchus) has high densities of OTR in this region much like the prairie vole [17].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [17]
In monogamous marmosets, AVPR1a is densely expressed in the ventral pallidum and OXTR in the nucleus accumbens.
“AVPR1a is densely expressed in the ventral pallidum and OXTR in the nucleus accumbens of monogamous marmosets (Wang et al. 1997; Schorscher-Petcu et al. 2009).”
From Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species (2022) · cites this paper as Schorscher-Petcu et al. 2009
Much of what is known about OTR and V1aR density and distribution in primate brain should be cautiously evaluated in light of limitations of radioligands used for receptor autoradiography in primates.
“Thus, much of what is known about OTR and V1aR density and distribution in the primate brain (Loup et al., 1991, 1989; Schorscher-Petcu et al., 2009; Wang et al., 1997b; Young et al., 1999) should be cautiously evaluated in light of the limitations of radioligands utilized for receptor autoradiography in primates.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Schorscher-Petcu et al., 2009
Callithrix has dense OTR expression in the NAcc.
“In particular, Callithrix has dense OTR expression in the NAcc (Schorscher-Petcu et al., 2009).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Schorscher-Petcu et al., 2009
Callithrix show dense binding for V1aR in the NTS and OB, with moderate binding in the NBM; V1aR binding for the SC or V1 was not reported.
“Callithrix show dense binding for V1aR in the NTS and OB, with moderate binding in the NBM; V1aR binding for the SC or V1 was not reported (Schorscher-Petcu et al., 2009; Wang et al., 1997b).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Schorscher-Petcu et al., 2009
The ability of OT agonists to displace labeled AVP receptor antagonists in Callithrix provides a hint that cross-talk is a likely possibility in New World monkeys.
“The ability of OT agonists to displace labeled AVP receptor antagonists in Callithrix (Schorscher-Petcu et al., 2009) provides a hint that cross-talk is a likely possibility in NWM.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Schorscher-Petcu et al., 2009
While AVP immunoreactive cells were found in several brain regions of the social behavior network, only the bed nucleus of the stria terminalis (BNST) was found to be sexually dimorphic, with male marmosets expressing more AVP+ neurons than females.
“While AVP immunereactive cells were found in several brain regions of the social behavior network (Wang et al., 1997a,b; Schorscher-Petcu et al., 2009), only the bed nucleus of the stria terminalis (BSNT) was found to be sexually dimorphic, with male marmosets expressing more AVP+ neurons than females (Wang et al., 1997a).”
From Marmosets treated with oxytocin are more socially attractive to their long-term mate (2015) · cites this paper as Schorscher-Petcu et al., 2009
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- Authors
- Schorscher-Petcu, A., Dupré, A., & Tribollet, E.
- Affiliations
- Douglas Mental Health University Institute (CA)
- University of Geneva (CH)
- Corresponding author
- Tribollet, Eliane
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 461
- Issue
- 3
- Pages
- 217-222
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2028814694
- Cited by
- 111
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 18 · 2019: 4 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 6
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin, oxytocin, receptor binding sites, Callithrix jacchus, vasopressin V1a receptor, V1a receptor antagonist, species differences, hypothalamus, brain distribution, neurophysin, paraventricular nucleus, supraoptic nucleus, olfactory bulb, bed nucleus of the stria terminalis, nucleus accumbens, medial amygdala, nucleus tractus solitarius
- MeSH terms
- Animals, Arginine Vasopressin, Binding Sites, Brain, Callithrix, Female, Iodine Radioisotopes, Male, Oxytocin, Radioligand Assay, Spinal Cord, Tritium, Receptors, Vasopressin, Receptors, Oxytocin, Antidiuretic Hormone Receptor Antagonists, In Vitro Techniques
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