Cited by 397Vitamin K Research StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

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Determination of Phylloquinone and Menaquinones in Food

Schurgers, Leon J., Vermeer, Cees·2000·Pathophysiology of Haemostasis and Thrombosis

DOI 10.1159/000054147

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Abstract

Fluctuations in international normalized ratio values are often ascribed to dietary changes in vitamin K intake. Here we present a database with vitamin K(1) and K(2) contents of a wide variety of food items. K(1) was mainly present in green vegetables and plant margarins, K(2) in meat, liver, butter, egg yolk, natto, cheese and curd cheese. To investigate the effect of the food matrix on vitamin K bioavailability, 6 healthy male volunteers consumed either a detergent-solubilized K(1) (3.5 micromol) or a meal consisting 400 g of spinach (3.5 micromol K(1)) and 200 g of natto (3.1 micromol K(2)). The absorption of pure K(1) was faster than that of food-bound K vitamins (serum peak values at 4 h vs. 6 h after ingestion). Moreover, circulating K(2) concentrations after the consumption of natto were about 10 times higher than those of K(1) after eating spinach. It is concluded that the contribution of K(2) vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.

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Authors: Schurgers, L. J., & Vermeer, C.
Affiliations: Maastricht University (NL)
ORCID: Schurgers, Leon J.
Vermeer, Cees
Venue: Pathophysiology of Haemostasis and Thrombosis
Publisher: S. Karger AG
Published: 2000
Volume: 30
Issue: 6
Pages: 298-307
ISSN: 1424-8832 (ISSN-L)
1424-8840
DOI: 10.1159/000054147
OpenAlex: W2032942340
Cited by: 397
References: 33
Citations by year: 2026: 12 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 23 · 2021: 37 · 2020: 28 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 20 · 2014: 16 · 2013: 20 · 2012: 24
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Pathophysiology of Haemostasis and Thrombosis (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: vitamin K1, vitamin K2, vitamin K intake, food matrix, natto, spinach, oral anticoagulants, international normalized ratio

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Determination of Phylloquinone and Menaquinones in Food

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