The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
Search for Natural Products Related to Regeneration of the Neuronal Network
Abstract
The reconstruction of neuronal networks in the damaged brain is necessary for the therapeutic treatment of neurodegenerative diseases. We have screened the neurite outgrowth activity of herbal drugs, and identified several active constituents. In each compound, neurite outgrowth activity was investigated under amyloid-beta-induced neuritic atrophy. Most of the compounds with neurite regenerative activity also demonstrated memory improvement activity in Alzheimer's disease-model mice. Protopanaxadiol-type saponins in Ginseng drugs and their metabolite, M1 (20-O-beta-D-glucopyranosyl-(20S)-protopanaxadiol), showed potent regeneration activity for axons and synapses, and amelioration of memory impairment. Withanolide derivatives (withanolide A, withanoside IV, and withanoside VI) isolated from the Indian herbal drug Ashwagandha, also showed neurite extension in normal and damaged cortical neurons. Trigonelline, a constituent of coffee beans, demonstrated the regeneration of dendrites and axons, in addition to memory improvement.
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“Subsequently, aqueous extracts of W. somnifera elevated the activity of choline acetyl transferase and acetylcholine in rats, potentially explicating the memory- and cognition-enhancing effects [87,90].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [90]
In the citing paper
“Subsequently, aqueous extracts of W. somnifera elevated the activity of choline acetyl transferase and acetylcholine in rats, potentially explicating the memory- and cognition-enhancing effects [87,90].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [90]
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Cites
1 retracted
Retracted:Nootropic‐like effect of ashwagandha (Withania somnifera L.) in mice
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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
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DEGRADATION OF GINSENOSIDES IN HUMANS AFTER ORAL ADMINISTRATION
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Neuritic regeneration and synaptic reconstruction induced by withanolide A
Kuboyama, T., Tohda, C., & Komatsu, K. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706122 · Cited by 339
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β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons
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Cited by
Sorted by citations
Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009) · Molecules · doi:10.3390/molecules14072373 · Cited by 657
Coffee and its Consumption: Benefits and Risks
Butt, M. S., & Sultan, M. T. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903586412 · Cited by 631
Coffee: Biochemistry and Potential Impact on Health
Ludwig, I. A., Clifford, M. N., Lean, M. E. J., Ashihara, H., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00042k · Cited by 537
Withania somnifera: an Indian ginseng
Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416
Zhou, J., Chan, L., & Zhou, S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801323171 · Cited by 395
Metadata
- Authors
- Tohda, C., Kuboyama, T., & Komatsu, K.
- Affiliations
- University of Toyama (JP)
- Venue
- Neurosignals
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 14
- Issue
- 1-2
- Pages
- 34-45
- ISSN
- 1424-862X (ISSN-L)
- 1424-8638
- OpenAlex
- W1986604088
- Cited by
- 257
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 17 · 2022: 13 · 2021: 14 · 2020: 15 · 2019: 9 · 2018: 12 · 2017: 13 · 2016: 20 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 18
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosignals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- neurite outgrowth, neurodegenerative diseases, Alzheimer's disease, amyloid-beta, ginseng, withanolides, Withania somnifera, trigonelline, memory impairment, herbal drugs, synapse regeneration
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Male, Memory Disorders, Nerve Degeneration, Nerve Net, Nerve Regeneration, Molecular Structure, Neurites, Treatment Outcome, Neuroprotective Agents, Plant Preparations, Cell Line, Tumor, Mice, Rats
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