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Search for Natural Products Related to Regeneration of the Neuronal Network
Abstract
The reconstruction of neuronal networks in the damaged brain is necessary for the therapeutic treatment of neurodegenerative diseases. We have screened the neurite outgrowth activity of herbal drugs, and identified several active constituents. In each compound, neurite outgrowth activity was investigated under amyloid-beta-induced neuritic atrophy. Most of the compounds with neurite regenerative activity also demonstrated memory improvement activity in Alzheimer's disease-model mice. Protopanaxadiol-type saponins in Ginseng drugs and their metabolite, M1 (20-O-beta-D-glucopyranosyl-(20S)-protopanaxadiol), showed potent regeneration activity for axons and synapses, and amelioration of memory impairment. Withanolide derivatives (withanolide A, withanoside IV, and withanoside VI) isolated from the Indian herbal drug Ashwagandha, also showed neurite extension in normal and damaged cortical neurons. Trigonelline, a constituent of coffee beans, demonstrated the regeneration of dendrites and axons, in addition to memory improvement.
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“Subsequently, aqueous extracts of W. somnifera elevated the activity of choline acetyl transferase and acetylcholine in rats, potentially explicating the memory- and cognition-enhancing effects [87,90].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [90]
In the citing paper
“Subsequently, aqueous extracts of W. somnifera elevated the activity of choline acetyl transferase and acetylcholine in rats, potentially explicating the memory- and cognition-enhancing effects [87,90].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [90]
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Metadata
- Authors
- Tohda, C., Kuboyama, T., & Komatsu, K.
- Affiliations
- University of Toyama (JP)
- Venue
- Neurosignals
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 14
- Issue
- 1-2
- Pages
- 34-45
- ISSN
- 1424-862X (ISSN-L)
- 1424-8638
- OpenAlex
- W1986604088
- Cited by
- 257
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 17 · 2022: 13 · 2021: 14 · 2020: 15 · 2019: 9 · 2018: 12 · 2017: 13 · 2016: 20 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 18
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosignals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- neurite outgrowth, neurodegenerative diseases, Alzheimer's disease, amyloid-beta, ginseng, withanolides, Withania somnifera, trigonelline, memory impairment, herbal drugs, synapse regeneration
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Male, Memory Disorders, Nerve Degeneration, Nerve Net, Nerve Regeneration, Molecular Structure, Neurites, Treatment Outcome, Neuroprotective Agents, Plant Preparations, Cell Line, Tumor, Mice, Rats
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