Search for Natural Products Related to Regeneration of the Neuronal Network

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

LIN, H., Bhatia, R., & Lal, R. (2001) · The FASEB Journal · doi:10.1096/fj.01-0377com · Cited by 656

DEGRADATION OF GINSENOSIDES IN HUMANS AFTER ORAL ADMINISTRATION

Tawab, M. A., Bahr, U., Karas, M., Wurglics, M., & Schubert‐Zsilavecz, M. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.8.1065 · Cited by 440

Neuritic regeneration and synaptic reconstruction induced by withanolide A

Kuboyama, T., Tohda, C., & Komatsu, K. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706122 · Cited by 339

The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease

Dickson, T. C., & Vickers, J. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00169-5 · Cited by 294

Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide 1–42 - and Lipopolysaccharide-Activated Microglia

Xie, Z., Wei, M., Morgan, T. E., Fabrizio, P., Han, D., Finch, C. E., & Longo, V. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03484.2002 · Cited by 272

β-Amyloid Fragment 25–35 Causes Mitochondrial Dysfunction in Primary Cortical Neurons

Casley, C. S., Land, J. M., Sharpe, M. A., Clark, J. B., Duchen, M. R., & Canevari, L. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0516 · Cited by 207

Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities.

Zhao, J., Nakamura, N., Hattori, M., Kuboyama, T., Tohda, C., & Komatsu, K. (2002) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.50.760 · Cited by 194

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

Heinonen, O., Soininen, H., Sorvari, H., Kosunen, O., Paljärvi, L., Koivisto, E., & Riekkinen, P. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00422-2 · Cited by 188

Role of Human IntestinalPrevotella orisin Hydrolyzing Ginseng Saponins

Hasegawa, H., Sung, J.-H., & Benno, Y. (1997) · Planta Medica · doi:10.1055/s-2006-957729 · Cited by 171

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

Grace, E. A., Rabiner, C. A., & Busciglio, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00241-5 · Cited by 153

Caffeine attenuates scopolamine-induced memory impairment in humans

Reidel, W., Hogervorst, E., Leboux, R., Verhey, F., van Praag, H., & Jolles, J. (1995) · Psychopharmacology · doi:10.1007/bf02246090 · Cited by 152

Studies on Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. VII. Comparison of the Decomposition Modes of Ginsenoside-Rb1 and -Rb2 in the Digestive Tract of Rats.

Karikura, M., Miyase, T., Tanizawa, H., TANIYAMA, T., & Takino, Y. (1991) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.39.2357 · Cited by 148

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha

Kuboyama, T., Tohda, C., Zhao, J., Nakamura, N., Hattori, M., & Komatsu, K. (2002) · Neuroreport · doi:10.1097/00001756-200210070-00005 · Cited by 146

Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice

Mook‐Jung, I., Hong, H., Boo, J. H., Lee, K. H., Yun, S. H., Cheong, M. Y., Joo, I.-S., Huh, K., & Jung, M. W. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1045 · Cited by 144

Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins

Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300388 · Cited by 142

Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat.

Odani, T., Tanizawa, H., & Takino, Y. (1983) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.31.292 · Cited by 124

Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy

Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00493.2003 · Cited by 113

Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells

Tohda, C., Kuboyama, T., & Komatsu, K. (2000) · Neuroreport · doi:10.1097/00001756-200006260-00035 · Cited by 109

Comparative Study on Triterpene Saponins of Ginseng Drugs

Zhu, S., Zou, K., Fushimi, H., Cai, S., & Komatsu, K. (2004) · Planta Medica · doi:10.1055/s-2004-827192 · Cited by 98

Neuritic degeneration in the hippocampus and amygdala in Parkinson’s disease in relation to Alzheimer pathology

Mattila, P., Rinne, J., Helenius, H., & Röyttä, M. (1999) · Acta Neuropathologica · doi:10.1007/s004010051064 · Cited by 95

Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons

Fukuyama, Y., Nakade, K., Minoshima, Y., Yokoyama, R., Zhai, H., & Mitsumoto, Y. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00112-9 · Cited by 93

Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. III. The absorption, distribution and excretion of ginsenoside Rb1 in the rat.

Odani, T., Tanizawa, H., & Takino, Y. (1983) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.31.1059 · Cited by 92

The cortical neuritic pathology of Huntington's disease

Jackson, M., Gentleman, S. M., Lennox, G. G., Ward, L., Gray, T. B., Randall, K., Morrell, K., & Lowe, J. S. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01024.x · Cited by 89

Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats

Ogura, H., Kosasa, T., Kuriya, Y., & Yamanishi, Y. (2000) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2000.22.2.796070 · Cited by 81

Neuritogenic Effect of Natural Iridoid Compounds on PC12h Cells and Its Possible Relation to Signaling Protein Kinases.

