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Neurotransplantation of Fetal Porcine Cells in Patients with Basal Ganglia Infarcts: A Preliminary Safety and Feasibility Study
Abstract
Background: Cell transplantation is safe in animal models and enhances recovery from stroke in rats. Methods: We studied the safety and feasibility of fetal porcine transplantation in 5 patients with basal ganglia infarcts and stable neurological deficits. To prevent rejection, cells were pretreated with an anti-MHC1 antibody and no immunosuppressive drugs were given to the patients. Results: The first 3 patients had no adverse cell, procedure, or imaging-defined effects. The fourth patient had temporary worsening of motor deficits 3 weeks after transplantation, and the fifth patient developed seizures 1 week after transplantation. MRI in both patients demonstrated areas of enhancement remote from the transplant site, which resolved on subsequent imaging. Two patients showed improvement in speech, language, and/or motor impairments over several months and persisted at 4 years. The study was terminated by the FDA after the inclusion of 5 patients. Conclusion: This is the first report on the transplantation of nontumor cells in ischemic stroke patients.
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Citations
Cited by
Cell transplantation therapy for stroke
Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007) · Stroke · doi:10.1161/01.str.0000247888.25985.62 · Cited by 374
Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain
Andres, R. H., Horie, N., Slikker, W., Keren-Gill, H., Zhan, K., Sun, G., Manley, N. C., Pereira, M. P., Sheikh, L. A., McMillan, E. L., et al. (2011) · Brain · doi:10.1093/brain/awr094 · Cited by 329
Neural stem/precursor cells for the treatment of ischemic stroke
Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.012 · Cited by 111
Engineering islets from stem cells: The optimal solution for the treatment of diabetes
Du, S., Li, Y., Geng, Z., Zhang, Q., Buhler, L. H., Gonelle-Gispert, C., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869514 · Cited by 9
Metadata
- Authors
- Savitz, S. I., Dinsmore, J., Wu, J., Henderson, G. V., Stieg, P., & Caplan, L. R.
- Venue
- Cerebrovascular Diseases
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 20
- Issue
- 2
- Pages
- 101-107
- ISSN
- 1015-9770 (ISSN-L)
- 1421-9786
- OpenAlex
- W1987907711
- Cited by
- 227
- References
- 0
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Savitz, S. I., Dinsmore, J., Wu, J., Henderson, G. V., Stieg, P., & Caplan, L. R. (2005). Neurotransplantation of Fetal Porcine Cells in Patients with Basal Ganglia Infarcts: A Preliminary Safety and Feasibility Study. Cerebrovascular Diseases. https://doi.org/10.1159/000086518
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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