CoChat
Sign Up
Cited by 97Schizophrenia research and treatmentMental Health and PsychiatryFamily Caregiving in Mental Illness

PANSS syndromes and quality of life in schizophrenia.

Karow, A., Moritz, S., Lambert, M., Schoder, S., Krausz, M.·2005·Psychopathology
DOI 10.1159/000088921
Open this paper in CoChat — free account

Abstract

BACKGROUND: Results from factor analysis studies have suggested that a five-dimensional structure appears to be a better representation of the psychopathological data of the PANSS. The purpose of this study was the detailed investigation of the association of schizophrenia syndromes and single symptoms with quality of life (QOL) in acute and remitted patients. The leading hypotheses were: (1) affective symptoms, especially depression and anxiety, are mostly associated with QOL longitudinally and (2) in the acute phase, QOL is also associated with positive schizophrenia symptoms. METHODS: For the present study, schizophrenia and schizophreniform patients were studied on admission, at the end of the acute phase and 6 months after hospitalization. Psychopathology was measured using the PANSS syndromes, QOL was assessed using disease-specific (SWN) and generic (MLDL, EDLQ) scales. RESULTS: Eighty-four patients entered the study and were assessed during the acute phase taking into account their history and actual treatment. Results revealed anxiety as the most important symptom and depression as the most important syndrome associated with different areas of QOL during and after hospitalization. Also cognitive and negative symptoms were associated with different QOL domains, but both positive symptom clusters showed no substantial association with QOL. CONCLUSIONS: Results of this longitudinal study investigating psychopathology and QOL in schizophrenia provide further support for the need to consider the psychopathological state and treatment setting when measuring QOL in schizophrenia and the need for a differential analysis of schizophrenia symptoms and QOL in the acute, mid-term and long-term phase. Anxiety reduction should be a critical goal of treatment in order to prevent further QOL impairment.

Integrity signals

Registry

Crossref · 10.1159/000088921

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Both severe positive symptoms and crisis-associated hospitalization are believed to contribute to secondary activation of negative symptoms and comorbid mood/anxiety disorders, resulting in increased chronification risk.

    “Both are believed to contribute to the secondary activation of negative symptoms such as poor rapport (83) and comorbid disorders like mood and anxiety disorders (84) resulting in an increased chronification risk (85).”

    From Developing a mechanism-based therapy for acute psychiatric inpatients with psychotic symptoms: an Intervention Mapping approach (2023) · cites this paper as [83]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Karow, A., Moritz, S., Lambert, M., Schoder, S., & Krausz, M.
Affiliations
University Medical Center Hamburg-Eppendorf (DE)
ORCID
Venue
Psychopathology
Publisher
S. Karger AG
Published
2005
Volume
38
Issue
6
Pages
320-326
ISSN
  • 0254-4962 (ISSN-L)
  • 1423-033X
DOI
10.1159/000088921
OpenAlex
W2025885047
Cited by
97
References
33
Citations by year
2025: 2 · 2023: 1 · 2022: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 1 · 2014: 5 · 2013: 9 · 2012: 9
FWCI
4.61
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
Keywords
schizophrenia, quality of life, schizophrenia syndromes, affective symptoms, depression, anxiety, positive symptoms, negative symptoms, cognitive symptoms, acute phase, schizophreniform disorder
MeSH terms
Acute Disease, Adult, Anxiety, Depression, Female, Humans, Longitudinal Studies, Male, Periodicity, Psychiatric Status Rating Scales, Quality of Life, Schizophrenia, Schizophrenic Psychology, Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review