Yamazaki, M., Chiba, K., & Mohri, T. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.791 · Cited by 80

Dammarane-type Triterpene Saponins from Panax japonicus

Zou, K., Zhu, S., Tohda, C., Cai, & Komatsu, K. (2002) · Journal of Natural Products · doi:10.1021/np010354j · Cited by 67

Trigonelline-Induced Neurite Outgrowth in Human Neuroblastoma SK-N-SH Cells.

Tohda, C., Nakamura, N., Komatsu, K., & Hattori, M. (1999) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.22.679 · Cited by 62

Dammarane-Type Saponins from Panax japonicus and Their Neurite Outgrowth Activity in SK-N-SH Cells

Zou, K., Zhu, S., Meselhy, M. R., Tohda, C., Cai, S., & Komatsu, K. (2002) · Journal of Natural Products · doi:10.1021/np0201117 · Cited by 61

Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells

Li, P., Matsunaga, K., Yamakuni, T., & Ohizumi, Y. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00662-2 · Cited by 57

Red ginseng ameliorated place navigation deficits in young rats with hippocampal lesions and aged rats

Zhong, Y., Nishijo, H., Uwano, T., Tamura, R., Kawanishi, K., & Ono, T. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00206-7 · Cited by 56

Substrate‐Bound β‐Amyloid Peptides Inhibit Cell Adhesion and Neurite Outgrowth in Primary Neuronal Cultures

Postuma, R. B., He, W., Nunan, J., Beyreuther, K. T., Masters, C. L., Barrow, C. J., & Small, D. H. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.741122.x · Cited by 56

Ginseng improves strategic learning by normal and brain-damaged rats

Zhao, R., & McDaniel, W. F. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00066 · Cited by 56

Neuroaxonal pathology in Creutzfeldt-Jakob disease

Liberski, P. P., & Budka, H. (1999) · Acta Neuropathologica · doi:10.1007/s004010050995 · Cited by 53

Proliferative effect of ginseng saponin on neurite extension of primary cultured neurons of the rat cerebral cortex

Sugaya, A., Yuzurihara, M., Tsuda, T., Yasuda, K., Kajiwara, K., & Sugaya, E. (1988) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(88)90125-0 · Cited by 48

Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells

Li, P., Matsunaga, K., Yamamoto, K., Yoshikawa, R., Kawashima, K., & Ohizumi, Y. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00629-1 · Cited by 47

Malonylginsenoside Rb1 Potentiates Nerve Growth Factor (NGF)-Induced Neurite Outgrowth of Cultured Chick Embryonic Dorsal Root Ganglia.

Nishiyama, N., Cho, S.-I., KITAGAWA, I., & Saito, H. (1994) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.17.509 · Cited by 47

Axonal and Dendritic Extension by Protopanaxadiol-Type Saponins From Ginseng Drugs in SK-N-SH Cells

Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.90.254 · Cited by 46

POTENTIATION OF THE NGF-MEDIATED NERVE FIBER OUTGROWTH BY GINSENOSIDE Rb1 IN ORGAN CULTURES OF CHICKEN DORSAL ROOT GANGLIA

Saitō, H., Suda, K., Schwab, M. E., & Thoenen, H. (1977) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.27.445 · Cited by 31

(−)-3,5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: through tyrosine kinase cascade signaling

Hur, J. Y., Lee, P., Kim, H., Kang, I., Lee, K. R., & Kim, S. Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.178 · Cited by 31

Kaffee und Gesundheit

Czok, G. (1977) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf02023704 · Cited by 10

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009) · Molecules · doi:10.3390/molecules14072373 · Cited by 657

Coffee and its Consumption: Benefits and Risks

Butt, M. S., & Sultan, M. T. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903586412 · Cited by 631

Coffee: Biochemistry and Potential Impact on Health

Ludwig, I. A., Clifford, M. N., Lean, M. E. J., Ashihara, H., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00042k · Cited by 537

Withania somnifera: an Indian ginseng

Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416

Trigonelline: A Plant Alkaloid with Therapeutic Potential for Diabetes and Central Nervous System Disease

Zhou, J., Chan, L., & Zhou, S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801323171 · Cited by 395

Neuritic regeneration and synaptic reconstruction induced by withanolide A

Kuboyama, T., Tohda, C., & Komatsu, K. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706122 · Cited by 339

Development of New Therapies for Neurodegenerative Diseases via Axonal Growth

Kuboyama, T. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00147 · Cited by 1

New Age Therapy for Alzheimer’s Disease by Neuronal Network Reconstruction

Tohda, C. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00438 · Cited by 14

Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins

Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300388 · Cited by 142

Axonal and Dendritic Extension by Protopanaxadiol-Type Saponins From Ginseng Drugs in SK-N-SH Cells

Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.90.254 · Cited by 46